Click here to switch to the map view.

The map label for this gene is cvrA [H]

Identifier: 93004987

GI number: 93004987

Start: 183977

End: 186271

Strand: Reverse

Name: cvrA [H]

Synonym: Pcryo_0156

Alternate gene names: 93004987

Gene position: 186271-183977 (Counterclockwise)

Preceding gene: 93004992

Following gene: 93004984

Centisome position: 6.09

GC content: 44.97

Gene sequence:

>2295_bases
ATGGATACCGCCCTATTGTTATCCGGCGTGGTTGGGATCGGCATTGCCGCCCAATGGTTGGCTTGGTATTTAAAGCAACC
GTCCATTTTGTTTTTATTACTGATTGGTATTATAGTTGGTCCAGTATTAGGGGTTTTCGATCCTGACTTAGTACTCGGCG
AACTGATGTTTCCCTTTATCTCACTAGGCGTAGCGATTATCTTATTTGAAGGATCGCTGACCTTGGAGTTTGAGGAGATT
AAACAACACGGCTCTGTAGTACAGATGCTGGTTTCCGTCGGTGTGCTAATCACTATCGCTATCGTGTCGCTGTCGACGTA
TTTGCTCTTCGATATCGACCCTATTATTGCCTTGTTGTTTGGGGCACTGGTCTGCGTGACTGGTCCAACGGTCATTATGC
CGTTACTGCGCAGTGTACGACCCAATAAAACCATCTCCAATATCTTAAAATGGGAAGGTATCATTATCGACCCTATCGGC
GCGATTGCGGTGGTATTGGTCTATGAATATATTATCTCAGGTGGTGAAGCCAGTAGTATTTTGCTGTTTGCTAAGATTGT
GGTATTGGCAGTAGCAATGGGGCTAGCTGGCGCGTGGGCATTAGCATTTTTGATGCGTCGCCATATGATTCCTGAATTTT
TACGCAATGTTTTTACCCTTGCTTTTGTACTGGTGTTGTTTTCAATCTCCAACCATCTGGAACATGAATCCGGTTTATTG
ACGGTGACTGTACTTGGGGTTGCGCTGGCTAATTGGCCAAAATTCCCACGTGATACGATTTTAGAGTTCAATGAATCGCT
CACCATCTTATTGGTGTCGGTCTTATTTATTATTCTTGCAGCGCGTGTTGAGCTGGAAAGCTTATTGAGTGTCGGCTTTG
CAGGTCTCGTGCTACTAGCGATTGTAATGTTTGTCGCCCGCCCCCTATCGGTTTGGGTGTCGTCTATCGGCTCTAACCTA
AAGACCAAAGAAAAACTGATGATCAGCTGGATTGGTCCGCGCGGTATCGTTGCTGCTGCCATCTCATCACTCTTTGCCAT
TCGTTTACAAGAGTATGATATTCAAGGGGTTGAGCTACTAGTGCCTTTGGTGTTTTTGGTCATTATTGGTACGGTGATGA
TTCAGGGCTTGGGCGCAAAAATGGTAGGGAACTTTTTGGGTGTCCGTGAGCCTGAAACCAACGGTATCTTGGTCGTTGGC
TCAAACCCTGTCGCTTTGTTGGTTGCTACTTCGTTAAAGGATCAGGGCTTTGATGTCATCGTTGCTCATAATAACTATAC
CAACATCGCTAGCGCGCGCATGAGTGGCTTGCGTACTTACTTTGGCAATCCTGTCTCTGACCACGCTGACCATCATTTGG
ATCTCATCGGTATCGGACGTTTATTTGCCATGAGTATGGATAAAGAGCTGAATACTTTATCCGAGATTCACTATCGTCAT
GAGTTCGGTGAGCGCAAACTGTACCGCTTAAAGTTTAGCGATGAAAAAGTCAAAAGTGAGCGCGATGACAAGCAAGGAAA
CTTCCATTCGCAGTGGCTATTTGGCAAAGATGTGACCTATACCAAGCTTGCCAGTATGCTGTCCAAGAAAGCCCGTATTA
AAATCACCAATATCACCGACAGCTATAGCTTTGAGCAATATAAAGCCGATAATAAGCAATTTGTGCCGCTTTATACGGTC
GATAAAGAAGGCAAGCTACATGTAATTACTGACAAATTCGATGGTACGGTGCCGCGTGATCGCAAGCTTGTTTCATTGGT
CGTCGATGATGACGTACAGCCAAAACCGGTCGATGTGACGCCGCAACAAGAGCAAGCGCGCGCTGCAGCTGACGCAAGCT
TTGAGTCCGACTCTAAAGCGCCTGAAAAACGCCAAGAAATAGAGCTGGCGGACGATGATAGTGATGTAGAGGAAGCATCT
TTGATAGATAACGACAAAGACGCTGAACAAAATCTACCTAATGATGTGTCAGCTGATGCTAGCTTAGCGTCTAATCCATC
TTCAACCATGCCAACAGCATTAAATGATGAAGCAGCTAACGAAAAAATAGCAACATCTGAATCTGCCAGTACTAGTCAGG
TCAATCCCGAAGTATTGCCTGCGAATCCTAATACGCCAGTAATACCTAAAACAGCCAGCAGTAATAAAAACAGTGGTAAC
GGTAATGGCAGTGCGCCTAAAAATAAAAACGGCTCTCTAGACCCTAACCGTTTACCGGACTCAGGCCAAGATAAAGCGGC
CAAGAGTAATACTGCTGAAGTTATATTAAATAAAGATATAGGTAAAAATGATTGA

Upstream 100 bases:

>100_bases
GTGATGTGAATGAATCATGAACTAAAAAACCGTCTATGCTAAATGCTATAGCCTCGAATCGCTCTACAGCATGACTATAT
TATTATAAAAGGATTAATTT

Downstream 100 bases:

>100_bases
GATACTGGTCATATAGCTAAAACCTAAATAAACAACGCTTAAATAGTGTTTATTAAATGCCTATCAATGAACAAAGCCCC
AACTAGTTAGTTGGGGCTTT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 764

Protein sequence:

>764_residues
MDTALLLSGVVGIGIAAQWLAWYLKQPSILFLLLIGIIVGPVLGVFDPDLVLGELMFPFISLGVAIILFEGSLTLEFEEI
KQHGSVVQMLVSVGVLITIAIVSLSTYLLFDIDPIIALLFGALVCVTGPTVIMPLLRSVRPNKTISNILKWEGIIIDPIG
AIAVVLVYEYIISGGEASSILLFAKIVVLAVAMGLAGAWALAFLMRRHMIPEFLRNVFTLAFVLVLFSISNHLEHESGLL
TVTVLGVALANWPKFPRDTILEFNESLTILLVSVLFIILAARVELESLLSVGFAGLVLLAIVMFVARPLSVWVSSIGSNL
KTKEKLMISWIGPRGIVAAAISSLFAIRLQEYDIQGVELLVPLVFLVIIGTVMIQGLGAKMVGNFLGVREPETNGILVVG
SNPVALLVATSLKDQGFDVIVAHNNYTNIASARMSGLRTYFGNPVSDHADHHLDLIGIGRLFAMSMDKELNTLSEIHYRH
EFGERKLYRLKFSDEKVKSERDDKQGNFHSQWLFGKDVTYTKLASMLSKKARIKITNITDSYSFEQYKADNKQFVPLYTV
DKEGKLHVITDKFDGTVPRDRKLVSLVVDDDVQPKPVDVTPQQEQARAAADASFESDSKAPEKRQEIELADDDSDVEEAS
LIDNDKDAEQNLPNDVSADASLASNPSSTMPTALNDEAANEKIATSESASTSQVNPEVLPANPNTPVIPKTASSNKNSGN
GNGSAPKNKNGSLDPNRLPDSGQDKAAKSNTAEVILNKDIGKND

Sequences:

>Translated_764_residues
MDTALLLSGVVGIGIAAQWLAWYLKQPSILFLLLIGIIVGPVLGVFDPDLVLGELMFPFISLGVAIILFEGSLTLEFEEI
KQHGSVVQMLVSVGVLITIAIVSLSTYLLFDIDPIIALLFGALVCVTGPTVIMPLLRSVRPNKTISNILKWEGIIIDPIG
AIAVVLVYEYIISGGEASSILLFAKIVVLAVAMGLAGAWALAFLMRRHMIPEFLRNVFTLAFVLVLFSISNHLEHESGLL
TVTVLGVALANWPKFPRDTILEFNESLTILLVSVLFIILAARVELESLLSVGFAGLVLLAIVMFVARPLSVWVSSIGSNL
KTKEKLMISWIGPRGIVAAAISSLFAIRLQEYDIQGVELLVPLVFLVIIGTVMIQGLGAKMVGNFLGVREPETNGILVVG
SNPVALLVATSLKDQGFDVIVAHNNYTNIASARMSGLRTYFGNPVSDHADHHLDLIGIGRLFAMSMDKELNTLSEIHYRH
EFGERKLYRLKFSDEKVKSERDDKQGNFHSQWLFGKDVTYTKLASMLSKKARIKITNITDSYSFEQYKADNKQFVPLYTV
DKEGKLHVITDKFDGTVPRDRKLVSLVVDDDVQPKPVDVTPQQEQARAAADASFESDSKAPEKRQEIELADDDSDVEEAS
LIDNDKDAEQNLPNDVSADASLASNPSSTMPTALNDEAANEKIATSESASTSQVNPEVLPANPNTPVIPKTASSNKNSGN
GNGSAPKNKNGSLDPNRLPDSGQDKAAKSNTAEVILNKDIGKND
>Mature_764_residues
MDTALLLSGVVGIGIAAQWLAWYLKQPSILFLLLIGIIVGPVLGVFDPDLVLGELMFPFISLGVAIILFEGSLTLEFEEI
KQHGSVVQMLVSVGVLITIAIVSLSTYLLFDIDPIIALLFGALVCVTGPTVIMPLLRSVRPNKTISNILKWEGIIIDPIG
AIAVVLVYEYIISGGEASSILLFAKIVVLAVAMGLAGAWALAFLMRRHMIPEFLRNVFTLAFVLVLFSISNHLEHESGLL
TVTVLGVALANWPKFPRDTILEFNESLTILLVSVLFIILAARVELESLLSVGFAGLVLLAIVMFVARPLSVWVSSIGSNL
KTKEKLMISWIGPRGIVAAAISSLFAIRLQEYDIQGVELLVPLVFLVIIGTVMIQGLGAKMVGNFLGVREPETNGILVVG
SNPVALLVATSLKDQGFDVIVAHNNYTNIASARMSGLRTYFGNPVSDHADHHLDLIGIGRLFAMSMDKELNTLSEIHYRH
EFGERKLYRLKFSDEKVKSERDDKQGNFHSQWLFGKDVTYTKLASMLSKKARIKITNITDSYSFEQYKADNKQFVPLYTV
DKEGKLHVITDKFDGTVPRDRKLVSLVVDDDVQPKPVDVTPQQEQARAAADASFESDSKAPEKRQEIELADDDSDVEEAS
LIDNDKDAEQNLPNDVSADASLASNPSSTMPTALNDEAANEKIATSESASTSQVNPEVLPANPNTPVIPKTASSNKNSGN
GNGSAPKNKNGSLDPNRLPDSGQDKAAKSNTAEVILNKDIGKND

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=330, Percent_Identity=27.8787878787879, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 83011; Mature: 83011

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTALLLSGVVGIGIAAQWLAWYLKQPSILFLLLIGIIVGPVLGVFDPDLVLGELMFPFI
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SLGVAIILFEGSLTLEFEEIKQHGSVVQMLVSVGVLITIAIVSLSTYLLFDIDPIIALLF
HHHHEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALVCVTGPTVIMPLLRSVRPNKTISNILKWEGIIIDPIGAIAVVLVYEYIISGGEASSI
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCHHHH
LLFAKIVVLAVAMGLAGAWALAFLMRRHMIPEFLRNVFTLAFVLVLFSISNHLEHESGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
TVTVLGVALANWPKFPRDTILEFNESLTILLVSVLFIILAARVELESLLSVGFAGLVLLA
HHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVMFVARPLSVWVSSIGSNLKTKEKLMISWIGPRGIVAAAISSLFAIRLQEYDIQGVELL
HHHHHHHHHHHHHHHHCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
VPLVFLVIIGTVMIQGLGAKMVGNFLGVREPETNGILVVGSNPVALLVATSLKDQGFDVI
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCEEE
VAHNNYTNIASARMSGLRTYFGNPVSDHADHHLDLIGIGRLFAMSMDKELNTLSEIHYRH
EEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
EFGERKLYRLKFSDEKVKSERDDKQGNFHSQWLFGKDVTYTKLASMLSKKARIKITNITD
HHCCCEEEEEECCHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHCCCCEEEEEECCC
SYSFEQYKADNKQFVPLYTVDKEGKLHVITDKFDGTVPRDRKLVSLVVDDDVQPKPVDVT
CCCHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCC
PQQEQARAAADASFESDSKAPEKRQEIELADDDSDVEEASLIDNDKDAEQNLPNDVSADA
CCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCHHHCCCCCCCCCC
SLASNPSSTMPTALNDEAANEKIATSESASTSQVNPEVLPANPNTPVIPKTASSNKNSGN
HHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
GNGSAPKNKNGSLDPNRLPDSGQDKAAKSNTAEVILNKDIGKND
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MDTALLLSGVVGIGIAAQWLAWYLKQPSILFLLLIGIIVGPVLGVFDPDLVLGELMFPFI
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SLGVAIILFEGSLTLEFEEIKQHGSVVQMLVSVGVLITIAIVSLSTYLLFDIDPIIALLF
HHHHEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GALVCVTGPTVIMPLLRSVRPNKTISNILKWEGIIIDPIGAIAVVLVYEYIISGGEASSI
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCCHHHH
LLFAKIVVLAVAMGLAGAWALAFLMRRHMIPEFLRNVFTLAFVLVLFSISNHLEHESGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
TVTVLGVALANWPKFPRDTILEFNESLTILLVSVLFIILAARVELESLLSVGFAGLVLLA
HHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVMFVARPLSVWVSSIGSNLKTKEKLMISWIGPRGIVAAAISSLFAIRLQEYDIQGVELL
HHHHHHHHHHHHHHHHCCCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
VPLVFLVIIGTVMIQGLGAKMVGNFLGVREPETNGILVVGSNPVALLVATSLKDQGFDVI
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCEEE
VAHNNYTNIASARMSGLRTYFGNPVSDHADHHLDLIGIGRLFAMSMDKELNTLSEIHYRH
EEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
EFGERKLYRLKFSDEKVKSERDDKQGNFHSQWLFGKDVTYTKLASMLSKKARIKITNITD
HHCCCEEEEEECCHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHCCCCEEEEEECCC
SYSFEQYKADNKQFVPLYTVDKEGKLHVITDKFDGTVPRDRKLVSLVVDDDVQPKPVDVT
CCCHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCC
PQQEQARAAADASFESDSKAPEKRQEIELADDDSDVEEASLIDNDKDAEQNLPNDVSADA
CCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCHHHCCCCCCCCCC
SLASNPSSTMPTALNDEAANEKIATSESASTSQVNPEVLPANPNTPVIPKTASSNKNSGN
HHCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
GNGSAPKNKNGSLDPNRLPDSGQDKAAKSNTAEVILNKDIGKND
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]