Click here to switch to the map view.

The map label for this gene is hisC2 [H]

Identifier: 92115272

GI number: 92115272

Start: 3522142

End: 3523251

Strand: Direct

Name: hisC2 [H]

Synonym: Csal_3157

Alternate gene names: 92115272

Gene position: 3522142-3523251 (Clockwise)

Preceding gene: 92115271

Following gene: 92115273

Centisome position: 95.28

GC content: 70.09

Gene sequence:

>1110_bases
ATGTCCCGCTATGCTCGCCACCTAGACCGCTCGGGCCCGACCAATCCCTTCCCCGGCCTCAAGGCGCTGGAGCGCAAGCT
GGGCCGAGAAGTCCCCCACCGGCTGGGCTCCAACGAAGGCCTCGACATGCCGCACCGGGCGCTCAAGGCGCGCTTTGGCG
ACGCGGTCGCCGAGCTTGCCCGGGCTTACGGCGACGCCGAGGCCATGGAGGTGCGTCAGCGGCTCGTCTCGCTGCTCGGC
ACGCCACTGGAGGCGCTGCTGGTCGATGCCGGCGCCGACAGCCTGATGGCGCTCGCCCTGCGCACGCTGTGTGACCCCGG
CAGCACGGTGATCGCCAGCGCGGGCACCTATCCCACCTTTCGCTACTTCGCCGAGGGGCAAGGATGTCGCTTGGTCGAGG
TCGACTACCACGACGCCCCCGGCAGGTTGGCGCCGGATCTCGACGCCCTGGCCGCCAGAGCGGTGCATGAACAAGCCCGC
GTGGTCTATCTGGCCAACCCCGACAACCCCAGCGGTCACCTGCACAGCGATGCCGACGTCCTCGCGCTGCGCAATGCCCT
GCCCGAGGACTGCACGCTGTTGCTCGACGAGGCCTATCACGACTTCCGTGACGATGCCGACGCCCCCGCCGCCGGTGAGG
TGTGGCCCGGCGTGGTGCGTCTGCGAACCTTCTCCAAGGCCCATGGTCTGGCCGGCCTGCGGATCGGTTACACCATTGCC
GAACCGGCACTGATCGACATCATGCACAAGGTGCGCATTCATTATGCCGTCTCGTCGCTGGCTCTGGCGGCCGCCGAGAC
CGTGCTCGATCACCCGGAGGAAACCGCACAACACATCCGGGACGTGAACGCCCGTCGCGATGCCCTGGCCGACCACCTGC
GAACGCTGGGCGCCGACGTGCCACCCAGCGCCACCAACTTCATCGCCGTGCGCCTGCCCGACGCGGACCTTGCCGCCCGC
GTGCACCGCGAGCTGCTCGAGGCCGGCACGCTCGTGCACCGCCCCGCGCATCCGGCACTGGGCCACGTGCTGCGCATCAG
TACGCTCGAGGACGCCCTGGTGCCCGGCCGGCTGGCCGCGCTGGAGCGCGCACTCGAGCCACGGGCCTGA

Upstream 100 bases:

>100_bases
GGCACTGGATGCCAGCGCGTTGTAGCCGGCACGGGCCCGGCCACGTTGTTTCAGGCCCGTCACGGTCGCACAATGCGCCT
TTTGCCCTCAGGAGTCTTGC

Downstream 100 bases:

>100_bases
GCATGACACGCGGCTGGGTGGCATCGCTGTGGCACGGGGTCCTGGCCAGCCTCATGGCGCTGCTCATCATTGCCAGCAGC
GGCTGGGCGGTGCTGGCGCT

Product: aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSRYARHLDRSGPTNPFPGLKALERKLGREVPHRLGSNEGLDMPHRALKARFGDAVAELARAYGDAEAMEVRQRLVSLLG
TPLEALLVDAGADSLMALALRTLCDPGSTVIASAGTYPTFRYFAEGQGCRLVEVDYHDAPGRLAPDLDALAARAVHEQAR
VVYLANPDNPSGHLHSDADVLALRNALPEDCTLLLDEAYHDFRDDADAPAAGEVWPGVVRLRTFSKAHGLAGLRIGYTIA
EPALIDIMHKVRIHYAVSSLALAAAETVLDHPEETAQHIRDVNARRDALADHLRTLGADVPPSATNFIAVRLPDADLAAR
VHRELLEAGTLVHRPAHPALGHVLRISTLEDALVPGRLAALERALEPRA

Sequences:

>Translated_369_residues
MSRYARHLDRSGPTNPFPGLKALERKLGREVPHRLGSNEGLDMPHRALKARFGDAVAELARAYGDAEAMEVRQRLVSLLG
TPLEALLVDAGADSLMALALRTLCDPGSTVIASAGTYPTFRYFAEGQGCRLVEVDYHDAPGRLAPDLDALAARAVHEQAR
VVYLANPDNPSGHLHSDADVLALRNALPEDCTLLLDEAYHDFRDDADAPAAGEVWPGVVRLRTFSKAHGLAGLRIGYTIA
EPALIDIMHKVRIHYAVSSLALAAAETVLDHPEETAQHIRDVNARRDALADHLRTLGADVPPSATNFIAVRLPDADLAAR
VHRELLEAGTLVHRPAHPALGHVLRISTLEDALVPGRLAALERALEPRA
>Mature_368_residues
SRYARHLDRSGPTNPFPGLKALERKLGREVPHRLGSNEGLDMPHRALKARFGDAVAELARAYGDAEAMEVRQRLVSLLGT
PLEALLVDAGADSLMALALRTLCDPGSTVIASAGTYPTFRYFAEGQGCRLVEVDYHDAPGRLAPDLDALAARAVHEQARV
VYLANPDNPSGHLHSDADVLALRNALPEDCTLLLDEAYHDFRDDADAPAAGEVWPGVVRLRTFSKAHGLAGLRIGYTIAE
PALIDIMHKVRIHYAVSSLALAAAETVLDHPEETAQHIRDVNARRDALADHLRTLGADVPPSATNFIAVRLPDADLAARV
HRELLEAGTLVHRPAHPALGHVLRISTLEDALVPGRLAALERALEPRA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=296, Percent_Identity=28.3783783783784, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322075, Length=289, Percent_Identity=26.643598615917, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39887; Mature: 39756

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYARHLDRSGPTNPFPGLKALERKLGREVPHRLGSNEGLDMPHRALKARFGDAVAELA
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RAYGDAEAMEVRQRLVSLLGTPLEALLVDAGADSLMALALRTLCDPGSTVIASAGTYPTF
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCCCH
RYFAEGQGCRLVEVDYHDAPGRLAPDLDALAARAVHEQARVVYLANPDNPSGHLHSDADV
HHEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHH
LALRNALPEDCTLLLDEAYHDFRDDADAPAAGEVWPGVVRLRTFSKAHGLAGLRIGYTIA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECHHHH
EPALIDIMHKVRIHYAVSSLALAAAETVLDHPEETAQHIRDVNARRDALADHLRTLGADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PPSATNFIAVRLPDADLAARVHRELLEAGTLVHRPAHPALGHVLRISTLEDALVPGRLAA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHCCHHHHH
LERALEPRA
HHHHHCCCC
>Mature Secondary Structure 
SRYARHLDRSGPTNPFPGLKALERKLGREVPHRLGSNEGLDMPHRALKARFGDAVAELA
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RAYGDAEAMEVRQRLVSLLGTPLEALLVDAGADSLMALALRTLCDPGSTVIASAGTYPTF
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCCCH
RYFAEGQGCRLVEVDYHDAPGRLAPDLDALAARAVHEQARVVYLANPDNPSGHLHSDADV
HHEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHH
LALRNALPEDCTLLLDEAYHDFRDDADAPAAGEVWPGVVRLRTFSKAHGLAGLRIGYTIA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECHHHH
EPALIDIMHKVRIHYAVSSLALAAAETVLDHPEETAQHIRDVNARRDALADHLRTLGADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PPSATNFIAVRLPDADLAARVHRELLEAGTLVHRPAHPALGHVLRISTLEDALVPGRLAA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHCCHHHHH
LERALEPRA
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]