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The map label for this gene is proC [H]

Identifier: 92115170

GI number: 92115170

Start: 3404181

End: 3405005

Strand: Direct

Name: proC [H]

Synonym: Csal_3055

Alternate gene names: 92115170

Gene position: 3404181-3405005 (Clockwise)

Preceding gene: 92115169

Following gene: 92115171

Centisome position: 92.09

GC content: 68.61

Gene sequence:

>825_bases
ATGACCAGCCAAGTCACATTCATCGGTGCCGGCAACATGGCGAGCGCCATCTTCGGAGGCATGGTCGAGGGCGGTTATCC
CGCCGAGGCCATCACCGCCACCGGGCGGGATCCCCAGGCGCTCGCCGCACTTGCCGAGCGCCATGGCATCCGTACCACCA
CCGACAACCTCGCCGCCGTGGACGGTGCCGATGTCGTGGTGCTCGCCGTCAAACCGCAGATCATGCGCGAGGTGTGCCAT
GAGCTTCGCGACACGGTGCAGGCGCAGCGGCCCCTGATCGTCTCCGTGGCCGCCGGCTTGAACGCCGCGACGCTGGAGAA
CTGGCTCGGCGGCGAGCTCGCCGTGATTCGCTGCATGCCCAACACCCCCAGTCTCGTCGGCCAGGGTGCGGCAGGCTTGT
TCGCCAACGCGCGGGTCAGCGAATCGCAGAAGCAACTGGCCACCACCCTGCTGGAAGCCGTGGGTCTGGTGGAATGGGTC
GCCGATGAAACGCTGCTCGAGGCCGTCACCGCCGTGTCGGGAAGCGGCCCGGCCTACTTCTTCCTGATCATGGAAGCGCT
CGAGGATGCCGGCAAGAAACTCGGCCTCCCCGCCGACAGCGCTCGCCGCCTGGCCTTGCAGACCGCCTTCGGCGCGGCGA
GCATGGCTCGCGAAAGCGAGTTCGAGCCGGCCGAGTTGCGCCGCCGCGTCACCTCGCCCAATGGCACCACCGAGCGTGCC
ATCGCCAGTTTCGAGGACGACGGCCTGCGCCGCCTCTTCGAGAACGCGACGCAAGCCTGCGCCACCCGCGCCCGGGAGCT
GTCCGACGAACTGAGCCGCGACTGA

Upstream 100 bases:

>100_bases
TGGGTACGCCTGGGCACGGCCATTTTCGGCCAGCGTGCGCCGCGCGCCTGACTGCCTTGTCCCCAACCGTATCGCGTCGC
CGCGACATTCAGGAGATACC

Downstream 100 bases:

>100_bases
CACTACTCTTATCACCCATTCGACATGGAGGAGCCCCATGGGCAGCCAAATGGGAAGCGCCGGCTTGATGCTGGTCAACA
CGCTAGTCAATGTGTATCTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MTSQVTFIGAGNMASAIFGGMVEGGYPAEAITATGRDPQALAALAERHGIRTTTDNLAAVDGADVVVLAVKPQIMREVCH
ELRDTVQAQRPLIVSVAAGLNAATLENWLGGELAVIRCMPNTPSLVGQGAAGLFANARVSESQKQLATTLLEAVGLVEWV
ADETLLEAVTAVSGSGPAYFFLIMEALEDAGKKLGLPADSARRLALQTAFGAASMARESEFEPAELRRRVTSPNGTTERA
IASFEDDGLRRLFENATQACATRARELSDELSRD

Sequences:

>Translated_274_residues
MTSQVTFIGAGNMASAIFGGMVEGGYPAEAITATGRDPQALAALAERHGIRTTTDNLAAVDGADVVVLAVKPQIMREVCH
ELRDTVQAQRPLIVSVAAGLNAATLENWLGGELAVIRCMPNTPSLVGQGAAGLFANARVSESQKQLATTLLEAVGLVEWV
ADETLLEAVTAVSGSGPAYFFLIMEALEDAGKKLGLPADSARRLALQTAFGAASMARESEFEPAELRRRVTSPNGTTERA
IASFEDDGLRRLFENATQACATRARELSDELSRD
>Mature_273_residues
TSQVTFIGAGNMASAIFGGMVEGGYPAEAITATGRDPQALAALAERHGIRTTTDNLAAVDGADVVVLAVKPQIMREVCHE
LRDTVQAQRPLIVSVAAGLNAATLENWLGGELAVIRCMPNTPSLVGQGAAGLFANARVSESQKQLATTLLEAVGLVEWVA
DETLLEAVTAVSGSGPAYFFLIMEALEDAGKKLGLPADSARRLALQTAFGAASMARESEFEPAELRRRVTSPNGTTERAI
ASFEDDGLRRLFENATQACATRARELSDELSRD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=38.4328358208955, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=38.4328358208955, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=39.1791044776119, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI198041662, Length=271, Percent_Identity=36.5313653136531, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=34.8148148148148, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=275, Percent_Identity=36.3636363636364, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=30.6338028169014, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=30.2405498281787, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21358587, Length=278, Percent_Identity=34.8920863309352, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=35.4838709677419, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=39.4117647058824, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28889; Mature: 28758

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQVTFIGAGNMASAIFGGMVEGGYPAEAITATGRDPQALAALAERHGIRTTTDNLAAV
CCCCEEEEECCCHHHHHHHHHCCCCCCHHHEEECCCCHHHHHHHHHHCCCCCCCCCEEEE
DGADVVVLAVKPQIMREVCHELRDTVQAQRPLIVSVAAGLNAATLENWLGGELAVIRCMP
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHCCCCEEEEEECC
NTPSLVGQGAAGLFANARVSESQKQLATTLLEAVGLVEWVADETLLEAVTAVSGSGPAYF
CCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
FLIMEALEDAGKKLGLPADSARRLALQTAFGAASMARESEFEPAELRRRVTSPNGTTERA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
IASFEDDGLRRLFENATQACATRARELSDELSRD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSQVTFIGAGNMASAIFGGMVEGGYPAEAITATGRDPQALAALAERHGIRTTTDNLAAV
CCCEEEEECCCHHHHHHHHHCCCCCCHHHEEECCCCHHHHHHHHHHCCCCCCCCCEEEE
DGADVVVLAVKPQIMREVCHELRDTVQAQRPLIVSVAAGLNAATLENWLGGELAVIRCMP
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHCCCCEEEEEECC
NTPSLVGQGAAGLFANARVSESQKQLATTLLEAVGLVEWVADETLLEAVTAVSGSGPAYF
CCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
FLIMEALEDAGKKLGLPADSARRLALQTAFGAASMARESEFEPAELRRRVTSPNGTTERA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
IASFEDDGLRRLFENATQACATRARELSDELSRD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]