Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 92115027

GI number: 92115027

Start: 3241682

End: 3242947

Strand: Direct

Name: fabF [H]

Synonym: Csal_2911

Alternate gene names: 92115027

Gene position: 3241682-3242947 (Clockwise)

Preceding gene: 92115024

Following gene: 92115030

Centisome position: 87.69

GC content: 69.19

Gene sequence:

>1266_bases
ATGTCATCACCGCTCGTTATCACCGGCATGGGCATGGTCAGTCCCCTTGGTTGCGGCGTCAACGCCAACTGGGAGCGCCT
GCTGGCCGGCCGCTCCGGCGTTTCCTCTATCACGCGCTTCGAGACCGGCGAGCTGCCGATCAAGGTCGCGGGTACGGTCC
CCGGTAGGGAGAGCGACCCGGAAGCGGGCTTCGACCCCGATCGCGTGGCCGATGCAAAAGAACGTCGCAAGATGGAGCTG
TTCAGCCTTTATGCCATGGCCGCCGCCGAAGAGGCGCTGACCCAGGCGAACTGGTTTCCATCGAGCGATGAGGACCGGTT
GGCCACCGCCACCATCGTGGGCTCCGGCATCGGCGGCTTCCCGACCATCACCCAGGCGCAGAACACGCTTTCGACACGCG
GCTATCGCCGACTCTCGCCGTTCACCGTGCCGGCCTTTTTGGCCAACCTGGCGGCGGGCAATGTGTCGATTCGCTATGGC
CTGCGCGGGCCGCTGGGCTGCCCGGTCACGGCCTGCGCGGCGGGGGTGCAGGCCATCGGCGATGGCATGCGCCTGATCCG
CAGCGGCGAGGCCGAAGTGGCCCTGGTGGGTGGCGCCGAGGCCTGTATCGACCCGCTCTCGCTGGCCAGCTTCCATGCCA
TGAAGGCGCTCTCCACCGAGCAGGCGGCGCCTGCCAAGGCGTCGCGGCCTTTCGATCAGGCCCGTAACGGCTTCGTCATG
GGCGAAGGCGCGGGGCTCCTGGTGATCGAGACCCTGGCCCACGCCGAGGCGCGCGGGGCGACACCACTGGCTTTTCTCAG
CGGCTATGGCACCAGCGCGGATGCCCATCACATCACGGCCGGACCGGAAGATGGCGCCGGGGCCGCGGCGGCCATTCGGG
CCGCGCTGCGGATGGCGGGACTCGCCCCCGAGGCCATCGATCACATCAACGCCCACGCCACCTCGACCCCGGTCGGCGAC
CGGGCGGAAATCGCCGCGCTGCGCAACGCGTTCGGTGACGCTCTGCCTGGCATTCCGATCTCCGCCACCAAGTCGGCCAC
CGGGCACCTGCTCGGTGCCGCCGGCGGTGTGGAGAGCATCTTCTCGGCCCTGGCGGCCATCCAGGATCGCCTGCCCCCGA
CCCTGAATCTGGAACACGCCGACGCGGACCTGAGCGATCTGGACCTCGTCCCTGGCGAGGCGCGCGAGCATCGCTGCCGG
CACGTGCTGTGCAACGGGTTCGGCTTCGGCGGGGTGAATGCCGCGCTGATCGTCAGCAAGGCCTGA

Upstream 100 bases:

>100_bases
TGCTGCTCAGAATAGGTGCTGAATACACGCTGAATATTATCTTGATCATATCAAGCCCGGTGCTAGCGTGGCGTAAACTC
CAACAGTTCAGGACACTCGC

Downstream 100 bases:

>100_bases
GCCCTTTTCGGACTCGGTCCAGGCACTTGTCGGATCAGGCTCAGCCATCACCCACAAAAATGCCGCTTCCGAGGAAGCGG
CAAAGCATGAGTCGGACGCG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSSPLVITGMGMVSPLGCGVNANWERLLAGRSGVSSITRFETGELPIKVAGTVPGRESDPEAGFDPDRVADAKERRKMEL
FSLYAMAAAEEALTQANWFPSSDEDRLATATIVGSGIGGFPTITQAQNTLSTRGYRRLSPFTVPAFLANLAAGNVSIRYG
LRGPLGCPVTACAAGVQAIGDGMRLIRSGEAEVALVGGAEACIDPLSLASFHAMKALSTEQAAPAKASRPFDQARNGFVM
GEGAGLLVIETLAHAEARGATPLAFLSGYGTSADAHHITAGPEDGAGAAAAIRAALRMAGLAPEAIDHINAHATSTPVGD
RAEIAALRNAFGDALPGIPISATKSATGHLLGAAGGVESIFSALAAIQDRLPPTLNLEHADADLSDLDLVPGEAREHRCR
HVLCNGFGFGGVNAALIVSKA

Sequences:

>Translated_421_residues
MSSPLVITGMGMVSPLGCGVNANWERLLAGRSGVSSITRFETGELPIKVAGTVPGRESDPEAGFDPDRVADAKERRKMEL
FSLYAMAAAEEALTQANWFPSSDEDRLATATIVGSGIGGFPTITQAQNTLSTRGYRRLSPFTVPAFLANLAAGNVSIRYG
LRGPLGCPVTACAAGVQAIGDGMRLIRSGEAEVALVGGAEACIDPLSLASFHAMKALSTEQAAPAKASRPFDQARNGFVM
GEGAGLLVIETLAHAEARGATPLAFLSGYGTSADAHHITAGPEDGAGAAAAIRAALRMAGLAPEAIDHINAHATSTPVGD
RAEIAALRNAFGDALPGIPISATKSATGHLLGAAGGVESIFSALAAIQDRLPPTLNLEHADADLSDLDLVPGEAREHRCR
HVLCNGFGFGGVNAALIVSKA
>Mature_420_residues
SSPLVITGMGMVSPLGCGVNANWERLLAGRSGVSSITRFETGELPIKVAGTVPGRESDPEAGFDPDRVADAKERRKMELF
SLYAMAAAEEALTQANWFPSSDEDRLATATIVGSGIGGFPTITQAQNTLSTRGYRRLSPFTVPAFLANLAAGNVSIRYGL
RGPLGCPVTACAAGVQAIGDGMRLIRSGEAEVALVGGAEACIDPLSLASFHAMKALSTEQAAPAKASRPFDQARNGFVMG
EGAGLLVIETLAHAEARGATPLAFLSGYGTSADAHHITAGPEDGAGAAAAIRAALRMAGLAPEAIDHINAHATSTPVGDR
AEIAALRNAFGDALPGIPISATKSATGHLLGAAGGVESIFSALAAIQDRLPPTLNLEHADADLSDLDLVPGEAREHRCRH
VLCNGFGFGGVNAALIVSKA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=45.4545454545455, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI223972627, Length=187, Percent_Identity=39.572192513369, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI41872631, Length=275, Percent_Identity=28, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1787337, Length=417, Percent_Identity=45.8033573141487, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=34.9282296650718, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=39.1923990498812, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=41.5094339622642, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=336, Percent_Identity=25.5952380952381, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=282, Percent_Identity=25.531914893617, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=454, Percent_Identity=38.5462555066079, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=45.2153110047847, Blast_Score=334, Evalue=6e-92,
Organism=Drosophila melanogaster, GI19920632, Length=282, Percent_Identity=27.3049645390071, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330659, Length=278, Percent_Identity=27.3381294964029, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24581345, Length=275, Percent_Identity=25.4545454545455, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43108; Mature: 42977

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPLVITGMGMVSPLGCGVNANWERLLAGRSGVSSITRFETGELPIKVAGTVPGRESDP
CCCCEEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEEECCCCCCCCC
EAGFDPDRVADAKERRKMELFSLYAMAAAEEALTQANWFPSSDEDRLATATIVGSGIGGF
CCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCC
PTITQAQNTLSTRGYRRLSPFTVPAFLANLAAGNVSIRYGLRGPLGCPVTACAAGVQAIG
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHH
DGMRLIRSGEAEVALVGGAEACIDPLSLASFHAMKALSTEQAAPAKASRPFDQARNGFVM
HHHHHHHCCCCCEEEECCHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEE
GEGAGLLVIETLAHAEARGATPLAFLSGYGTSADAHHITAGPEDGAGAAAAIRAALRMAG
ECCCCEEEEHHHHHHHHCCCCCCHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHC
LAPEAIDHINAHATSTPVGDRAEIAALRNAFGDALPGIPISATKSATGHLLGAAGGVESI
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHH
FSALAAIQDRLPPTLNLEHADADLSDLDLVPGEAREHRCRHVLCNGFGFGGVNAALIVSK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEC
A
C
>Mature Secondary Structure 
SSPLVITGMGMVSPLGCGVNANWERLLAGRSGVSSITRFETGELPIKVAGTVPGRESDP
CCCEEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEEECCCCCCCCC
EAGFDPDRVADAKERRKMELFSLYAMAAAEEALTQANWFPSSDEDRLATATIVGSGIGGF
CCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCC
PTITQAQNTLSTRGYRRLSPFTVPAFLANLAAGNVSIRYGLRGPLGCPVTACAAGVQAIG
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHH
DGMRLIRSGEAEVALVGGAEACIDPLSLASFHAMKALSTEQAAPAKASRPFDQARNGFVM
HHHHHHHCCCCCEEEECCHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEE
GEGAGLLVIETLAHAEARGATPLAFLSGYGTSADAHHITAGPEDGAGAAAAIRAALRMAG
ECCCCEEEEHHHHHHHHCCCCCCHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHC
LAPEAIDHINAHATSTPVGDRAEIAALRNAFGDALPGIPISATKSATGHLLGAAGGVESI
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHH
FSALAAIQDRLPPTLNLEHADADLSDLDLVPGEAREHRCRHVLCNGFGFGGVNAALIVSK
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]