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The map label for this gene is cvrA [H]

Identifier: 92114439

GI number: 92114439

Start: 2606689

End: 2608488

Strand: Direct

Name: cvrA [H]

Synonym: Csal_2318

Alternate gene names: 92114439

Gene position: 2606689-2608488 (Clockwise)

Preceding gene: 92114438

Following gene: 92114443

Centisome position: 70.51

GC content: 67.11

Gene sequence:

>1800_bases
ATGGAGCACGCTGCCTTCGACCTGACATTGATCGGCCTGCTTGCGCTGATCTGCCAATGGCTGGCCTGGCGTCTCAAACT
GCCGGCGATCCTGCCGCTCTTGATCGCGGGTATCGTCATGGGGCCGGTGACCGGCTTGCTCCAGCCCGACGCCTTGCTCG
GCGACCTGCTGTTTCCGCTCGTCTCGCTGGCGGTGGCGGTGATCCTGTTCGAGGGCAGCCTGACGCTCGACTTCGGCGAC
CTGCGCGGCCACGGCCACATCGTGCGCCGGCTGGTCACCTGGGGCGCGCTGGTCACGGGAATCATCGCCATCGTGGCGGC
GCGCTACACCCTGGGGCTGTCGTGGGAAATGGCCAGCGTGCTCGGCGCGGTCCTGGTGGTCACCGGGCCCACCGTGGTCC
TGCCCCTGCTGCAGACGCTGCGTGCCCGCGAACACCTCTCGCAGATCCTGCGCTGGGAAGGCATCCTCATCGATCCGGTG
GGAGCCATCGGCGCGGTACTGGTGTATGAGTTCGTCGCGCTGGGCGCCTCCAACGGCGCCGCCACCTATACCCTGGTACT
GTTCGCCAAGACCGCCCTGATCGGGTTCGGTCTGGGCGGCCTGGGCGGCTATCTATGGGGGTGCGTGCTGCGGCACCACT
GGCTGCCGCAGCGTCTGCACAGCTTCGGCACGCTGATGGCCATGCTGACGCTGTTCACGCTGTCCAACATGCTCTTCCAC
GAGTCCGGCCTGCTGACGGTGACGGTGATGGGCGTGTGGCTGGCGAACATGCGCGGCGTGCCCACGCAGCAGATCATCGA
GTTCAAGGAAACGCTCTCGGTGCTCCTGATCTCGGGCCTGTTCATCCTGCTCGCGGCGCGGCTGACCACCGACCAGCTCG
CGCAGCTGTCCTGGCCGGCCTGGGCGTTCCTGCTCATTCTGGTGGGCGTGGCCCGCCCGCTCGCGGTCTGGGTATGCACC
GCGGGCACACGACTCAACTGGCGGGAAAAAGCCTTGCTGGCCTGGCTGTCGCCGCGCGGTATCGTGGCCGCCGCGGTGGC
GTCGCTGTTCGCCATCAAGCTCGAGAATCTGGGCATGCCCGGCGCCGAGATGCTGGTCCCGGTGACCTTTCTGGTCATCA
TCAGCACCGTCGTGGTGCAGAGCCTGTTGTCGCGCCCGATCGCCCTGGCCCTGAAGGTCAGCGAGCCACCTCCCACCGGC
TTTCTGATCATCGGTGCCAACCCCGTGGCACGCGCCATCGCCAAGGCACTGGAAGAATCCGGCTTCACCGTGCGGCTCAC
CGACAACAGCTGGGACGCGGTGCAGGAAGCGCGCATGGCAGGGCTCCCGGTCTACTACGGCAACCCGCTTTCGGAGCATG
CCGCGCAACACCTGGAACTGACCGGCATCGGTCATCTGCTGCCGCTGTCGCCCTATCGCGAGTTGAACAACCTGGCGGTC
CTGCATTTCGAACACGTGCTGGGGCACGGCAAGGTCTTCCGTCTCGCGGCGGGCACCGGCAAGCACGCCCATCGCCATCA
GGAACAGGCGCTGGACCACCTGCCGCTGGTGTTCGGCGAGAGCGTCACCTATGCCCAGCTGTCGAGCGTGGTCCACCGTG
GCGGCGAGGTACGCAAGGCCAAGCTGTCGGCCAGTTTCAGCTTCGAGGACTATCGCCAGGCACACCAGGACCGCCTGCTG
CCGCTGTTCTGCATCGGCCCCAACGGCCGCATCCGCGTCGCCAACGACCGGGTGCCGCTGGCGCCTCGCGCCGGCGACAC
CGTGATCAGCCTGATCCAGGTGGACTCTCCCGAGTACTGA

Upstream 100 bases:

>100_bases
AGCGATGCCAATCCATCCGTCATTGAGCGTTCACGGCGCATTGCAACTGGCGTGAGGCGACGCTAGGCTTCGCGCTTCCG
TTTTCCCAAGGAGCGCGACC

Downstream 100 bases:

>100_bases
CCGACGTACGCCCCCCATGACGCCATCGGGCCGCACGCAGCGGCCCGATGGCGATCGACTCGAGGCAATGGCGCGCCTAG
AAAAACAGGCGACGCAAGGC

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MEHAAFDLTLIGLLALICQWLAWRLKLPAILPLLIAGIVMGPVTGLLQPDALLGDLLFPLVSLAVAVILFEGSLTLDFGD
LRGHGHIVRRLVTWGALVTGIIAIVAARYTLGLSWEMASVLGAVLVVTGPTVVLPLLQTLRAREHLSQILRWEGILIDPV
GAIGAVLVYEFVALGASNGAATYTLVLFAKTALIGFGLGGLGGYLWGCVLRHHWLPQRLHSFGTLMAMLTLFTLSNMLFH
ESGLLTVTVMGVWLANMRGVPTQQIIEFKETLSVLLISGLFILLAARLTTDQLAQLSWPAWAFLLILVGVARPLAVWVCT
AGTRLNWREKALLAWLSPRGIVAAAVASLFAIKLENLGMPGAEMLVPVTFLVIISTVVVQSLLSRPIALALKVSEPPPTG
FLIIGANPVARAIAKALEESGFTVRLTDNSWDAVQEARMAGLPVYYGNPLSEHAAQHLELTGIGHLLPLSPYRELNNLAV
LHFEHVLGHGKVFRLAAGTGKHAHRHQEQALDHLPLVFGESVTYAQLSSVVHRGGEVRKAKLSASFSFEDYRQAHQDRLL
PLFCIGPNGRIRVANDRVPLAPRAGDTVISLIQVDSPEY

Sequences:

>Translated_599_residues
MEHAAFDLTLIGLLALICQWLAWRLKLPAILPLLIAGIVMGPVTGLLQPDALLGDLLFPLVSLAVAVILFEGSLTLDFGD
LRGHGHIVRRLVTWGALVTGIIAIVAARYTLGLSWEMASVLGAVLVVTGPTVVLPLLQTLRAREHLSQILRWEGILIDPV
GAIGAVLVYEFVALGASNGAATYTLVLFAKTALIGFGLGGLGGYLWGCVLRHHWLPQRLHSFGTLMAMLTLFTLSNMLFH
ESGLLTVTVMGVWLANMRGVPTQQIIEFKETLSVLLISGLFILLAARLTTDQLAQLSWPAWAFLLILVGVARPLAVWVCT
AGTRLNWREKALLAWLSPRGIVAAAVASLFAIKLENLGMPGAEMLVPVTFLVIISTVVVQSLLSRPIALALKVSEPPPTG
FLIIGANPVARAIAKALEESGFTVRLTDNSWDAVQEARMAGLPVYYGNPLSEHAAQHLELTGIGHLLPLSPYRELNNLAV
LHFEHVLGHGKVFRLAAGTGKHAHRHQEQALDHLPLVFGESVTYAQLSSVVHRGGEVRKAKLSASFSFEDYRQAHQDRLL
PLFCIGPNGRIRVANDRVPLAPRAGDTVISLIQVDSPEY
>Mature_599_residues
MEHAAFDLTLIGLLALICQWLAWRLKLPAILPLLIAGIVMGPVTGLLQPDALLGDLLFPLVSLAVAVILFEGSLTLDFGD
LRGHGHIVRRLVTWGALVTGIIAIVAARYTLGLSWEMASVLGAVLVVTGPTVVLPLLQTLRAREHLSQILRWEGILIDPV
GAIGAVLVYEFVALGASNGAATYTLVLFAKTALIGFGLGGLGGYLWGCVLRHHWLPQRLHSFGTLMAMLTLFTLSNMLFH
ESGLLTVTVMGVWLANMRGVPTQQIIEFKETLSVLLISGLFILLAARLTTDQLAQLSWPAWAFLLILVGVARPLAVWVCT
AGTRLNWREKALLAWLSPRGIVAAAVASLFAIKLENLGMPGAEMLVPVTFLVIISTVVVQSLLSRPIALALKVSEPPPTG
FLIIGANPVARAIAKALEESGFTVRLTDNSWDAVQEARMAGLPVYYGNPLSEHAAQHLELTGIGHLLPLSPYRELNNLAV
LHFEHVLGHGKVFRLAAGTGKHAHRHQEQALDHLPLVFGESVTYAQLSSVVHRGGEVRKAKLSASFSFEDYRQAHQDRLL
PLFCIGPNGRIRVANDRVPLAPRAGDTVISLIQVDSPEY

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 64780; Mature: 64780

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure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HHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]