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The map label for this gene is accC [H]

Identifier: 92114406

GI number: 92114406

Start: 2573425

End: 2574771

Strand: Direct

Name: accC [H]

Synonym: Csal_2285

Alternate gene names: 92114406

Gene position: 2573425-2574771 (Clockwise)

Preceding gene: 92114405

Following gene: 92114407

Centisome position: 69.62

GC content: 63.77

Gene sequence:

>1347_bases
ATGTTGGACAAGGTACTCATCGCCAATCGTGGCGAGATCGCTTTGCGCATACTGCGCGCTTGCAAGGAACTCGGCATCAA
GACCGTGGCGGTGCATTCCAAGGCCGACCGCGAGCTCATGCACGTGCGCCTGGCCGATGAAGCCGTGTGCATCGGCCCCG
CGTCCTCGGCGCAGTCCTACCTGAACATCCCGGCGTTGATCAGCGCCGCCGAGGTCACCGATTCAAGCGCCATCCATCCC
GGCTACGGCTTCCTCTCCGAGAATGCCAACTTCGCCGAACAGGTGGAGCGCTCCGGCTTCGTCTTCGTGGGACCGCGCGC
CGAAACCATCCGCATGATGGGCGACAAGGTCAGCGCCATTTCGGCGATGAAGAAGGCCGGCGTACCCACGGTGCCCGGCT
CCGACGGCCCGCTCCCCGAAGACAACGACGACGCCATTCTGGCCACCGCCAAGCGCATCGGTTATCCGGTCATCATCAAG
GCGGCCGCCGGCGGCGGCGGACGTGGCATGCGCGTGGTGCACAGCGAAGGCAGCCTGCTCTCCTCGGTCAGCGTGACACG
CAACGAAGCCAATGCGGCGTTCGGCGACGGCACGCTGTACATGGAGAAGTTCCTCGAGAACCCGCGTCACGTCGAAGTCC
AGGTGCTGGCCGACGGACAGGGCAATGCCATCCACCTCTACGATCGCGACTGCTCCCTGCAGCGCCGTCACCAGAAGGTG
CTGGAAGAAGCCCCCGCGCCGCATCTCGATCCGAAAGCCCGCGCCGATGTTCTCCAGGCCTGCGTGGATGCCTGCAACGA
GATCAACTATCGCGGAGCCGGCACGTTCGAGTTCCTGTACGAGAACGGCGAGTTCTTCTTCATCGAGATGAACACGCGCG
TGCAGGTCGAGCACCCCGTGTCCGAGATGGTCACCGGCGTCGACATCGTCAAGGAGCAGCTGCGCATTGCTTCCGGACTG
CCGCTGTCGATCACCCAGGATGACGTTCAGCTCAACGGGCACGCCTTCGAATGCCGGATCAACGCCGAGGACTCGCGCAC
CTTCATGCCCTCCCCCGGCAAGATCGATCTGTATCACGCTCCCGGCGGCCTGGGCGTGCGCATGGATTCGCACATCTACA
CCGGCTACAGCGTACCGCCCCACTACGATTCGCTGCTCGGCAAGCTGATCACCTGGGGCGCCAGCCGCGAGACGGCGTTG
ACGCGCATGCGCAATGCCCTCGACGAGCTCCTGGTCGAAGGCATCAAGACCAACATCGACCTGCAGAAGGACCTCGTCCG
CGACAGCGCGTTCATGCAAGGCGGTGTCAACATCCACTACCTCGAGAAGAAACTCGGCCTGACCTAG

Upstream 100 bases:

>100_bases
TTCGACCAGCCGATGGTCATCATCTCTTGAAGCCGTTTGCGATCGCCCAGAGTGAACGATCGCCAACCGCTTCCGAGCTT
ACATAGAGACGGACGACACT

Downstream 100 bases:

>100_bases
TCGGGTCGAGCGACTCGTCACGGGGCGGCCTAGGCCGTCCCGTTTGCGTTGATGCCCAAGGAGGCCCCATGCCCTGGCTG
CAACTCAAGGCGCATATCGC

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLDKVLIANRGEIALRILRACKELGIKTVAVHSKADRELMHVRLADEAVCIGPASSAQSYLNIPALISAAEVTDSSAIHP
GYGFLSENANFAEQVERSGFVFVGPRAETIRMMGDKVSAISAMKKAGVPTVPGSDGPLPEDNDDAILATAKRIGYPVIIK
AAAGGGGRGMRVVHSEGSLLSSVSVTRNEANAAFGDGTLYMEKFLENPRHVEVQVLADGQGNAIHLYDRDCSLQRRHQKV
LEEAPAPHLDPKARADVLQACVDACNEINYRGAGTFEFLYENGEFFFIEMNTRVQVEHPVSEMVTGVDIVKEQLRIASGL
PLSITQDDVQLNGHAFECRINAEDSRTFMPSPGKIDLYHAPGGLGVRMDSHIYTGYSVPPHYDSLLGKLITWGASRETAL
TRMRNALDELLVEGIKTNIDLQKDLVRDSAFMQGGVNIHYLEKKLGLT

Sequences:

>Translated_448_residues
MLDKVLIANRGEIALRILRACKELGIKTVAVHSKADRELMHVRLADEAVCIGPASSAQSYLNIPALISAAEVTDSSAIHP
GYGFLSENANFAEQVERSGFVFVGPRAETIRMMGDKVSAISAMKKAGVPTVPGSDGPLPEDNDDAILATAKRIGYPVIIK
AAAGGGGRGMRVVHSEGSLLSSVSVTRNEANAAFGDGTLYMEKFLENPRHVEVQVLADGQGNAIHLYDRDCSLQRRHQKV
LEEAPAPHLDPKARADVLQACVDACNEINYRGAGTFEFLYENGEFFFIEMNTRVQVEHPVSEMVTGVDIVKEQLRIASGL
PLSITQDDVQLNGHAFECRINAEDSRTFMPSPGKIDLYHAPGGLGVRMDSHIYTGYSVPPHYDSLLGKLITWGASRETAL
TRMRNALDELLVEGIKTNIDLQKDLVRDSAFMQGGVNIHYLEKKLGLT
>Mature_448_residues
MLDKVLIANRGEIALRILRACKELGIKTVAVHSKADRELMHVRLADEAVCIGPASSAQSYLNIPALISAAEVTDSSAIHP
GYGFLSENANFAEQVERSGFVFVGPRAETIRMMGDKVSAISAMKKAGVPTVPGSDGPLPEDNDDAILATAKRIGYPVIIK
AAAGGGGRGMRVVHSEGSLLSSVSVTRNEANAAFGDGTLYMEKFLENPRHVEVQVLADGQGNAIHLYDRDCSLQRRHQKV
LEEAPAPHLDPKARADVLQACVDACNEINYRGAGTFEFLYENGEFFFIEMNTRVQVEHPVSEMVTGVDIVKEQLRIASGL
PLSITQDDVQLNGHAFECRINAEDSRTFMPSPGKIDLYHAPGGLGVRMDSHIYTGYSVPPHYDSLLGKLITWGASRETAL
TRMRNALDELLVEGIKTNIDLQKDLVRDSAFMQGGVNIHYLEKKLGLT

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=48.4234234234234, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=47.0720720720721, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=47.0720720720721, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=47.0720720720721, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=46.5478841870824, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=46.5478841870824, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=46.5478841870824, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=30.1369863013699, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=30.1369863013699, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=30.1369863013699, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=30.1369863013699, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=30.1369863013699, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=30.078125, Blast_Score=228, Evalue=9e-60,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=72.2595078299776, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=186, Percent_Identity=25.8064516129032, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=46.3963963963964, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=46.1711711711712, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=42.7616926503341, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=28.2352941176471, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=28.2352941176471, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=26.530612244898, Blast_Score=180, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=42.7927927927928, Blast_Score=355, Evalue=8e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=44.671201814059, Blast_Score=352, Evalue=9e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=45.578231292517, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=30.2325581395349, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=457, Percent_Identity=31.7286652078775, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=42.6339285714286, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=46.1883408071749, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=46.1883408071749, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=46.1883408071749, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=46.1883408071749, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=46.1883408071749, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=46.1883408071749, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=46.1883408071749, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=46.1883408071749, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=46.1883408071749, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=46.1883408071749, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=41.9512195121951, Blast_Score=347, Evalue=8e-96,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=30.6930693069307, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=30.6930693069307, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=30.6930693069307, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=30.6930693069307, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48738; Mature: 48738

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKVLIANRGEIALRILRACKELGIKTVAVHSKADRELMHVRLADEAVCIGPASSAQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEECCCHHHHHH
LNIPALISAAEVTDSSAIHPGYGFLSENANFAEQVERSGFVFVGPRAETIRMMGDKVSAI
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
SAMKKAGVPTVPGSDGPLPEDNDDAILATAKRIGYPVIIKAAAGGGGRGMRVVHSEGSLL
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCEEEEEECCCCCCCEEEEECCCCEE
SSVSVTRNEANAAFGDGTLYMEKFLENPRHVEVQVLADGQGNAIHLYDRDCSLQRRHQKV
EHEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHH
LEEAPAPHLDPKARADVLQACVDACNEINYRGAGTFEFLYENGEFFFIEMNTRVQVEHPV
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCEEEEECCH
SEMVTGVDIVKEQLRIASGLPLSITQDDVQLNGHAFECRINAEDSRTFMPSPGKIDLYHA
HHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEECCCCCCEECCCCCEEEEEEC
PGGLGVRMDSHIYTGYSVPPHYDSLLGKLITWGASRETALTRMRNALDELLVEGIKTNID
CCCCEEEECCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQKDLVRDSAFMQGGVNIHYLEKKLGLT
HHHHHHHHHHHHHCCCEEEEEHHHHCCC
>Mature Secondary Structure
MLDKVLIANRGEIALRILRACKELGIKTVAVHSKADRELMHVRLADEAVCIGPASSAQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEECCCHHHHHH
LNIPALISAAEVTDSSAIHPGYGFLSENANFAEQVERSGFVFVGPRAETIRMMGDKVSAI
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
SAMKKAGVPTVPGSDGPLPEDNDDAILATAKRIGYPVIIKAAAGGGGRGMRVVHSEGSLL
HHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCEEEEEECCCCCCCEEEEECCCCEE
SSVSVTRNEANAAFGDGTLYMEKFLENPRHVEVQVLADGQGNAIHLYDRDCSLQRRHQKV
EHEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHH
LEEAPAPHLDPKARADVLQACVDACNEINYRGAGTFEFLYENGEFFFIEMNTRVQVEHPV
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCEEEEECCH
SEMVTGVDIVKEQLRIASGLPLSITQDDVQLNGHAFECRINAEDSRTFMPSPGKIDLYHA
HHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEECCCCCCEECCCCCEEEEEEC
PGGLGVRMDSHIYTGYSVPPHYDSLLGKLITWGASRETALTRMRNALDELLVEGIKTNID
CCCCEEEECCEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQKDLVRDSAFMQGGVNIHYLEKKLGLT
HHHHHHHHHHHHHCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]