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The map label for this gene is atoC [H]

Identifier: 92114207

GI number: 92114207

Start: 2352772

End: 2354133

Strand: Direct

Name: atoC [H]

Synonym: Csal_2085

Alternate gene names: 92114207

Gene position: 2352772-2354133 (Clockwise)

Preceding gene: 92114197

Following gene: 92114208

Centisome position: 63.65

GC content: 63.95

Gene sequence:

>1362_bases
ATGACCGCATCCACCGAATTGCCTACCGCCTCCGTGCTGATCGTCGATGACGAGCCCGGCATGCGTAGCTATCTGAGCAA
GGCGTTGGCGTCGCGATTCGCGCTGATCGAAACCGCCGATTCGCTCACCGCGGCGGAGGCCCTGCGTCAACGGCTGCACT
TCGATCTGCTGCTGGTCGACATCCGGCTCCCCGACCGCTCCGGCATCGAGTGGCACGAGGCACTCGGCCCCGAGCGGCGC
AGCGACATCATTTTCATGACGGCCTACGCCGATCTCGACATTGCGGTGAAGGCATTACGCGCCGGCGCCAGCGACTTCAT
CATCAAGCCGTTCCGGCTGGAACAGCTGCAAAGCGCCGTCGATCGCTGCCTGGCCCAGCGCCGACTGGCACGCGAGAACT
TCGTTCTCAAGCGCGAGGCGCAACGTCTGCACAGTCCCGACGAGAGCATGATCGGCGACAGTCAGGCCATGGCACGGGTC
AGGACGATCATCGAGCGCGTGGCGCCTACTCCCTCGGCGGTCTTGATCTATGGCGAGTCGGGCACCGGCAAGGAGCTCGT
GGCCCGCGACCTGCATCGCCTGTCGGGACGTTTCGGCGCCTTCGTACCGCTAAACTGCGGCGCCATCGCCGGCGACTTGC
TGGAATCGGAGCTGTTCGGACACACCAGGGGCGCGTTCACCGGCGCGGTGAAGACCCGTGAAGGGCTTTTCACCTATGCC
GACGGTGGCACTCTCTTCCTCGACGAAATCGCCGAAATGCCGCTGGCCATGCAGGCCAAGCTGTTGCGGGTGCTCGAAAG
CAAGCGCATCCGTCCGGTGGGCAGCGAGCAGGAACAGCCGGTGGATGTGCGCATCGTCGCGGCCACGCATCGCAATCTGC
AGCATGAGGTCAACGAGGGTCGCTTCCGCGAGGACCTGTATTTTCGCCTCAACGTGCTGACACTACCGTTGCCGGCGTTG
CGCGAACGTCCCGAAGACATACCCGCTCTGGCACATCATTTCTCGCGACAGTTGTCCCGCGACCTGGGACTCGACGCCCT
GCCGTGGCAGCATGCCGACCTCGAGCGCCTGACGCATTATTCCTGGCCGGGCAACATCCGCGAGCTCAAGAACTTCATCG
AACGCTGCATCCTGCTCGGCCAATTGCCGAGCGACATGTTCGATGATGCCGTCGTTGCCGAAACCAACCTCAACGCCGAC
GGCTACCCCACGGACTGGACTCTGGACGCCGTCGAACGAGCGCATATCCTCAACGTGCTGGACGCGCACGCCAACAACAA
GTCCAGTGCCGCTCGCGCGCTCGGCGTGTCGCGCAAGACGCTCGATCGCAAGCTCACCGCCTGGCAAGACCTCGACGCAT
GA

Upstream 100 bases:

>100_bases
GTCGCGCCTTTTACCATGAAAATAATCTTGCCGCGCACCAAATGTAACAAATTGACCCAATGACGAGACATACTGTCCCG
TCGCGTAGGGAATGCCGCCC

Downstream 100 bases:

>100_bases
ACGGCCTGCGCCGCTGGTTGCGCGCCTCGATCCGTCGCCGCCTGCTATGGCTGGCCTTCGCGCCGCTGGTCCTGCTGGCA
TTGGCGCTCGCCGGGCTCAC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTASTELPTASVLIVDDEPGMRSYLSKALASRFALIETADSLTAAEALRQRLHFDLLLVDIRLPDRSGIEWHEALGPERR
SDIIFMTAYADLDIAVKALRAGASDFIIKPFRLEQLQSAVDRCLAQRRLARENFVLKREAQRLHSPDESMIGDSQAMARV
RTIIERVAPTPSAVLIYGESGTGKELVARDLHRLSGRFGAFVPLNCGAIAGDLLESELFGHTRGAFTGAVKTREGLFTYA
DGGTLFLDEIAEMPLAMQAKLLRVLESKRIRPVGSEQEQPVDVRIVAATHRNLQHEVNEGRFREDLYFRLNVLTLPLPAL
RERPEDIPALAHHFSRQLSRDLGLDALPWQHADLERLTHYSWPGNIRELKNFIERCILLGQLPSDMFDDAVVAETNLNAD
GYPTDWTLDAVERAHILNVLDAHANNKSSAARALGVSRKTLDRKLTAWQDLDA

Sequences:

>Translated_453_residues
MTASTELPTASVLIVDDEPGMRSYLSKALASRFALIETADSLTAAEALRQRLHFDLLLVDIRLPDRSGIEWHEALGPERR
SDIIFMTAYADLDIAVKALRAGASDFIIKPFRLEQLQSAVDRCLAQRRLARENFVLKREAQRLHSPDESMIGDSQAMARV
RTIIERVAPTPSAVLIYGESGTGKELVARDLHRLSGRFGAFVPLNCGAIAGDLLESELFGHTRGAFTGAVKTREGLFTYA
DGGTLFLDEIAEMPLAMQAKLLRVLESKRIRPVGSEQEQPVDVRIVAATHRNLQHEVNEGRFREDLYFRLNVLTLPLPAL
RERPEDIPALAHHFSRQLSRDLGLDALPWQHADLERLTHYSWPGNIRELKNFIERCILLGQLPSDMFDDAVVAETNLNAD
GYPTDWTLDAVERAHILNVLDAHANNKSSAARALGVSRKTLDRKLTAWQDLDA
>Mature_452_residues
TASTELPTASVLIVDDEPGMRSYLSKALASRFALIETADSLTAAEALRQRLHFDLLLVDIRLPDRSGIEWHEALGPERRS
DIIFMTAYADLDIAVKALRAGASDFIIKPFRLEQLQSAVDRCLAQRRLARENFVLKREAQRLHSPDESMIGDSQAMARVR
TIIERVAPTPSAVLIYGESGTGKELVARDLHRLSGRFGAFVPLNCGAIAGDLLESELFGHTRGAFTGAVKTREGLFTYAD
GGTLFLDEIAEMPLAMQAKLLRVLESKRIRPVGSEQEQPVDVRIVAATHRNLQHEVNEGRFREDLYFRLNVLTLPLPALR
ERPEDIPALAHHFSRQLSRDLGLDALPWQHADLERLTHYSWPGNIRELKNFIERCILLGQLPSDMFDDAVVAETNLNADG
YPTDWTLDAVERAHILNVLDAHANNKSSAARALGVSRKTLDRKLTAWQDLDA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=41.5584415584416, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=42.5675675675676, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=41.1637931034483, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI1788905, Length=451, Percent_Identity=39.9113082039911, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1789233, Length=335, Percent_Identity=42.3880597014925, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082117, Length=313, Percent_Identity=44.7284345047923, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789087, Length=347, Percent_Identity=42.9394812680115, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1786524, Length=320, Percent_Identity=42.8125, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI87082152, Length=233, Percent_Identity=49.7854077253219, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87081872, Length=247, Percent_Identity=46.1538461538462, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787583, Length=336, Percent_Identity=38.3928571428571, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789828, Length=243, Percent_Identity=41.1522633744856, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI87081858, Length=281, Percent_Identity=30.2491103202847, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50591; Mature: 50460

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASTELPTASVLIVDDEPGMRSYLSKALASRFALIETADSLTAAEALRQRLHFDLLLVD
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
IRLPDRSGIEWHEALGPERRSDIIFMTAYADLDIAVKALRAGASDFIIKPFRLEQLQSAV
EECCCCCCCCHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCEECCHHHHHHHHHH
DRCLAQRRLARENFVLKREAQRLHSPDESMIGDSQAMARVRTIIERVAPTPSAVLIYGES
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
GTGKELVARDLHRLSGRFGAFVPLNCGAIAGDLLESELFGHTRGAFTGAVKTREGLFTYA
CCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCHHHCCCEEEEE
DGGTLFLDEIAEMPLAMQAKLLRVLESKRIRPVGSEQEQPVDVRIVAATHRNLQHEVNEG
CCCEEHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCC
RFREDLYFRLNVLTLPLPALRERPEDIPALAHHFSRQLSRDLGLDALPWQHADLERLTHY
CHHHHHEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SWPGNIRELKNFIERCILLGQLPSDMFDDAVVAETNLNADGYPTDWTLDAVERAHILNVL
CCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
DAHANNKSSAARALGVSRKTLDRKLTAWQDLDA
HHCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TASTELPTASVLIVDDEPGMRSYLSKALASRFALIETADSLTAAEALRQRLHFDLLLVD
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
IRLPDRSGIEWHEALGPERRSDIIFMTAYADLDIAVKALRAGASDFIIKPFRLEQLQSAV
EECCCCCCCCHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCEECCHHHHHHHHHH
DRCLAQRRLARENFVLKREAQRLHSPDESMIGDSQAMARVRTIIERVAPTPSAVLIYGES
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCC
GTGKELVARDLHRLSGRFGAFVPLNCGAIAGDLLESELFGHTRGAFTGAVKTREGLFTYA
CCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCHHHCCCEEEEE
DGGTLFLDEIAEMPLAMQAKLLRVLESKRIRPVGSEQEQPVDVRIVAATHRNLQHEVNEG
CCCEEHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHCC
RFREDLYFRLNVLTLPLPALRERPEDIPALAHHFSRQLSRDLGLDALPWQHADLERLTHY
CHHHHHEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SWPGNIRELKNFIERCILLGQLPSDMFDDAVVAETNLNADGYPTDWTLDAVERAHILNVL
CCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
DAHANNKSSAARALGVSRKTLDRKLTAWQDLDA
HHCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]