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The map label for this gene is sthA

Identifier: 92113701

GI number: 92113701

Start: 1796170

End: 1797561

Strand: Direct

Name: sthA

Synonym: Csal_1577

Alternate gene names: 92113701

Gene position: 1796170-1797561 (Clockwise)

Preceding gene: 92113700

Following gene: 92113702

Centisome position: 48.59

GC content: 61.93

Gene sequence:

>1392_bases
ATGGCAGTTCACAATTTTGATGTGGTGGTGATTGGCTCGGGACCCGCCGGGGAGAGTGCGGCCATCAATGCGGCCAAGCA
CGGCAAGCGCGTGGCCATCGTCGAGAAGCAGCAGGCGGTCGGCGGCAATTGCACGCACTGGGGCACGATTCCCTCCAAGG
CGCTGCGTCACCAGGTCAAGCAGATCATGCAGTTCAATACCAACCGCATGTTCCGCGACATCGGCGAACCGCGCTGGTTT
TCCTTTCCTCGCGTGCTGGAGCGTTCCAAGGTCACCATCGACCAGCAGGTCGAGATGCGCACGCAGTTCTATTCGCGCAA
CCGCATCAACCTGTTCTTCGGCGTTGCCCGTTTCCGCGACGAGCACACCCTGACCGTGCGCGACAACCAGGATGGCGTCG
AGGAACTCTGCGCCCAGCAGTTCGTCATCGCCACGGGATCGCGGCCGTATCGCCCGGCCGATATCAATTTCCGGCATCCG
CGTATCTATTGCTCGGATACCATCCTGGGGCTGTCGCACACGCCGCGCACCTTGATCATCTTCGGGGCCGGGGTCATCGG
TTCCGAGTACGCGTCGATCTTCTCGGGGCTGGGGGTCAAGGTCGACCTGATCGACATGCGCGAGCGGCTGTTGTCGTTCC
TCGACGACGAGATCAGCGACGCGTTGTCCTATCATCTGCGCCAGAACGGCGTACTGGTGCGTCACAACGAAGACTACGAG
AGCATCGAGGGCGATGAGTCGGGCGTGATCGTCAAGCTCAAGTCGGGCAAGCGGTTGCGCGCCGACGCCTTTCTCTGGGC
GAACGGGCGGACCGGCAATACCGACGAGCTGGGGCTGGAAAACATCGGCCTCGAGCCCAACGGGCGTGGTCAGCTGCAGG
TCGATGAGCATTACCGCACCATGGTGCCGCACATCTATGCCGTGGGCGATGTCATCGGCTGGCCGAGCCTGGCCAGCGCG
GCGTACGACCAGGGCCGCAGCGCCAGCGATGACTTCCTCGACGAGGACTTCCGCTTCGTCGAGGACATTCCCACGGGCAT
CTACACCATTCCCGAGATCAGCTCGGTGGGCAAGAACGAGCGCGAGCTGACCGAGGCCAAGGTGCCTTACGAGGTGGCGC
AGGCATTCTTCAAGGACACGGCGCGTGCGCAGATCACCGGCGATACCGTCGGCATGCTCAAGATTCTCTTCCATCGCGAG
ACGCTGGAGATCCTGGGCATTCACTGCTTCGGCGACCAGGCCTCCGAGATCCTGCATATCGGCCAGGCGATCATGCAGCA
GAAGGGTGAGGCCAACACCTTGAAGTACTTCATCAATACCACGTTCAATTACCCGACCATGGCCGAGGCCTATCGGGTCG
CGGCGCAGAACGGCTTGAACCGCGTGTTTTGA

Upstream 100 bases:

>100_bases
GCTCATCGCCGCGCTTCGTGCGACTCCTGTGCCGTGACCGGTCTTGCGTTGAGACTTATCGCAGCGGTTCCTCATGCACC
AAGAGGAGCAGGCGAACCTA

Downstream 100 bases:

>100_bases
TGAGGTCCGATGATGTCGGGCGCGGCTGCGTGCAGCGGCCCCGGCGAGCCGACCGAGGTCGGCCCGCGACGAGCCGGCTT
GCAAGCCGGCTCGTCGCGTT

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAVHNFDVVVIGSGPAGESAAINAAKHGKRVAIVEKQQAVGGNCTHWGTIPSKALRHQVKQIMQFNTNRMFRDIGEPRWF
SFPRVLERSKVTIDQQVEMRTQFYSRNRINLFFGVARFRDEHTLTVRDNQDGVEELCAQQFVIATGSRPYRPADINFRHP
RIYCSDTILGLSHTPRTLIIFGAGVIGSEYASIFSGLGVKVDLIDMRERLLSFLDDEISDALSYHLRQNGVLVRHNEDYE
SIEGDESGVIVKLKSGKRLRADAFLWANGRTGNTDELGLENIGLEPNGRGQLQVDEHYRTMVPHIYAVGDVIGWPSLASA
AYDQGRSASDDFLDEDFRFVEDIPTGIYTIPEISSVGKNERELTEAKVPYEVAQAFFKDTARAQITGDTVGMLKILFHRE
TLEILGIHCFGDQASEILHIGQAIMQQKGEANTLKYFINTTFNYPTMAEAYRVAAQNGLNRVF

Sequences:

>Translated_463_residues
MAVHNFDVVVIGSGPAGESAAINAAKHGKRVAIVEKQQAVGGNCTHWGTIPSKALRHQVKQIMQFNTNRMFRDIGEPRWF
SFPRVLERSKVTIDQQVEMRTQFYSRNRINLFFGVARFRDEHTLTVRDNQDGVEELCAQQFVIATGSRPYRPADINFRHP
RIYCSDTILGLSHTPRTLIIFGAGVIGSEYASIFSGLGVKVDLIDMRERLLSFLDDEISDALSYHLRQNGVLVRHNEDYE
SIEGDESGVIVKLKSGKRLRADAFLWANGRTGNTDELGLENIGLEPNGRGQLQVDEHYRTMVPHIYAVGDVIGWPSLASA
AYDQGRSASDDFLDEDFRFVEDIPTGIYTIPEISSVGKNERELTEAKVPYEVAQAFFKDTARAQITGDTVGMLKILFHRE
TLEILGIHCFGDQASEILHIGQAIMQQKGEANTLKYFINTTFNYPTMAEAYRVAAQNGLNRVF
>Mature_462_residues
AVHNFDVVVIGSGPAGESAAINAAKHGKRVAIVEKQQAVGGNCTHWGTIPSKALRHQVKQIMQFNTNRMFRDIGEPRWFS
FPRVLERSKVTIDQQVEMRTQFYSRNRINLFFGVARFRDEHTLTVRDNQDGVEELCAQQFVIATGSRPYRPADINFRHPR
IYCSDTILGLSHTPRTLIIFGAGVIGSEYASIFSGLGVKVDLIDMRERLLSFLDDEISDALSYHLRQNGVLVRHNEDYES
IEGDESGVIVKLKSGKRLRADAFLWANGRTGNTDELGLENIGLEPNGRGQLQVDEHYRTMVPHIYAVGDVIGWPSLASAA
YDQGRSASDDFLDEDFRFVEDIPTGIYTIPEISSVGKNERELTEAKVPYEVAQAFFKDTARAQITGDTVGMLKILFHRET
LEILGIHCFGDQASEILHIGQAIMQQKGEANTLKYFINTTFNYPTMAEAYRVAAQNGLNRVF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=29.6536796536797, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI50301238, Length=470, Percent_Identity=28.5106382978723, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI22035672, Length=479, Percent_Identity=27.348643006263, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI291045266, Length=470, Percent_Identity=23.1914893617021, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI33519430, Length=491, Percent_Identity=25.050916496945, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI33519428, Length=491, Percent_Identity=25.050916496945, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI33519426, Length=491, Percent_Identity=25.050916496945, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI148277065, Length=491, Percent_Identity=25.050916496945, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI148277071, Length=491, Percent_Identity=25.050916496945, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI291045268, Length=337, Percent_Identity=24.9258160237389, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=62.5541125541125, Blast_Score=603, Evalue=1e-174,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=30.4824561403509, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87081717, Length=463, Percent_Identity=28.7257019438445, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1789915, Length=437, Percent_Identity=28.3752860411899, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=455, Percent_Identity=29.8901098901099, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17557007, Length=487, Percent_Identity=25.4620123203285, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=382, Percent_Identity=26.4397905759162, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71983429, Length=382, Percent_Identity=26.4397905759162, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=31.2896405919662, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=26.8817204301075, Blast_Score=153, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6325240, Length=483, Percent_Identity=26.7080745341615, Blast_Score=153, Evalue=7e-38,
Organism=Drosophila melanogaster, GI21358499, Length=470, Percent_Identity=31.2765957446809, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=27.8008298755187, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640549, Length=482, Percent_Identity=27.8008298755187, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24640551, Length=482, Percent_Identity=27.8008298755187, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17737741, Length=493, Percent_Identity=26.9776876267748, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): STHA_CHRSD (Q1QX78)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573629.1
- ProteinModelPortal:   Q1QX78
- STRING:   Q1QX78
- GeneID:   4027596
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1577
- NMPDR:   fig|290398.4.peg.2933
- eggNOG:   COG1249
- HOGENOM:   HBG515043
- OMA:   NVKVDLI
- ProtClustDB:   PRK05249
- BioCyc:   CSAL290398:CSAL_1577-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00247
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962
- Gene3D:   G3DSA:3.30.390.30
- PRINTS:   PR00368

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim; SSF55424 FAD/NAD-linked_reductase_dimer

EC number: =1.6.1.1

Molecular weight: Translated: 51953; Mature: 51822

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVHNFDVVVIGSGPAGESAAINAAKHGKRVAIVEKQQAVGGNCTHWGTIPSKALRHQVK
CCEEEEEEEEECCCCCCCCCEEEHHHCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHH
QIMQFNTNRMFRDIGEPRWFSFPRVLERSKVTIDQQVEMRTQFYSRNRINLFFGVARFRD
HHHHHCHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEEHHCC
EHTLTVRDNQDGVEELCAQQFVIATGSRPYRPADINFRHPRIYCSDTILGLSHTPRTLII
CCEEEEECCCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEEECCEEEECCCCCCEEEE
FGAGVIGSEYASIFSGLGVKVDLIDMRERLLSFLDDEISDALSYHLRQNGVLVRHNEDYE
EECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
SIEGDESGVIVKLKSGKRLRADAFLWANGRTGNTDELGLENIGLEPNGRGQLQVDEHYRT
HCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEECHHHHH
MVPHIYAVGDVIGWPSLASAAYDQGRSASDDFLDEDFRFVEDIPTGIYTIPEISSVGKNE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHCCCCH
RELTEAKVPYEVAQAFFKDTARAQITGDTVGMLKILFHRETLEILGIHCFGDQASEILHI
HHHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHH
GQAIMQQKGEANTLKYFINTTFNYPTMAEAYRVAAQNGLNRVF
HHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVHNFDVVVIGSGPAGESAAINAAKHGKRVAIVEKQQAVGGNCTHWGTIPSKALRHQVK
CEEEEEEEEECCCCCCCCCEEEHHHCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHH
QIMQFNTNRMFRDIGEPRWFSFPRVLERSKVTIDQQVEMRTQFYSRNRINLFFGVARFRD
HHHHHCHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEEHHCC
EHTLTVRDNQDGVEELCAQQFVIATGSRPYRPADINFRHPRIYCSDTILGLSHTPRTLII
CCEEEEECCCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEEECCEEEECCCCCCEEEE
FGAGVIGSEYASIFSGLGVKVDLIDMRERLLSFLDDEISDALSYHLRQNGVLVRHNEDYE
EECCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
SIEGDESGVIVKLKSGKRLRADAFLWANGRTGNTDELGLENIGLEPNGRGQLQVDEHYRT
HCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEECHHHHH
MVPHIYAVGDVIGWPSLASAAYDQGRSASDDFLDEDFRFVEDIPTGIYTIPEISSVGKNE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHCCCCH
RELTEAKVPYEVAQAFFKDTARAQITGDTVGMLKILFHRETLEILGIHCFGDQASEILHI
HHHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHH
GQAIMQQKGEANTLKYFINTTFNYPTMAEAYRVAAQNGLNRVF
HHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA