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The map label for this gene is rnd [H]

Identifier: 92113585

GI number: 92113585

Start: 1655253

End: 1656380

Strand: Direct

Name: rnd [H]

Synonym: Csal_1461

Alternate gene names: 92113585

Gene position: 1655253-1656380 (Clockwise)

Preceding gene: 92113584

Following gene: 92113586

Centisome position: 44.78

GC content: 66.93

Gene sequence:

>1128_bases
ATGACCCCGAACTTCGAGATTCGCTGGGTGGCAACGCCCGGCGCGCTGGATGACGCGTGCGACGCACTGGCTGGCGCCGA
GTGGCTGGCGGTGGACACCGAGTTTCACCGCGAATCGACCTTTTTTCCCATTGCCGCGCTCGTGCAGCTGTACGCAGGGG
GCGATGCGGTCTACATGGTCGATCCCCGGGCCGTCTCGGCCAGTCCGGCGCTGCAAGCGCTGCTGAGCGTATCCGGTCCT
CTCAAGCTGCTGCACGCCAGCGGCGAGGATCTCGAAGTACTGGAAAGCTGGGCCGAGGTCGGTGTCGCCCCCATCGCCGA
CACCCAGGTCGCGCAGAGCTTGCTGGGCACCCAGGCGTCACTGGGTTATCAGCGCTTGGTCGAGCATTGGACAGGCGATG
TCCTGCCCAAGGAAGAAACGCGCTCGGACTGGTTGCAACGCCCGCTGTCGGACGCGCAGTTGCAATACGCCGCGCTGGAC
GTGGTCTACCTGCCGCGTATCTGGGAGGCACAGCGCGACGCCCTGATGAGGGAGGGACGTCTGGCCTGGCTGGAAGAAGA
ATGCGCACGTCTGTGCGATGCCAATCGTCGCGACGTCAACGCCGACGAGCACTGGTACCGTCGCCACCGCCAGTTGTGGC
GTCTCGAGCCGCGTCAGCTGGCGCTGTATCAGTCGCTGACGCGCTGGCGCGAAGGCGAGGTGCGTCGGCGCGACGTGCCA
CGTGGCTGGCTGGCGAGCGACAAGGTGCTGTTTGCGATCGCCATGGCGATGCCGCGCAATCGGCATCAACTGGCGGCCGT
CGAAGGTGTCCGGCCGACCTTGATCAAGCATGACGGCGATGCCCTGCTGGAGATGGTGCAGGCCGCCGCTCACCTGGCGG
AAGATGCCTTGCCGCGTGCCTTGCCGGCACCGCAGTCGCCGGCCTTCAAGTCACGGCTCAAGGCGCTCAAGAGCGTCGTC
AACCGCGAGGCCGAGCGTCTGGACATCGCCCCGGAAGTGCTCGCCAATCGCCGTGATCTCGAGGCGCTGGTGATGGCCGA
CCTCGATGGGGTGCCGCTGTCGCTGCCCCAGGGATGGCGCGGCACGCTGCTCGGCGACGCATTCACCCAGGCCCTGGCGG
ACCACTGA

Upstream 100 bases:

>100_bases
GGCGGCACCTTGAGCCGTGCCTTCAACGGCCGCCTGCCGTTTGCGCAAGAGTCGAGCTGATCGCGCCGTCGATAACCTTA
CCGTCAATAAAGGAAACGGG

Downstream 100 bases:

>100_bases
GAGGCTGCGACGATGACGAGACGTCTGTGTGAAATCTTCAAGAGCCCGCGCCGCGACGAGATGTACCTGTATGTGGACCG
TGCGCGCGGGCTGGCGGATA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTPNFEIRWVATPGALDDACDALAGAEWLAVDTEFHRESTFFPIAALVQLYAGGDAVYMVDPRAVSASPALQALLSVSGP
LKLLHASGEDLEVLESWAEVGVAPIADTQVAQSLLGTQASLGYQRLVEHWTGDVLPKEETRSDWLQRPLSDAQLQYAALD
VVYLPRIWEAQRDALMREGRLAWLEEECARLCDANRRDVNADEHWYRRHRQLWRLEPRQLALYQSLTRWREGEVRRRDVP
RGWLASDKVLFAIAMAMPRNRHQLAAVEGVRPTLIKHDGDALLEMVQAAAHLAEDALPRALPAPQSPAFKSRLKALKSVV
NREAERLDIAPEVLANRRDLEALVMADLDGVPLSLPQGWRGTLLGDAFTQALADH

Sequences:

>Translated_375_residues
MTPNFEIRWVATPGALDDACDALAGAEWLAVDTEFHRESTFFPIAALVQLYAGGDAVYMVDPRAVSASPALQALLSVSGP
LKLLHASGEDLEVLESWAEVGVAPIADTQVAQSLLGTQASLGYQRLVEHWTGDVLPKEETRSDWLQRPLSDAQLQYAALD
VVYLPRIWEAQRDALMREGRLAWLEEECARLCDANRRDVNADEHWYRRHRQLWRLEPRQLALYQSLTRWREGEVRRRDVP
RGWLASDKVLFAIAMAMPRNRHQLAAVEGVRPTLIKHDGDALLEMVQAAAHLAEDALPRALPAPQSPAFKSRLKALKSVV
NREAERLDIAPEVLANRRDLEALVMADLDGVPLSLPQGWRGTLLGDAFTQALADH
>Mature_374_residues
TPNFEIRWVATPGALDDACDALAGAEWLAVDTEFHRESTFFPIAALVQLYAGGDAVYMVDPRAVSASPALQALLSVSGPL
KLLHASGEDLEVLESWAEVGVAPIADTQVAQSLLGTQASLGYQRLVEHWTGDVLPKEETRSDWLQRPLSDAQLQYAALDV
VYLPRIWEAQRDALMREGRLAWLEEECARLCDANRRDVNADEHWYRRHRQLWRLEPRQLALYQSLTRWREGEVRRRDVPR
GWLASDKVLFAIAMAMPRNRHQLAAVEGVRPTLIKHDGDALLEMVQAAAHLAEDALPRALPAPQSPAFKSRLKALKSVVN
REAERLDIAPEVLANRRDLEALVMADLDGVPLSLPQGWRGTLLGDAFTQALADH

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=294, Percent_Identity=22.7891156462585, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI50301240, Length=294, Percent_Identity=22.7891156462585, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788105, Length=378, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17531757, Length=288, Percent_Identity=24.6527777777778, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=322, Percent_Identity=21.7391304347826, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161078302, Length=331, Percent_Identity=24.4712990936556, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 41872; Mature: 41741

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPNFEIRWVATPGALDDACDALAGAEWLAVDTEFHRESTFFPIAALVQLYAGGDAVYMV
CCCCCEEEEEECCCCHHHHHHHHCCCCEEEECCHHHCCCCCHHHHHHHHHHCCCCEEEEE
DPRAVSASPALQALLSVSGPLKLLHASGEDLEVLESWAEVGVAPIADTQVAQSLLGTQAS
CCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LGYQRLVEHWTGDVLPKEETRSDWLQRPLSDAQLQYAALDVVYLPRIWEAQRDALMREGR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LAWLEEECARLCDANRRDVNADEHWYRRHRQLWRLEPRQLALYQSLTRWREGEVRRRDVP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHCCC
RGWLASDKVLFAIAMAMPRNRHQLAAVEGVRPTLIKHDGDALLEMVQAAAHLAEDALPRA
CCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCC
LPAPQSPAFKSRLKALKSVVNREAERLDIAPEVLANRRDLEALVMADLDGVPLSLPQGWR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCC
GTLLGDAFTQALADH
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
TPNFEIRWVATPGALDDACDALAGAEWLAVDTEFHRESTFFPIAALVQLYAGGDAVYMV
CCCCEEEEEECCCCHHHHHHHHCCCCEEEECCHHHCCCCCHHHHHHHHHHCCCCEEEEE
DPRAVSASPALQALLSVSGPLKLLHASGEDLEVLESWAEVGVAPIADTQVAQSLLGTQAS
CCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LGYQRLVEHWTGDVLPKEETRSDWLQRPLSDAQLQYAALDVVYLPRIWEAQRDALMREGR
HHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LAWLEEECARLCDANRRDVNADEHWYRRHRQLWRLEPRQLALYQSLTRWREGEVRRRDVP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHCCC
RGWLASDKVLFAIAMAMPRNRHQLAAVEGVRPTLIKHDGDALLEMVQAAAHLAEDALPRA
CCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCC
LPAPQSPAFKSRLKALKSVVNREAERLDIAPEVLANRRDLEALVMADLDGVPLSLPQGWR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCC
GTLLGDAFTQALADH
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]