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The map label for this gene is dnaX [H]

Identifier: 92113582

GI number: 92113582

Start: 1652042

End: 1654213

Strand: Direct

Name: dnaX [H]

Synonym: Csal_1458

Alternate gene names: 92113582

Gene position: 1652042-1654213 (Clockwise)

Preceding gene: 92113579

Following gene: 92113583

Centisome position: 44.69

GC content: 70.12

Gene sequence:

>2172_bases
ATGAGTTACCAGGTTCTGGCCCGTAAATGGCGCCCGCGCACGTTTCATGAACTGGTCGGCCAGGAGCACGTCTCGCGCGC
GCTGGTCAACGCGCTCGATCAGGGGCGTCTTCACCATGCCTATCTGTTCACCGGCACGCGCGGCGTCGGCAAGACGACGC
TGGCGCGGATTCTCGCCAAGTGCCTGAACTGCCGGCAGGGCGTGACCTCGGTGCCGTGCGGTGAGTGCGAAACCTGCCGG
GAGATCGACGAGGGGCGTTTCGTCGACCTGATCGAGGTCGATGCCGCCTCCCGCACCAAGGTCGAGGATACCCGCGAGCT
GCTCGACAACGTGCAGTACGCGCCGACCCAGGGACGCTACAAGGTGTACCTCATCGACGAGGTGCACATGCTTTCCACGC
ACAGTTTCAACGCACTGCTCAAGACGCTCGAAGAGCCGCCGCCCCACGTCAAGTTCCTGCTGGCGACCACCGATCCGCAG
AAACTGCCGGTGACGGTGCTTTCGCGTTGCCTGCAGTTCACGCTCAAGAACATGCCGCCCGAGCGCGTGGTGGGGCATCT
GTCGCATATTCTGCAGGCCGAGTCGGTGGCCTACGACGAGCAGGCCTTGTGGCTGCTCGGCAAGGCGGCCGATGGGTCGA
TGCGCGATGCCATGAGCCTGACCGACCAGGCCATCGCCTTTGGGCAGGGCGAGGTGCGTCATGCCGATGTCGCCGCGATG
CTGGGCACGCTGGATCACCGCCATCTGCTGGCGCTGGCCGAGGCGCTGGCCGAGGTCGATGCCGCGCGCGTGCTGCAGGA
GGTCGCCAGCCTGGCCGAACAAGGGCCGGATTTCGGCGGCATTCTCGATGACCTGGCGGGCATCTTCCACCGCCTGGCGA
TCGCCCAGATGGTGCCGGATGCGCTGGACAACGGCCACGGCGACCGCGATACCCTGCTGCCCCTTGCCGCGCGCTTCACC
GCGGAGGACGTGCAGCTCTACTACCAGATTGCCCTGCAGGGACGCGGCGACATGGAAAGCGCGCCGGACCCGCGCACCGC
GCTGGAAATGACGCTGCTGCGCATGCTGGCGTTCCGCCCCCAGGGCGTGCCCAAGCCGCCGCAGACGCCGTTGCCGATTC
GTGGCGCGGCGGAAGGCCAGGCCACAGCGAGCACCCCAACGGCGGACGCGCCCGGCCAGCTCGCGGCGGCGCCGAGCCAG
CCGTCGCCTGCCGACACGCCGCCGCCCGCTGCCGATGCCGCGCCGGCCCACCCGCCGTCGCGTCCCGATACCCAGGCTCC
CGTCGCCGAGGAAGAACATGGCGCCGCGGCAGGCGCCGATGCATCGTCTGCGTCGCCCGCAGACGAGCCAGCCGCCCCGG
GGACGTTGGAATCCGAGTCGTTCGCAACGCAGGCATTTGACAACGAGCCGCTGGAAAGCGCACCGCCTGACATCGAATCG
GCCGTTGCCGCTCCCCCCGAGCCTGCCGCGCCGGTGACGGAGGCGGTGCCGCCCGTGGCCGACGCCCAGGCGACCGCCGC
CGAGGACGCGCTCGAGGACGCGCTCGAGGACGAGGCGCAGCGCCAGGCGGATGCCGATGGCGCCGTCGACGTGGACGACG
CGCCCCCCTGGGTGCTCGACGATGCCCAGATGCCCGCCGACGAAATATCGGCTCCTCCCGAGCCGCCGAGCGCGCCCGAC
GCGCCGGCCACGGAGGTTGCCGAGGATGCCGACGCCCCGGCGCCCACGGCACAGGCGCCTGCCGTCGCCACGCCCGACAC
CGGGGCGTTCGATCATGCCCGCTGGCTGGCCAGCTTCGCGTCGCTGGGACTGGGCGGGCTGACACGCAACCTGGCGGCGC
ATTGCATCGTCGAGGAGGACGACGGCGATACCTTGACGTTGCGTCTGGACCCGTCGCAGTCGGCGATGCTGGCGGACGTG
CACGTCGAGCGCATGACCAAGGCGCTGGCCGAGCAGGGCGTGGCCCGACGCTTGCACGTCACGGTGGCGGCGATTCCCGA
GGGCTGGGAAACGCCGCGTGCGCAAGGCGAGCGGCTGGCGCAGGCACGTCATGCCCAGGCGGTTGAAGCCCTGCGTCGCG
ACCCGCATATTCAGATGCTGGAACAGGATTTCGGCGCTCAGCTGCTCGAGCGCAGCGTCACGCCGAGCGACGAGGCCGCC
GCCCGGCGGTAG

Upstream 100 bases:

>100_bases
CGCTAGCCGCTAGAATGGACGTTTCAATGGGTTCCCTCCGTACCGAGCGTTCGGTGCTGCACGTGGGAATCGGCCCGATC
TGCAAGGACATCCTCACGGT

Downstream 100 bases:

>100_bases
GCCGTGCCAGGCGTCATCGGCGACCTGGATATTGTCAAACCCCTTGAGGATACGATCATGATGAAGGGCGGAATGGGCAA
CTTGATGAAGCAAGCCCAGG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MSYQVLARKWRPRTFHELVGQEHVSRALVNALDQGRLHHAYLFTGTRGVGKTTLARILAKCLNCRQGVTSVPCGECETCR
EIDEGRFVDLIEVDAASRTKVEDTRELLDNVQYAPTQGRYKVYLIDEVHMLSTHSFNALLKTLEEPPPHVKFLLATTDPQ
KLPVTVLSRCLQFTLKNMPPERVVGHLSHILQAESVAYDEQALWLLGKAADGSMRDAMSLTDQAIAFGQGEVRHADVAAM
LGTLDHRHLLALAEALAEVDAARVLQEVASLAEQGPDFGGILDDLAGIFHRLAIAQMVPDALDNGHGDRDTLLPLAARFT
AEDVQLYYQIALQGRGDMESAPDPRTALEMTLLRMLAFRPQGVPKPPQTPLPIRGAAEGQATASTPTADAPGQLAAAPSQ
PSPADTPPPAADAAPAHPPSRPDTQAPVAEEEHGAAAGADASSASPADEPAAPGTLESESFATQAFDNEPLESAPPDIES
AVAAPPEPAAPVTEAVPPVADAQATAAEDALEDALEDEAQRQADADGAVDVDDAPPWVLDDAQMPADEISAPPEPPSAPD
APATEVAEDADAPAPTAQAPAVATPDTGAFDHARWLASFASLGLGGLTRNLAAHCIVEEDDGDTLTLRLDPSQSAMLADV
HVERMTKALAEQGVARRLHVTVAAIPEGWETPRAQGERLAQARHAQAVEALRRDPHIQMLEQDFGAQLLERSVTPSDEAA
ARR

Sequences:

>Translated_723_residues
MSYQVLARKWRPRTFHELVGQEHVSRALVNALDQGRLHHAYLFTGTRGVGKTTLARILAKCLNCRQGVTSVPCGECETCR
EIDEGRFVDLIEVDAASRTKVEDTRELLDNVQYAPTQGRYKVYLIDEVHMLSTHSFNALLKTLEEPPPHVKFLLATTDPQ
KLPVTVLSRCLQFTLKNMPPERVVGHLSHILQAESVAYDEQALWLLGKAADGSMRDAMSLTDQAIAFGQGEVRHADVAAM
LGTLDHRHLLALAEALAEVDAARVLQEVASLAEQGPDFGGILDDLAGIFHRLAIAQMVPDALDNGHGDRDTLLPLAARFT
AEDVQLYYQIALQGRGDMESAPDPRTALEMTLLRMLAFRPQGVPKPPQTPLPIRGAAEGQATASTPTADAPGQLAAAPSQ
PSPADTPPPAADAAPAHPPSRPDTQAPVAEEEHGAAAGADASSASPADEPAAPGTLESESFATQAFDNEPLESAPPDIES
AVAAPPEPAAPVTEAVPPVADAQATAAEDALEDALEDEAQRQADADGAVDVDDAPPWVLDDAQMPADEISAPPEPPSAPD
APATEVAEDADAPAPTAQAPAVATPDTGAFDHARWLASFASLGLGGLTRNLAAHCIVEEDDGDTLTLRLDPSQSAMLADV
HVERMTKALAEQGVARRLHVTVAAIPEGWETPRAQGERLAQARHAQAVEALRRDPHIQMLEQDFGAQLLERSVTPSDEAA
ARR
>Mature_722_residues
SYQVLARKWRPRTFHELVGQEHVSRALVNALDQGRLHHAYLFTGTRGVGKTTLARILAKCLNCRQGVTSVPCGECETCRE
IDEGRFVDLIEVDAASRTKVEDTRELLDNVQYAPTQGRYKVYLIDEVHMLSTHSFNALLKTLEEPPPHVKFLLATTDPQK
LPVTVLSRCLQFTLKNMPPERVVGHLSHILQAESVAYDEQALWLLGKAADGSMRDAMSLTDQAIAFGQGEVRHADVAAML
GTLDHRHLLALAEALAEVDAARVLQEVASLAEQGPDFGGILDDLAGIFHRLAIAQMVPDALDNGHGDRDTLLPLAARFTA
EDVQLYYQIALQGRGDMESAPDPRTALEMTLLRMLAFRPQGVPKPPQTPLPIRGAAEGQATASTPTADAPGQLAAAPSQP
SPADTPPPAADAAPAHPPSRPDTQAPVAEEEHGAAAGADASSASPADEPAAPGTLESESFATQAFDNEPLESAPPDIESA
VAAPPEPAAPVTEAVPPVADAQATAAEDALEDALEDEAQRQADADGAVDVDDAPPWVLDDAQMPADEISAPPEPPSAPDA
PATEVAEDADAPAPTAQAPAVATPDTGAFDHARWLASFASLGLGGLTRNLAAHCIVEEDDGDTLTLRLDPSQSAMLADVH
VERMTKALAEQGVARRLHVTVAAIPEGWETPRAQGERLAQARHAQAVEALRRDPHIQMLEQDFGAQLLERSVTPSDEAAA
RR

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=372, Percent_Identity=60.752688172043, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1787341, Length=164, Percent_Identity=32.9268292682927, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787119, Length=209, Percent_Identity=25.3588516746411, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=215, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 76917; Mature: 76786

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPRTFHELVGQEHVSRALVNALDQGRLHHAYLFTGTRGVGKTTLARILAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHH
CLNCRQGVTSVPCGECETCREIDEGRFVDLIEVDAASRTKVEDTRELLDNVQYAPTQGRY
HHHHHCCCCCCCCCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSTHSFNALLKTLEEPPPHVKFLLATTDPQKLPVTVLSRCLQFTLKNMPP
EEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
ERVVGHLSHILQAESVAYDEQALWLLGKAADGSMRDAMSLTDQAIAFGQGEVRHADVAAM
HHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LGTLDHRHLLALAEALAEVDAARVLQEVASLAEQGPDFGGILDDLAGIFHRLAIAQMVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALDNGHGDRDTLLPLAARFTAEDVQLYYQIALQGRGDMESAPDPRTALEMTLLRMLAFRP
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
QGVPKPPQTPLPIRGAAEGQATASTPTADAPGQLAAAPSQPSPADTPPPAADAAPAHPPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCC
RPDTQAPVAEEEHGAAAGADASSASPADEPAAPGTLESESFATQAFDNEPLESAPPDIES
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHH
AVAAPPEPAAPVTEAVPPVADAQATAAEDALEDALEDEAQRQADADGAVDVDDAPPWVLD
HCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEC
DAQMPADEISAPPEPPSAPDAPATEVAEDADAPAPTAQAPAVATPDTGAFDHARWLASFA
CCCCCHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SLGLGGLTRNLAAHCIVEEDDGDTLTLRLDPSQSAMLADVHVERMTKALAEQGVARRLHV
HHCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEE
TVAAIPEGWETPRAQGERLAQARHAQAVEALRRDPHIQMLEQDFGAQLLERSVTPSDEAA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
ARR
CCC
>Mature Secondary Structure 
SYQVLARKWRPRTFHELVGQEHVSRALVNALDQGRLHHAYLFTGTRGVGKTTLARILAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHH
CLNCRQGVTSVPCGECETCREIDEGRFVDLIEVDAASRTKVEDTRELLDNVQYAPTQGRY
HHHHHCCCCCCCCCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSTHSFNALLKTLEEPPPHVKFLLATTDPQKLPVTVLSRCLQFTLKNMPP
EEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCH
ERVVGHLSHILQAESVAYDEQALWLLGKAADGSMRDAMSLTDQAIAFGQGEVRHADVAAM
HHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LGTLDHRHLLALAEALAEVDAARVLQEVASLAEQGPDFGGILDDLAGIFHRLAIAQMVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALDNGHGDRDTLLPLAARFTAEDVQLYYQIALQGRGDMESAPDPRTALEMTLLRMLAFRP
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
QGVPKPPQTPLPIRGAAEGQATASTPTADAPGQLAAAPSQPSPADTPPPAADAAPAHPPS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCC
RPDTQAPVAEEEHGAAAGADASSASPADEPAAPGTLESESFATQAFDNEPLESAPPDIES
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHH
AVAAPPEPAAPVTEAVPPVADAQATAAEDALEDALEDEAQRQADADGAVDVDDAPPWVLD
HCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEC
DAQMPADEISAPPEPPSAPDAPATEVAEDADAPAPTAQAPAVATPDTGAFDHARWLASFA
CCCCCHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SLGLGGLTRNLAAHCIVEEDDGDTLTLRLDPSQSAMLADVHVERMTKALAEQGVARRLHV
HHCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEE
TVAAIPEGWETPRAQGERLAQARHAQAVEALRRDPHIQMLEQDFGAQLLERSVTPSDEAA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
ARR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]