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The map label for this gene is sdhA [H]

Identifier: 92113341

GI number: 92113341

Start: 1389421

End: 1391193

Strand: Direct

Name: sdhA [H]

Synonym: Csal_1215

Alternate gene names: 92113341

Gene position: 1389421-1391193 (Clockwise)

Preceding gene: 92113340

Following gene: 92113342

Centisome position: 37.59

GC content: 62.77

Gene sequence:

>1773_bases
ATGTCCAATATGCGTAGCCTGACATTCGACGCAATCATCATCGGCGGTGGTGGCTCCGGCCTGCGCGCCGCGCTCGAGCT
GGCCAAGTCGGGCAAGAAGACGGCGGTCATCACCAAGGTCTTCCCGACGCGCTCGCACACCGTTTCCGCACAGGGCGGCA
TTACCTGCGCCATCGCTTCCGCCGATCCCAACGACGATTGGCGCTGGCACATGTACGACACCGTCAAAGGCGGTGACTAC
ATTACCGACCAGGAAGCCGCCGAGTACATGTGTTCCGAAGGGCCCAAGGCGGTCTTCGAGCTGGAACACATGGGGCTGCC
GTTTTCACGCTTCGACAACGGCCGCATCTATCAGCGCCCCTTCGGCGGTCAGTCCAAGGACTTCGGCAAGGGCGGCCAGG
CCGCGCGGACCTGTGCCGCCGCCGACCGTACCGGCCATGCGCTGCTGCATACCTTGTATCAGAACAACCTGAAGAACAAC
ACCGTCTTCCTGAACGAGTGGTACGCGGTCGATCTGGTCAAGAACGCCAACGGCGACGTGGTCGGCTGCATTGCCATGTG
CATCGAGACCGGTGAAGTCGTGCACATCAAATCCAAGGCGACGGTGCTGGCCACCGGCGGCTCGGGCCGCATCTACGCGT
CCACGACCAATGCCCTGATCAATACCGGCGACGGGATCGGCATGGCCCTGCGTGCGGGCTTCCCCATGCAGGACATGGAA
ATGTGGCAGTTCCACCCCACCGGCATTTACGGCGCAGGGGTGTTGGTCACCGAAGGCTGTCGTGGCGAAGGCGGCTACCT
GATCAACAAGGACGGCGAGCGCTTCATGGAGCGTTATGCGCCGAACGCCAAGGACCTCGCCGGTCGTGACGTCGTGGCGC
GCGCCATGGTCATGGAGATCCTGGAAGGTCGTGGCTGCGGCGAAAACGGCGATCACGTCATGCTCAAGCTCGATCACCTG
GGTGAAGAGGTACTGAGCAAGCGTCTGCCGGGGATCGTCGAACTCTCCAAGACCTTCGCTCACGTCGATCCGGCCAAGGA
TCCGATTCCCGTCGTGCCGACGTGTCACTACATGATGGGGGGCGTGCCGACCAACGTGCACGGCCAGGCCATCATGCAGG
ATGCCGACGGCAACGATCAGATCGTCAACGGCCTGTTCGCCTGCGGCGAAGCGGCATGCGTCTCGGTGCACGGCGCCAAC
CGTCTGGGCGGCAACTCGTTGCTCGACCTGGTGGTGTTCGGGCGTGCTGCCGGCATGTTCATCGAGGAAGCCCTCAACGA
GGGGGTCGATTACCTCGAGGCGGCCCAGTCCGACATCGACAGCGCCATGGCGCGCATCACTCGCTGGGACGAGTCCAGCG
GCGGCGAAGCGGTGCCCGACCTGCGCGCCGAACTGCAGGACATCATGCAGAATGACTTCGGCGTCTTCCGTCAGGAAGAC
AACATGCAGCAGGGCGTCAAGAAGCTGGCCGATCTGCGCGAGCGCATCGCCAATGCTCACTTGTCCGACAAGTCCAACGC
CTTCAACACCGCGCGTGTCGAGGCGCTGGAGCTCGACAACCTGCTCGAAGTTGCGGAGGCTACGGCCATTTCCGCCCTGG
AGCGCAAGGAAAGCCGTGGTGCGCATTCGCGCTACGACTACCCGGACCGCGACGACGCCAATTGGCTCAAGCACTCCATG
TACTTCCCGGTCGAAAAGCGCCTGGGACAGCGTGATGTGAACTTTGCGCCGAAGACCGTCGATACCTTCGAGCCGAAAAT
CCGCACTTACTAA

Upstream 100 bases:

>100_bases
CAAACAGACGGGCGTGCGTTTCGCGTTTCAAGCGGTCGTCATGCTGGCCATCTTCGTTTTTCTGGTGTGGGGCGTTCAAG
TCCTCTGGGGAGCCTAATCC

Downstream 100 bases:

>100_bases
GGGGTTGTCCAAGATGTCCACGCTTCAGGTATCTATCTACCGCTACAACCCGGAAACCGACTCCGCGCCCTACATGCAGG
AGTTCCAACTGGACACCCAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MSNMRSLTFDAIIIGGGGSGLRAALELAKSGKKTAVITKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGGDY
ITDQEAAEYMCSEGPKAVFELEHMGLPFSRFDNGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQNNLKNN
TVFLNEWYAVDLVKNANGDVVGCIAMCIETGEVVHIKSKATVLATGGSGRIYASTTNALINTGDGIGMALRAGFPMQDME
MWQFHPTGIYGAGVLVTEGCRGEGGYLINKDGERFMERYAPNAKDLAGRDVVARAMVMEILEGRGCGENGDHVMLKLDHL
GEEVLSKRLPGIVELSKTFAHVDPAKDPIPVVPTCHYMMGGVPTNVHGQAIMQDADGNDQIVNGLFACGEAACVSVHGAN
RLGGNSLLDLVVFGRAAGMFIEEALNEGVDYLEAAQSDIDSAMARITRWDESSGGEAVPDLRAELQDIMQNDFGVFRQED
NMQQGVKKLADLRERIANAHLSDKSNAFNTARVEALELDNLLEVAEATAISALERKESRGAHSRYDYPDRDDANWLKHSM
YFPVEKRLGQRDVNFAPKTVDTFEPKIRTY

Sequences:

>Translated_590_residues
MSNMRSLTFDAIIIGGGGSGLRAALELAKSGKKTAVITKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGGDY
ITDQEAAEYMCSEGPKAVFELEHMGLPFSRFDNGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQNNLKNN
TVFLNEWYAVDLVKNANGDVVGCIAMCIETGEVVHIKSKATVLATGGSGRIYASTTNALINTGDGIGMALRAGFPMQDME
MWQFHPTGIYGAGVLVTEGCRGEGGYLINKDGERFMERYAPNAKDLAGRDVVARAMVMEILEGRGCGENGDHVMLKLDHL
GEEVLSKRLPGIVELSKTFAHVDPAKDPIPVVPTCHYMMGGVPTNVHGQAIMQDADGNDQIVNGLFACGEAACVSVHGAN
RLGGNSLLDLVVFGRAAGMFIEEALNEGVDYLEAAQSDIDSAMARITRWDESSGGEAVPDLRAELQDIMQNDFGVFRQED
NMQQGVKKLADLRERIANAHLSDKSNAFNTARVEALELDNLLEVAEATAISALERKESRGAHSRYDYPDRDDANWLKHSM
YFPVEKRLGQRDVNFAPKTVDTFEPKIRTY
>Mature_589_residues
SNMRSLTFDAIIIGGGGSGLRAALELAKSGKKTAVITKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGGDYI
TDQEAAEYMCSEGPKAVFELEHMGLPFSRFDNGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQNNLKNNT
VFLNEWYAVDLVKNANGDVVGCIAMCIETGEVVHIKSKATVLATGGSGRIYASTTNALINTGDGIGMALRAGFPMQDMEM
WQFHPTGIYGAGVLVTEGCRGEGGYLINKDGERFMERYAPNAKDLAGRDVVARAMVMEILEGRGCGENGDHVMLKLDHLG
EEVLSKRLPGIVELSKTFAHVDPAKDPIPVVPTCHYMMGGVPTNVHGQAIMQDADGNDQIVNGLFACGEAACVSVHGANR
LGGNSLLDLVVFGRAAGMFIEEALNEGVDYLEAAQSDIDSAMARITRWDESSGGEAVPDLRAELQDIMQNDFGVFRQEDN
MQQGVKKLADLRERIANAHLSDKSNAFNTARVEALELDNLLEVAEATAISALERKESRGAHSRYDYPDRDDANWLKHSMY
FPVEKRLGQRDVNFAPKTVDTFEPKIRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=589, Percent_Identity=51.1035653650255, Blast_Score=577, Evalue=1e-164,
Organism=Escherichia coli, GI1786942, Length=583, Percent_Identity=67.7530017152659, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=574, Percent_Identity=40.9407665505227, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=568, Percent_Identity=32.5704225352113, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=589, Percent_Identity=51.1035653650255, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17505833, Length=609, Percent_Identity=49.9178981937603, Blast_Score=558, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322416, Length=594, Percent_Identity=53.8720538720539, Blast_Score=622, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=51.5254237288136, Blast_Score=609, Evalue=1e-175,
Organism=Drosophila melanogaster, GI17137288, Length=605, Percent_Identity=50.9090909090909, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24655642, Length=605, Percent_Identity=50.9090909090909, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24655647, Length=605, Percent_Identity=50.9090909090909, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24663005, Length=609, Percent_Identity=46.4696223316913, Blast_Score=533, Evalue=1e-151,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64204; Mature: 64073

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMRSLTFDAIIIGGGGSGLRAALELAKSGKKTAVITKVFPTRSHTVSAQGGITCAIAS
CCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCEEEEEEC
ADPNDDWRWHMYDTVKGGDYITDQEAAEYMCSEGPKAVFELEHMGLPFSRFDNGRIYQRP
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCHHHCCCCEEEECC
FGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQNNLKNNTVFLNEWYAVDLVKNANGDV
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCC
VGCIAMCIETGEVVHIKSKATVLATGGSGRIYASTTNALINTGDGIGMALRAGFPMQDME
HHHHHHHHCCCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCH
MWQFHPTGIYGAGVLVTEGCRGEGGYLINKDGERFMERYAPNAKDLAGRDVVARAMVMEI
HHEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
LEGRGCGENGDHVMLKLDHLGEEVLSKRLPGIVELSKTFAHVDPAKDPIPVVPTCHYMMG
HHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
GVPTNVHGQAIMQDADGNDQIVNGLFACGEAACVSVHGANRLGGNSLLDLVVFGRAAGMF
CCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
IEEALNEGVDYLEAAQSDIDSAMARITRWDESSGGEAVPDLRAELQDIMQNDFGVFRQED
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCC
NMQQGVKKLADLRERIANAHLSDKSNAFNTARVEALELDNLLEVAEATAISALERKESRG
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCC
AHSRYDYPDRDDANWLKHSMYFPVEKRLGQRDVNFAPKTVDTFEPKIRTY
CCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNMRSLTFDAIIIGGGGSGLRAALELAKSGKKTAVITKVFPTRSHTVSAQGGITCAIAS
CCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCEEEEEEC
ADPNDDWRWHMYDTVKGGDYITDQEAAEYMCSEGPKAVFELEHMGLPFSRFDNGRIYQRP
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCHHHCCCCEEEECC
FGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQNNLKNNTVFLNEWYAVDLVKNANGDV
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCC
VGCIAMCIETGEVVHIKSKATVLATGGSGRIYASTTNALINTGDGIGMALRAGFPMQDME
HHHHHHHHCCCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCH
MWQFHPTGIYGAGVLVTEGCRGEGGYLINKDGERFMERYAPNAKDLAGRDVVARAMVMEI
HHEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
LEGRGCGENGDHVMLKLDHLGEEVLSKRLPGIVELSKTFAHVDPAKDPIPVVPTCHYMMG
HHCCCCCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHC
GVPTNVHGQAIMQDADGNDQIVNGLFACGEAACVSVHGANRLGGNSLLDLVVFGRAAGMF
CCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
IEEALNEGVDYLEAAQSDIDSAMARITRWDESSGGEAVPDLRAELQDIMQNDFGVFRQED
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCC
NMQQGVKKLADLRERIANAHLSDKSNAFNTARVEALELDNLLEVAEATAISALERKESRG
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCC
AHSRYDYPDRDDANWLKHSMYFPVEKRLGQRDVNFAPKTVDTFEPKIRTY
CCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]