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The map label for this gene is cysG [H]

Identifier: 92113247

GI number: 92113247

Start: 1277482

End: 1278282

Strand: Direct

Name: cysG [H]

Synonym: Csal_1120

Alternate gene names: 92113247

Gene position: 1277482-1278282 (Clockwise)

Preceding gene: 92113246

Following gene: 92113250

Centisome position: 34.56

GC content: 69.16

Gene sequence:

>801_bases
ATGGCCACGATGTGCCGGGAGACACCCGCCACGCATGTGGCGCCGGCGGTGCAGCCGGGCCATGTGTATCTGGTGGGCGC
CGGTGCCGGTCACGCCGATCTGCTGACCCTGCGTGCCTGGCGACTGCTCACGCAGGCTGATGTCATCGTCTATGACCGTC
TGGTCGGCGACGATATCCTGGCCATGATTCCTCCGTCGCGCGAACGCTATTACGTCGGCAAGGCCCGCGGGCATCACAGC
GTGCCACAGGCCGAGATCGGCGCCTTGCTGGCTCGGCTGGCGCGGGAAGGGAAGTCGGTCGTGCGTCTGAAGGGCGGCGA
CCCCGGGATTTTCGGTCGCATGGGCGAGGAACTCGCAATTCTCGGCGAGGCCGGCCTGCCCACGGAGGTCGTCCCCGGCA
TCACGGCGGCCTCCGCCGCCGCCGCCACCCTCGGCATGCCGCTCACCGACCGCGCCCATGCACAGCAGTTGCGCCTGGTG
ACCGCCCAGCACTGCCGCGAAGGTGGCGAGCCGAACTGGCACGACCTGGCGCGGCGTGACGAGACGCTGGTGTTCTACAT
GGGGCTTTCCAGGGTCGACGCGATCTGTCGCGGATTGCGCGACGCCGGCCTGCCCGGCGACTGGCCGATCATGCTTGCCG
CCAATGCCTCGCTGCCCGAACAGCAAACCCTGGTCGGCACCCTCGACGACATGCCCGAAAGGCTCGCCGCCACGCCGCTG
CCCTCACCGTGCCTGATCGTCGTGGGCAGCGTGGTCACGATGGCCGACGTGGTGCAGTGTCGTGAGGCGGCCACGGCATA
A

Upstream 100 bases:

>100_bases
ACCCATGCTCGCGCTGCTGACACGCTGGAAACGGCCTGAGGGTCGCGTCGCTTCCTGGAGCGCCTGGCTGGGACGCATGA
CCCACCGGCCGGGGAATGGC

Downstream 100 bases:

>100_bases
GATGCGATCAGAGGCCAGCTGTCTGCATGTAGGCACTATCGCTTGATGCCTAAACGAAAAATGGCCGCCTCGAAAGGCGG
CCGCACGACGAGAGAAAAGC

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MATMCRETPATHVAPAVQPGHVYLVGAGAGHADLLTLRAWRLLTQADVIVYDRLVGDDILAMIPPSRERYYVGKARGHHS
VPQAEIGALLARLAREGKSVVRLKGGDPGIFGRMGEELAILGEAGLPTEVVPGITAASAAAATLGMPLTDRAHAQQLRLV
TAQHCREGGEPNWHDLARRDETLVFYMGLSRVDAICRGLRDAGLPGDWPIMLAANASLPEQQTLVGTLDDMPERLAATPL
PSPCLIVVGSVVTMADVVQCREAATA

Sequences:

>Translated_266_residues
MATMCRETPATHVAPAVQPGHVYLVGAGAGHADLLTLRAWRLLTQADVIVYDRLVGDDILAMIPPSRERYYVGKARGHHS
VPQAEIGALLARLAREGKSVVRLKGGDPGIFGRMGEELAILGEAGLPTEVVPGITAASAAAATLGMPLTDRAHAQQLRLV
TAQHCREGGEPNWHDLARRDETLVFYMGLSRVDAICRGLRDAGLPGDWPIMLAANASLPEQQTLVGTLDDMPERLAATPL
PSPCLIVVGSVVTMADVVQCREAATA
>Mature_265_residues
ATMCRETPATHVAPAVQPGHVYLVGAGAGHADLLTLRAWRLLTQADVIVYDRLVGDDILAMIPPSRERYYVGKARGHHSV
PQAEIGALLARLAREGKSVVRLKGGDPGIFGRMGEELAILGEAGLPTEVVPGITAASAAAATLGMPLTDRAHAQQLRLVT
AQHCREGGEPNWHDLARRDETLVFYMGLSRVDAICRGLRDAGLPGDWPIMLAANASLPEQQTLVGTLDDMPERLAATPLP
SPCLIVVGSVVTMADVVQCREAATA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=242, Percent_Identity=49.5867768595041, Blast_Score=224, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6322922, Length=234, Percent_Identity=34.1880341880342, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 28227; Mature: 28096

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMCRETPATHVAPAVQPGHVYLVGAGAGHADLLTLRAWRLLTQADVIVYDRLVGDDIL
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEE
AMIPPSRERYYVGKARGHHSVPQAEIGALLARLAREGKSVVRLKGGDPGIFGRMGEELAI
EECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCEEEE
LGEAGLPTEVVPGITAASAAAATLGMPLTDRAHAQQLRLVTAQHCREGGEPNWHDLARRD
EECCCCCHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
ETLVFYMGLSRVDAICRGLRDAGLPGDWPIMLAANASLPEQQTLVGTLDDMPERLAATPL
CEEEEEECHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHCCHHHHHHHHHCCCC
PSPCLIVVGSVVTMADVVQCREAATA
CCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATMCRETPATHVAPAVQPGHVYLVGAGAGHADLLTLRAWRLLTQADVIVYDRLVGDDIL
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCEE
AMIPPSRERYYVGKARGHHSVPQAEIGALLARLAREGKSVVRLKGGDPGIFGRMGEELAI
EECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCEEEE
LGEAGLPTEVVPGITAASAAAATLGMPLTDRAHAQQLRLVTAQHCREGGEPNWHDLARRD
EECCCCCHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
ETLVFYMGLSRVDAICRGLRDAGLPGDWPIMLAANASLPEQQTLVGTLDDMPERLAATPL
CEEEEEECHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHCCHHHHHHHHHCCCC
PSPCLIVVGSVVTMADVVQCREAATA
CCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA