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The map label for this gene is iadA [H]

Identifier: 92113242

GI number: 92113242

Start: 1268446

End: 1269627

Strand: Direct

Name: iadA [H]

Synonym: Csal_1115

Alternate gene names: 92113242

Gene position: 1268446-1269627 (Clockwise)

Preceding gene: 92113241

Following gene: 92113246

Centisome position: 34.31

GC content: 69.97

Gene sequence:

>1182_bases
ATGATGTCCGGCAAGGCGCGTCAGGCCGCGCCCATGACCTTGTTGCGCGTGGCTGAGGTGTTCGCCCCCGAACGGCTGGC
GGCCACCGACATTCTCATGGCGGGCGGACGGATCGTCGCCCTGGGACAGGGGCTCGCCGTTCCCCAGGGCTGGCCGGTCC
AGGTGGTGGACGCGCGCCACCTGATCGCCGTGCCCGCCTTCATCGATCAGCACGTGCATGTCACCGGGGGCGGTGGCGAA
GGCGGTTGCGGCACCCGCTGCCCGCCGATCACCACCCGCGACATCGTGGCGATGGGCATCGGCACGGTGGTGGGCGTGCT
GGGGACCGACAGCATCAGCCGCTCGCCGGCCGACCTGCTGGCCGCGGTGCGAGGACTGGCGGCCGACGGGCTGGCCGCCT
ACATGTACACGGGCGCGTATCGAGTGCCGGCGCCGACCCTCACCGGCGATATCCAGCGCGACCTGGCCTGGATTCCCGAG
GTCATCGGGGTGGGCGAAATCGCCATTTCGGATCACCGCTCTAGCCAGCCGCGCCAGGACGAGCTCGAACGGCTGGTGAG
CGACGCGCGGGTCGGCGCCATGCTGGCCGGCAAGCGGGGCATCTGTCATTTCCATCTCGGCGACGGCAAGCGGGGCCTGG
AGCCTCTGCGGCGCTTGCTGACGGAGACCGAGATTCCGGCGGATCAAGTGATCCCCACCCACGTCAATCGTCGTGCCGAG
CTGCTCGAGGAGGCGGCGGAGTATGCGCTGGCATTCGATGCCAGCGTGGACGTCACCGCGTTCGAGGATGCCGGCGACGG
GCTTTCCGCGTTCGATGCGGTGTCGCGCCTGCTGGCGCGTGGCGTGTCGCCGGCACGCATCACCCTGAGTTCGGACTGCA
ATGGCAGCCTGCCGGAATTCGATGCCGATGGCGCCTACGTGGGCATGCAGGTGGCGCGCAATACCACGTTGATCGCGGAT
TGGCGCCGATTGGTCCATGCCCGGGTGCTGCCGCTCGAATCGGCGCTGGGGCTGCTCGCCGGCAATGTCGCGCGCGTGCT
GGGGCTGGCCGACAAGGGCCGCCTGGCGGTGGGCAGCGATGCCGACATCACGCTGCTCGACAAGGCCCTGCAGCCCCAGC
GCACGTTCGTCGCGGGGCGCTGTCTGTACGGCGCCGTCGACCATCACGAGACCGCGCGGTGA

Upstream 100 bases:

>100_bases
TGGTATTGCTGGTCGACGATGTCGAGGGTGTTCTCGAACGTCTGCGTGGCCGCCGCTTCCTGCCGTCCCATGCAACGCAC
GACACGCCGGGAGATCGCCC

Downstream 100 bases:

>100_bases
GCAGGTCGCCGGGCCGCCGACGAGGCTTTCGCGTCGGCGGTCCTTGCTCGACGCTCAGACCCTGATCATGACCCGATCGC
CGTCGATCTTGACCTCCCAG

Product: isoaspartyl dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MMSGKARQAAPMTLLRVAEVFAPERLAATDILMAGGRIVALGQGLAVPQGWPVQVVDARHLIAVPAFIDQHVHVTGGGGE
GGCGTRCPPITTRDIVAMGIGTVVGVLGTDSISRSPADLLAAVRGLAADGLAAYMYTGAYRVPAPTLTGDIQRDLAWIPE
VIGVGEIAISDHRSSQPRQDELERLVSDARVGAMLAGKRGICHFHLGDGKRGLEPLRRLLTETEIPADQVIPTHVNRRAE
LLEEAAEYALAFDASVDVTAFEDAGDGLSAFDAVSRLLARGVSPARITLSSDCNGSLPEFDADGAYVGMQVARNTTLIAD
WRRLVHARVLPLESALGLLAGNVARVLGLADKGRLAVGSDADITLLDKALQPQRTFVAGRCLYGAVDHHETAR

Sequences:

>Translated_393_residues
MMSGKARQAAPMTLLRVAEVFAPERLAATDILMAGGRIVALGQGLAVPQGWPVQVVDARHLIAVPAFIDQHVHVTGGGGE
GGCGTRCPPITTRDIVAMGIGTVVGVLGTDSISRSPADLLAAVRGLAADGLAAYMYTGAYRVPAPTLTGDIQRDLAWIPE
VIGVGEIAISDHRSSQPRQDELERLVSDARVGAMLAGKRGICHFHLGDGKRGLEPLRRLLTETEIPADQVIPTHVNRRAE
LLEEAAEYALAFDASVDVTAFEDAGDGLSAFDAVSRLLARGVSPARITLSSDCNGSLPEFDADGAYVGMQVARNTTLIAD
WRRLVHARVLPLESALGLLAGNVARVLGLADKGRLAVGSDADITLLDKALQPQRTFVAGRCLYGAVDHHETAR
>Mature_393_residues
MMSGKARQAAPMTLLRVAEVFAPERLAATDILMAGGRIVALGQGLAVPQGWPVQVVDARHLIAVPAFIDQHVHVTGGGGE
GGCGTRCPPITTRDIVAMGIGTVVGVLGTDSISRSPADLLAAVRGLAADGLAAYMYTGAYRVPAPTLTGDIQRDLAWIPE
VIGVGEIAISDHRSSQPRQDELERLVSDARVGAMLAGKRGICHFHLGDGKRGLEPLRRLLTETEIPADQVIPTHVNRRAE
LLEEAAEYALAFDASVDVTAFEDAGDGLSAFDAVSRLLARGVSPARITLSSDCNGSLPEFDADGAYVGMQVARNTTLIAD
WRRLVHARVLPLESALGLLAGNVARVLGLADKGRLAVGSDADITLLDKALQPQRTFVAGRCLYGAVDHHETAR

Specific function: Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The best substrate for the enzyme reported thus far is iso-Asp-Leu [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M38 family [H]

Homologues:

Organism=Escherichia coli, GI1790784, Length=374, Percent_Identity=40.1069518716578, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR010229 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.4.19.- [C]

Molecular weight: Translated: 41430; Mature: 41430

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSGKARQAAPMTLLRVAEVFAPERLAATDILMAGGRIVALGQGLAVPQGWPVQVVDARH
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCH
LIAVPAFIDQHVHVTGGGGEGGCGTRCPPITTRDIVAMGIGTVVGVLGTDSISRSPADLL
HEEEHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
AAVRGLAADGLAAYMYTGAYRVPAPTLTGDIQRDLAWIPEVIGVGEIAISDHRSSQPRQD
HHHHHHHHCCHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHH
ELERLVSDARVGAMLAGKRGICHFHLGDGKRGLEPLRRLLTETEIPADQVIPTHVNRRAE
HHHHHHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
LLEEAAEYALAFDASVDVTAFEDAGDGLSAFDAVSRLLARGVSPARITLSSDCNGSLPEF
HHHHHHHHHEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
DADGAYVGMQVARNTTLIADWRRLVHARVLPLESALGLLAGNVARVLGLADKGRLAVGSD
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCC
ADITLLDKALQPQRTFVAGRCLYGAVDHHETAR
CCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMSGKARQAAPMTLLRVAEVFAPERLAATDILMAGGRIVALGQGLAVPQGWPVQVVDARH
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCH
LIAVPAFIDQHVHVTGGGGEGGCGTRCPPITTRDIVAMGIGTVVGVLGTDSISRSPADLL
HEEEHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
AAVRGLAADGLAAYMYTGAYRVPAPTLTGDIQRDLAWIPEVIGVGEIAISDHRSSQPRQD
HHHHHHHHCCHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHH
ELERLVSDARVGAMLAGKRGICHFHLGDGKRGLEPLRRLLTETEIPADQVIPTHVNRRAE
HHHHHHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHH
LLEEAAEYALAFDASVDVTAFEDAGDGLSAFDAVSRLLARGVSPARITLSSDCNGSLPEF
HHHHHHHHHEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
DADGAYVGMQVARNTTLIADWRRLVHARVLPLESALGLLAGNVARVLGLADKGRLAVGSD
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCC
ADITLLDKALQPQRTFVAGRCLYGAVDHHETAR
CCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7876157; 7610040; 9278503 [H]