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The map label for this gene is estA [H]

Identifier: 92113234

GI number: 92113234

Start: 1257736

End: 1258413

Strand: Direct

Name: estA [H]

Synonym: Csal_1107

Alternate gene names: 92113234

Gene position: 1257736-1258413 (Clockwise)

Preceding gene: 92113233

Following gene: 92113235

Centisome position: 34.02

GC content: 67.85

Gene sequence:

>678_bases
ATGGCCGACTCTTCGCCTCTGATCATCGAACCCCGACAGGCACGCGCGGCCGATGCCACGGTCATTCTCCTGCACGGCCT
GGGCGCCGACGGGCATGACTTCGAGCCGCTGGTGCCGGCGCTGCCCCTGGCCAAGGACCTGGCGGTGCGTTTCGTGCTTC
CGCATGCGCCGCGCATGCCGGTGACGGTCAACGGCGGCATGGAAATGCCGGCCTGGTACGACATCCTCGACATGAACCTC
GGCCGGCGCATCGACGAAGCGCAGCTCAAGGCATCGGCGGACATGGTGCATGGGCTGATCGATGCCGAGATCGCCCGCGG
CATCGACAGCCGGCGCATCATCGTCGCGGGGTTCTCGCAGGGCGGTGCGGTGGCCTATCACGCGGCGCTGACGTACCCCA
AGCCGCTGGGCGGGCTGCTGGCGTTGTCCACGTACTTCGCGACCGCGACCTCCATCGAGCCCAGCGAGGCCAATCGCGCA
CTGCCCATCGAAGTGCATCATGGCAGTTTCGATCCGGTGGTGCCCGAGGCGCTGGGGCACGAAGGTGCCGAGCGGGCCGA
GGCGCTGGGCTATGCGGTGACCTACCGCACCTATCCCATGCAGCACGCGCTGTGTCCTGAGCAGATCGAGGACATCGGCC
AGTGGCTGAACGCTCGGCTGGGCGCGAAGGAGGCATGA

Upstream 100 bases:

>100_bases
TGGCCGTTCTGACGCACGCTCGGGAGGCGTGGACAGGGCCGCCCGTTTGCCACATCCTGTGCCTTCTCATCCGCGCAAAT
CGTTTCAAGGAGCCCAGCCG

Downstream 100 bases:

>100_bases
TGCAGAGCATGGAAACGCCCGAGCCCGGTGACGGCGTGCGTCTTTCCACGCCCGCCGCGAAGCGCAACCGCGAGCCGATC
CTGGCGCTGCTGCGCGAGGT

Product: carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MADSSPLIIEPRQARAADATVILLHGLGADGHDFEPLVPALPLAKDLAVRFVLPHAPRMPVTVNGGMEMPAWYDILDMNL
GRRIDEAQLKASADMVHGLIDAEIARGIDSRRIIVAGFSQGGAVAYHAALTYPKPLGGLLALSTYFATATSIEPSEANRA
LPIEVHHGSFDPVVPEALGHEGAERAEALGYAVTYRTYPMQHALCPEQIEDIGQWLNARLGAKEA

Sequences:

>Translated_225_residues
MADSSPLIIEPRQARAADATVILLHGLGADGHDFEPLVPALPLAKDLAVRFVLPHAPRMPVTVNGGMEMPAWYDILDMNL
GRRIDEAQLKASADMVHGLIDAEIARGIDSRRIIVAGFSQGGAVAYHAALTYPKPLGGLLALSTYFATATSIEPSEANRA
LPIEVHHGSFDPVVPEALGHEGAERAEALGYAVTYRTYPMQHALCPEQIEDIGQWLNARLGAKEA
>Mature_224_residues
ADSSPLIIEPRQARAADATVILLHGLGADGHDFEPLVPALPLAKDLAVRFVLPHAPRMPVTVNGGMEMPAWYDILDMNLG
RRIDEAQLKASADMVHGLIDAEIARGIDSRRIIVAGFSQGGAVAYHAALTYPKPLGGLLALSTYFATATSIEPSEANRAL
PIEVHHGSFDPVVPEALGHEGAERAEALGYAVTYRTYPMQHALCPEQIEDIGQWLNARLGAKEA

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI5453722, Length=223, Percent_Identity=37.219730941704, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI9966764, Length=226, Percent_Identity=36.283185840708, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI20270341, Length=210, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508057, Length=222, Percent_Identity=38.7387387387387, Blast_Score=156, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6323147, Length=221, Percent_Identity=32.579185520362, Blast_Score=112, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45553055, Length=220, Percent_Identity=35.4545454545455, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45553057, Length=220, Percent_Identity=35.4545454545455, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357257, Length=220, Percent_Identity=35.4545454545455, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI161078179, Length=212, Percent_Identity=30.6603773584906, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 24130; Mature: 23999

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSSPLIIEPRQARAADATVILLHGLGADGHDFEPLVPALPLAKDLAVRFVLPHAPRMP
CCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCCC
VTVNGGMEMPAWYDILDMNLGRRIDEAQLKASADMVHGLIDAEIARGIDSRRIIVAGFSQ
EEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
GGAVAYHAALTYPKPLGGLLALSTYFATATSIEPSEANRALPIEVHHGSFDPVVPEALGH
CCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHCC
EGAERAEALGYAVTYRTYPMQHALCPEQIEDIGQWLNARLGAKEA
CCHHHHHHHCEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ADSSPLIIEPRQARAADATVILLHGLGADGHDFEPLVPALPLAKDLAVRFVLPHAPRMP
CCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCCC
VTVNGGMEMPAWYDILDMNLGRRIDEAQLKASADMVHGLIDAEIARGIDSRRIIVAGFSQ
EEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
GGAVAYHAALTYPKPLGGLLALSTYFATATSIEPSEANRALPIEVHHGSFDPVVPEALGH
CCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHCC
EGAERAEALGYAVTYRTYPMQHALCPEQIEDIGQWLNARLGAKEA
CCHHHHHHHCEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA