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The map label for this gene is ttcA

Identifier: 92113003

GI number: 92113003

Start: 983433

End: 984287

Strand: Direct

Name: ttcA

Synonym: Csal_0875

Alternate gene names: 92113003

Gene position: 983433-984287 (Clockwise)

Preceding gene: 92113002

Following gene: 92113005

Centisome position: 26.6

GC content: 61.05

Gene sequence:

>855_bases
ATGCACGAACTCACCGGCAAAGACAAACTTGCTTTCAACAAGTTGCAAAAGCGCCTGCGGCGTCAGGTGGGAAACGCCAT
CGTCGATTACGGCATGATCCGTGACGGCGACAAGGTCATGGTGTGCCTCTCCGGGGGCAAGGACAGCTACACCATGCTGG
ACATCCTCATGAACCTGCAGCGCAACGCGCCGGTTGCGTTCGAGCTGGTGGCCGTCAATCTGGACCAGAAGCAGCCGGGG
TTCCCCGAGCACGTATTGCCCGAATACCTGGAACGCGTGGGCGTGCCCTATCATATCGTCGAGCGCGATACGTATTCGGT
GGTCAAGGAGAAAACCCCCGAGGGCAAGACGACCTGTGCGCTCTGCTCGCGGCTGAGGCGCGGCACGCTGTACGGCTTCG
CCGAAGAGATCGGCGCCAACAAGGTCGCGCTGGGACACCACCGCGAAGACATGCTGGAAACCCTGTTTCTCAACATGTTC
TTCGGCGGCAGTCTCAAGTCGATGCCGCCCAAGCTGCTTTCCGACGATGGCAAGCACATCGTCATTCGGCCCCTGGCCTA
CTGCCGCGAAGCCGATATCGCCGAATACGCCGAGTGGCGCGAATTTCCGATCATCCCCTGCAACCTGTGTGGCTCGCAGC
CCAACCTCCAGCGTCAGGTGGTCAAGGAAATGCTGACGGAGTGGGAAGAAAAGCACCCCGGGCGGCTGGAAACCATGTTC
AAGGCGATCACCAACGTGGCGCCGTCCCAGCTGGCCGATCGCGCCATGTTCGACTTCGAGGGGCTCGAAGACAAGCAGCG
CGATTTCCTGGCACGGCGCATCGAGACCTTCGACGTGCTGGCGCGCGAAGCCTGA

Upstream 100 bases:

>100_bases
GCCTGAGTCGCGCGATGCGTGGGCGGTCGCTTCGCCGTACCGGCATGCGGTGGTAGCATAGGCGGCCTCATTCACCACGG
CACTCTAAAGCGCAACCTTC

Downstream 100 bases:

>100_bases
ACCTCAAGCGTCGGCGCGTTCGCCGATGGGCGCCCCCCGGGCGATGCCTGCGAGACGTTCGGGGGCGAGCAGGGTGACCT
CGCGCCGTGCCACGTGGAGC

Product: PP-loop

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MHELTGKDKLAFNKLQKRLRRQVGNAIVDYGMIRDGDKVMVCLSGGKDSYTMLDILMNLQRNAPVAFELVAVNLDQKQPG
FPEHVLPEYLERVGVPYHIVERDTYSVVKEKTPEGKTTCALCSRLRRGTLYGFAEEIGANKVALGHHREDMLETLFLNMF
FGGSLKSMPPKLLSDDGKHIVIRPLAYCREADIAEYAEWREFPIIPCNLCGSQPNLQRQVVKEMLTEWEEKHPGRLETMF
KAITNVAPSQLADRAMFDFEGLEDKQRDFLARRIETFDVLAREA

Sequences:

>Translated_284_residues
MHELTGKDKLAFNKLQKRLRRQVGNAIVDYGMIRDGDKVMVCLSGGKDSYTMLDILMNLQRNAPVAFELVAVNLDQKQPG
FPEHVLPEYLERVGVPYHIVERDTYSVVKEKTPEGKTTCALCSRLRRGTLYGFAEEIGANKVALGHHREDMLETLFLNMF
FGGSLKSMPPKLLSDDGKHIVIRPLAYCREADIAEYAEWREFPIIPCNLCGSQPNLQRQVVKEMLTEWEEKHPGRLETMF
KAITNVAPSQLADRAMFDFEGLEDKQRDFLARRIETFDVLAREA
>Mature_284_residues
MHELTGKDKLAFNKLQKRLRRQVGNAIVDYGMIRDGDKVMVCLSGGKDSYTMLDILMNLQRNAPVAFELVAVNLDQKQPG
FPEHVLPEYLERVGVPYHIVERDTYSVVKEKTPEGKTTCALCSRLRRGTLYGFAEEIGANKVALGHHREDMLETLFLNMF
FGGSLKSMPPKLLSDDGKHIVIRPLAYCREADIAEYAEWREFPIIPCNLCGSQPNLQRQVVKEMLTEWEEKHPGRLETMF
KAITNVAPSQLADRAMFDFEGLEDKQRDFLARRIETFDVLAREA

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=261, Percent_Identity=69.7318007662835, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI193211090, Length=243, Percent_Identity=34.9794238683128, Blast_Score=140, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17540090, Length=220, Percent_Identity=28.6363636363636, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24651972, Length=222, Percent_Identity=23.8738738738739, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_CHRSD (Q1QZ76)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572931.1
- ProteinModelPortal:   Q1QZ76
- SMR:   Q1QZ76
- STRING:   Q1QZ76
- GeneID:   4027878
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0875
- NMPDR:   fig|290398.4.peg.755
- eggNOG:   COG0037
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- BioCyc:   CSAL290398:CSAL_0875-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 32437; Mature: 32437

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELTGKDKLAFNKLQKRLRRQVGNAIVDYGMIRDGDKVMVCLSGGKDSYTMLDILMNLQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEECCCCHHHHHHHHHHHH
RNAPVAFELVAVNLDQKQPGFPEHVLPEYLERVGVPYHIVERDTYSVVKEKTPEGKTTCA
CCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCHHHH
LCSRLRRGTLYGFAEEIGANKVALGHHREDMLETLFLNMFFGGSLKSMPPKLLSDDGKHI
HHHHHHHCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEE
VIRPLAYCREADIAEYAEWREFPIIPCNLCGSQPNLQRQVVKEMLTEWEEKHPGRLETMF
EECHHHHHHCCCHHHHHHHHCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
KAITNVAPSQLADRAMFDFEGLEDKQRDFLARRIETFDVLAREA
HHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHELTGKDKLAFNKLQKRLRRQVGNAIVDYGMIRDGDKVMVCLSGGKDSYTMLDILMNLQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEECCCCHHHHHHHHHHHH
RNAPVAFELVAVNLDQKQPGFPEHVLPEYLERVGVPYHIVERDTYSVVKEKTPEGKTTCA
CCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCHHHH
LCSRLRRGTLYGFAEEIGANKVALGHHREDMLETLFLNMFFGGSLKSMPPKLLSDDGKHI
HHHHHHHCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEE
VIRPLAYCREADIAEYAEWREFPIIPCNLCGSQPNLQRQVVKEMLTEWEEKHPGRLETMF
EECHHHHHHCCCHHHHHHHHCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
KAITNVAPSQLADRAMFDFEGLEDKQRDFLARRIETFDVLAREA
HHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA