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The map label for this gene is cytR [H]

Identifier: 92112896

GI number: 92112896

Start: 860062

End: 861060

Strand: Direct

Name: cytR [H]

Synonym: Csal_0768

Alternate gene names: 92112896

Gene position: 860062-861060 (Clockwise)

Preceding gene: 92112891

Following gene: 92112899

Centisome position: 23.27

GC content: 65.17

Gene sequence:

>999_bases
ATGACCAATATTCGCAAGGTGGCCGAGCTGGCCGGTGTGTCGGTGGCGACGGTGTCGCGCGCCTTGAAGACCCCCGACGT
CGTTTCGCCGGGCACGCGTGACAAAGTGTTGGCCGCCGTCGAGCAGGCCGACTATCGACCGAACCTCACGGCGGTGCAGT
TCCGGTCGCAACGCACCCGTAACCTGGTGGTGCTGGTGCCGACCATCGCCAACACCTTCTTTTCCCAGGTGATTGGCGGC
ATCCAGGAAGCGGCGCAGCGGCGAGGGTACGGCATTCTGCTGTGCAATACACTCGGCGATGAACGTACCGAGCGGGCTTA
CGCCGGCCTGGTGTCGACCCGTCAGGCCGATGGTCTCATCCAGTTGCGCGCCTATAATCCCTTCACGGCCTCGGACGGCA
AGGCGCGACCGCCGATGGTCAATGCCTGTGAGGTGCTCGACGAGGCACCGTGCCCCACCGTCAAGCTCGACAACCGAGCC
GCCGCCCGGGCGGTGACCGAGCATCTGCTGGCACTGGGGCACCGCCGTATCGGCATGATCAAGGGGCCGCGCAACAGTCC
CTTGACCCGGGATCGTCTGCTGGGCTTTCAGGATGCCCTGGCCGTCGCCGGCCTGGCGCCGGACGAAAGCCTCGTGTGTC
CCGGTGACTTCACGCCATCCTCAGGGTACCGGGCGGCTGGCGATCTGCTGTCGCAAGCTGACCCACCCACGGCGATCTTC
TGCGAAAATGATGAAATGGCCATGGGTGCCATGCGGCGCATCAAGGAAGCGGGGCTGCGGATACCTGAGGACATCTCGGT
GGCGGGATTCGACGATATCGCCTTCGCTTCCTTCTGCGATCCTCCCCTGACGACCATCGCCCAGCCCGCCGAGGATTTCG
GTCGCGAGGCCGTGGCCCTGTTGCTCGACATCATCGATGACCGGGATGGCGCAACGGGTGAGCATCGCATCATGCCCTTC
GAGCTGGTGATACGCGAGAGCACCGGGCCGGCCGCTTGA

Upstream 100 bases:

>100_bases
GAGGCGAACGGGAGTAGCGGTGAGCCAGGGGCGATGATGCAGTAGACTGGCCCGCATGATGGTGCCGAGGTAGGCGACGA
GGGGAGGTAGACAGCCAGGC

Downstream 100 bases:

>100_bases
TCCCGGAGGCACGTGACGAGCCAGCTCATCTCCATCGAGGGCGATCTGCTGTTGGGTTGAGGCATCGGTGCACCATATCC
ACTGTGAGAATGTCCCTCGT

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTNIRKVAELAGVSVATVSRALKTPDVVSPGTRDKVLAAVEQADYRPNLTAVQFRSQRTRNLVVLVPTIANTFFSQVIGG
IQEAAQRRGYGILLCNTLGDERTERAYAGLVSTRQADGLIQLRAYNPFTASDGKARPPMVNACEVLDEAPCPTVKLDNRA
AARAVTEHLLALGHRRIGMIKGPRNSPLTRDRLLGFQDALAVAGLAPDESLVCPGDFTPSSGYRAAGDLLSQADPPTAIF
CENDEMAMGAMRRIKEAGLRIPEDISVAGFDDIAFASFCDPPLTTIAQPAEDFGREAVALLLDIIDDRDGATGEHRIMPF
ELVIRESTGPAA

Sequences:

>Translated_332_residues
MTNIRKVAELAGVSVATVSRALKTPDVVSPGTRDKVLAAVEQADYRPNLTAVQFRSQRTRNLVVLVPTIANTFFSQVIGG
IQEAAQRRGYGILLCNTLGDERTERAYAGLVSTRQADGLIQLRAYNPFTASDGKARPPMVNACEVLDEAPCPTVKLDNRA
AARAVTEHLLALGHRRIGMIKGPRNSPLTRDRLLGFQDALAVAGLAPDESLVCPGDFTPSSGYRAAGDLLSQADPPTAIF
CENDEMAMGAMRRIKEAGLRIPEDISVAGFDDIAFASFCDPPLTTIAQPAEDFGREAVALLLDIIDDRDGATGEHRIMPF
ELVIRESTGPAA
>Mature_331_residues
TNIRKVAELAGVSVATVSRALKTPDVVSPGTRDKVLAAVEQADYRPNLTAVQFRSQRTRNLVVLVPTIANTFFSQVIGGI
QEAAQRRGYGILLCNTLGDERTERAYAGLVSTRQADGLIQLRAYNPFTASDGKARPPMVNACEVLDEAPCPTVKLDNRAA
ARAVTEHLLALGHRRIGMIKGPRNSPLTRDRLLGFQDALAVAGLAPDESLVCPGDFTPSSGYRAAGDLLSQADPPTAIFC
ENDEMAMGAMRRIKEAGLRIPEDISVAGFDDIAFASFCDPPLTTIAQPAEDFGREAVALLLDIIDDRDGATGEHRIMPFE
LVIRESTGPAA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=42.6829268292683, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1787948, Length=314, Percent_Identity=33.1210191082803, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1790194, Length=310, Percent_Identity=34.8387096774194, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1789068, Length=318, Percent_Identity=32.7044025157233, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=34.3642611683849, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1786540, Length=332, Percent_Identity=33.433734939759, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788474, Length=338, Percent_Identity=33.4319526627219, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1787580, Length=313, Percent_Identity=27.7955271565495, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI48994940, Length=300, Percent_Identity=31.3333333333333, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790715, Length=309, Percent_Identity=27.5080906148867, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789456, Length=330, Percent_Identity=26.3636363636364, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787906, Length=307, Percent_Identity=28.0130293159609, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786268, Length=313, Percent_Identity=24.2811501597444, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790192, Length=227, Percent_Identity=27.3127753303965, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790689, Length=313, Percent_Identity=23.3226837060703, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35628; Mature: 35497

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIRKVAELAGVSVATVSRALKTPDVVSPGTRDKVLAAVEQADYRPNLTAVQFRSQRTR
CCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHCCC
NLVVLVPTIANTFFSQVIGGIQEAAQRRGYGILLCNTLGDERTERAYAGLVSTRQADGLI
CEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEE
QLRAYNPFTASDGKARPPMVNACEVLDEAPCPTVKLDNRAAARAVTEHLLALGHRRIGMI
EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCHHEEEE
KGPRNSPLTRDRLLGFQDALAVAGLAPDESLVCPGDFTPSSGYRAAGDLLSQADPPTAIF
ECCCCCCCCHHHHHCHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHCCCCCCEEE
CENDEMAMGAMRRIKEAGLRIPEDISVAGFDDIAFASFCDPPLTTIAQPAEDFGREAVAL
ECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
LLDIIDDRDGATGEHRIMPFELVIRESTGPAA
HHHHHCCCCCCCCCCEECEEEEEEECCCCCCC
>Mature Secondary Structure 
TNIRKVAELAGVSVATVSRALKTPDVVSPGTRDKVLAAVEQADYRPNLTAVQFRSQRTR
CHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHCCC
NLVVLVPTIANTFFSQVIGGIQEAAQRRGYGILLCNTLGDERTERAYAGLVSTRQADGLI
CEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEE
QLRAYNPFTASDGKARPPMVNACEVLDEAPCPTVKLDNRAAARAVTEHLLALGHRRIGMI
EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHCCHHEEEE
KGPRNSPLTRDRLLGFQDALAVAGLAPDESLVCPGDFTPSSGYRAAGDLLSQADPPTAIF
ECCCCCCCCHHHHHCHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHCCCCCCEEE
CENDEMAMGAMRRIKEAGLRIPEDISVAGFDDIAFASFCDPPLTTIAQPAEDFGREAVAL
ECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
LLDIIDDRDGATGEHRIMPFELVIRESTGPAA
HHHHHCCCCCCCCCCEECEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]