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The map label for this gene is mdh [H]

Identifier: 92112813

GI number: 92112813

Start: 765046

End: 766191

Strand: Direct

Name: mdh [H]

Synonym: Csal_0681

Alternate gene names: 92112813

Gene position: 765046-766191 (Clockwise)

Preceding gene: 92112812

Following gene: 92112814

Centisome position: 20.7

GC content: 63.96

Gene sequence:

>1146_bases
ATGTCATTGACTGGAAACTGGACGTATCCCACCGCCATCCGTTTCGGGGCGGGTCGGATCAAGGAGTTGCCCGCGGCCTG
TGCCGAGGCGGGCATCACCCGACCGCTGCTGGTGACGGATCGCGGTCTGGCCGAGCTGCCTGTCACCGCTGCCGCGCTGG
ACATTCTGGAGGCCTCGGGGCTGGGACGGGGGCTCTTCGCCGAAGTCGATCCCAACCCCAACGAGCGCAACCTGACGGCA
GGGATCGAGGCCTTTCGGGCGGGGGGGCATGACGGGGTGGTCGCGTTTGGCGGTGGCTCCGGGCTGGACCTGGGCAAGAT
GGTGGCCTTCATGTCGGGTCAGACGCGCCCGGTGTGGGACTTCGAGGATATCGACGACTGGTGGACGCGGGCCGATGCCG
ACGCGATCGCCCCCATCGTGGCCGTGCCTACCACGGCCGGGACCGGCTCGGAGGTGGGGCGGGCCAGCGTCATTACCAAC
GCCAAGACCCATGAAAAGAAGATCATCTTCCACCCCAGAGTCCTGCCCAGGGTGGTGATCTGTGATCCCGAACTGACGAT
AGGCATGCCCAGGGCGATCACCGCTGGCACCGGGCTCGATGCGTTTGCCCACTGCGTGGAAGCGTTCTCGAGCCCGCATT
ATCATCCGATGAGCCAAGGCATCGCACTGGAAGGGATGCGGCTGGTCAAGGAATATCTGCCACGCGCTTATGCCGACGGC
ACCGATATCGAGGCACGTGCGCACATGATGAGTGCGGCGATGATGGGCTCAACTGCCTTTCAGAAGGGGTTGGGGGCCAT
CCATGCGATGAGTCATCCCATTGGCGCGGTGTTCAATGCTCACCATGGCACCACTAATGCGATCTGCATGCCGGCGGTGC
TGGCGTTCAACGCCGATAGCATCCGCGAACGGTTCGACATGGCGGCGGCCTACCTGGGGATCGAGGGTGGTTTCGACGGT
TTCAGGGCATTCGTGCAAGCACTCAACGACCAGATGGGTATCCCGCGTACGCTCTCCGAGGTCGGCGCCGACCCGGCGCG
CATCGACGAATTGGCTGCCATGGCTATCGAGGACCCCAGCTGTGGAGGGAACCCTGTGGCCTTGACCGTCGAGGATTTCA
AGGTGCTGTTCCGTCGGTGCATGTGA

Upstream 100 bases:

>100_bases
GCTATCACAACCTGACACGCCCCAAGTCCTACTATCTAAAGAAAACGACATAAAGAAAAACGACATGAAGAAAAAAACAA
CAGGCTAAAAAGGTGACGAC

Downstream 100 bases:

>100_bases
GCATTGGACGGCAACGCTGAAAAGCGGCTTACGCACGACAGGGCCCTTCATGACAGGGCCCTGTGGCGTGCATGTCTATC
AAGAGCCTCGCGCGAAAGTG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSLTGNWTYPTAIRFGAGRIKELPAACAEAGITRPLLVTDRGLAELPVTAAALDILEASGLGRGLFAEVDPNPNERNLTA
GIEAFRAGGHDGVVAFGGGSGLDLGKMVAFMSGQTRPVWDFEDIDDWWTRADADAIAPIVAVPTTAGTGSEVGRASVITN
AKTHEKKIIFHPRVLPRVVICDPELTIGMPRAITAGTGLDAFAHCVEAFSSPHYHPMSQGIALEGMRLVKEYLPRAYADG
TDIEARAHMMSAAMMGSTAFQKGLGAIHAMSHPIGAVFNAHHGTTNAICMPAVLAFNADSIRERFDMAAAYLGIEGGFDG
FRAFVQALNDQMGIPRTLSEVGADPARIDELAAMAIEDPSCGGNPVALTVEDFKVLFRRCM

Sequences:

>Translated_381_residues
MSLTGNWTYPTAIRFGAGRIKELPAACAEAGITRPLLVTDRGLAELPVTAAALDILEASGLGRGLFAEVDPNPNERNLTA
GIEAFRAGGHDGVVAFGGGSGLDLGKMVAFMSGQTRPVWDFEDIDDWWTRADADAIAPIVAVPTTAGTGSEVGRASVITN
AKTHEKKIIFHPRVLPRVVICDPELTIGMPRAITAGTGLDAFAHCVEAFSSPHYHPMSQGIALEGMRLVKEYLPRAYADG
TDIEARAHMMSAAMMGSTAFQKGLGAIHAMSHPIGAVFNAHHGTTNAICMPAVLAFNADSIRERFDMAAAYLGIEGGFDG
FRAFVQALNDQMGIPRTLSEVGADPARIDELAAMAIEDPSCGGNPVALTVEDFKVLFRRCM
>Mature_380_residues
SLTGNWTYPTAIRFGAGRIKELPAACAEAGITRPLLVTDRGLAELPVTAAALDILEASGLGRGLFAEVDPNPNERNLTAG
IEAFRAGGHDGVVAFGGGSGLDLGKMVAFMSGQTRPVWDFEDIDDWWTRADADAIAPIVAVPTTAGTGSEVGRASVITNA
KTHEKKIIFHPRVLPRVVICDPELTIGMPRAITAGTGLDAFAHCVEAFSSPHYHPMSQGIALEGMRLVKEYLPRAYADGT
DIEARAHMMSAAMMGSTAFQKGLGAIHAMSHPIGAVFNAHHGTTNAICMPAVLAFNADSIRERFDMAAAYLGIEGGFDGF
RAFVQALNDQMGIPRTLSEVGADPARIDELAAMAIEDPSCGGNPVALTVEDFKVLFRRCM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=337, Percent_Identity=28.486646884273, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI48994951, Length=381, Percent_Identity=31.496062992126, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1789163, Length=372, Percent_Identity=31.4516129032258, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082107, Length=376, Percent_Identity=31.3829787234043, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1787493, Length=407, Percent_Identity=29.7297297297297, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1789386, Length=364, Percent_Identity=28.021978021978, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=290, Percent_Identity=27.2413793103448, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=383, Percent_Identity=32.6370757180157, Blast_Score=206, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24657991, Length=434, Percent_Identity=27.4193548387097, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 40366; Mature: 40234

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTGNWTYPTAIRFGAGRIKELPAACAEAGITRPLLVTDRGLAELPVTAAALDILEASG
CCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEECCCCHHCCHHHHHHHHHHHCC
LGRGLFAEVDPNPNERNLTAGIEAFRAGGHDGVVAFGGGSGLDLGKMVAFMSGQTRPVWD
CCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIDDWWTRADADAIAPIVAVPTTAGTGSEVGRASVITNAKTHEKKIIFHPRVLPRVVI
CCCHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCEEEE
CDPELTIGMPRAITAGTGLDAFAHCVEAFSSPHYHPMSQGIALEGMRLVKEYLPRAYADG
ECCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHCCHHHCCC
TDIEARAHMMSAAMMGSTAFQKGLGAIHAMSHPIGAVFNAHHGTTNAICMPAVLAFNADS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHCCHHH
IRERFDMAAAYLGIEGGFDGFRAFVQALNDQMGIPRTLSEVGADPARIDELAAMAIEDPS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCC
CGGNPVALTVEDFKVLFRRCM
CCCCEEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
SLTGNWTYPTAIRFGAGRIKELPAACAEAGITRPLLVTDRGLAELPVTAAALDILEASG
CCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEECCCCHHCCHHHHHHHHHHHCC
LGRGLFAEVDPNPNERNLTAGIEAFRAGGHDGVVAFGGGSGLDLGKMVAFMSGQTRPVWD
CCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCC
FEDIDDWWTRADADAIAPIVAVPTTAGTGSEVGRASVITNAKTHEKKIIFHPRVLPRVVI
CCCHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCEEEE
CDPELTIGMPRAITAGTGLDAFAHCVEAFSSPHYHPMSQGIALEGMRLVKEYLPRAYADG
ECCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHCCHHHCCC
TDIEARAHMMSAAMMGSTAFQKGLGAIHAMSHPIGAVFNAHHGTTNAICMPAVLAFNADS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHCCHHH
IRERFDMAAAYLGIEGGFDGFRAFVQALNDQMGIPRTLSEVGADPARIDELAAMAIEDPS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCC
CGGNPVALTVEDFKVLFRRCM
CCCCEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]