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The map label for this gene is lysC [H]

Identifier: 92112759

GI number: 92112759

Start: 703543

End: 704787

Strand: Direct

Name: lysC [H]

Synonym: Csal_0626

Alternate gene names: 92112759

Gene position: 703543-704787 (Clockwise)

Preceding gene: 92112758

Following gene: 92112760

Centisome position: 19.03

GC content: 62.25

Gene sequence:

>1245_bases
ATGGCGCTATACGTACAGAAGTTCGGGGGGACCTCGGTGGGCTCGGTGGAGCGCATCAAGGCCGTCGCCGAAAAAGTGAA
GCGATTCCGCGACGAGGGCCACCAAGTGGTCGTCGTGGTCTCGGCAATGAGCGGGGAGACCAACCGGCTGATCGATCTGG
CCAGCCAGATCAACGATGAGCCCACGCCGCGCGAAATGGACATGCTGGTGTCCACCGGCGAGCAGGTGACCATTTCCCTG
CTGGCGATGGCCTTGCACAAGCTGGATGTGGAGGCGACTTCCTATACGGGGGCCCAGGTGGGCATCCGCACCGACAGCGC
CCACACCAAGGCGCGTATCCAGCGCATCGAGACCGATGACATCCAGGCCGATCTCGACGATGGTCAGGTCGTGGTCGTGG
CCGGTTTCCAGGGGGTCGATGACGAGGGCAACATCACGACCCTCGGACGCGGCGGCTCGGACACCACCGGCGTGGCCCTG
GCGGCGGCGCTCAAGGCCGACGAATGCCAGATCTACACCGATGTGGATGGCGTCTACACCACCGATCCGCGCGTGTGCTC
AAAGGCGCAACGGCTATCGGCCATCACCGTCGAGGAAATGCTCGAGCTGGCGAGCCTGGGGTCGAAGGTGCTGCAGATTC
GCGCCGTCGAGTTCGCCGGCAAATACAATGTACCGCTGCGCGTGCTGTCCAGCTTCGAGGACGGCCCGGGTACGCTGATC
GTCGCTGAAGAAGAAGAGACCACTATGGAAGAACCGCTGATCTCCGGTATCGCCTTCACTGCCAGTGAAGCCAAGCTGAC
GCTGCTCAACACGCCGGACGTGCCGGGCGTGGCCTCCAAGATTCTGGGGCCCATCGCCGATGCCAATATCGAAATCGACA
TGATCGTGCAGAACGTGGCCCCGGCCGGGGACTACACCGACTTCACGTTCACCGTGGCCAAGAGCGATTACAAGCAGACC
AAGAGCATTCTGCAGGACCAGGTGATCCCGGCGCTGGGCGGTGGCGAACTGCGCGGCGACGACAATATCGCCAAGGTGTC
GCTGGTGGGCGTGGGCATGCGCTCGCATGCCGGCGTGGCGTCCAAGATGTTCCGCGTGCTGGCTGACGAGAACATCAACA
TTCGCATGGTCTCCACCTCGGAAATCAAGATCTCCGTGGTCATCGACGAGAAGCAGATGGAGCTGGCCGTGCGTGCGCTG
CACACTGCATTCGGACTCGATAAAGACAGCATACAAGGTGAATGA

Upstream 100 bases:

>100_bases
GAGGCCCGGCTCGGCGAGTGAGAACGTGGAAAGGGTCGTGCGCATGGCGCCGGCCCTTTTCTTCATTCATGCTTGTGAAA
ACCACCACGGATAGGCAGCT

Downstream 100 bases:

>100_bases
AGAAAGAATCTTGGCTTTCCGGCCCCATTCGCTTCTACGCTTGAGGGGTAGCGTCAGGACGACGCCGGAAGGCCTGGGTC
GCGGCCTTTCATTCAACGAG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MALYVQKFGGTSVGSVERIKAVAEKVKRFRDEGHQVVVVVSAMSGETNRLIDLASQINDEPTPREMDMLVSTGEQVTISL
LAMALHKLDVEATSYTGAQVGIRTDSAHTKARIQRIETDDIQADLDDGQVVVVAGFQGVDDEGNITTLGRGGSDTTGVAL
AAALKADECQIYTDVDGVYTTDPRVCSKAQRLSAITVEEMLELASLGSKVLQIRAVEFAGKYNVPLRVLSSFEDGPGTLI
VAEEEETTMEEPLISGIAFTASEAKLTLLNTPDVPGVASKILGPIADANIEIDMIVQNVAPAGDYTDFTFTVAKSDYKQT
KSILQDQVIPALGGGELRGDDNIAKVSLVGVGMRSHAGVASKMFRVLADENINIRMVSTSEIKISVVIDEKQMELAVRAL
HTAFGLDKDSIQGE

Sequences:

>Translated_414_residues
MALYVQKFGGTSVGSVERIKAVAEKVKRFRDEGHQVVVVVSAMSGETNRLIDLASQINDEPTPREMDMLVSTGEQVTISL
LAMALHKLDVEATSYTGAQVGIRTDSAHTKARIQRIETDDIQADLDDGQVVVVAGFQGVDDEGNITTLGRGGSDTTGVAL
AAALKADECQIYTDVDGVYTTDPRVCSKAQRLSAITVEEMLELASLGSKVLQIRAVEFAGKYNVPLRVLSSFEDGPGTLI
VAEEEETTMEEPLISGIAFTASEAKLTLLNTPDVPGVASKILGPIADANIEIDMIVQNVAPAGDYTDFTFTVAKSDYKQT
KSILQDQVIPALGGGELRGDDNIAKVSLVGVGMRSHAGVASKMFRVLADENINIRMVSTSEIKISVVIDEKQMELAVRAL
HTAFGLDKDSIQGE
>Mature_413_residues
ALYVQKFGGTSVGSVERIKAVAEKVKRFRDEGHQVVVVVSAMSGETNRLIDLASQINDEPTPREMDMLVSTGEQVTISLL
AMALHKLDVEATSYTGAQVGIRTDSAHTKARIQRIETDDIQADLDDGQVVVVAGFQGVDDEGNITTLGRGGSDTTGVALA
AALKADECQIYTDVDGVYTTDPRVCSKAQRLSAITVEEMLELASLGSKVLQIRAVEFAGKYNVPLRVLSSFEDGPGTLIV
AEEEETTMEEPLISGIAFTASEAKLTLLNTPDVPGVASKILGPIADANIEIDMIVQNVAPAGDYTDFTFTVAKSDYKQTK
SILQDQVIPALGGGELRGDDNIAKVSLVGVGMRSHAGVASKMFRVLADENINIRMVSTSEIKISVVIDEKQMELAVRALH
TAFGLDKDSIQGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=350, Percent_Identity=31.4285714285714, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1790455, Length=463, Percent_Identity=29.5896328293737, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790376, Length=289, Percent_Identity=27.3356401384083, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=296, Percent_Identity=29.0540540540541, Blast_Score=100, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44249; Mature: 44118

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYVQKFGGTSVGSVERIKAVAEKVKRFRDEGHQVVVVVSAMSGETNRLIDLASQINDE
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCC
PTPREMDMLVSTGEQVTISLLAMALHKLDVEATSYTGAQVGIRTDSAHTKARIQRIETDD
CCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCC
IQADLDDGQVVVVAGFQGVDDEGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYT
CEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCEEE
TDPRVCSKAQRLSAITVEEMLELASLGSKVLQIRAVEFAGKYNVPLRVLSSFEDGPGTLI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHECCCCCCCCEEE
VAEEEETTMEEPLISGIAFTASEAKLTLLNTPDVPGVASKILGPIADANIEIDMIVQNVA
EECCCHHHHHHHHHHCEEEEECCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEEECCC
PAGDYTDFTFTVAKSDYKQTKSILQDQVIPALGGGELRGDDNIAKVSLVGVGMRSHAGVA
CCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCHHCCCHH
SKMFRVLADENINIRMVSTSEIKISVVIDEKQMELAVRALHTAFGLDKDSIQGE
HHHHHHHCCCCCEEEEEEECCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ALYVQKFGGTSVGSVERIKAVAEKVKRFRDEGHQVVVVVSAMSGETNRLIDLASQINDE
EEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCC
PTPREMDMLVSTGEQVTISLLAMALHKLDVEATSYTGAQVGIRTDSAHTKARIQRIETDD
CCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCC
IQADLDDGQVVVVAGFQGVDDEGNITTLGRGGSDTTGVALAAALKADECQIYTDVDGVYT
CEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCEEE
TDPRVCSKAQRLSAITVEEMLELASLGSKVLQIRAVEFAGKYNVPLRVLSSFEDGPGTLI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHECCCCCCCCEEE
VAEEEETTMEEPLISGIAFTASEAKLTLLNTPDVPGVASKILGPIADANIEIDMIVQNVA
EECCCHHHHHHHHHHCEEEEECCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEEECCC
PAGDYTDFTFTVAKSDYKQTKSILQDQVIPALGGGELRGDDNIAKVSLVGVGMRSHAGVA
CCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCHHCCCHH
SKMFRVLADENINIRMVSTSEIKISVVIDEKQMELAVRALHTAFGLDKDSIQGE
HHHHHHHCCCCCEEEEEEECCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]