Click here to switch to the map view.

The map label for this gene is lldD

Identifier: 92112537

GI number: 92112537

Start: 450240

End: 451418

Strand: Direct

Name: lldD

Synonym: Csal_0404

Alternate gene names: 92112537

Gene position: 450240-451418 (Clockwise)

Preceding gene: 92112535

Following gene: 92112538

Centisome position: 12.18

GC content: 65.9

Gene sequence:

>1179_bases
ATGATCATTTCCGCTTCCACGGACTACCGTCACGCCGCCAAGCGACGCCTTCCGCCCTTTCTCTTTCACTATGCCGACGG
GGGCGCCTACGCCGAGCATACGCTGCGTCGCAATGTCGAGGATCTTGCCGGTATCGCGTTGCGTCAACGCGTATTGAAGG
ACATGTCCCATTTGTCCCTGGAGACCGAGCTGTTCGGCGAACCTCTGGCCATGCCCGTCGCCCTGGCCCCCGTGGGGCTG
GCCGGCATGTATGCCCGGCGCGGCGAGGTGCAGGCGGCGCGCGCCGCGGCCTCGAAAGGCATCCCGTTCACGCTGTCGAC
GGTGTCGGTGTGTCCCATCGCTGAGGTGGCCTCGGCCATCGAGCGGCCTCTCTGGTTCCAGCTCTATGTACTGCGGGACA
GGGGCTTCATGAAGCATGTGCTGGAGCGTGCCAAGGCCGCCGGCGTCAAGACGCTCGTCTTCACGGTCGACATGCCGGTG
CCCGGCGCGCGCTATCGCGATGCGCACTCCGGCATGAGCGGCAAGCACGGGGGCCTTCGGCGCATGCTGCAGGCCGTGAC
GCATCCGTCCTGGGCCTGGGACGTGGGGCTTCACGGCCGGCCGCACGATCTGGGCAACGTGTCCGATTATCGCGGCCAGC
CGACGGAGCTCGAAGACTACATTGCCTGGCTCGGCAACAACTTCGATCCTTCCATTTCCTGGAAGGATCTGGAATGGATC
CGCGAGTTCTGGGACGGGCCGATGATCATCAAGGGCATTCTCGACCCCGAGGATGCCCGCGATGCGGTGCGCTTCGGCGC
GGATGGCATCGTCGTGTCCAATCACGGCGGCCGTCAGCTCGACGGTGTGCCCTCCACCGCGCGTGCTCTGCCGGCGATCG
CCGATGCGGTCAAGGGCGACCTGGCCATCCTGGCCGATTCCGGCGTGCGCAATGGGCTCGATGTCGTGCGGATGATCGCC
ATGGGGGCTGATACTATATTGTTGGGGCGTGCCTATATCTATGCGCTGGCCACCGCCGGCGAGGCGGGCGTTGCCCACCT
GCTCGAGCTGTTCGAGAAGGAGATGCGGGTCGCGATGACGCTCACCGGCGCGCGCTCCATCGCCGAGCTGGGTTCGGATT
CGCTGGTCACCGGGTCTGCGGCGGCGTCGATCGAACGCACGCTTTCGCCGAGCCTGTAA

Upstream 100 bases:

>100_bases
CCGATGTATATTGTAAATTGGTAATACCAATATCGCCGAGGCTAGAGATGTTGCCGCGGCGATCGCTCATCGCCAGCGCC
TCATTTGCACAGGGTTCGTC

Downstream 100 bases:

>100_bases
TGATCGCGGCTCGGGTGCCGTCGTCGCGCGAGCGCCTGGGCCGCCGAGACAAGGGCGCAACGGGGTGGCGGTCGATGCCC
CGGTCTTGCTTTCGCTGTCG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MIISASTDYRHAAKRRLPPFLFHYADGGAYAEHTLRRNVEDLAGIALRQRVLKDMSHLSLETELFGEPLAMPVALAPVGL
AGMYARRGEVQAARAAASKGIPFTLSTVSVCPIAEVASAIERPLWFQLYVLRDRGFMKHVLERAKAAGVKTLVFTVDMPV
PGARYRDAHSGMSGKHGGLRRMLQAVTHPSWAWDVGLHGRPHDLGNVSDYRGQPTELEDYIAWLGNNFDPSISWKDLEWI
REFWDGPMIIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVPSTARALPAIADAVKGDLAILADSGVRNGLDVVRMIA
MGADTILLGRAYIYALATAGEAGVAHLLELFEKEMRVAMTLTGARSIAELGSDSLVTGSAAASIERTLSPSL

Sequences:

>Translated_392_residues
MIISASTDYRHAAKRRLPPFLFHYADGGAYAEHTLRRNVEDLAGIALRQRVLKDMSHLSLETELFGEPLAMPVALAPVGL
AGMYARRGEVQAARAAASKGIPFTLSTVSVCPIAEVASAIERPLWFQLYVLRDRGFMKHVLERAKAAGVKTLVFTVDMPV
PGARYRDAHSGMSGKHGGLRRMLQAVTHPSWAWDVGLHGRPHDLGNVSDYRGQPTELEDYIAWLGNNFDPSISWKDLEWI
REFWDGPMIIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVPSTARALPAIADAVKGDLAILADSGVRNGLDVVRMIA
MGADTILLGRAYIYALATAGEAGVAHLLELFEKEMRVAMTLTGARSIAELGSDSLVTGSAAASIERTLSPSL
>Mature_392_residues
MIISASTDYRHAAKRRLPPFLFHYADGGAYAEHTLRRNVEDLAGIALRQRVLKDMSHLSLETELFGEPLAMPVALAPVGL
AGMYARRGEVQAARAAASKGIPFTLSTVSVCPIAEVASAIERPLWFQLYVLRDRGFMKHVLERAKAAGVKTLVFTVDMPV
PGARYRDAHSGMSGKHGGLRRMLQAVTHPSWAWDVGLHGRPHDLGNVSDYRGQPTELEDYIAWLGNNFDPSISWKDLEWI
REFWDGPMIIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVPSTARALPAIADAVKGDLAILADSGVRNGLDVVRMIA
MGADTILLGRAYIYALATAGEAGVAHLLELFEKEMRVAMTLTGARSIAELGSDSLVTGSAAASIERTLSPSL

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=362, Percent_Identity=35.9116022099448, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=34.4919786096257, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=34.4919786096257, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1790033, Length=378, Percent_Identity=82.010582010582, Blast_Score=650, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=370, Percent_Identity=34.5945945945946, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=283, Percent_Identity=32.8621908127208, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=29.8153034300792, Blast_Score=169, Evalue=8e-43,
Organism=Drosophila melanogaster, GI78707188, Length=385, Percent_Identity=33.2467532467532, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281363140, Length=385, Percent_Identity=33.2467532467532, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI78707190, Length=385, Percent_Identity=33.2467532467532, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_CHRSD (Q1R0J2)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572465.1
- ProteinModelPortal:   Q1R0J2
- SMR:   Q1R0J2
- STRING:   Q1R0J2
- GeneID:   4025998
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0404
- NMPDR:   fig|290398.4.peg.512
- eggNOG:   COG1304
- HOGENOM:   HBG517781
- OMA:   NFDPSIG
- ProtClustDB:   PRK11197
- BioCyc:   CSAL290398:CSAL_0404-MONOMER
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 42414; Mature: 42414

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISASTDYRHAAKRRLPPFLFHYADGGAYAEHTLRRNVEDLAGIALRQRVLKDMSHLSL
CEECCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCH
ETELFGEPLAMPVALAPVGLAGMYARRGEVQAARAAASKGIPFTLSTVSVCPIAEVASAI
HHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECHHCCCCHHHHHHHH
ERPLWFQLYVLRDRGFMKHVLERAKAAGVKTLVFTVDMPVPGARYRDAHSGMSGKHGGLR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAVTHPSWAWDVGLHGRPHDLGNVSDYRGQPTELEDYIAWLGNNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWDGPMIIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVPSTARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
LAILADSGVRNGLDVVRMIAMGADTILLGRAYIYALATAGEAGVAHLLELFEKEMRVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHE
LTGARSIAELGSDSLVTGSAAASIERTLSPSL
EHHHHHHHHCCCCCEECCHHHHHHHHHCCCCC
>Mature Secondary Structure
MIISASTDYRHAAKRRLPPFLFHYADGGAYAEHTLRRNVEDLAGIALRQRVLKDMSHLSL
CEECCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCH
ETELFGEPLAMPVALAPVGLAGMYARRGEVQAARAAASKGIPFTLSTVSVCPIAEVASAI
HHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECHHCCCCHHHHHHHH
ERPLWFQLYVLRDRGFMKHVLERAKAAGVKTLVFTVDMPVPGARYRDAHSGMSGKHGGLR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAVTHPSWAWDVGLHGRPHDLGNVSDYRGQPTELEDYIAWLGNNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWDGPMIIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVPSTARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
LAILADSGVRNGLDVVRMIAMGADTILLGRAYIYALATAGEAGVAHLLELFEKEMRVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHE
LTGARSIAELGSDSLVTGSAAASIERTLSPSL
EHHHHHHHHCCCCCEECCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA