Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 91790290

GI number: 91790290

Start: 4709826

End: 4711406

Strand: Reverse

Name: trpE [H]

Synonym: Bpro_4457

Alternate gene names: 91790290

Gene position: 4711406-4709826 (Counterclockwise)

Preceding gene: 91790293

Following gene: 91790289

Centisome position: 90.6

GC content: 63.82

Gene sequence:

>1581_bases
GTGATTACTGAACTCGAATTTAAAAGCCTGGCCAGCCAGGGCTACAACCGCATTCCGCTGATGCTGGAGGCGTTTGCCGA
TCTCGAAACCCCGCTGTCGCTCTACCTCAAGCTTGCCAACGCCAAAGACGGCGGCAAGTTCAGCTTTTTGCTGGAGTCGG
TGGTGGGTGGCGAGCGTTTTGGCCGCTACAGCTTTATTGGCTTGCCCGCGCGTACGCTGATACGCTGCTCGGGCTTCGGG
GCCGACATGCTCACCGAGGTGGTGAAGGACGGCCGGGTCATCGAAACCTCGCGAGTCAATCCGCTGGATTTCATCAGTGA
CTACCAAAAACGGTTCAAGGTCGCGCTCAGGCCCGGCCTGCCGCGCTTTTGCGGCGGACTGGCCGGTTACTTTGGCTATG
ACACGGTGCGCTACATCGAGAAAAAACTCGAAGCCTCCTGCCCGCCGGACACGCTGGGCTGCCCCGACATCATGCTGCTG
CAGTGCGAAGAACTGGCCGTGATCGACAACCTCTCGGGCAAGCTCTACCTGATCGTGTACGCGGATCCGGCCCAGCCCGA
GGCCTTTGCCAACGCCAAGAAGCGCCTGCGTGAGCTCAAGGAGCAGCTCAAATACTCCGTCAGCGCGCCGGTCGTCAAGC
CCTCGCAGGGCTATCCGGCCGAGCGTGACTTTGCCAAGGCCGACTACATTGCCGCGGTAGAGCGCGCCAAGCGGCTGATC
GAGGCCGGCGATTTCATGCAGGTGCAGGTGGGCCAGCGCATCAAGAAGCGCTACACCGAGTCGCCGCTGAGCCTGTACCG
GGCGCTGCGCGCGCTCAACCCCTCGCCCTACATGTACTACTACCACTTTGGCGACTTCCATGTGGTGGGGGCGTCGCCTG
AGATTCTGGTGCGGCAGGAGCAGGTGGCTCGCGTCGCCGGGCCGCCCCAAGACGCGAACGCCCCCTCGGGGGGCAGCGAG
TACACGCCAGTGACGAGCGTGGGGGCCCAGTTCGAGCAGAAGATCACGATCCGGCCCCTGGCCGGCACCCGCCCGCGCGC
TTCGTCCATCGAGGCTGACAAGGCGGTCGAGCAGGAGCTGGTCAATGACCCGAAGGAGCGCGCCGAGCACGTGATGCTGA
TCGACCTGGCGCGCAACGACATCGGCCGCATCGCCAAAACCGGCACCGTCAAGGTGACCGAAGCCTTTGCGGTGGAGCGC
TACAGCCATGTGATGCACATCGTGAGCAACGTCGAAGGCGTCTTGCTCGATGGCATGACCAGCATGGATGTGCTCAAGGC
GACCTTCCCGGCCGGCACGCTGACCGGCGCGCCCAAGGTGCATGCGATGGAACTGATCGACCAGCTGGAGCCCACCAAGC
GCGGCCTGTATGGCGGCGCCTGCGGTTACCTCAGTTATGCGGGCGACATGGACGTGGCCATTGCGATCCGCACCGGCATC
ATCAAGGACCAGACCCTGTATGTGCAGGCGGCGGCCGGCGTGGTGGCTGACTCGGTGCCCGAGCTGGAATGGAAAGAAAC
CGAAGCCAAGGCGCGCGCCTTGCTGCGCGCCAGCGAACTGGTCGAGGAGGGCCTGGAATGA

Upstream 100 bases:

>100_bases
CTCGTGCGCCACGCAACGAGCATCCCGGCCCCGGACTTCGGGGCGTTTTGAATGACAGGCGCAGGCGTCCACAACGCGCC
GCCCTGATGAAGGACCCACA

Downstream 100 bases:

>100_bases
GCACGGTAGTCGTCCAACATTGCGACACCATGGCCGACGTGCGCCGGCACATCGATGCGCTCGATGACCGCATCGTGGCC
CTGCTGGCCGAGCGCAGCGG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MITELEFKSLASQGYNRIPLMLEAFADLETPLSLYLKLANAKDGGKFSFLLESVVGGERFGRYSFIGLPARTLIRCSGFG
ADMLTEVVKDGRVIETSRVNPLDFISDYQKRFKVALRPGLPRFCGGLAGYFGYDTVRYIEKKLEASCPPDTLGCPDIMLL
QCEELAVIDNLSGKLYLIVYADPAQPEAFANAKKRLRELKEQLKYSVSAPVVKPSQGYPAERDFAKADYIAAVERAKRLI
EAGDFMQVQVGQRIKKRYTESPLSLYRALRALNPSPYMYYYHFGDFHVVGASPEILVRQEQVARVAGPPQDANAPSGGSE
YTPVTSVGAQFEQKITIRPLAGTRPRASSIEADKAVEQELVNDPKERAEHVMLIDLARNDIGRIAKTGTVKVTEAFAVER
YSHVMHIVSNVEGVLLDGMTSMDVLKATFPAGTLTGAPKVHAMELIDQLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGI
IKDQTLYVQAAAGVVADSVPELEWKETEAKARALLRASELVEEGLE

Sequences:

>Translated_526_residues
MITELEFKSLASQGYNRIPLMLEAFADLETPLSLYLKLANAKDGGKFSFLLESVVGGERFGRYSFIGLPARTLIRCSGFG
ADMLTEVVKDGRVIETSRVNPLDFISDYQKRFKVALRPGLPRFCGGLAGYFGYDTVRYIEKKLEASCPPDTLGCPDIMLL
QCEELAVIDNLSGKLYLIVYADPAQPEAFANAKKRLRELKEQLKYSVSAPVVKPSQGYPAERDFAKADYIAAVERAKRLI
EAGDFMQVQVGQRIKKRYTESPLSLYRALRALNPSPYMYYYHFGDFHVVGASPEILVRQEQVARVAGPPQDANAPSGGSE
YTPVTSVGAQFEQKITIRPLAGTRPRASSIEADKAVEQELVNDPKERAEHVMLIDLARNDIGRIAKTGTVKVTEAFAVER
YSHVMHIVSNVEGVLLDGMTSMDVLKATFPAGTLTGAPKVHAMELIDQLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGI
IKDQTLYVQAAAGVVADSVPELEWKETEAKARALLRASELVEEGLE
>Mature_526_residues
MITELEFKSLASQGYNRIPLMLEAFADLETPLSLYLKLANAKDGGKFSFLLESVVGGERFGRYSFIGLPARTLIRCSGFG
ADMLTEVVKDGRVIETSRVNPLDFISDYQKRFKVALRPGLPRFCGGLAGYFGYDTVRYIEKKLEASCPPDTLGCPDIMLL
QCEELAVIDNLSGKLYLIVYADPAQPEAFANAKKRLRELKEQLKYSVSAPVVKPSQGYPAERDFAKADYIAAVERAKRLI
EAGDFMQVQVGQRIKKRYTESPLSLYRALRALNPSPYMYYYHFGDFHVVGASPEILVRQEQVARVAGPPQDANAPSGGSE
YTPVTSVGAQFEQKITIRPLAGTRPRASSIEADKAVEQELVNDPKERAEHVMLIDLARNDIGRIAKTGTVKVTEAFAVER
YSHVMHIVSNVEGVLLDGMTSMDVLKATFPAGTLTGAPKVHAMELIDQLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGI
IKDQTLYVQAAAGVVADSVPELEWKETEAKARALLRASELVEEGLE

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=401, Percent_Identity=35.6608478802993, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI1788114, Length=481, Percent_Identity=28.0665280665281, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1786809, Length=252, Percent_Identity=25, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=506, Percent_Identity=35.9683794466403, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324361, Length=478, Percent_Identity=25.9414225941423, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57843; Mature: 57843

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITELEFKSLASQGYNRIPLMLEAFADLETPLSLYLKLANAKDGGKFSFLLESVVGGERF
CCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHEEEECCCCCCHHHHHHHHHHCCHHC
GRYSFIGLPARTLIRCSGFGADMLTEVVKDGRVIETSRVNPLDFISDYQKRFKVALRPGL
CCEEEECCCHHHHHEECCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCC
PRFCGGLAGYFGYDTVRYIEKKLEASCPPDTLGCPDIMLLQCEELAVIDNLSGKLYLIVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHEEECCCCCEEEEEE
ADPAQPEAFANAKKRLRELKEQLKYSVSAPVVKPSQGYPAERDFAKADYIAAVERAKRLI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
EAGDFMQVQVGQRIKKRYTESPLSLYRALRALNPSPYMYYYHFGDFHVVGASPEILVRQE
HCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCHHEEEHH
QVARVAGPPQDANAPSGGSEYTPVTSVGAQFEQKITIRPLAGTRPRASSIEADKAVEQEL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHH
VNDPKERAEHVMLIDLARNDIGRIAKTGTVKVTEAFAVERYSHVMHIVSNVEGVLLDGMT
HCCHHHHHCEEEEEEEHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEECCCC
SMDVLKATFPAGTLTGAPKVHAMELIDQLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGI
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCHHHHEECCCCCEEEEEEECC
IKDQTLYVQAAAGVVADSVPELEWKETEAKARALLRASELVEEGLE
CCCCEEEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITELEFKSLASQGYNRIPLMLEAFADLETPLSLYLKLANAKDGGKFSFLLESVVGGERF
CCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHEEEECCCCCCHHHHHHHHHHCCHHC
GRYSFIGLPARTLIRCSGFGADMLTEVVKDGRVIETSRVNPLDFISDYQKRFKVALRPGL
CCEEEECCCHHHHHEECCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCC
PRFCGGLAGYFGYDTVRYIEKKLEASCPPDTLGCPDIMLLQCEELAVIDNLSGKLYLIVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHEEECCCCCEEEEEE
ADPAQPEAFANAKKRLRELKEQLKYSVSAPVVKPSQGYPAERDFAKADYIAAVERAKRLI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
EAGDFMQVQVGQRIKKRYTESPLSLYRALRALNPSPYMYYYHFGDFHVVGASPEILVRQE
HCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEEECCCCHHEEEHH
QVARVAGPPQDANAPSGGSEYTPVTSVGAQFEQKITIRPLAGTRPRASSIEADKAVEQEL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCCHHHHHHHHH
VNDPKERAEHVMLIDLARNDIGRIAKTGTVKVTEAFAVERYSHVMHIVSNVEGVLLDGMT
HCCHHHHHCEEEEEEEHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEECCCC
SMDVLKATFPAGTLTGAPKVHAMELIDQLEPTKRGLYGGACGYLSYAGDMDVAIAIRTGI
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCHHHHEECCCCCEEEEEEECC
IKDQTLYVQAAAGVVADSVPELEWKETEAKARALLRASELVEEGLE
CCCCEEEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]