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The map label for this gene is ilvA [H]

Identifier: 91790083

GI number: 91790083

Start: 4471177

End: 4472184

Strand: Direct

Name: ilvA [H]

Synonym: Bpro_4245

Alternate gene names: 91790083

Gene position: 4471177-4472184 (Clockwise)

Preceding gene: 91790082

Following gene: 91790084

Centisome position: 85.98

GC content: 68.06

Gene sequence:

>1008_bases
ATGAGCACCACGCTGCACGGCACGCCCACGGTCACCCCGCGGGCCGATGGCCTTCCTTCGCTGCGCGCCATCGAAGAGGC
GGCCGGCGTGGTCTACCGGGAGTTCCAGGCCACGCCGCAATACCGCTGGGGCCTGTCCAGCCAGCGGCTGGGCACCGACT
GCTGGATCAAGCACGAGAACCACACGCCGGTTGGCGCCTTCAAGATCCGCGGCGGCCTCACCTACTTTGACGCCCTGAAA
AAAAGCGGCACGCTCCCCCTCGAGGTCATCAGCGCCACACGGGGCAACCACGGCCAGAGCATAGGCTGGGCCGCCCGCGC
CCATGGTGTGGCCTGCACCATCGTCGTTCCGCACGGCAATTCGATCGAGAAGAATGCAGCCATGCGTGCGCTCGGCGTGA
CGCTGATCGAGCACGGCCAGGACTTCCAGGAGAGCCGCGAATTTGCCATCCAGCTGGCCGCCGAACGCGGCGCCCACATG
GTGCCCAGCTTTCACGCTGACCTGCTGCGCGGCGTGGCTACCAGCTGGTGGGAATTCATGCAGGCCGTGCCGCAGCTGGA
CGTGGTGTACGTGCCGATTGGCCAGGGCTCCGGGGCCTGCTCGGCCATTGCCGCCAAACTGGCGCTCGGACGTAAGCTGC
GCATCGTCGGCGTGGTGAGCGCGCATGCCACCACCTACGCCGATTCCCTGGCGGCAGGCCGCGTGGTCGAGGCACCGGTG
ACAACCCGGCTGGCCGACGGCATGGCCTGTCGTATCGCGGACCCTGCGGCGCTCGAACTCATGGCGCCCCATATCGACCA
CCTGGTGCAGGTCACCGATGACGAGGTCGCGCAGGCGATGCGCGATCTGTATGCGGACACGCACAACGTGGCCGAAGGGG
CAGGCGCGGCCAGCTTTGCCGCCGCCATGCAGGAGCGCAGCGAGCTCAAGGGACAGGTGGTCGGCACCACGCTGTGCGGC
AGCAATGTGGACAGCACCACGCTGGCCAGCGTACTCGGGGCCTGCTGA

Upstream 100 bases:

>100_bases
CTGGCGCTACGCCTGCTGTCCGAGAAGCGGGCTGCGGCATGAGCCGCCGGGCCGCTCCCAAGGCGAAAGGCACCGCAGCG
CGCAGTGCGGAGGTCAAGCA

Downstream 100 bases:

>100_bases
CGCCCGCCCTGTCGTCGCACTTGGGACAGGCTGCGGCGCCCGCCTGGCCTAAATTCACGCCATGGGAACCCTTTACCTCG
TGCGCCATGGCCAGGCCTCG

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSTTLHGTPTVTPRADGLPSLRAIEEAAGVVYREFQATPQYRWGLSSQRLGTDCWIKHENHTPVGAFKIRGGLTYFDALK
KSGTLPLEVISATRGNHGQSIGWAARAHGVACTIVVPHGNSIEKNAAMRALGVTLIEHGQDFQESREFAIQLAAERGAHM
VPSFHADLLRGVATSWWEFMQAVPQLDVVYVPIGQGSGACSAIAAKLALGRKLRIVGVVSAHATTYADSLAAGRVVEAPV
TTRLADGMACRIADPAALELMAPHIDHLVQVTDDEVAQAMRDLYADTHNVAEGAGAASFAAAMQERSELKGQVVGTTLCG
SNVDSTTLASVLGAC

Sequences:

>Translated_335_residues
MSTTLHGTPTVTPRADGLPSLRAIEEAAGVVYREFQATPQYRWGLSSQRLGTDCWIKHENHTPVGAFKIRGGLTYFDALK
KSGTLPLEVISATRGNHGQSIGWAARAHGVACTIVVPHGNSIEKNAAMRALGVTLIEHGQDFQESREFAIQLAAERGAHM
VPSFHADLLRGVATSWWEFMQAVPQLDVVYVPIGQGSGACSAIAAKLALGRKLRIVGVVSAHATTYADSLAAGRVVEAPV
TTRLADGMACRIADPAALELMAPHIDHLVQVTDDEVAQAMRDLYADTHNVAEGAGAASFAAAMQERSELKGQVVGTTLCG
SNVDSTTLASVLGAC
>Mature_334_residues
STTLHGTPTVTPRADGLPSLRAIEEAAGVVYREFQATPQYRWGLSSQRLGTDCWIKHENHTPVGAFKIRGGLTYFDALKK
SGTLPLEVISATRGNHGQSIGWAARAHGVACTIVVPHGNSIEKNAAMRALGVTLIEHGQDFQESREFAIQLAAERGAHMV
PSFHADLLRGVATSWWEFMQAVPQLDVVYVPIGQGSGACSAIAAKLALGRKLRIVGVVSAHATTYADSLAAGRVVEAPVT
TRLADGMACRIADPAALELMAPHIDHLVQVTDDEVAQAMRDLYADTHNVAEGAGAASFAAAMQERSELKGQVVGTTLCGS
NVDSTTLASVLGAC

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=323, Percent_Identity=26.3157894736842, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1790207, Length=337, Percent_Identity=29.3768545994065, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789505, Length=322, Percent_Identity=26.3975155279503, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71991565, Length=326, Percent_Identity=27.9141104294479, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17537387, Length=288, Percent_Identity=30.2083333333333, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508781, Length=282, Percent_Identity=24.468085106383, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=28.8401253918495, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320930, Length=302, Percent_Identity=29.1390728476821, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355833, Length=333, Percent_Identity=29.4294294294294, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24645328, Length=222, Percent_Identity=31.0810810810811, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35402; Mature: 35270

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLHGTPTVTPRADGLPSLRAIEEAAGVVYREFQATPQYRWGLSSQRLGTDCWIKHEN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEECC
HTPVGAFKIRGGLTYFDALKKSGTLPLEVISATRGNHGQSIGWAARAHGVACTIVVPHGN
CCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHCCCEEEEEEEECCC
SIEKNAAMRALGVTLIEHGQDFQESREFAIQLAAERGAHMVPSFHADLLRGVATSWWEFM
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
QAVPQLDVVYVPIGQGSGACSAIAAKLALGRKLRIVGVVSAHATTYADSLAAGRVVEAPV
HHCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEEEEHHHHHHHHHHHCCCEEECCH
TTRLADGMACRIADPAALELMAPHIDHLVQVTDDEVAQAMRDLYADTHNVAEGAGAASFA
HHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCCHHHHH
AAMQERSELKGQVVGTTLCGSNVDSTTLASVLGAC
HHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
STTLHGTPTVTPRADGLPSLRAIEEAAGVVYREFQATPQYRWGLSSQRLGTDCWIKHEN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEECC
HTPVGAFKIRGGLTYFDALKKSGTLPLEVISATRGNHGQSIGWAARAHGVACTIVVPHGN
CCCCEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHCCCEEEEEEEECCC
SIEKNAAMRALGVTLIEHGQDFQESREFAIQLAAERGAHMVPSFHADLLRGVATSWWEFM
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
QAVPQLDVVYVPIGQGSGACSAIAAKLALGRKLRIVGVVSAHATTYADSLAAGRVVEAPV
HHCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEEEEHHHHHHHHHHHCCCEEECCH
TTRLADGMACRIADPAALELMAPHIDHLVQVTDDEVAQAMRDLYADTHNVAEGAGAASFA
HHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCCHHHHH
AAMQERSELKGQVVGTTLCGSNVDSTTLASVLGAC
HHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]