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The map label for this gene is livM [H]

Identifier: 91789918

GI number: 91789918

Start: 4289448

End: 4290419

Strand: Direct

Name: livM [H]

Synonym: Bpro_4079

Alternate gene names: 91789918

Gene position: 4289448-4290419 (Clockwise)

Preceding gene: 91789917

Following gene: 91789920

Centisome position: 82.49

GC content: 61.63

Gene sequence:

>972_bases
ATGAATAACGCACAAAAATTGACCCGTATCACCTACCTGGCCCTGCTGGCGCTGGCGCTGGTGGCGCCCGTGATCGGGCT
GTACCCGGTGTTTGTCATGAAGCTTCTGTGCTTTGCCCTGTTTGCCTGTGCTTTCAACCTGCTGTTGGGTTTTACCGGCT
TGCTGTCCTTCGGTCACGCCGCATTTTTTGGCTCGGCCGCCTACGTCACCGGCTGGTTCATCAAGTCGCAAAGCTGGACG
CCTGAACTGGGCATTCTTGCCGGCACGGTCGCGGCCGGCTTGATTGGCCTGGTCGTCGGCGCGGTCGCCATCCGGCGCCA
GGGCATTTACTTTGCCATGATCACACTGGCGATTGCACAAATGGTGTTTTTTGTCTGCCTGCAGGCGCCGTTTACCGGCG
GTGAAGACGGCTTGCAGGGCGTGCCGCGCGGCCGCCTGTTGGGCCTGCTCTCGCTCGAATCCGACACCACCATGTATTAC
TTTGTGGTCGCGGTGTTCGTGCTGTGCTTTTTGGGCATCTCGCGCATCGTGCACTCGCCATTTGGCCAGGTACTCAAGAT
GATCCGTGAGAATGAACCCCGCGCCATTTCACTGGGCTACCAGGTAGACCGCTACAAGCTGCTGGCCTTTGTGCTGTCGT
CCGCCCTGGCCGGGCTGGCAGGCTCGCTCAAGACCCTGGTAATGGGTTTTGCCACGCTGTCGGATGTGCACTGGTCCATG
TCGGGCGAAGTGATCCTGATGACCCTGCTGGGTGGCGTGGGCACCTTCTTTGGCCCGGTCTTCGGCGCCGGCATCGTGAT
CTCGCTGCAAAACCTGCTGGCCGACAAGGTCGGCTCATGGGTCACCGTCATCATCGGCGCGATCTTCGTGGTCTGCGTGC
TGGCCTTCCGCAAGGGCGTGGTGGGTGAGTTGCAGGCTTTCCTCGATCGCCGCCGTCAGGCCTCAGCCGAGGCCGCCCCG
CCGCCGGCCTGA

Upstream 100 bases:

>100_bases
CACTTCGTGTAATGCGCTGCCCCCGGGGGGCGCTGCGCCTGCGGCCCCTGCTGGAACGGGAACCCCGCGCTCGCCACTTG
GCGGTTCGATGGATATCTGA

Downstream 100 bases:

>100_bases
ACCGCCGAGCAAGTGTCTTCTGCGGCACAAGCCGCAATTGCTACTGTTTTTATAGCAGTCAGGTCCCGTCATATATAGGC
CCACAGCCATTTCCAAAAAG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MNNAQKLTRITYLALLALALVAPVIGLYPVFVMKLLCFALFACAFNLLLGFTGLLSFGHAAFFGSAAYVTGWFIKSQSWT
PELGILAGTVAAGLIGLVVGAVAIRRQGIYFAMITLAIAQMVFFVCLQAPFTGGEDGLQGVPRGRLLGLLSLESDTTMYY
FVVAVFVLCFLGISRIVHSPFGQVLKMIRENEPRAISLGYQVDRYKLLAFVLSSALAGLAGSLKTLVMGFATLSDVHWSM
SGEVILMTLLGGVGTFFGPVFGAGIVISLQNLLADKVGSWVTVIIGAIFVVCVLAFRKGVVGELQAFLDRRRQASAEAAP
PPA

Sequences:

>Translated_323_residues
MNNAQKLTRITYLALLALALVAPVIGLYPVFVMKLLCFALFACAFNLLLGFTGLLSFGHAAFFGSAAYVTGWFIKSQSWT
PELGILAGTVAAGLIGLVVGAVAIRRQGIYFAMITLAIAQMVFFVCLQAPFTGGEDGLQGVPRGRLLGLLSLESDTTMYY
FVVAVFVLCFLGISRIVHSPFGQVLKMIRENEPRAISLGYQVDRYKLLAFVLSSALAGLAGSLKTLVMGFATLSDVHWSM
SGEVILMTLLGGVGTFFGPVFGAGIVISLQNLLADKVGSWVTVIIGAIFVVCVLAFRKGVVGELQAFLDRRRQASAEAAP
PPA
>Mature_323_residues
MNNAQKLTRITYLALLALALVAPVIGLYPVFVMKLLCFALFACAFNLLLGFTGLLSFGHAAFFGSAAYVTGWFIKSQSWT
PELGILAGTVAAGLIGLVVGAVAIRRQGIYFAMITLAIAQMVFFVCLQAPFTGGEDGLQGVPRGRLLGLLSLESDTTMYY
FVVAVFVLCFLGISRIVHSPFGQVLKMIRENEPRAISLGYQVDRYKLLAFVLSSALAGLAGSLKTLVMGFATLSDVHWSM
SGEVILMTLLGGVGTFFGPVFGAGIVISLQNLLADKVGSWVTVIIGAIFVVCVLAFRKGVVGELQAFLDRRRQASAEAAP
PPA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=294, Percent_Identity=25.1700680272109, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 34418; Mature: 34418

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNAQKLTRITYLALLALALVAPVIGLYPVFVMKLLCFALFACAFNLLLGFTGLLSFGHA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFFGSAAYVTGWFIKSQSWTPELGILAGTVAAGLIGLVVGAVAIRRQGIYFAMITLAIAQ
HHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MVFFVCLQAPFTGGEDGLQGVPRGRLLGLLSLESDTTMYYFVVAVFVLCFLGISRIVHSP
HHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
FGQVLKMIRENEPRAISLGYQVDRYKLLAFVLSSALAGLAGSLKTLVMGFATLSDVHWSM
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGEVILMTLLGGVGTFFGPVFGAGIVISLQNLLADKVGSWVTVIIGAIFVVCVLAFRKGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VGELQAFLDRRRQASAEAAPPPA
HHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNNAQKLTRITYLALLALALVAPVIGLYPVFVMKLLCFALFACAFNLLLGFTGLLSFGHA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFFGSAAYVTGWFIKSQSWTPELGILAGTVAAGLIGLVVGAVAIRRQGIYFAMITLAIAQ
HHHCCHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MVFFVCLQAPFTGGEDGLQGVPRGRLLGLLSLESDTTMYYFVVAVFVLCFLGISRIVHSP
HHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
FGQVLKMIRENEPRAISLGYQVDRYKLLAFVLSSALAGLAGSLKTLVMGFATLSDVHWSM
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGEVILMTLLGGVGTFFGPVFGAGIVISLQNLLADKVGSWVTVIIGAIFVVCVLAFRKGV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VGELQAFLDRRRQASAEAAPPPA
HHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]