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The map label for this gene is rfbD [H]

Identifier: 91789861

GI number: 91789861

Start: 4219186

End: 4220112

Strand: Reverse

Name: rfbD [H]

Synonym: Bpro_4021

Alternate gene names: 91789861

Gene position: 4220112-4219186 (Counterclockwise)

Preceding gene: 91789862

Following gene: 91789860

Centisome position: 81.15

GC content: 63.65

Gene sequence:

>927_bases
TTGAAAATCCTGCTTTTCGGCAAAAACGGCCAGGTCGGCTGGGAACTACAGCGCAGCCTGGCTCCTTTGGGTGAACTCAC
GGCGCTCGACCGTCACAGCACAGACCTGTGCGGCGACCTCGGCAATCTGCAGGGCCTGGCTGCCACGGTGCAACAACTCC
GGCCCGACGTCATCGTCAATGCCGCCGCCCACACCGCCGTAGACAAGGCTGAAAGTGAGCCAGCACTTGCGCGCACACTC
AATGCGCTGGCCCCCAGCGTGCTGGCGCAGGAGGCGGCCAGACTCGGTTCCCTGCTGGTTCACTACAGTACCGACTACGT
ATTTGACGGCAGCGGCACCCGCCCATGGACAGAGGCCGACACCCCGGCGCCGCTCAGCGTTTACGGCCAGTCCAAGCTTG
AGGGCGAGCAGCTCATCCAGGCGGCCAGCCCGCGCCACCTGATCTTTCGCACCAGCTGGGTCTATGCCGCGCGCGGTGGC
AATTTCGCCAAGACCATGCTGCGCCTGGCGCAGGAGCGGGAGCGCCTCATCGTGATTGACGACCAGTTTGGCGCACCCAC
CGGCGCCGAGTTGCTGGCCGATGTGAGCGCCCACGCCATCCGCCAGGTACTCCAGCGCCCCGCTGATGCCGGCCTTTACC
ATCTGGTGGCCAGTGGCGAAACCAGCTGGCATGGTTATGCGAAATACGTCCTCGCCCAGGCAGAACGGAGCCAGGAACAA
GGGCGTGTCGCTATAAAAATAATAGCCAAAGCGGTAGACCCCGTTCCCACCAGTGCGTTTCCAACACCCGCCAAACGGCC
CCACAACTCCCGGCTGGACACCACCAGGCTGCAAACCACCTTTGGCCTGACTCTGCCGCCGTGGCAGCAGGGTGTGGACC
GCATGTTGGAGGAGGTGCTGGGGAGTAGGGAGTTGCATGCCCTATAA

Upstream 100 bases:

>100_bases
ACCTGGCCAACCCCGACTGGGTGGCCCATGTGCAAAGCGGGGCCTACCGCGAGTGGACGGCCAAACAGTACGAGTACGGA
CAAACCCAAAAGGCTGCAGC

Downstream 100 bases:

>100_bases
CTCCGCGTATAGGGCTGCTTGCGCGAGTTGATTGCATTGATTACAATGACTTCATTGATATCAATTGCTGGAGGTCAGCA
TGAGTAGCATCACTGTGCGT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKILLFGKNGQVGWELQRSLAPLGELTALDRHSTDLCGDLGNLQGLAATVQQLRPDVIVNAAAHTAVDKAESEPALARTL
NALAPSVLAQEAARLGSLLVHYSTDYVFDGSGTRPWTEADTPAPLSVYGQSKLEGEQLIQAASPRHLIFRTSWVYAARGG
NFAKTMLRLAQERERLIVIDDQFGAPTGAELLADVSAHAIRQVLQRPADAGLYHLVASGETSWHGYAKYVLAQAERSQEQ
GRVAIKIIAKAVDPVPTSAFPTPAKRPHNSRLDTTRLQTTFGLTLPPWQQGVDRMLEEVLGSRELHAL

Sequences:

>Translated_308_residues
MKILLFGKNGQVGWELQRSLAPLGELTALDRHSTDLCGDLGNLQGLAATVQQLRPDVIVNAAAHTAVDKAESEPALARTL
NALAPSVLAQEAARLGSLLVHYSTDYVFDGSGTRPWTEADTPAPLSVYGQSKLEGEQLIQAASPRHLIFRTSWVYAARGG
NFAKTMLRLAQERERLIVIDDQFGAPTGAELLADVSAHAIRQVLQRPADAGLYHLVASGETSWHGYAKYVLAQAERSQEQ
GRVAIKIIAKAVDPVPTSAFPTPAKRPHNSRLDTTRLQTTFGLTLPPWQQGVDRMLEEVLGSRELHAL
>Mature_308_residues
MKILLFGKNGQVGWELQRSLAPLGELTALDRHSTDLCGDLGNLQGLAATVQQLRPDVIVNAAAHTAVDKAESEPALARTL
NALAPSVLAQEAARLGSLLVHYSTDYVFDGSGTRPWTEADTPAPLSVYGQSKLEGEQLIQAASPRHLIFRTSWVYAARGG
NFAKTMLRLAQERERLIVIDDQFGAPTGAELLADVSAHAIRQVLQRPADAGLYHLVASGETSWHGYAKYVLAQAERSQEQ
GRVAIKIIAKAVDPVPTSAFPTPAKRPHNSRLDTTRLQTTFGLTLPPWQQGVDRMLEEVLGSRELHAL

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=255, Percent_Identity=28.6274509803922, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI33519455, Length=255, Percent_Identity=28.6274509803922, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1788352, Length=300, Percent_Identity=60.6666666666667, Blast_Score=388, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33434; Mature: 33434

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLFGKNGQVGWELQRSLAPLGELTALDRHSTDLCGDLGNLQGLAATVQQLRPDVIVN
CEEEEECCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
AAAHTAVDKAESEPALARTLNALAPSVLAQEAARLGSLLVHYSTDYVFDGSGTRPWTEAD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCCC
TPAPLSVYGQSKLEGEQLIQAASPRHLIFRTSWVYAARGGNFAKTMLRLAQERERLIVID
CCCCEEECCCCCCCHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEE
DQFGAPTGAELLADVSAHAIRQVLQRPADAGLYHLVASGETSWHGYAKYVLAQAERSQEQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
GRVAIKIIAKAVDPVPTSAFPTPAKRPHNSRLDTTRLQTTFGLTLPPWQQGVDRMLEEVL
CCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHH
GSRELHAL
CCCCCCCC
>Mature Secondary Structure
MKILLFGKNGQVGWELQRSLAPLGELTALDRHSTDLCGDLGNLQGLAATVQQLRPDVIVN
CEEEEECCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
AAAHTAVDKAESEPALARTLNALAPSVLAQEAARLGSLLVHYSTDYVFDGSGTRPWTEAD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCCC
TPAPLSVYGQSKLEGEQLIQAASPRHLIFRTSWVYAARGGNFAKTMLRLAQERERLIVID
CCCCEEECCCCCCCHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEE
DQFGAPTGAELLADVSAHAIRQVLQRPADAGLYHLVASGETSWHGYAKYVLAQAERSQEQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
GRVAIKIIAKAVDPVPTSAFPTPAKRPHNSRLDTTRLQTTFGLTLPPWQQGVDRMLEEVL
CCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHH
GSRELHAL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]