Click here to switch to the map view.

The map label for this gene is comC [H]

Identifier: 91789812

GI number: 91789812

Start: 4165555

End: 4166616

Strand: Reverse

Name: comC [H]

Synonym: Bpro_3972

Alternate gene names: 91789812

Gene position: 4166616-4165555 (Counterclockwise)

Preceding gene: 91789813

Following gene: 91789811

Centisome position: 80.12

GC content: 67.98

Gene sequence:

>1062_bases
ATGACCACAGCCCAACGCCACACCCCCGCCGACCTGACCCGATTTGCCAGCCAGTTGCTCACAGCCGCTGGCCTGCCCGC
CGCCAAGGCAGACACCGTGGCCCGCCTGCTGGTGCTGACCGACATGATGCAGCGCCACACCCACGGCGTGGCGCTGTGCC
CGCTCTATATCGATCAATTGAAAAACGGGCTGATGGGCACAGACGGTGAGCCCGAAGTGGTGCGGGACACGGGAGCCACC
GTGGTGTGGGACGGCCATTACCTGCCCGGCCTGTGGCTGGTTGACAAGGCCTTGAGCCTGGCGTTCGAGCGTGTCGCCCA
GCACGGCGTCGTGACCTTCGCCATGCGCCGCAGCCACCACATCGCCTGCCTGGCCGCGCTGGTCAAACAGGCCACCGACC
GGGGCCTGGTGGCCATCCTCGCCACGTCCGATCCGGGTGGCAAGTTTGTCGCGCCTTTCGGCGGACGTGACCCGGTGTTG
ACGCCCAACCCGTTTGCCATCGGCTACCCCGGCAGCAAGGCACCCGTGCTGGTGGACATCTGCGCCTCCATCACCACGGT
CTCCATGGCCCGCACCAAGGCCGCAGCCGGCGTGCAGTTCGAACACCCCTGGCTGATGGACAACGCCGGCCAGCCGACCA
CCGATCCGCGTGTGCTGGAGCAGACCACGCCGCGCGGCTCCCTGCTGCTGCTCGGCGGTGCGGAATACGGCCACAAGGGT
TTTGGCCTGGCCCTGATGGTCGAAGCCCTGACCCAGGGGCTGGCCGGCCACGGCCGCATTGATGCCCCCAACCGCTGGGG
CGCCAACGTGTTTCTGCAGGTCATGGACCCGGAGGCCTTTGCCGGCCGCGACAACTTCCTCACCCAGATGGATTTCATTG
GCGACGCCTGCCGCGCCAGCACGCCGGTCCAGCCCGACGGCCTGGTGCGTTTGCCGGGCGACCAGGCCAGCGGCAATATC
GCGCGCGCGCAGCAACAGGGCATTGCCCTGAGTGACGCCACGCTGGACAAACTCGCGGCCTGCGCGACCCAATTGGGCGT
TGCACCACTCGGCAACGCATGA

Upstream 100 bases:

>100_bases
CAGGCAGTTCATTGGCGGCAGCCTGAAATAGCCGTCCTTGTCCTTCATTGCAACGCCTCGTTCCATTCACTTACCCCATC
CAAATTTGCGATTCAAGTCC

Downstream 100 bases:

>100_bases
CCACGGCAGCCGCCCCGGCGGGTAAAAGGCAGATCGCCCTCTCGGCCGTCGACGGCAAGCTGGTGCTGGACAAGGGCGCC
ATCAAAGTCATCAACCACGG

Product: malate/L-lactate dehydrogenase

Products: pyruvate; NADH; H+

Alternate protein names: (R)-sulfolactate dehydrogenase [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTTAQRHTPADLTRFASQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQLKNGLMGTDGEPEVVRDTGAT
VVWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHHIACLAALVKQATDRGLVAILATSDPGGKFVAPFGGRDPVL
TPNPFAIGYPGSKAPVLVDICASITTVSMARTKAAAGVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKG
FGLALMVEALTQGLAGHGRIDAPNRWGANVFLQVMDPEAFAGRDNFLTQMDFIGDACRASTPVQPDGLVRLPGDQASGNI
ARAQQQGIALSDATLDKLAACATQLGVAPLGNA

Sequences:

>Translated_353_residues
MTTAQRHTPADLTRFASQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQLKNGLMGTDGEPEVVRDTGAT
VVWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHHIACLAALVKQATDRGLVAILATSDPGGKFVAPFGGRDPVL
TPNPFAIGYPGSKAPVLVDICASITTVSMARTKAAAGVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKG
FGLALMVEALTQGLAGHGRIDAPNRWGANVFLQVMDPEAFAGRDNFLTQMDFIGDACRASTPVQPDGLVRLPGDQASGNI
ARAQQQGIALSDATLDKLAACATQLGVAPLGNA
>Mature_352_residues
TTAQRHTPADLTRFASQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQLKNGLMGTDGEPEVVRDTGATV
VWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHHIACLAALVKQATDRGLVAILATSDPGGKFVAPFGGRDPVLT
PNPFAIGYPGSKAPVLVDICASITTVSMARTKAAAGVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKGF
GLALMVEALTQGLAGHGRIDAPNRWGANVFLQVMDPEAFAGRDNFLTQMDFIGDACRASTPVQPDGLVRLPGDQASGNIA
RAQQQGIALSDATLDKLAACATQLGVAPLGNA

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha- ketoglutarate) [H]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=355, Percent_Identity=29.2957746478873, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790000, Length=333, Percent_Identity=24.9249249249249, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786727, Length=343, Percent_Identity=25.9475218658892, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17507179, Length=350, Percent_Identity=26.5714285714286, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17536633, Length=349, Percent_Identity=25.214899713467, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45553211, Length=357, Percent_Identity=28.0112044817927, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667912, Length=357, Percent_Identity=28.0112044817927, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24667908, Length=357, Percent_Identity=28.0112044817927, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24667904, Length=357, Percent_Identity=28.0112044817927, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24658010, Length=345, Percent_Identity=23.768115942029, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648360, Length=352, Percent_Identity=25, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.27

Molecular weight: Translated: 37182; Mature: 37051

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAQRHTPADLTRFASQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQL
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
KNGLMGTDGEPEVVRDTGATVVWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHH
HCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCH
IACLAALVKQATDRGLVAILATSDPGGKFVAPFGGRDPVLTPNPFAIGYPGSKAPVLVDI
HHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCHHHH
CASITTVSMARTKAAAGVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKG
HHHHHHHHHHHHHHHCCCEECCCEEECCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCC
FGLALMVEALTQGLAGHGRIDAPNRWGANVFLQVMDPEAFAGRDNFLTQMDFIGDACRAS
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCHHHHHHHHHHHHHHCC
TPVQPDGLVRLPGDQASGNIARAQQQGIALSDATLDKLAACATQLGVAPLGNA
CCCCCCCEEECCCCCCCCCHHHHHHCCCEECHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTAQRHTPADLTRFASQLLTAAGLPAAKADTVARLLVLTDMMQRHTHGVALCPLYIDQL
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
KNGLMGTDGEPEVVRDTGATVVWDGHYLPGLWLVDKALSLAFERVAQHGVVTFAMRRSHH
HCCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCH
IACLAALVKQATDRGLVAILATSDPGGKFVAPFGGRDPVLTPNPFAIGYPGSKAPVLVDI
HHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCHHHH
CASITTVSMARTKAAAGVQFEHPWLMDNAGQPTTDPRVLEQTTPRGSLLLLGGAEYGHKG
HHHHHHHHHHHHHHHCCCEECCCEEECCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCC
FGLALMVEALTQGLAGHGRIDAPNRWGANVFLQVMDPEAFAGRDNFLTQMDFIGDACRAS
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCHHHHHHHHHHHHHHCC
TPVQPDGLVRLPGDQASGNIARAQQQGIALSDATLDKLAACATQLGVAPLGNA
CCCCCCCEEECCCCCCCCCHHHHHHCCCEECHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-lactate; NAD+

Specific reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]