Click here to switch to the map view.

The map label for this gene is argH [H]

Identifier: 91789520

GI number: 91789520

Start: 3882530

End: 3883939

Strand: Direct

Name: argH [H]

Synonym: Bpro_3672

Alternate gene names: 91789520

Gene position: 3882530-3883939 (Clockwise)

Preceding gene: 91789515

Following gene: 91789521

Centisome position: 74.66

GC content: 63.9

Gene sequence:

>1410_bases
GTGAATCAATTCGACAAAAAATCCCAAGCCTGGTCAGCCCTGTTCTCCGAGCCCATGAGCGATCTGGTCAAGCGCTACAC
CGCCAGCGTGTTTTTTGACAAGCGCCTCTGGCAGGCTGACATCACCGGCTCGCTGGCCCACGCCGACATGCTGGCCGCGC
AAAAGGTCATCGCCCCCAGCGACCTCGCGGCCATCCAGAACGGCATGGCGCAAATCACCGCCGAAATCGAGGCGGGCACG
TTTGAATGGAAACTGGACCTCGAGGATGTGCACCTCAACATCGAGGCGCGCCTGACCCAGCTGGTGGGCGATGCCGGCAA
GCGCCTGCACACCGGCCGCAGCCGCAACGACCAGGTCGCCACCGACGTGCGCCTGTGGCTGCGCGGCGAAATTGACCTCA
TTGGCGGCCTGCTCGGTGACCTGCAAAAGGCACTGGTTGACATCGCCGAGAAAAACGTCGACGTGATCCTGCCCGGCTTC
ACCCACCTGCAGGTGGCGCAGCCTGTGAGCTTTGGCCACCACATGCTGGCCTATGTGGAAATGTTTGCGCGGGACGCCGA
ACGCATGGCCGAGATCCGCCAGCGTGTCAACCGGCTGCCGCTGGGCGCTGCCGCCCTGGCCGGCACCAGCTACCCGCTGG
ACCGCGAGCGCGTGGCCAAAACCCTGGGCATGGTGGACGAGCAGGGCCGCGCCTGCGTCTGCCAGAACAGCCTGGACGCC
GTGAGCGACCGCGACTTTGCCATTGAATTCACCGCTGCCGCCACGCTGGCCATGGTGCACATCAGCCGCATGAGCGAGGA
ACTGGTGCTGTGGATGAGCCAGAGCTTCGGTTTTATCGACATTGCCGACCGTTTCTGCACCGGCAGCTCCATCATGCCGC
AGAAGAAAAACCCCGACGTGCCCGAGCTGGCGCGCGGCAAGACCGGCCGCGTGGTTGGCCACCTGATGGGCCTGATCACT
TTGATGAAAGGCCAGCCGCTGGCCTACAACAAGGACAACCAGGAAGACAAGGAGCCGCTGTTTGACACGGTGGACACGCT
GAAAGACACACTGCGCATCTTTGCCGAGATGGTCGGCGGCATCACCGTCAAGCCCGAAGCCATGGAGCGCGCCGCCCTCA
AGGGCTACGCCACCGCCACCGATCTGGCCGACTACCTGGTGAAAAAAGGCCTGCCCTTTCGCGATGCGCATGAAACGGTG
GCGCATGCCGTCAAGGCCGCCATCTCGCATGCGGTGGACCTGTCGGAGTTGCCGCTGGCGGTGCTGCAGCAGTTCAACCC
GAGCATCGAAAAAGACGTTTACGATGCCTTAAGCCTGCGCGGCTCGCTCAATGCCCGCAACATCCTGGGCGGCACCGCCC
CGGCCCAGGTGCGGGCGCAGATTGCAAGGCACCGCGCCCGGCTGGGTTAA

Upstream 100 bases:

>100_bases
ATACCTGCGAATACCTGCCCAGAATAGCGCACCTGGCGCCCTAACCCATGGCGCGCGGCCTCGCAGCCCTGCCGCGCAAC
CGCCCGAAAGAAAGCCCGAC

Downstream 100 bases:

>100_bases
GAAGTTATCCGTAAATAGTACACTCTCGTCCTGAGCCGTACTTCACACGGCGTCGGGGCGAATGTATGGCGACACGCAAG
CGAGTCGAATCGTGGGTGGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNQFDKKSQAWSALFSEPMSDLVKRYTASVFFDKRLWQADITGSLAHADMLAAQKVIAPSDLAAIQNGMAQITAEIEAGT
FEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVATDVRLWLRGEIDLIGGLLGDLQKALVDIAEKNVDVILPGF
THLQVAQPVSFGHHMLAYVEMFARDAERMAEIRQRVNRLPLGAAALAGTSYPLDRERVAKTLGMVDEQGRACVCQNSLDA
VSDRDFAIEFTAAATLAMVHISRMSEELVLWMSQSFGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVVGHLMGLIT
LMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGGITVKPEAMERAALKGYATATDLADYLVKKGLPFRDAHETV
AHAVKAAISHAVDLSELPLAVLQQFNPSIEKDVYDALSLRGSLNARNILGGTAPAQVRAQIARHRARLG

Sequences:

>Translated_469_residues
MNQFDKKSQAWSALFSEPMSDLVKRYTASVFFDKRLWQADITGSLAHADMLAAQKVIAPSDLAAIQNGMAQITAEIEAGT
FEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVATDVRLWLRGEIDLIGGLLGDLQKALVDIAEKNVDVILPGF
THLQVAQPVSFGHHMLAYVEMFARDAERMAEIRQRVNRLPLGAAALAGTSYPLDRERVAKTLGMVDEQGRACVCQNSLDA
VSDRDFAIEFTAAATLAMVHISRMSEELVLWMSQSFGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVVGHLMGLIT
LMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGGITVKPEAMERAALKGYATATDLADYLVKKGLPFRDAHETV
AHAVKAAISHAVDLSELPLAVLQQFNPSIEKDVYDALSLRGSLNARNILGGTAPAQVRAQIARHRARLG
>Mature_469_residues
MNQFDKKSQAWSALFSEPMSDLVKRYTASVFFDKRLWQADITGSLAHADMLAAQKVIAPSDLAAIQNGMAQITAEIEAGT
FEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVATDVRLWLRGEIDLIGGLLGDLQKALVDIAEKNVDVILPGF
THLQVAQPVSFGHHMLAYVEMFARDAERMAEIRQRVNRLPLGAAALAGTSYPLDRERVAKTLGMVDEQGRACVCQNSLDA
VSDRDFAIEFTAAATLAMVHISRMSEELVLWMSQSFGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVVGHLMGLIT
LMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGGITVKPEAMERAALKGYATATDLADYLVKKGLPFRDAHETV
AHAVKAAISHAVDLSELPLAVLQQFNPSIEKDVYDALSLRGSLNARNILGGTAPAQVRAQIARHRARLG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=41.0480349344978, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=41.0480349344978, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=38.8646288209607, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=38.4279475982533, Blast_Score=321, Evalue=1e-87,
Organism=Escherichia coli, GI1790398, Length=460, Percent_Identity=46.304347826087, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=473, Percent_Identity=40.3805496828753, Blast_Score=343, Evalue=4e-95,
Organism=Drosophila melanogaster, GI221473854, Length=453, Percent_Identity=37.9690949227373, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI78706858, Length=453, Percent_Identity=37.9690949227373, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51514; Mature: 51514

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQFDKKSQAWSALFSEPMSDLVKRYTASVFFDKRLWQADITGSLAHADMLAAQKVIAPS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
DLAAIQNGMAQITAEIEAGTFEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVA
HHHHHHCCHHHEEEEEECCEEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHH
TDVRLWLRGEIDLIGGLLGDLQKALVDIAEKNVDVILPGFTHLQVAQPVSFGHHMLAYVE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCHHHHHHHHHHHH
MFARDAERMAEIRQRVNRLPLGAAALAGTSYPLDRERVAKTLGMVDEQGRACVCQNSLDA
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCHHH
VSDRDFAIEFTAAATLAMVHISRMSEELVLWMSQSFGFIDIADRFCTGSSIMPQKKNPDV
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCCCCC
PELARGKTGRVVGHLMGLITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGG
CHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
ITVKPEAMERAALKGYATATDLADYLVKKGLPFRDAHETVAHAVKAAISHAVDLSELPLA
EECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
VLQQFNPSIEKDVYDALSLRGSLNARNILGGTAPAQVRAQIARHRARLG
HHHHCCCCHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQFDKKSQAWSALFSEPMSDLVKRYTASVFFDKRLWQADITGSLAHADMLAAQKVIAPS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
DLAAIQNGMAQITAEIEAGTFEWKLDLEDVHLNIEARLTQLVGDAGKRLHTGRSRNDQVA
HHHHHHCCHHHEEEEEECCEEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHH
TDVRLWLRGEIDLIGGLLGDLQKALVDIAEKNVDVILPGFTHLQVAQPVSFGHHMLAYVE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCHHHHHHHHHHHH
MFARDAERMAEIRQRVNRLPLGAAALAGTSYPLDRERVAKTLGMVDEQGRACVCQNSLDA
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCHHH
VSDRDFAIEFTAAATLAMVHISRMSEELVLWMSQSFGFIDIADRFCTGSSIMPQKKNPDV
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCCCCC
PELARGKTGRVVGHLMGLITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDTLRIFAEMVGG
CHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
ITVKPEAMERAALKGYATATDLADYLVKKGLPFRDAHETVAHAVKAAISHAVDLSELPLA
EECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
VLQQFNPSIEKDVYDALSLRGSLNARNILGGTAPAQVRAQIARHRARLG
HHHHCCCCHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA