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The map label for this gene is folK [H]

Identifier: 91789414

GI number: 91789414

Start: 3759563

End: 3760069

Strand: Reverse

Name: folK [H]

Synonym: Bpro_3560

Alternate gene names: 91789414

Gene position: 3760069-3759563 (Counterclockwise)

Preceding gene: 91789415

Following gene: 91789412

Centisome position: 72.31

GC content: 68.44

Gene sequence:

>507_bases
ATGGCCGCTGAGCGCGTCGTCCAGGCCTATATCGCCTTGGGAGCCAACCTCGGTGATGCGGCGGCCGCGCTGAGACGGGC
GGCAAGCGCCCTGGACCGTCTGCCGCTCACGCGAGTCCGCCGGATGTCCGGCCTCTACAAAACAGCACCGCTGGACACCG
ATTCGGGCGAGGCCATCGCGCCGGGCGGCGACTACCTCAATGCGGTGGTCGAACTGGAAACAGGCCTGGCCGCGCCGGCG
TTGCTGGAGCAACTGCAGCGGATCGAGCAGGAGGCCGGCCGCCAAAGACCCTACCGGAACGCCCCGCGCACGCTGGACCT
GGATCTGCTGCTCTATGGCAGCGCCCGCATTGAGTCAGCGCAACTGACGGTGCCGCATCCACGCATGCTGCTGCGGGCTT
TTGTGCTGGTGCCGCTGGCGGAAATTGCACCGGAGCGGGTGAGCCCCGAACAGCTCGCGGCGGTGGCGCACCAGGCCATT
GAGCGGCTGGGCGACTTCACGGTCTGA

Upstream 100 bases:

>100_bases
ATGCGACCGATTCCGGCAGTGCAGAAGGCGGCGCTGGTGGCGGCGACCAGTCCTCGCCCGGTGTTGCCTCCAACCCTTGA
GCCTTGTTGAGCCGTAAGCC

Downstream 100 bases:

>100_bases
GAAGAAAGCTCAGGGCGCCAGGCGCTCGCGCAGCCAGCTGGAGTCGGCTTGCAGCGTGTAACGCAGGCGGTCATGCAGCC
GGCTTTTGCGGCCCTGCCAG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MAAERVVQAYIALGANLGDAAAALRRAASALDRLPLTRVRRMSGLYKTAPLDTDSGEAIAPGGDYLNAVVELETGLAAPA
LLEQLQRIEQEAGRQRPYRNAPRTLDLDLLLYGSARIESAQLTVPHPRMLLRAFVLVPLAEIAPERVSPEQLAAVAHQAI
ERLGDFTV

Sequences:

>Translated_168_residues
MAAERVVQAYIALGANLGDAAAALRRAASALDRLPLTRVRRMSGLYKTAPLDTDSGEAIAPGGDYLNAVVELETGLAAPA
LLEQLQRIEQEAGRQRPYRNAPRTLDLDLLLYGSARIESAQLTVPHPRMLLRAFVLVPLAEIAPERVSPEQLAAVAHQAI
ERLGDFTV
>Mature_167_residues
AAERVVQAYIALGANLGDAAAALRRAASALDRLPLTRVRRMSGLYKTAPLDTDSGEAIAPGGDYLNAVVELETGLAAPAL
LEQLQRIEQEAGRQRPYRNAPRTLDLDLLLYGSARIESAQLTVPHPRMLLRAFVLVPLAEIAPERVSPEQLAAVAHQAIE
RLGDFTV

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=162, Percent_Identity=44.4444444444444, Blast_Score=111, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324073, Length=159, Percent_Identity=31.4465408805031, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18130; Mature: 17999

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAERVVQAYIALGANLGDAAAALRRAASALDRLPLTRVRRMSGLYKTAPLDTDSGEAIA
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEC
PGGDYLNAVVELETGLAAPALLEQLQRIEQEAGRQRPYRNAPRTLDLDLLLYGSARIESA
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECHHEEEECCCCCCCC
QLTVPHPRMLLRAFVLVPLAEIAPERVSPEQLAAVAHQAIERLGDFTV
EECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAERVVQAYIALGANLGDAAAALRRAASALDRLPLTRVRRMSGLYKTAPLDTDSGEAIA
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCEEC
PGGDYLNAVVELETGLAAPALLEQLQRIEQEAGRQRPYRNAPRTLDLDLLLYGSARIESA
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECHHEEEECCCCCCCC
QLTVPHPRMLLRAFVLVPLAEIAPERVSPEQLAAVAHQAIERLGDFTV
EECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]