Click here to switch to the map view.

The map label for this gene is ald [H]

Identifier: 91789082

GI number: 91789082

Start: 3411138

End: 3412256

Strand: Direct

Name: ald [H]

Synonym: Bpro_3222

Alternate gene names: 91789082

Gene position: 3411138-3412256 (Clockwise)

Preceding gene: 91789081

Following gene: 91789083

Centisome position: 65.6

GC content: 67.83

Gene sequence:

>1119_bases
ATGCTCATCGGAATTCCCAAGGAAATCAAGAACCATGAATACCGTGTCGGCCTGACACCGTCGTCCGTGCGTGAGCTGGC
GGCGGCCGGCCACCGCGTGATCGTGGAGCACAACGCAGGCTCCGGCATCGGTGCCAGCGACGCCGAGTACGAAAAAGCGG
GTGCCGGCATTGTCCAGGGGGCAGATGAAGTGTTTGCGCGCGCCGACATGGTGGTGAAGGTCAAGGAGCCGCAAGCCGCG
GAGCGCGCACAGCTTCGGCCCGGCCAGTTGCTGTTCACTTACCTGCATCTGGCGCCCGACCCGCAGCAATGCAAGGAACT
GGTCGACAGCGGCGCGGTCTGCATCGCCTACGAAACCGTGACCCAGGCCGGTGGCGGCCTGCCCTTGCTGGCGCCGATGT
CCGAAGTGGCCGGCCGCATGTCGGTGCAGGCGGCTGCGCACAGCCTGGAGCGGGCCCATGGCGGCCGCGGCATACTGCTC
GGAGGCGTGCCCGGTGTGGCGCCCGCCAAAATCGTGATCCTCGGCGCGGGCGTGGTCGGCTCCAACGCGGCACAGATCGC
CGTGGGCACCGGTGCCCAGGTGGTGGTGATAGACCGCAGCCTCGATGCGCTGCGCCGCATGGACCGCCTGCTGGGGGCGC
GCGTGATCACCCTGTTCTCGAACCGCGACAACATCGAGGAGCAGGTGCTGTCGGCAGACGCGGTGATCGGCGGCGTGCTG
ATTCCCGGCGCGGCCGCCCCCAAGCTCGTGTCGCGCGAGCTGCTGTCGCGCATGAAGCCGGGCTCGGTGGTGGTTGATGT
GGCCATCGACCAGGGCGGCTGCTTCGAAACCTCGCACGCCACCACCCACGCCGACCCCACCTACGTGGTGGACGGCGTCG
TGCACTACTGCGTGGCCAACATGCCGGGCGGCGTGCCGCGCACCTCCACCTATGCCCTGAACAACGCCACCCTGCCCTTT
GTGCTGGCCTTGGCGAACAAAGGGTGGCGGCAGGCACTGAAGGACGACGTGCACCTGCGCAACGGCCTCAACGTCGCTGA
CGGCAAGGTCACCTGCCTGGAGGTGGCGAATGACCTGCGCTACGTCTACCATGCCCCGCAAACCCTGCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
TGCCTTTGCCCCTTTTTTTAGCCCCTTCTTGCTTTATTGCTTTTATTGCCTTATTACTTCATTGACTTCATTGACTTCAT
TGATCCAGGAGACAAACACC

Downstream 100 bases:

>100_bases
ACGATGGAGCAACGCCCCTATTGGCTGTCGCAGGCACTCGCCGCCGAGCAAGGCGGCCCGGCCCCGGCGCTGGTGAGCGA
CACGCGTGCCCAGTTGTGCA

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MLIGIPKEIKNHEYRVGLTPSSVRELAAAGHRVIVEHNAGSGIGASDAEYEKAGAGIVQGADEVFARADMVVKVKEPQAA
ERAQLRPGQLLFTYLHLAPDPQQCKELVDSGAVCIAYETVTQAGGGLPLLAPMSEVAGRMSVQAAAHSLERAHGGRGILL
GGVPGVAPAKIVILGAGVVGSNAAQIAVGTGAQVVVIDRSLDALRRMDRLLGARVITLFSNRDNIEEQVLSADAVIGGVL
IPGAAAPKLVSRELLSRMKPGSVVVDVAIDQGGCFETSHATTHADPTYVVDGVVHYCVANMPGGVPRTSTYALNNATLPF
VLALANKGWRQALKDDVHLRNGLNVADGKVTCLEVANDLRYVYHAPQTLLAA

Sequences:

>Translated_372_residues
MLIGIPKEIKNHEYRVGLTPSSVRELAAAGHRVIVEHNAGSGIGASDAEYEKAGAGIVQGADEVFARADMVVKVKEPQAA
ERAQLRPGQLLFTYLHLAPDPQQCKELVDSGAVCIAYETVTQAGGGLPLLAPMSEVAGRMSVQAAAHSLERAHGGRGILL
GGVPGVAPAKIVILGAGVVGSNAAQIAVGTGAQVVVIDRSLDALRRMDRLLGARVITLFSNRDNIEEQVLSADAVIGGVL
IPGAAAPKLVSRELLSRMKPGSVVVDVAIDQGGCFETSHATTHADPTYVVDGVVHYCVANMPGGVPRTSTYALNNATLPF
VLALANKGWRQALKDDVHLRNGLNVADGKVTCLEVANDLRYVYHAPQTLLAA
>Mature_372_residues
MLIGIPKEIKNHEYRVGLTPSSVRELAAAGHRVIVEHNAGSGIGASDAEYEKAGAGIVQGADEVFARADMVVKVKEPQAA
ERAQLRPGQLLFTYLHLAPDPQQCKELVDSGAVCIAYETVTQAGGGLPLLAPMSEVAGRMSVQAAAHSLERAHGGRGILL
GGVPGVAPAKIVILGAGVVGSNAAQIAVGTGAQVVVIDRSLDALRRMDRLLGARVITLFSNRDNIEEQVLSADAVIGGVL
IPGAAAPKLVSRELLSRMKPGSVVVDVAIDQGGCFETSHATTHADPTYVVDGVVHYCVANMPGGVPRTSTYALNNATLPF
VLALANKGWRQALKDDVHLRNGLNVADGKVTCLEVANDLRYVYHAPQTLLAA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=397, Percent_Identity=31.7380352644836, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI122939153, Length=397, Percent_Identity=31.7380352644836, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1787887, Length=377, Percent_Identity=29.973474801061, Blast_Score=130, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17550456, Length=371, Percent_Identity=30.4582210242588, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38867; Mature: 38867

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGIPKEIKNHEYRVGLTPSSVRELAAAGHRVIVEHNAGSGIGASDAEYEKAGAGIVQG
CCCCCCHHHCCCCEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHCCCHHCC
ADEVFARADMVVKVKEPQAAERAQLRPGQLLFTYLHLAPDPQQCKELVDSGAVCIAYETV
HHHHHHHCCEEEEECCCCCHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEHH
TQAGGGLPLLAPMSEVAGRMSVQAAAHSLERAHGGRGILLGGVPGVAPAKIVILGAGVVG
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCC
SNAAQIAVGTGAQVVVIDRSLDALRRMDRLLGARVITLFSNRDNIEEQVLSADAVIGGVL
CCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCEE
IPGAAAPKLVSRELLSRMKPGSVVVDVAIDQGGCFETSHATTHADPTYVVDGVVHYCVAN
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHC
MPGGVPRTSTYALNNATLPFVLALANKGWRQALKDDVHLRNGLNVADGKVTCLEVANDLR
CCCCCCCCCEEEECCCCHHHHEEHHCHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHH
YVYHAPQTLLAA
HHHCCCHHHHCC
>Mature Secondary Structure
MLIGIPKEIKNHEYRVGLTPSSVRELAAAGHRVIVEHNAGSGIGASDAEYEKAGAGIVQG
CCCCCCHHHCCCCEEEECCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHCCCHHCC
ADEVFARADMVVKVKEPQAAERAQLRPGQLLFTYLHLAPDPQQCKELVDSGAVCIAYETV
HHHHHHHCCEEEEECCCCCHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEHH
TQAGGGLPLLAPMSEVAGRMSVQAAAHSLERAHGGRGILLGGVPGVAPAKIVILGAGVVG
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCC
SNAAQIAVGTGAQVVVIDRSLDALRRMDRLLGARVITLFSNRDNIEEQVLSADAVIGGVL
CCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCEE
IPGAAAPKLVSRELLSRMKPGSVVVDVAIDQGGCFETSHATTHADPTYVVDGVVHYCVAN
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHC
MPGGVPRTSTYALNNATLPFVLALANKGWRQALKDDVHLRNGLNVADGKVTCLEVANDLR
CCCCCCCCCEEEECCCCHHHHEEHHCHHHHHHHHHHHHHHCCCEECCCCEEEEHHHHHHH
YVYHAPQTLLAA
HHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]