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The map label for this gene is cobQ

Identifier: 91788622

GI number: 91788622

Start: 2903583

End: 2905106

Strand: Reverse

Name: cobQ

Synonym: Bpro_2760

Alternate gene names: 91788622

Gene position: 2905106-2903583 (Counterclockwise)

Preceding gene: 91788623

Following gene: 91788615

Centisome position: 55.86

GC content: 65.16

Gene sequence:

>1524_bases
ATGAGCGGCACATTGGCCAGAAGCGTCATGGTTCTGGGTACCACCAGCGGCGCCGGCAAAAGCTGGCTGACCACCGCACT
GTGCCGTTACTACGCGCGGCAGGGGTTGAAGGTTGCGCCTTTCAAGGCGCAGAACATGAGCAACAATGCCCGCGTTGTCG
CGGGCGGCGAGATTGGCAGCGCCCAGTATTTCCAGGCGCTGGCGGCGCGCGCCGAGCCTGATGTGCGCATGAACCCCTTG
CTGCTCAAGCCCGAAAAAGACACGCAAAGCCAGGTCATCCTGATGGGCCAGGTCGATGCCGAGCTCTCGCGCATGCCCTG
GCGCGGCCGCAGCGCTTCGGTGTGGCCGGTCATCGCCCGGGCGCTGGACGAACTGCTGGCCGAGAATGACGTGGTGGTGA
TTGAAGGCGCGGGCTCGCCGGCGGAGATCAACCTCAAATCCAGCGACATCGTCAATATGCGCGTGGCGCAGCACACCGGG
GCTTCCTGCCTGCTGGTCACCGACATCGACCGCGGCGGCGCCTTTGCCCACCTGTATGGCACCTGGGCCATGCTCGATGA
GGCGGAACGCCAGCTGATCAAGGGCTTTGTGCTCAACAAGTTTCGCGGCGACGCCAGCCTGCTGGCGCCCGGACCACAAA
TGTTGCAGGAGATGACCGGTGTGCCCACCGTGGCGACACTGCCGATGTGGTGGCAGCATGGCCTGCCCGAAGAAGACGGC
GTGTTTGATATGGCCCCCACGCTCGGCACTGGCGTGTCCACACTGCCCCCCGAGGGGGCTGAACTTGCTCGGGGCGGCCC
TTCGCTGCGTTCACCGCGACCTGTGATCGCCGTCATCGCCTACCCGCGCATCAGCAACCTGGACGAATTTCAGCCGCTCA
AAAATGTGCCGGGCGTGCACCTGAAGTGGGTGCGCAGCCCCGGCGAGCTGGCCGGCGTTGACTGGATCATCCTGCCCGGC
TCCAAGCACACCAGCGGCGACCTGGCCTGGCTGCGCGCGCAGGGGCTGGACCGTGCGGTGGCCGCCCATGCAGAGCAGGG
CGGTGCGGTGCTGGGCGTCTGCGGCGGCCTGCAAATGCTCGGCGAGGCGCTGATCGACCCGCATGGCATTGACGGCAATG
CGCCGGGGCTGGGGCTGCTGCCTGTGGTCACCGTGTTTGAAGAAGGCAAAACCGTGCAGCGCAGGCAAGCCCGGTTTGGC
GAGCTGGCCGGAGCCTGGGCGGCCTTGTCAGGCGTGGGCCTACAGGGCTACGAAATTCATCACGGCCAAACGGCGCCCCA
CACGGCCATGGCGGCTGCAGGGGACATTGCCCATGGCGTGATGGCCGAAGGCCTGGCCTGGCAAAACACTCGAGGCAATG
TGCTGGGCCTGTATTTGCATGGCATGTTTGAAGATCCGGCCGTGCTGCAGGCGCTCTTTGGCGCCACGGTACCCACGCTG
GATGCCGTATTTGACGGACTGGCCGATTACATAGAGCAGCACTTTGAGCCGGGCGTTTTGCAATCACTGATAGCGACCCC
TTAA

Upstream 100 bases:

>100_bases
CCTCCTTCGGCCTGCCCGGCCATGTGCGCATCAGCGTCCAGCCGCCCGCTGCGCAGGACGCATTGCACAATGCATGGCAA
TACATCACACGAAAGTCAGC

Downstream 100 bases:

>100_bases
CCGGAGACGCGCTTCAGGGGCCCAAAGCAGGCCTGGAGCGACTCGGCCTTGCAGACGATGAACTGGTCCCGCTGGGGGTT
GAATTGGATGAAGCGCGTGA

Product: adenosylcobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSGTLARSVMVLGTTSGAGKSWLTTALCRYYARQGLKVAPFKAQNMSNNARVVAGGEIGSAQYFQALAARAEPDVRMNPL
LLKPEKDTQSQVILMGQVDAELSRMPWRGRSASVWPVIARALDELLAENDVVVIEGAGSPAEINLKSSDIVNMRVAQHTG
ASCLLVTDIDRGGAFAHLYGTWAMLDEAERQLIKGFVLNKFRGDASLLAPGPQMLQEMTGVPTVATLPMWWQHGLPEEDG
VFDMAPTLGTGVSTLPPEGAELARGGPSLRSPRPVIAVIAYPRISNLDEFQPLKNVPGVHLKWVRSPGELAGVDWIILPG
SKHTSGDLAWLRAQGLDRAVAAHAEQGGAVLGVCGGLQMLGEALIDPHGIDGNAPGLGLLPVVTVFEEGKTVQRRQARFG
ELAGAWAALSGVGLQGYEIHHGQTAPHTAMAAAGDIAHGVMAEGLAWQNTRGNVLGLYLHGMFEDPAVLQALFGATVPTL
DAVFDGLADYIEQHFEPGVLQSLIATP

Sequences:

>Translated_507_residues
MSGTLARSVMVLGTTSGAGKSWLTTALCRYYARQGLKVAPFKAQNMSNNARVVAGGEIGSAQYFQALAARAEPDVRMNPL
LLKPEKDTQSQVILMGQVDAELSRMPWRGRSASVWPVIARALDELLAENDVVVIEGAGSPAEINLKSSDIVNMRVAQHTG
ASCLLVTDIDRGGAFAHLYGTWAMLDEAERQLIKGFVLNKFRGDASLLAPGPQMLQEMTGVPTVATLPMWWQHGLPEEDG
VFDMAPTLGTGVSTLPPEGAELARGGPSLRSPRPVIAVIAYPRISNLDEFQPLKNVPGVHLKWVRSPGELAGVDWIILPG
SKHTSGDLAWLRAQGLDRAVAAHAEQGGAVLGVCGGLQMLGEALIDPHGIDGNAPGLGLLPVVTVFEEGKTVQRRQARFG
ELAGAWAALSGVGLQGYEIHHGQTAPHTAMAAAGDIAHGVMAEGLAWQNTRGNVLGLYLHGMFEDPAVLQALFGATVPTL
DAVFDGLADYIEQHFEPGVLQSLIATP
>Mature_506_residues
SGTLARSVMVLGTTSGAGKSWLTTALCRYYARQGLKVAPFKAQNMSNNARVVAGGEIGSAQYFQALAARAEPDVRMNPLL
LKPEKDTQSQVILMGQVDAELSRMPWRGRSASVWPVIARALDELLAENDVVVIEGAGSPAEINLKSSDIVNMRVAQHTGA
SCLLVTDIDRGGAFAHLYGTWAMLDEAERQLIKGFVLNKFRGDASLLAPGPQMLQEMTGVPTVATLPMWWQHGLPEEDGV
FDMAPTLGTGVSTLPPEGAELARGGPSLRSPRPVIAVIAYPRISNLDEFQPLKNVPGVHLKWVRSPGELAGVDWIILPGS
KHTSGDLAWLRAQGLDRAVAAHAEQGGAVLGVCGGLQMLGEALIDPHGIDGNAPGLGLLPVVTVFEEGKTVQRRQARFGE
LAGAWAALSGVGLQGYEIHHGQTAPHTAMAAAGDIAHGVMAEGLAWQNTRGNVLGLYLHGMFEDPAVLQALFGATVPTLD
AVFDGLADYIEQHFEPGVLQSLIATP

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_POLSJ (Q129W6)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_549574.1
- ProteinModelPortal:   Q129W6
- SMR:   Q129W6
- STRING:   Q129W6
- GeneID:   4014564
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_2760
- NMPDR:   fig|296591.1.peg.5347
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   CLSK951555
- BioCyc:   PSP296591:BPRO_2760-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 53760; Mature: 53629

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 354-354 ACT_SITE 460-460

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTLARSVMVLGTTSGAGKSWLTTALCRYYARQGLKVAPFKAQNMSNNARVVAGGEIGS
CCCCHHEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEECCCCCCCCEEEECCCCCC
AQYFQALAARAEPDVRMNPLLLKPEKDTQSQVILMGQVDAELSRMPWRGRSASVWPVIAR
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEEECCHHHHHCCCCCCCCCHHHHHHH
ALDELLAENDVVVIEGAGSPAEINLKSSDIVNMRVAQHTGASCLLVTDIDRGGAFAHLYG
HHHHHHCCCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEHH
TWAMLDEAERQLIKGFVLNKFRGDASLLAPGPQMLQEMTGVPTVATLPMWWQHGLPEEDG
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHCCCCCEEECCHHHHCCCCCCCC
VFDMAPTLGTGVSTLPPEGAELARGGPSLRSPRPVIAVIAYPRISNLDEFQPLKNVPGVH
CEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCE
LKWVRSPGELAGVDWIILPGSKHTSGDLAWLRAQGLDRAVAAHAEQGGAVLGVCGGLQML
EEEECCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEHHHHHHH
GEALIDPHGIDGNAPGLGLLPVVTVFEEGKTVQRRQARFGELAGAWAALSGVGLQGYEIH
HHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
HGQTAPHTAMAAAGDIAHGVMAEGLAWQNTRGNVLGLYLHGMFEDPAVLQALFGATVPTL
CCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCHHHHHHHHCCCCHHH
DAVFDGLADYIEQHFEPGVLQSLIATP
HHHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
SGTLARSVMVLGTTSGAGKSWLTTALCRYYARQGLKVAPFKAQNMSNNARVVAGGEIGS
CCCHHEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEECCCCCCCCEEEECCCCCC
AQYFQALAARAEPDVRMNPLLLKPEKDTQSQVILMGQVDAELSRMPWRGRSASVWPVIAR
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEEECCHHHHHCCCCCCCCCHHHHHHH
ALDELLAENDVVVIEGAGSPAEINLKSSDIVNMRVAQHTGASCLLVTDIDRGGAFAHLYG
HHHHHHCCCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEHH
TWAMLDEAERQLIKGFVLNKFRGDASLLAPGPQMLQEMTGVPTVATLPMWWQHGLPEEDG
HHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHCCCCCEEECCHHHHCCCCCCCC
VFDMAPTLGTGVSTLPPEGAELARGGPSLRSPRPVIAVIAYPRISNLDEFQPLKNVPGVH
CEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCE
LKWVRSPGELAGVDWIILPGSKHTSGDLAWLRAQGLDRAVAAHAEQGGAVLGVCGGLQML
EEEECCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEHHHHHHH
GEALIDPHGIDGNAPGLGLLPVVTVFEEGKTVQRRQARFGELAGAWAALSGVGLQGYEIH
HHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
HGQTAPHTAMAAAGDIAHGVMAEGLAWQNTRGNVLGLYLHGMFEDPAVLQALFGATVPTL
CCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCCHHHHHHHHCCCCHHH
DAVFDGLADYIEQHFEPGVLQSLIATP
HHHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA