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The map label for this gene is prpE [H]

Identifier: 91788495

GI number: 91788495

Start: 2766635

End: 2768560

Strand: Reverse

Name: prpE [H]

Synonym: Bpro_2633

Alternate gene names: 91788495

Gene position: 2768560-2766635 (Counterclockwise)

Preceding gene: 91788496

Following gene: 91788494

Centisome position: 53.24

GC content: 63.08

Gene sequence:

>1926_bases
ATGAGCAGCACAGCGGAAACCTACAAGGCGTTCTACCAGCGTTCGATAGACCAGCCTGACGCCTTCTGGGCCGAGCAGGC
TCAACTGATTGACTGGCACAAGCCGTTCAACCGGGTGTGCAACTACGACAAGCCGCCATTTGTGCACTGGTATGAGGGCG
GGCAGACCAACCTGTGCCACAACGCGGTAGACCGGCACCTCAAGGACAGGGCGAACCAGGCGGCGCTGATTTATGTCTCG
AGCGAGACTGGCCAGGAAAAAACCTACACCTTTGCCGAGCTGCATGTGGAAGTGCAGCGCATGGCGGCCAGCCTGAAGGC
GCTGGGCGTGCAAAAGGGCGACCGGGTGCTGATCTACATGCCGATGATTGCCGAGGCGGCATTTGCCATGCTGGCCTGCG
CACGCATTGGCGCCATTCACTGCGTGGTGTTTGGCGGCTTTGCCAGCGGTTCGCTGGCGTCGCGCATCGACGATGCCACC
CCCAAAGTGATTGTCAGCGCGGATGCCGGCTCGCGCGGCGGCAAGGTGGTGGCGTACAAGCCGCTGCTCGACGAAGCCAT
ACGCCTTTCCCGCCACCAGCCCGAGTCGGTTTTGCTGGTGGACCGCAAGCTGGCGCCCATGGCGCTGGTGGCGGGGCGCG
ACCAGCTATGGGGCGATTTGCGTCAGCAGCATCTGGATGCGCAGGTGCCATGTGAGTGGCTGGACTCCACGGCCATCAGC
TACACGATTTACACCAGCGGCACCACTGGCAAACCCAAGGGCGTGCAGCGCGACACGGGCGGGTATGCCGTGGCGCTGGC
GGCCAGCATGAAACATATTTTTGACGGCCGTGCCGGGGAAACCTATTTCTCCACCAGCGACATTGGCTGGGTGGTGGGCC
ACAGCTACATCATTTACGGGCCACTGATCGCCGGCATGGCGACCATCATGTACGAAGGCCTGCCGACGCAGGGCATGGAC
GGCCACGCCGATGGCGCCATCTGGTGGCGCCTGGTGGAGAAATACAAGGTCACCGCGATGTTCAGCGCTCCGACTGCCGT
GCGCGTGCTGAAAAAGCAGGATCCGGCGCTCCTGAAAAAACACGATCTTTCCAGCCTGCGTGCGCTGTTTCTGGCGGGCG
AGCCGCTCGATGAGCCGACCGCCCGATGGATCAGTGACGGGCTGGGTGTGCCCATCATCGACAACTACTGGCAAACCGAA
ACCGGCTGGCCGCTGCTGACGGTGGCCAACGGCGTGGAGCGCACGCCCAGCAAGTTTGGCAGCCCCGGCGTTCCGATGTA
TGGCTACCGTGTCAAGCTGTTGCATGAGGCGACGGGCGAAGAACTCACGCAGCCCAATGAAAAAGGCGTGGTGGTCCTTG
AAGGCCCCACGCCACCGGGCTTCATGCAAACCGTCTGGCAAGACGACGCGCGCTTTGTCAACACCTACTGGAAGAGCGTG
CCGGGCAAGATGGTCTACAGCACCTTCGACTGGGGCATACGCGACGAGGACGGTTACTACTTCATTCTGGGCCGTACTGA
CGACGTGATCAATGTCGCCGGGCACCGTCTGGGCACGCGCGAGATTGAAGAAAGCATCTCCGGCCATCCGCTGGTGGCCG
AGGTGGCGGTGGTGGGTGTGGCCGACGCGCTGAAAGGACAGGTGGCCATGGCGTTTGCCGTGCTCAAGGATGCCAGTTTG
CTGCAAGACGGTGCGGCGACGCTCAAGCTGGAGGGCGAGATCATGAAGCGCGTTGATGGTGACCTGGGTGCGGTCGCGCG
GCCGGCCAGGGTGCGCTTTGTCACGGCGCTGCCCAAGACCCGCAGCGGCAAGCTGCTGCGTCGCGCCATCCAGGCCGTGT
GTGAAGGGCGAGATGCCGGAGATCTGACCACCATGGACGACCCTGCCGCGCTGCAGCAAATTCGCGACCGGGTGTCGGCT
TCCTGA

Upstream 100 bases:

>100_bases
CGACCTGATGGCGGGCAAGGTCCGCGGCCGCGTGGTCGTCAAGATCTGAAGCGGGCATGAAGCCAACCAAGTCATAAAGC
CATAAAACCGGAGACACACG

Downstream 100 bases:

>100_bases
CGCATTCCTGGCATTGAACCTAGAAACAGCAGTTGACCGCTCGCAAACTTCAGGAAAGCCGCATGCCCATGGACTTTCCC
CTCTTCGATGGCGTTTACCT

Product: propionyl-CoA synthetase

Products: NA

Alternate protein names: Propionyl-CoA synthetase [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSSTAETYKAFYQRSIDQPDAFWAEQAQLIDWHKPFNRVCNYDKPPFVHWYEGGQTNLCHNAVDRHLKDRANQAALIYVS
SETGQEKTYTFAELHVEVQRMAASLKALGVQKGDRVLIYMPMIAEAAFAMLACARIGAIHCVVFGGFASGSLASRIDDAT
PKVIVSADAGSRGGKVVAYKPLLDEAIRLSRHQPESVLLVDRKLAPMALVAGRDQLWGDLRQQHLDAQVPCEWLDSTAIS
YTIYTSGTTGKPKGVQRDTGGYAVALAASMKHIFDGRAGETYFSTSDIGWVVGHSYIIYGPLIAGMATIMYEGLPTQGMD
GHADGAIWWRLVEKYKVTAMFSAPTAVRVLKKQDPALLKKHDLSSLRALFLAGEPLDEPTARWISDGLGVPIIDNYWQTE
TGWPLLTVANGVERTPSKFGSPGVPMYGYRVKLLHEATGEELTQPNEKGVVVLEGPTPPGFMQTVWQDDARFVNTYWKSV
PGKMVYSTFDWGIRDEDGYYFILGRTDDVINVAGHRLGTREIEESISGHPLVAEVAVVGVADALKGQVAMAFAVLKDASL
LQDGAATLKLEGEIMKRVDGDLGAVARPARVRFVTALPKTRSGKLLRRAIQAVCEGRDAGDLTTMDDPAALQQIRDRVSA
S

Sequences:

>Translated_641_residues
MSSTAETYKAFYQRSIDQPDAFWAEQAQLIDWHKPFNRVCNYDKPPFVHWYEGGQTNLCHNAVDRHLKDRANQAALIYVS
SETGQEKTYTFAELHVEVQRMAASLKALGVQKGDRVLIYMPMIAEAAFAMLACARIGAIHCVVFGGFASGSLASRIDDAT
PKVIVSADAGSRGGKVVAYKPLLDEAIRLSRHQPESVLLVDRKLAPMALVAGRDQLWGDLRQQHLDAQVPCEWLDSTAIS
YTIYTSGTTGKPKGVQRDTGGYAVALAASMKHIFDGRAGETYFSTSDIGWVVGHSYIIYGPLIAGMATIMYEGLPTQGMD
GHADGAIWWRLVEKYKVTAMFSAPTAVRVLKKQDPALLKKHDLSSLRALFLAGEPLDEPTARWISDGLGVPIIDNYWQTE
TGWPLLTVANGVERTPSKFGSPGVPMYGYRVKLLHEATGEELTQPNEKGVVVLEGPTPPGFMQTVWQDDARFVNTYWKSV
PGKMVYSTFDWGIRDEDGYYFILGRTDDVINVAGHRLGTREIEESISGHPLVAEVAVVGVADALKGQVAMAFAVLKDASL
LQDGAATLKLEGEIMKRVDGDLGAVARPARVRFVTALPKTRSGKLLRRAIQAVCEGRDAGDLTTMDDPAALQQIRDRVSA
S
>Mature_640_residues
SSTAETYKAFYQRSIDQPDAFWAEQAQLIDWHKPFNRVCNYDKPPFVHWYEGGQTNLCHNAVDRHLKDRANQAALIYVSS
ETGQEKTYTFAELHVEVQRMAASLKALGVQKGDRVLIYMPMIAEAAFAMLACARIGAIHCVVFGGFASGSLASRIDDATP
KVIVSADAGSRGGKVVAYKPLLDEAIRLSRHQPESVLLVDRKLAPMALVAGRDQLWGDLRQQHLDAQVPCEWLDSTAISY
TIYTSGTTGKPKGVQRDTGGYAVALAASMKHIFDGRAGETYFSTSDIGWVVGHSYIIYGPLIAGMATIMYEGLPTQGMDG
HADGAIWWRLVEKYKVTAMFSAPTAVRVLKKQDPALLKKHDLSSLRALFLAGEPLDEPTARWISDGLGVPIIDNYWQTET
GWPLLTVANGVERTPSKFGSPGVPMYGYRVKLLHEATGEELTQPNEKGVVVLEGPTPPGFMQTVWQDDARFVNTYWKSVP
GKMVYSTFDWGIRDEDGYYFILGRTDDVINVAGHRLGTREIEESISGHPLVAEVAVVGVADALKGQVAMAFAVLKDASLL
QDGAATLKLEGEIMKRVDGDLGAVARPARVRFVTALPKTRSGKLLRRAIQAVCEGRDAGDLTTMDDPAALQQIRDRVSAS

Specific function: Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI13375727, Length=644, Percent_Identity=40.6832298136646, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI8923896, Length=669, Percent_Identity=37.219730941704, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI253970489, Length=682, Percent_Identity=36.6568914956012, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI28416953, Length=649, Percent_Identity=36.8258859784284, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI42544132, Length=535, Percent_Identity=26.3551401869159, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI38505220, Length=567, Percent_Identity=26.984126984127, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI122937307, Length=552, Percent_Identity=28.2608695652174, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI58082049, Length=551, Percent_Identity=27.0417422867514, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI157311624, Length=554, Percent_Identity=26.8953068592058, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI157311622, Length=554, Percent_Identity=26.8953068592058, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI115511026, Length=547, Percent_Identity=25.9597806215722, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI31982927, Length=673, Percent_Identity=24.2199108469539, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI42544134, Length=369, Percent_Identity=23.0352303523035, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI195947378, Length=468, Percent_Identity=23.7179487179487, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI187761345, Length=414, Percent_Identity=24.6376811594203, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI187761343, Length=414, Percent_Identity=24.6376811594203, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786529, Length=629, Percent_Identity=64.3879173290938, Blast_Score=822, Evalue=0.0,
Organism=Escherichia coli, GI1790505, Length=644, Percent_Identity=38.5093167701863, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI221142682, Length=550, Percent_Identity=22.9090909090909, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1788107, Length=553, Percent_Identity=25.3164556962025, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI145693145, Length=543, Percent_Identity=23.2044198895028, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1786810, Length=542, Percent_Identity=21.2177121771218, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=658, Percent_Identity=35.8662613981763, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71982997, Length=658, Percent_Identity=35.8662613981763, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17531443, Length=557, Percent_Identity=26.3913824057451, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17569507, Length=652, Percent_Identity=21.1656441717791, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=571, Percent_Identity=24.6935201401051, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=535, Percent_Identity=23.7383177570093, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17557194, Length=598, Percent_Identity=23.2441471571906, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=561, Percent_Identity=23.7076648841355, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=593, Percent_Identity=22.2596964586847, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319264, Length=659, Percent_Identity=39.453717754173, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6323182, Length=656, Percent_Identity=38.719512195122, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319699, Length=381, Percent_Identity=23.0971128608924, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355225, Length=643, Percent_Identity=40.2799377916019, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24667955, Length=660, Percent_Identity=36.8181818181818, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI62472339, Length=564, Percent_Identity=37.9432624113475, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24667959, Length=534, Percent_Identity=37.0786516853933, Blast_Score=331, Evalue=1e-90,
Organism=Drosophila melanogaster, GI21355181, Length=552, Percent_Identity=25.9057971014493, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922652, Length=568, Percent_Identity=25.5281690140845, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24648255, Length=504, Percent_Identity=25.3968253968254, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24648253, Length=504, Percent_Identity=25.5952380952381, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358303, Length=486, Percent_Identity=22.2222222222222, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20130357, Length=383, Percent_Identity=25.8485639686684, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648257, Length=377, Percent_Identity=27.0557029177719, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648260, Length=369, Percent_Identity=27.10027100271, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR012694 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.17 [H]

Molecular weight: Translated: 70212; Mature: 70081

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00226 IF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTAETYKAFYQRSIDQPDAFWAEQAQLIDWHKPFNRVCNYDKPPFVHWYEGGQTNLCH
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHH
NAVDRHLKDRANQAALIYVSSETGQEKTYTFAELHVEVQRMAASLKALGVQKGDRVLIYM
HHHHHHHHHCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PMIAEAAFAMLACARIGAIHCVVFGGFASGSLASRIDDATPKVIVSADAGSRGGKVVAYK
CHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCCCEEEEEC
PLLDEAIRLSRHQPESVLLVDRKLAPMALVAGRDQLWGDLRQQHLDAQVPCEWLDSTAIS
HHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHCCCEEE
YTIYTSGTTGKPKGVQRDTGGYAVALAASMKHIFDGRAGETYFSTSDIGWVVGHSYIIYG
EEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCEEECCCCCHHHCCCEEEEH
PLIAGMATIMYEGLPTQGMDGHADGAIWWRLVEKYKVTAMFSAPTAVRVLKKQDPALLKK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHCCCCHHHHH
HDLSSLRALFLAGEPLDEPTARWISDGLGVPIIDNYWQTETGWPLLTVANGVERTPSKFG
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCEEEEECCCCCCCHHHCC
SPGVPMYGYRVKLLHEATGEELTQPNEKGVVVLEGPTPPGFMQTVWQDDARFVNTYWKSV
CCCCCCCCEEEEEEECCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
PGKMVYSTFDWGIRDEDGYYFILGRTDDVINVAGHRLGTREIEESISGHPLVAEVAVVGV
CCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
ADALKGQVAMAFAVLKDASLLQDGAATLKLEGEIMKRVDGDLGAVARPARVRFVTALPKT
HHHHCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCCCCCCEEEEEEECCCC
RSGKLLRRAIQAVCEGRDAGDLTTMDDPAALQQIRDRVSAS
CCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSTAETYKAFYQRSIDQPDAFWAEQAQLIDWHKPFNRVCNYDKPPFVHWYEGGQTNLCH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHH
NAVDRHLKDRANQAALIYVSSETGQEKTYTFAELHVEVQRMAASLKALGVQKGDRVLIYM
HHHHHHHHHCCCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PMIAEAAFAMLACARIGAIHCVVFGGFASGSLASRIDDATPKVIVSADAGSRGGKVVAYK
CHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCCCEEEEEC
PLLDEAIRLSRHQPESVLLVDRKLAPMALVAGRDQLWGDLRQQHLDAQVPCEWLDSTAIS
HHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHCCCEEE
YTIYTSGTTGKPKGVQRDTGGYAVALAASMKHIFDGRAGETYFSTSDIGWVVGHSYIIYG
EEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCEEECCCCCHHHCCCEEEEH
PLIAGMATIMYEGLPTQGMDGHADGAIWWRLVEKYKVTAMFSAPTAVRVLKKQDPALLKK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHCCCCHHHHH
HDLSSLRALFLAGEPLDEPTARWISDGLGVPIIDNYWQTETGWPLLTVANGVERTPSKFG
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCEEEEECCCCCCCHHHCC
SPGVPMYGYRVKLLHEATGEELTQPNEKGVVVLEGPTPPGFMQTVWQDDARFVNTYWKSV
CCCCCCCCEEEEEEECCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
PGKMVYSTFDWGIRDEDGYYFILGRTDDVINVAGHRLGTREIEESISGHPLVAEVAVVGV
CCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
ADALKGQVAMAFAVLKDASLLQDGAATLKLEGEIMKRVDGDLGAVARPARVRFVTALPKT
HHHHCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCCCCCCEEEEEEECCCC
RSGKLLRRAIQAVCEGRDAGDLTTMDDPAALQQIRDRVSAS
CCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006051; 10411265; 11677609; 10482501 [H]