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The map label for this gene is livM [H]

Identifier: 91788438

GI number: 91788438

Start: 2696932

End: 2698224

Strand: Reverse

Name: livM [H]

Synonym: Bpro_2576

Alternate gene names: 91788438

Gene position: 2698224-2696932 (Counterclockwise)

Preceding gene: 91788439

Following gene: 91788437

Centisome position: 51.89

GC content: 57.08

Gene sequence:

>1293_bases
ATGACACGGCAGTTTTACCAATTCAAACCCCTCAATGTTGGGCGTTTTCTGTTGTGGTCTCTTTTTGCACTGGTGCTGGC
ACTGGCTCCGCTGGTCTTTACTTCCAGCCTGAGCCACACCATTTTGAGCCAGATGGGTATCGCCATCATTGTTTGTCTGA
GCTACAACATCCTGCTGGGGCAGGGTGGGATGCTGAGCTTCGGCCATGCCGTTTATTCCGGGATGGGCTCCTTCCTGGCG
ATTCACACGCTAAACAAGATCAGCAGCGGGGCACTTGGGGTGCCCGTGAGCCTGATTCCCATTGCAGGAGGGCTGGCCAG
CATGCTGGTGGCCGTGGTGCTCGGCTGGGTCACCACCAAAAAATCGGGCACCACGTTTGCCATGATCACCCTCGGTGTGG
GTGAACTGATCTGGGCGATGTCGCTGATGTTCCCCGAGTTCTTTGGCGGGGAGGGGGGAGTGTCGGGCAACCGGGTGACA
GGCGCTAAAGTCTGGGGCATCACCTACGGCCCGCAGGTACAGCTGTACTACCTGATCGCCGCCTACACCCTGGTCTGTAC
AGCGCTCATGTTCGCTTTCACGCGCACCCCGCTGGGCCGCATGCTCAACGCGGTACGCGACAACCCGGAACGCGTCGAAT
TCGTGGGTTATGACACGCAGAAAGTACGGTACTTTTCCTTTATCGTGGCGGCTTTTTTCGCAGGCATTTCGGGTGGCCTG
GCTGCGCTTAATTTTGAAATCGTCACATCTGAGGTGGTCAGCGGGTATCGCTCGGGGGCGTATTTGCTGTTCACATTTTT
AGGGGGTGCGACTTTTTTCTTCGGGCCGATCATTGGTGCCGTTCTCATGGTGCTGGCTTTTGTCCTGTTGTCGGAGTTCA
CGAAGGCATGGCTGCTGTACCTCGGTTTGATTTTCCTGTTCATGGTGATGTACGCGCCGGGAGGGGTGGCGTCGCTCATC
ATGATGAATCTGCGGGTGGCCGTCTTTGGTCACCTGCGAAAACTCTGGGTCGGCTATCTGGCGTTGGCGCTGACGGCGCT
GGTGGTGCTGATAGGCGCTGCGGCGATGATCGAGATGATTTACCACCTGCAACTCAATGCTGCGCTTGGTCCGGAGTTGA
CCTTCCTGGGTGCCCGGCTTGACTCCAGAGGGCTGAACAGCTGGATTGGCGCCTTGTTTGTGACGTTAACGGGCTTGGGT
CTGTTTGAAGTCTGTCGCCGTCAGTTCGCCCGGGAGTGGGACCAGATTCAGCAAAGCATAGAAAAAGAGATCAAGCGCAG
GGAGACGCTGTGA

Upstream 100 bases:

>100_bases
GCTCAAGATAAGCCAAGTAGCACCCATCCTGCCCTATCTGTTACTGGTCCTGATGCTGACATTTCGGCCCAAAGGCCTTC
TGGGCACGCGGGAGGGCTAA

Downstream 100 bases:

>100_bases
CGTTCACTACCAACCAAACAGCAGCCAAAAGCTCCAGCATGGACCGCAATGCCGGGCCGTTCCAAGGTGAAATACCCCCC
TCGGAGGGCGGCGCAGTGCG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTRQFYQFKPLNVGRFLLWSLFALVLALAPLVFTSSLSHTILSQMGIAIIVCLSYNILLGQGGMLSFGHAVYSGMGSFLA
IHTLNKISSGALGVPVSLIPIAGGLASMLVAVVLGWVTTKKSGTTFAMITLGVGELIWAMSLMFPEFFGGEGGVSGNRVT
GAKVWGITYGPQVQLYYLIAAYTLVCTALMFAFTRTPLGRMLNAVRDNPERVEFVGYDTQKVRYFSFIVAAFFAGISGGL
AALNFEIVTSEVVSGYRSGAYLLFTFLGGATFFFGPIIGAVLMVLAFVLLSEFTKAWLLYLGLIFLFMVMYAPGGVASLI
MMNLRVAVFGHLRKLWVGYLALALTALVVLIGAAAMIEMIYHLQLNAALGPELTFLGARLDSRGLNSWIGALFVTLTGLG
LFEVCRRQFAREWDQIQQSIEKEIKRRETL

Sequences:

>Translated_430_residues
MTRQFYQFKPLNVGRFLLWSLFALVLALAPLVFTSSLSHTILSQMGIAIIVCLSYNILLGQGGMLSFGHAVYSGMGSFLA
IHTLNKISSGALGVPVSLIPIAGGLASMLVAVVLGWVTTKKSGTTFAMITLGVGELIWAMSLMFPEFFGGEGGVSGNRVT
GAKVWGITYGPQVQLYYLIAAYTLVCTALMFAFTRTPLGRMLNAVRDNPERVEFVGYDTQKVRYFSFIVAAFFAGISGGL
AALNFEIVTSEVVSGYRSGAYLLFTFLGGATFFFGPIIGAVLMVLAFVLLSEFTKAWLLYLGLIFLFMVMYAPGGVASLI
MMNLRVAVFGHLRKLWVGYLALALTALVVLIGAAAMIEMIYHLQLNAALGPELTFLGARLDSRGLNSWIGALFVTLTGLG
LFEVCRRQFAREWDQIQQSIEKEIKRRETL
>Mature_429_residues
TRQFYQFKPLNVGRFLLWSLFALVLALAPLVFTSSLSHTILSQMGIAIIVCLSYNILLGQGGMLSFGHAVYSGMGSFLAI
HTLNKISSGALGVPVSLIPIAGGLASMLVAVVLGWVTTKKSGTTFAMITLGVGELIWAMSLMFPEFFGGEGGVSGNRVTG
AKVWGITYGPQVQLYYLIAAYTLVCTALMFAFTRTPLGRMLNAVRDNPERVEFVGYDTQKVRYFSFIVAAFFAGISGGLA
ALNFEIVTSEVVSGYRSGAYLLFTFLGGATFFFGPIIGAVLMVLAFVLLSEFTKAWLLYLGLIFLFMVMYAPGGVASLIM
MNLRVAVFGHLRKLWVGYLALALTALVVLIGAAAMIEMIYHLQLNAALGPELTFLGARLDSRGLNSWIGALFVTLTGLGL
FEVCRRQFAREWDQIQQSIEKEIKRRETL

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=301, Percent_Identity=26.578073089701, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 46812; Mature: 46681

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQFYQFKPLNVGRFLLWSLFALVLALAPLVFTSSLSHTILSQMGIAIIVCLSYNILLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QGGMLSFGHAVYSGMGSFLAIHTLNKISSGALGVPVSLIPIAGGLASMLVAVVLGWVTTK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCC
KSGTTFAMITLGVGELIWAMSLMFPEFFGGEGGVSGNRVTGAKVWGITYGPQVQLYYLIA
CCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHH
AYTLVCTALMFAFTRTPLGRMLNAVRDNPERVEFVGYDTQKVRYFSFIVAAFFAGISGGL
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCH
AALNFEIVTSEVVSGYRSGAYLLFTFLGGATFFFGPIIGAVLMVLAFVLLSEFTKAWLLY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLIFLFMVMYAPGGVASLIMMNLRVAVFGHLRKLWVGYLALALTALVVLIGAAAMIEMI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YHLQLNAALGPELTFLGARLDSRGLNSWIGALFVTLTGLGLFEVCRRQFAREWDQIQQSI
HHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
EKEIKRRETL
HHHHHHHCCC
>Mature Secondary Structure 
TRQFYQFKPLNVGRFLLWSLFALVLALAPLVFTSSLSHTILSQMGIAIIVCLSYNILLG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QGGMLSFGHAVYSGMGSFLAIHTLNKISSGALGVPVSLIPIAGGLASMLVAVVLGWVTTK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCC
KSGTTFAMITLGVGELIWAMSLMFPEFFGGEGGVSGNRVTGAKVWGITYGPQVQLYYLIA
CCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHH
AYTLVCTALMFAFTRTPLGRMLNAVRDNPERVEFVGYDTQKVRYFSFIVAAFFAGISGGL
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCH
AALNFEIVTSEVVSGYRSGAYLLFTFLGGATFFFGPIIGAVLMVLAFVLLSEFTKAWLLY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLIFLFMVMYAPGGVASLIMMNLRVAVFGHLRKLWVGYLALALTALVVLIGAAAMIEMI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YHLQLNAALGPELTFLGARLDSRGLNSWIGALFVTLTGLGLFEVCRRQFAREWDQIQQSI
HHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
EKEIKRRETL
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]