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The map label for this gene is fadA [H]

Identifier: 91788434

GI number: 91788434

Start: 2691787

End: 2692962

Strand: Reverse

Name: fadA [H]

Synonym: Bpro_2572

Alternate gene names: 91788434

Gene position: 2692962-2691787 (Counterclockwise)

Preceding gene: 91788435

Following gene: 91788433

Centisome position: 51.79

GC content: 62.16

Gene sequence:

>1176_bases
ATGACCTCAGCCGTAATAGTTTCCACCGCCCGCACCCCCCTGGCCAAAAGCTGGAAGGGCTCTTTCAACATGACGCACGG
TGCTACCCTGGGCGGCCACGCCGTAGAGCATGCCCTCAAGCGCGCCGGCATTGATGCGGCCGAAGTTGACGACGTCATCA
TGGGTTGCGCCACACCCGAAGGCGCCACCGGCGCCAACATTGCGCGCCAGATTGCGCTGCGCGCCGGTTGCCCGGTCACC
GTGTCGGGCATGACCGTTAACCGTTTTTGCTCATCCGGCCTGCAGACCATCGCCCTGGCGGCGCAGCGCGTGATCGCCGG
TGAGGCCGATATCTACGTGGCTGGCGGCGTGGAAAGCATCTCCTGCGTGCAGCAGGAAATGAATACCCACATGCTGCAGG
AAAGCTGGCTTGCCAAAAACAAACCCGAGATTTACTGGAACATGCTGCAAACCGCCGAGCAGGTCGCCAAGCGCTACAAC
ATCTCGCGTGACCGCATGGACGAATACGGCGCGCTCAGCCAGCAAAAGGCCGCGGCTGCACTCGCTGCCGGCCGCTTTGA
AGCCGAGATCGCACCCATTACCGTCACAGCTGGCGTAGCCGATCCGGTGATGGGCCTGATCACCAAACAGGTCACCGTGA
GCAAGGATGAGGGCATTCGCGAAGGCACCACCAAGGAGGGCATCAGCGGCATCAAGCCGGCCATCCCCGGGGGTGTCATT
GCGGCCGGCAATGCCAGCCAGTTCTCCGATGGTGGTGGCGCGGTGGTGGTGATGGGCGAGAAAGTAGCTGAAAAAAAGGG
CCTGAAACCGCTGGGTCGTTTTCTGGGCTTTGCGGTGGCTGGCTGCGAGCCCGACGAAATGGGCATCGGTCCGGTTTTCG
CCATTCCCAAGGTGCTGGCCAAACTGGGCCTGAAGATCAGCGACATCGACCTCTGGGAGCTGAACGAAGCCTTTGCCGTG
CAGGTGCTGTACTGCGCCGACAAGCTGGGCATTCCCATGGACCGGCTCAATGTCAACGGTGGCGCCATTGCCGTCGGCCA
CCCTTACGGCGTCACGGGTCAGCGCCTCACCGGCCACGCCCTGATCGAAGGCAAGCGTCGCGGCGCCAAACGTGTTTGTG
TGACCATGTGCATTGGCGGCGGCATGGGTGCTGCAGGTATTTACGAAGTCCTGTAA

Upstream 100 bases:

>100_bases
TGGATGATGCAAGTTTCTGGAAGCCCGCCCCATTGCTGGCCCGGCTCGCAGCCGAAGGCAAGACTTTCAACTAATTTGAG
AACAAATTCCGGAGATTCCC

Downstream 100 bases:

>100_bases
GAGGCATCCTGTGCCATGAACGAAACCCTGCTCCTTCAGAAAGGGCAGGCGTTTTTGGCCCTGCAGCCTGCCGGTGTGCT
GATCGGCGCCGAACTGCATG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVEHALKRAGIDAAEVDDVIMGCATPEGATGANIARQIALRAGCPVT
VSGMTVNRFCSSGLQTIALAAQRVIAGEADIYVAGGVESISCVQQEMNTHMLQESWLAKNKPEIYWNMLQTAEQVAKRYN
ISRDRMDEYGALSQQKAAAALAAGRFEAEIAPITVTAGVADPVMGLITKQVTVSKDEGIREGTTKEGISGIKPAIPGGVI
AAGNASQFSDGGGAVVVMGEKVAEKKGLKPLGRFLGFAVAGCEPDEMGIGPVFAIPKVLAKLGLKISDIDLWELNEAFAV
QVLYCADKLGIPMDRLNVNGGAIAVGHPYGVTGQRLTGHALIEGKRRGAKRVCVTMCIGGGMGAAGIYEVL

Sequences:

>Translated_391_residues
MTSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVEHALKRAGIDAAEVDDVIMGCATPEGATGANIARQIALRAGCPVT
VSGMTVNRFCSSGLQTIALAAQRVIAGEADIYVAGGVESISCVQQEMNTHMLQESWLAKNKPEIYWNMLQTAEQVAKRYN
ISRDRMDEYGALSQQKAAAALAAGRFEAEIAPITVTAGVADPVMGLITKQVTVSKDEGIREGTTKEGISGIKPAIPGGVI
AAGNASQFSDGGGAVVVMGEKVAEKKGLKPLGRFLGFAVAGCEPDEMGIGPVFAIPKVLAKLGLKISDIDLWELNEAFAV
QVLYCADKLGIPMDRLNVNGGAIAVGHPYGVTGQRLTGHALIEGKRRGAKRVCVTMCIGGGMGAAGIYEVL
>Mature_390_residues
TSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVEHALKRAGIDAAEVDDVIMGCATPEGATGANIARQIALRAGCPVTV
SGMTVNRFCSSGLQTIALAAQRVIAGEADIYVAGGVESISCVQQEMNTHMLQESWLAKNKPEIYWNMLQTAEQVAKRYNI
SRDRMDEYGALSQQKAAAALAAGRFEAEIAPITVTAGVADPVMGLITKQVTVSKDEGIREGTTKEGISGIKPAIPGGVIA
AGNASQFSDGGGAVVVMGEKVAEKKGLKPLGRFLGFAVAGCEPDEMGIGPVFAIPKVLAKLGLKISDIDLWELNEAFAVQ
VLYCADKLGIPMDRLNVNGGAIAVGHPYGVTGQRLTGHALIEGKRRGAKRVCVTMCIGGGMGAAGIYEVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=42.0103092783505, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=38.1313131313131, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=36.2944162436548, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=35.2357320099256, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=29.9539170506912, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI194353979, Length=386, Percent_Identity=31.6062176165803, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=38.7254901960784, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=40.1477832512315, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI87082165, Length=405, Percent_Identity=37.5308641975309, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=38.3838383838384, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=29.126213592233, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=38.8471177944862, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=35.1898734177215, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=33.502538071066, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=28.8329519450801, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=374, Percent_Identity=29.6791443850267, Blast_Score=151, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=38.676844783715, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=32.75, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24655093, Length=405, Percent_Identity=40.4938271604938, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=38.4422110552764, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=35.6608478802993, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=29.8611111111111, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40680; Mature: 40548

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVEHALKRAGIDAAEVDDVIMGCATPE
CCCEEEEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GATGANIARQIALRAGCPVTVSGMTVNRFCSSGLQTIALAAQRVIAGEADIYVAGGVESI
CCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNTHMLQESWLAKNKPEIYWNMLQTAEQVAKRYNISRDRMDEYGALSQQKAAAA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHH
LAAGRFEAEIAPITVTAGVADPVMGLITKQVTVSKDEGIREGTTKEGISGIKPAIPGGVI
HHHCCCCCEEEEEEEECCCHHHHHHHHHHHEEECCCCCCCCCCCHHCCCCCCCCCCCCEE
AAGNASQFSDGGGAVVVMGEKVAEKKGLKPLGRFLGFAVAGCEPDEMGIGPVFAIPKVLA
ECCCCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
KLGLKISDIDLWELNEAFAVQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVTGQRLTGHA
HHCCEEECCCCEECCHHHHEEEEEEHHHHCCCHHHEECCCCEEEECCCCCCCCCCCCCHH
LIEGKRRGAKRVCVTMCIGGGMGAAGIYEVL
EECCCCCCHHHEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure 
TSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVEHALKRAGIDAAEVDDVIMGCATPE
CCEEEEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
GATGANIARQIALRAGCPVTVSGMTVNRFCSSGLQTIALAAQRVIAGEADIYVAGGVESI
CCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNTHMLQESWLAKNKPEIYWNMLQTAEQVAKRYNISRDRMDEYGALSQQKAAAA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHH
LAAGRFEAEIAPITVTAGVADPVMGLITKQVTVSKDEGIREGTTKEGISGIKPAIPGGVI
HHHCCCCCEEEEEEEECCCHHHHHHHHHHHEEECCCCCCCCCCCHHCCCCCCCCCCCCEE
AAGNASQFSDGGGAVVVMGEKVAEKKGLKPLGRFLGFAVAGCEPDEMGIGPVFAIPKVLA
ECCCCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
KLGLKISDIDLWELNEAFAVQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVTGQRLTGHA
HHCCEEECCCCEECCHHHHEEEEEEHHHHCCCHHHEECCCCEEEECCCCCCCCCCCCCHH
LIEGKRRGAKRVCVTMCIGGGMGAAGIYEVL
EECCCCCCHHHEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]