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The map label for this gene is tmk

Identifier: 91788382

GI number: 91788382

Start: 2633489

End: 2634166

Strand: Reverse

Name: tmk

Synonym: Bpro_2519

Alternate gene names: 91788382

Gene position: 2634166-2633489 (Counterclockwise)

Preceding gene: 91788383

Following gene: 91788381

Centisome position: 50.65

GC content: 64.31

Gene sequence:

>678_bases
ATGCACGGCCTGTTCATCAGCTTTGAAGGCATAGACGGTGCGGGCAAGTCCACGCATATTGCAGGACTGGCAGACGCCTT
CAGGGCACAGGGCCGGGCCGTGACCTTGACGCGCGAACCCGGGGGGACCCCGCTGGCCGAAAAGCTGCGCGACCTGGTAC
TGAACGATGCCATGGATTCGCTGACCGAGGCACTGCTGATTTTTGCGGCCCGGCGCGACCACCTCGTGCGCGTGATCGCG
CCGGCGCTGGTGCGCGGCGACGTTGTGTTGTGCGACCGCTTCACCGACGCCACCTTTGCCTACCAGGGGGCCGGACGTGG
TTTTGACCTGGCTGTGCTGGCTACGCTGGAGCAGTGGGTGCAGTCCGACGAAGGGTTGCTGGGCGATCCGGCCGGCAACT
TTCCCATGAAGCCTGAAGTCGAGACAGTCATCGAACCGCACCTCACGGTCTGGTTTGACCTGCCGCCCGAAGAAGCCGCC
CTGCGACTGCAAGGCGCGCGCGTGCCCGACAAGTTTGAAGCCCAACCGCTGGAGTTTTTCCGTCGCGTGGCGAAAGGCTA
TTCCGACCGCCAGCAAGGCCATCCGGAACGCTTTGCCCGGATCAATGCCTCACAACCGCGCGATGTGGTCTGGCAGGCGG
TGCGGCAGGTGTTTGTGGCCAAAGGGTGGCTGGCATGA

Upstream 100 bases:

>100_bases
CGATTTATTTTGTTGCCCGGGGCGACGGCAGCAGCCATTTCAGCGCCAGCCTGGACGAGCACAACCGTGCCGTCAATAAA
TATATCCGGGGTCAATAAAC

Downstream 100 bases:

>100_bases
GTGAGGCCGCCAGCGAGATAAGTACAAGTACTGTGGTCAAAAAAGCGCCTCTGGCGCCCTGGCTGCAAACCCAGCTGGAG
AGCCTGCTGGCCCAGCGCGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MHGLFISFEGIDGAGKSTHIAGLADAFRAQGRAVTLTREPGGTPLAEKLRDLVLNDAMDSLTEALLIFAARRDHLVRVIA
PALVRGDVVLCDRFTDATFAYQGAGRGFDLAVLATLEQWVQSDEGLLGDPAGNFPMKPEVETVIEPHLTVWFDLPPEEAA
LRLQGARVPDKFEAQPLEFFRRVAKGYSDRQQGHPERFARINASQPRDVVWQAVRQVFVAKGWLA

Sequences:

>Translated_225_residues
MHGLFISFEGIDGAGKSTHIAGLADAFRAQGRAVTLTREPGGTPLAEKLRDLVLNDAMDSLTEALLIFAARRDHLVRVIA
PALVRGDVVLCDRFTDATFAYQGAGRGFDLAVLATLEQWVQSDEGLLGDPAGNFPMKPEVETVIEPHLTVWFDLPPEEAA
LRLQGARVPDKFEAQPLEFFRRVAKGYSDRQQGHPERFARINASQPRDVVWQAVRQVFVAKGWLA
>Mature_225_residues
MHGLFISFEGIDGAGKSTHIAGLADAFRAQGRAVTLTREPGGTPLAEKLRDLVLNDAMDSLTEALLIFAARRDHLVRVIA
PALVRGDVVLCDRFTDATFAYQGAGRGFDLAVLATLEQWVQSDEGLLGDPAGNFPMKPEVETVIEPHLTVWFDLPPEEAA
LRLQGARVPDKFEAQPLEFFRRVAKGYSDRQQGHPERFARINASQPRDVVWQAVRQVFVAKGWLA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=222, Percent_Identity=34.6846846846847, Blast_Score=108, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_POLSJ (Q12AK6)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_549334.1
- ProteinModelPortal:   Q12AK6
- SMR:   Q12AK6
- STRING:   Q12AK6
- GeneID:   4014824
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_2519
- NMPDR:   fig|296591.1.peg.133
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   KSTHIAG
- PhylomeDB:   Q12AK6
- ProtClustDB:   PRK00698
- BioCyc:   PSP296591:BPRO_2519-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24803; Mature: 24803

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGLFISFEGIDGAGKSTHIAGLADAFRAQGRAVTLTREPGGTPLAEKLRDLVLNDAMDS
CCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LTEALLIFAARRDHLVRVIAPALVRGDVVLCDRFTDATFAYQGAGRGFDLAVLATLEQWV
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHH
QSDEGLLGDPAGNFPMKPEVETVIEPHLTVWFDLPPEEAALRLQGARVPDKFEAQPLEFF
HCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHEECCCCCCCCCCCCHHHHH
RRVAKGYSDRQQGHPERFARINASQPRDVVWQAVRQVFVAKGWLA
HHHHCCCCHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHGLFISFEGIDGAGKSTHIAGLADAFRAQGRAVTLTREPGGTPLAEKLRDLVLNDAMDS
CCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LTEALLIFAARRDHLVRVIAPALVRGDVVLCDRFTDATFAYQGAGRGFDLAVLATLEQWV
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHH
QSDEGLLGDPAGNFPMKPEVETVIEPHLTVWFDLPPEEAALRLQGARVPDKFEAQPLEFF
HCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHEECCCCCCCCCCCCHHHHH
RRVAKGYSDRQQGHPERFARINASQPRDVVWQAVRQVFVAKGWLA
HHHHCCCCHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA