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The map label for this gene is yngG [H]

Identifier: 91788220

GI number: 91788220

Start: 2450722

End: 2451705

Strand: Reverse

Name: yngG [H]

Synonym: Bpro_2353

Alternate gene names: 91788220

Gene position: 2451705-2450722 (Counterclockwise)

Preceding gene: 91788226

Following gene: 91788219

Centisome position: 47.15

GC content: 65.85

Gene sequence:

>984_bases
GTGAACATGCTTTCAAGCGCTTCAGCTTCCCCCCAAGCCGCCCTGCCCGAAAAGCCGGCCCTGCCGCGGCAAGTCAGCAT
TCGCGAAGTAGGCCTGCGCGACGGGCTGCAGAGCATTGCCACCGTCATGCCCACCGCGCGCAAGCTGGCGTGGATCCGTG
ATGCCTACGACGCCGGCCAGCGCGAAATCGAAGTCGGCTCGTTTGTCCCGGCCCGGCTGCTGCCGCAACTGGCCGACACT
GCGGAGCTGGTGGCCTATGCCAAAACCCTGCCTGGACTCGTCACCTCCGTGCTGGTGCCCAATCTCAAAGGCGCCGAACG
CGCCATCGAATCAGGCGCCGACTTGATGCTGCTGCCGATCTCGGCCAGCCATGCCCACAGCCTGGCCAACTTGCGCAAGA
CGCCCGATGAAGTGGTGCAGGAGATTGGCCGCATCCGGGCGGCGCGTGATGCCTCTGGCTCAAAAATCCTGATCGAGGTG
GGCTTTAGCACGGCATTTGGCTGCACGCTGCAGGGCCGGGTCGAGCCGTCCGAGGTGTTGCGCCTGTTGCAGCTGGTGCT
GGACGCCGGGGTGGACCGGGTCGGCCTGGCAGACACCGTGGGTTATGCCGATCCGGCCATGGTGCAAGACCTGTTCGAGG
CTGCGTTCGCCATAGCCGGCGACCGGCTGGCATGCGGCCACTTTCATGACACGCGCGGTATGGGCGTAGCCAATGTGTAC
GCCGCGCTGCAAACCGGGGTGACGCGCTTTGACGCCTGCCTGGCCGGCATTGGCGGCTGCCCGCACGCACCGGGCGCCAG
CGGCAACGTGGCCAGCGAAGACCTGGTCTACATGTTTGCCAGCATGGGCATCAGCACCGGCATCGATTTCGACAAGCTTA
TGGCGCTGCGCACCCAGGTGGCCGGCTGGCTGGAAGGCGAAACGCTGCACGGCACGCTGTGGCGCGCAGGCCTGCCCAAA
ACCATGCTGACCGCTACGGTGTAA

Upstream 100 bases:

>100_bases
ATTCCGATACGGAACGCTGAAGGTTCCAAAATTGATAACTATAACCAACCGGGAAATTCTAAACTGAGCCTCTGAATTTC
AAAATACCTGGAGACAGTCA

Downstream 100 bases:

>100_bases
ACACTCCCCATCCCGAAGAAACCTGTATGCAAAACAATCCAGCTTCAACCCCGCCCCAGCCCCTGGCCGGCTTGCGCGTC
GTCGAATTCACCCACATGGT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNMLSSASASPQAALPEKPALPRQVSIREVGLRDGLQSIATVMPTARKLAWIRDAYDAGQREIEVGSFVPARLLPQLADT
AELVAYAKTLPGLVTSVLVPNLKGAERAIESGADLMLLPISASHAHSLANLRKTPDEVVQEIGRIRAARDASGSKILIEV
GFSTAFGCTLQGRVEPSEVLRLLQLVLDAGVDRVGLADTVGYADPAMVQDLFEAAFAIAGDRLACGHFHDTRGMGVANVY
AALQTGVTRFDACLAGIGGCPHAPGASGNVASEDLVYMFASMGISTGIDFDKLMALRTQVAGWLEGETLHGTLWRAGLPK
TMLTATV

Sequences:

>Translated_327_residues
MNMLSSASASPQAALPEKPALPRQVSIREVGLRDGLQSIATVMPTARKLAWIRDAYDAGQREIEVGSFVPARLLPQLADT
AELVAYAKTLPGLVTSVLVPNLKGAERAIESGADLMLLPISASHAHSLANLRKTPDEVVQEIGRIRAARDASGSKILIEV
GFSTAFGCTLQGRVEPSEVLRLLQLVLDAGVDRVGLADTVGYADPAMVQDLFEAAFAIAGDRLACGHFHDTRGMGVANVY
AALQTGVTRFDACLAGIGGCPHAPGASGNVASEDLVYMFASMGISTGIDFDKLMALRTQVAGWLEGETLHGTLWRAGLPK
TMLTATV
>Mature_327_residues
MNMLSSASASPQAALPEKPALPRQVSIREVGLRDGLQSIATVMPTARKLAWIRDAYDAGQREIEVGSFVPARLLPQLADT
AELVAYAKTLPGLVTSVLVPNLKGAERAIESGADLMLLPISASHAHSLANLRKTPDEVVQEIGRIRAARDASGSKILIEV
GFSTAFGCTLQGRVEPSEVLRLLQLVLDAGVDRVGLADTVGYADPAMVQDLFEAAFAIAGDRLACGHFHDTRGMGVANVY
AALQTGVTRFDACLAGIGGCPHAPGASGNVASEDLVYMFASMGISTGIDFDKLMALRTQVAGWLEGETLHGTLWRAGLPK
TMLTATV

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=274, Percent_Identity=36.8613138686131, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI109150427, Length=275, Percent_Identity=36, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI109150422, Length=275, Percent_Identity=36, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI260654708, Length=105, Percent_Identity=43.8095238095238, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17510563, Length=281, Percent_Identity=33.4519572953737, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320019, Length=263, Percent_Identity=26.2357414448669, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320071, Length=273, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582381, Length=294, Percent_Identity=35.3741496598639, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34432; Mature: 34432

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00815 AIPM_HOMOCIT_SYNTH_1 ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLSSASASPQAALPEKPALPRQVSIREVGLRDGLQSIATVMPTARKLAWIRDAYDAGQ
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
REIEVGSFVPARLLPQLADTAELVAYAKTLPGLVTSVLVPNLKGAERAIESGADLMLLPI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEC
SASHAHSLANLRKTPDEVVQEIGRIRAARDASGSKILIEVGFSTAFGCTLQGRVEPSEVL
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCEEECCCCHHHHH
RLLQLVLDAGVDRVGLADTVGYADPAMVQDLFEAAFAIAGDRLACGHFHDTRGMGVANVY
HHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHH
AALQTGVTRFDACLAGIGGCPHAPGASGNVASEDLVYMFASMGISTGIDFDKLMALRTQV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AGWLEGETLHGTLWRAGLPKTMLTATV
HHHCCCCCHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MNMLSSASASPQAALPEKPALPRQVSIREVGLRDGLQSIATVMPTARKLAWIRDAYDAGQ
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
REIEVGSFVPARLLPQLADTAELVAYAKTLPGLVTSVLVPNLKGAERAIESGADLMLLPI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEC
SASHAHSLANLRKTPDEVVQEIGRIRAARDASGSKILIEVGFSTAFGCTLQGRVEPSEVL
CCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCEEECCCCHHHHH
RLLQLVLDAGVDRVGLADTVGYADPAMVQDLFEAAFAIAGDRLACGHFHDTRGMGVANVY
HHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHH
AALQTGVTRFDACLAGIGGCPHAPGASGNVASEDLVYMFASMGISTGIDFDKLMALRTQV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AGWLEGETLHGTLWRAGLPKTMLTATV
HHHCCCCCHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]