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The map label for this gene is uvrB [H]

Identifier: 91788049

GI number: 91788049

Start: 2271346

End: 2273466

Strand: Direct

Name: uvrB [H]

Synonym: Bpro_2176

Alternate gene names: 91788049

Gene position: 2271346-2273466 (Clockwise)

Preceding gene: 91788047

Following gene: 91788050

Centisome position: 43.68

GC content: 59.36

Gene sequence:

>2121_bases
ATGCCAGAAGTCACTGAAGTCATTACGGATTTGCCTGATTTATCCCCTGCCGGAGAATTTGTCAGCTTTCCCGATTCGCC
CTTTGAGCTGTTCATGCCTTACCCGCCGGCAGGTGACCAGCCGACCGCGATTGCCCAGCTGGTGGAAGGCGTCAACGATG
GCGAAGTGTTCCAGACCCTGCTGGGCGTCACGGGTTCGGGCAAGACCTTCACCATGGCCAACGTGATCGCGCGCCTGGGG
CGCCCGGCAATCGTATTTGCGCCCAACAAGACCCTGGCAGCGCAGCTTTACAGCGAGTTCCGGGAGTTTTTCCCGAAGAA
CGCGGTGGAGTATTTCGTCAGTTATTACGACTACTACCAGCCCGAGGCCTACGTGCCGCAGCGCGATCTTTTTATCGAAA
AAGACTCCGCCATCAACGAGCACATCGAGCAGATGCGCCTTTCAGCCACCAAGAGCGTGCTGGAGCGCCGGGACACCATC
ATCGTCGGCACCGTGAGCGCGATCTACGGCATTGGGGCACCCGAGGATTACACCCAGATGCGCTTCATCGCGCGTACTGG
CGACAAGATGGGACAGCGCGACGTCATTGCCCGCCTGATCCGCATGCAGTACACCCGTAATGAACAGGATTTTGCGCGCG
GCACCTTCCGGGTACGCGGCGACGTGATCGATATCTTTCCGGCCGAGCATTCCGAACTGGCCATCCGCATCGAGCTGTTT
GACGACGAGATCGAAAGCCTGCAGCTGTTTGACCCGCTCACCGGGCGTATCCGGCAAAAAGTCCCGCGTTTTGTCGTGTA
TCCCAAAAGCCACTACGTGACGCCGCGTGACAAGGTCATGGCGGCGGTGGAGACCATCAAGCTGGAGCTGTCCGAGCGGG
TGGGGCAGTTTGTGGCCGACGGCAAGCTGGTGGAGGCCCAGCGGATCGAGCAGCGCACCCGGTTTGACCTAGAGATGCTC
AGCGAGATCGGGCACTGCAAGGGGATTGAAAACTACACCCGCCACCTGAGCGGATCGGCGCCGGGTTCAGCACCGTCAAC
CCTGTGCGACTACCTGCCCAAGGATGCGGTGATGTTCCTGGATGAGAGCCACGTCATGATCGGTCAGCTCAACGCCATGT
ACAACGGCGACCGGGCGCGCAAGACCACGCTGGTGGAATACGGCTTCAGGCTGCCCAGCGCGCTGGACAACCGGCCGCTC
AAGTTTGACGAGTTCGAAGCCAAGATGCGCCAGGCCATCTTTGTGTCTGCCACACCGGCGGCCTACGAGCAGGAACACGC
GGGCCAGGTGGTGGAGCAGGTTGTCAGGCCCACCGGGCTGGTGGACCCGCAGGTGGAGGTGCGGCCGGCCACGCATCAGG
TCGATGATGTGCTGCAGGAAATCCGCATCCGGGTCGACCGGAACGAGCGGGTGCTGATCACCACCTTGACCAAGCGGATG
GCCGAGCAGCTCACCGATTACCTGGGCGACAACGGAGTGAAAGTTCGCTATCTGCACAGTGACGTGGATACGGTCGAGCG
CGTGGAAATTTTGCGCGACCTGCGGCTCGGTGCATTTGACGTGCTGGTCGGCATCAATTTGCTGCGCGAAGGCCTGGACA
TTCCCGAGGTCTCGCTGGTGGCGATTCTGGATGCGGACAAGGAAGGTTTTTTAAGGTCGGAGCGTAGCCTGATTCAAACC
ATTGGCCGGGCGGCCCGAAACCTGAACGGCCGTGCCATTCTGTATGCCGACCGCATCACCGATTCCATGAAAAAAGCCAT
GGACGAAACCGAGCGCCGCCGCAACAAACAAATTGCATTCAACCTGGAGCATGGCATTACGCCGCGAAGCATTGTCAAAC
GAATCAAAGACCTGATTGATGGCGTTTACAGCGAAAAATCCGGCAAGGAAGCTGAAAAGCTTGAAATGCAAAAGGCGCTC
GTGGAAGACATGAGCGAGAAAGACATCGCCCGTGAGATCAAGCGGCTGGAAAAGCAGATGGTTGAACACGCCAGGAACCT
GGAGTTCGAAAAAGCCGCCAGGATTCGAGACCAGCTGCACACGCTCAAGGAACAGGCTTTTGGCGCACCGGGCGCGGACA
ATGTGGAGGTTATTGCGGCTTCGGGTGCGGGGTCGCGCTAG

Upstream 100 bases:

>100_bases
CGGGCATTTCGGGGGTTTTGAGCTTGTTATTTCAGATTTCGTCCGAATGTCGTATTCTGTTTAGTTGCCCCTGATTTTAA
CGGGCCCAGATTGAGGTTCT

Downstream 100 bases:

>100_bases
CTTTCGGCGCGGGCACGCCTGTGCTTTCGCACCATGGCGGTGCATTGAGTGGGCTGGCGCCCCGGGCAGCGGGCCAGGGT
GGGAAAACCCGGCCTGTGGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MPEVTEVITDLPDLSPAGEFVSFPDSPFELFMPYPPAGDQPTAIAQLVEGVNDGEVFQTLLGVTGSGKTFTMANVIARLG
RPAIVFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDTI
IVGTVSAIYGIGAPEDYTQMRFIARTGDKMGQRDVIARLIRMQYTRNEQDFARGTFRVRGDVIDIFPAEHSELAIRIELF
DDEIESLQLFDPLTGRIRQKVPRFVVYPKSHYVTPRDKVMAAVETIKLELSERVGQFVADGKLVEAQRIEQRTRFDLEML
SEIGHCKGIENYTRHLSGSAPGSAPSTLCDYLPKDAVMFLDESHVMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPL
KFDEFEAKMRQAIFVSATPAAYEQEHAGQVVEQVVRPTGLVDPQVEVRPATHQVDDVLQEIRIRVDRNERVLITTLTKRM
AEQLTDYLGDNGVKVRYLHSDVDTVERVEILRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQT
IGRAARNLNGRAILYADRITDSMKKAMDETERRRNKQIAFNLEHGITPRSIVKRIKDLIDGVYSEKSGKEAEKLEMQKAL
VEDMSEKDIAREIKRLEKQMVEHARNLEFEKAARIRDQLHTLKEQAFGAPGADNVEVIAASGAGSR

Sequences:

>Translated_706_residues
MPEVTEVITDLPDLSPAGEFVSFPDSPFELFMPYPPAGDQPTAIAQLVEGVNDGEVFQTLLGVTGSGKTFTMANVIARLG
RPAIVFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDTI
IVGTVSAIYGIGAPEDYTQMRFIARTGDKMGQRDVIARLIRMQYTRNEQDFARGTFRVRGDVIDIFPAEHSELAIRIELF
DDEIESLQLFDPLTGRIRQKVPRFVVYPKSHYVTPRDKVMAAVETIKLELSERVGQFVADGKLVEAQRIEQRTRFDLEML
SEIGHCKGIENYTRHLSGSAPGSAPSTLCDYLPKDAVMFLDESHVMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPL
KFDEFEAKMRQAIFVSATPAAYEQEHAGQVVEQVVRPTGLVDPQVEVRPATHQVDDVLQEIRIRVDRNERVLITTLTKRM
AEQLTDYLGDNGVKVRYLHSDVDTVERVEILRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQT
IGRAARNLNGRAILYADRITDSMKKAMDETERRRNKQIAFNLEHGITPRSIVKRIKDLIDGVYSEKSGKEAEKLEMQKAL
VEDMSEKDIAREIKRLEKQMVEHARNLEFEKAARIRDQLHTLKEQAFGAPGADNVEVIAASGAGSR
>Mature_705_residues
PEVTEVITDLPDLSPAGEFVSFPDSPFELFMPYPPAGDQPTAIAQLVEGVNDGEVFQTLLGVTGSGKTFTMANVIARLGR
PAIVFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDTII
VGTVSAIYGIGAPEDYTQMRFIARTGDKMGQRDVIARLIRMQYTRNEQDFARGTFRVRGDVIDIFPAEHSELAIRIELFD
DEIESLQLFDPLTGRIRQKVPRFVVYPKSHYVTPRDKVMAAVETIKLELSERVGQFVADGKLVEAQRIEQRTRFDLEMLS
EIGHCKGIENYTRHLSGSAPGSAPSTLCDYLPKDAVMFLDESHVMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLK
FDEFEAKMRQAIFVSATPAAYEQEHAGQVVEQVVRPTGLVDPQVEVRPATHQVDDVLQEIRIRVDRNERVLITTLTKRMA
EQLTDYLGDNGVKVRYLHSDVDTVERVEILRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTI
GRAARNLNGRAILYADRITDSMKKAMDETERRRNKQIAFNLEHGITPRSIVKRIKDLIDGVYSEKSGKEAEKLEMQKALV
EDMSEKDIAREIKRLEKQMVEHARNLEFEKAARIRDQLHTLKEQAFGAPGADNVEVIAASGAGSR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=63.8805970149254, Blast_Score=853, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=242, Percent_Identity=24.7933884297521, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79829; Mature: 79698

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEVTEVITDLPDLSPAGEFVSFPDSPFELFMPYPPAGDQPTAIAQLVEGVNDGEVFQTL
CCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHH
LGVTGSGKTFTMANVIARLGRPAIVFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQ
HCCCCCCCEEHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDTIIVGTVSAIYGIGAPEDYTQM
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCHHHHH
RFIARTGDKMGQRDVIARLIRMQYTRNEQDFARGTFRVRGDVIDIFPAEHSELAIRIELF
HHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHCCEEEEECCEEEECCCCCCCEEEEEEEE
DDEIESLQLFDPLTGRIRQKVPRFVVYPKSHYVTPRDKVMAAVETIKLELSERVGQFVAD
CCCHHHHHHHCHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GKLVEAQRIEQRTRFDLEMLSEIGHCKGIENYTRHLSGSAPGSAPSTLCDYLPKDAVMFL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEE
DESHVMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLKFDEFEAKMRQAIFVSATPA
CCCCEEEEHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHEEEECCCH
AYEQEHAGQVVEQVVRPTGLVDPQVEVRPATHQVDDVLQEIRIRVDRNERVLITTLTKRM
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHEECCCCEEEEHHHHHHH
AEQLTDYLGDNGVKVRYLHSDVDTVERVEILRDLRLGAFDVLVGINLLREGLDIPEVSLV
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITDSMKKAMDETERRRNKQIAF
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEE
NLEHGITPRSIVKRIKDLIDGVYSEKSGKEAEKLEMQKALVEDMSEKDIAREIKRLEKQM
ECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
VEHARNLEFEKAARIRDQLHTLKEQAFGAPGADNVEVIAASGAGSR
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
PEVTEVITDLPDLSPAGEFVSFPDSPFELFMPYPPAGDQPTAIAQLVEGVNDGEVFQTL
CCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHH
LGVTGSGKTFTMANVIARLGRPAIVFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQ
HCCCCCCCEEHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PEAYVPQRDLFIEKDSAINEHIEQMRLSATKSVLERRDTIIVGTVSAIYGIGAPEDYTQM
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCHHHHH
RFIARTGDKMGQRDVIARLIRMQYTRNEQDFARGTFRVRGDVIDIFPAEHSELAIRIELF
HHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHCCEEEEECCEEEECCCCCCCEEEEEEEE
DDEIESLQLFDPLTGRIRQKVPRFVVYPKSHYVTPRDKVMAAVETIKLELSERVGQFVAD
CCCHHHHHHHCHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GKLVEAQRIEQRTRFDLEMLSEIGHCKGIENYTRHLSGSAPGSAPSTLCDYLPKDAVMFL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEEE
DESHVMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLKFDEFEAKMRQAIFVSATPA
CCCCEEEEHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHEEEECCCH
AYEQEHAGQVVEQVVRPTGLVDPQVEVRPATHQVDDVLQEIRIRVDRNERVLITTLTKRM
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHEECCCCEEEEHHHHHHH
AEQLTDYLGDNGVKVRYLHSDVDTVERVEILRDLRLGAFDVLVGINLLREGLDIPEVSLV
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITDSMKKAMDETERRRNKQIAF
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEE
NLEHGITPRSIVKRIKDLIDGVYSEKSGKEAEKLEMQKALVEDMSEKDIAREIKRLEKQM
ECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
VEHARNLEFEKAARIRDQLHTLKEQAFGAPGADNVEVIAASGAGSR
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA