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The map label for this gene is mutB [H]

Identifier: 91788034

GI number: 91788034

Start: 2253732

End: 2255903

Strand: Direct

Name: mutB [H]

Synonym: Bpro_2161

Alternate gene names: 91788034

Gene position: 2253732-2255903 (Clockwise)

Preceding gene: 91788032

Following gene: 91788035

Centisome position: 43.34

GC content: 62.06

Gene sequence:

>2172_bases
ATGAGCTCCAAAAAACCTTTCCCCCAGCCGGATTTCAATCCCGCCAGCCTCGAAGCATGGGCCAAATCGGCGGCCAAATC
AGCGCCCGGCGGCAATGTGAACGCGCTGAACTGGCAAACACCCGATGGCATCAGCGTCAAGCCGCTTTATACCGCCGAGG
ATATCGAGGGCCTGCCCTACACCAACACCTTGCCGGGCTTTGAGCCCTTCATCCGCGGTCCACAGGCCACCATGTATGCC
GTGCGTCCCTGGACGATTCGCCAGTACGCCGGGTTTTCCACGGCGGAAGAATCCAATGCGTTCTACCGCAAGGCGTTGGC
TGCCGGCGGGCAGGGGGTCTCTGTCGCCTTTGACCTGGCCACGCACCGCGGCTATGACAGCGACCATCCGCGGGTAACCG
GCGATGTCGGCAAGGCCGGCGTGGCGATCGACAGCGTGGAGGACATGAAGATACTGTTCGACCATATCCCGCTGGACAAG
GTCAGTGTCTCGATGACGATGAACGGCGCGGTGCTGCCGGTGCTGGCCGGCTATGTGGTGGCCGCTGAAGAGCAGGGCGT
CTCGCAGGACAAATTGAGCGGAACCATCCAGAACGACATCCTCAAGGAGTTCATGGTCCGCAATACCTATATCTACCCGC
CCCAGCCCAGCATCCGCATCATCGGCGACATCATCGAGTACACGGCACAGAACATGCCGAAGTTCAATTCGATTTCAATC
TCGGGCTACCACATGCAGGAAGCCGGCGCCAACCAGGCGCTGGAGCTGGCCTTCACGCTGGCCGACGGAAAAGAGTACGT
GAAAACCGCGCTGGGCAAGGGCCTGGACGTGGATGACTTCGCCGGGCGCCTGAGTTTCTTCTGGGCCATCGGCATGAACT
TTTACCTCGAAGTCGCCAAGATGCGAGCGGCGCGCCTGCTGTGGTGCCGCATCATGAAGGGCTTCAACGCCAGGAGCCCC
AAATCACTCATGCTGCGCACGCACTGCCAGACCTCCGGCTGGAGCCTGACCGAGCAGGATCCCTACAACAATGTGGTGCG
CACCACCATCGAGGCCATGGCGGCCGTGTTCGGCGGCACGCAGAGCCTGCACACCAATTCGTTTGACGAAGCGATTGCGC
TGCCCACCGAGTTTTCGTCGCGTATCGCCCGCAACACCCAGCTCATCATCCAGGAAGAAACCCACATCCCGCACGTGATC
GACCCCTGGGCCGGCAGCTACATGATGGAAAAACTCACCCAGGACATGGCTGATGCGGCCTGGGCCATCATTGAGGAAGT
CGAAGCCATGGGCGGCATGACCAAGGCGGTGGACAGCGGCTGGGCCAAGCTCAAGATTGAGGCGGCCGCGGCTGAAAAGC
AGGCGCGCATCGACAGCGGCAAGGACGTGATCGTCGGTGTCAACAAATACAAGCTCACAACCGAAGACGCCATCGAGTCG
CGCGACATCGACAACGTGGCCGTGCGCGACGGGCAGATTGAGCGCCTGAAGGCCATCAAGGCCGGGCGCGACGGGGCCGC
CGTGCAGGCCGCGCTGGACGCATTGAGCGCCGCGGCTGAAAATAACCACGGCAACCTGCTGGACCTGAGCATCAAGGCCG
TACGCCTGCGCGCCACTGTGGGCGAGGTCAGCGATGCACTGGAGAAAGTTTACGGGCGCCACCGCGCCGATACGCAAAAG
GTGACCGGTGTGTACGCTGCTGCCTATGACTCGGCCGAAGGCTGGGAAAACCTCAAATCTGAAATCAACGCTTTTGCCGA
GGCGCAAGGCCGCCGGCCGCGCGTGATGATTTCAAAACTGGGCCAGGACGGCCACGACCGCGGCGCCAAGGTGGTGGCCA
CGGCCTTCGCCGACCTGGGTTTTGACGTCGATATGGGGCCGCTGTTCCAGACACCCGAGGAATGCGCCCGCCAGGCGATT
GAAAACGACGTGCATGCGGTGGGCGTCTCGACGCTGGCCGCAGGCCACAAGACGCTGGTGCCGGCCATCATCGCCGAACT
CAAGAAGCAGGGCGCCGACGACATCATCGTGTTTGTCGGCGGTGTGATCCCGCGGCAGGACTACGAAATGCTTTACGAGG
CAGGCGTCAAGGGCATTTACGGCCCGGGTACACCGATTCCGGCCAGTGCCAAGGATGTGCTGGAGCAGATCAAGGCGGCG
GTGAAGGCTTGA

Upstream 100 bases:

>100_bases
ATAATTATAAATAATGTAAACTAGCCGAATTGTTAAAAAGCAAGGTAACAAGGTAAAGTGGATCGATAGCGTGCTTCGAT
CCTCTTGCCGCACATCCGTC

Downstream 100 bases:

>100_bases
TCCCGGTCATGCTCTCTCTTGCCCCCGTTGCTGCCTGCGATTTCGAGGAGATGCTAGCAATTCGCATGGAGACCCTGCGC
GAAAGTCTTGAGCGCTTGGG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MSSKKPFPQPDFNPASLEAWAKSAAKSAPGGNVNALNWQTPDGISVKPLYTAEDIEGLPYTNTLPGFEPFIRGPQATMYA
VRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDHIPLDK
VSVSMTMNGAVLPVLAGYVVAAEEQGVSQDKLSGTIQNDILKEFMVRNTYIYPPQPSIRIIGDIIEYTAQNMPKFNSISI
SGYHMQEAGANQALELAFTLADGKEYVKTALGKGLDVDDFAGRLSFFWAIGMNFYLEVAKMRAARLLWCRIMKGFNARSP
KSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNSFDEAIALPTEFSSRIARNTQLIIQEETHIPHVI
DPWAGSYMMEKLTQDMADAAWAIIEEVEAMGGMTKAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYKLTTEDAIES
RDIDNVAVRDGQIERLKAIKAGRDGAAVQAALDALSAAAENNHGNLLDLSIKAVRLRATVGEVSDALEKVYGRHRADTQK
VTGVYAAAYDSAEGWENLKSEINAFAEAQGRRPRVMISKLGQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAI
ENDVHAVGVSTLAAGHKTLVPAIIAELKKQGADDIIVFVGGVIPRQDYEMLYEAGVKGIYGPGTPIPASAKDVLEQIKAA
VKA

Sequences:

>Translated_723_residues
MSSKKPFPQPDFNPASLEAWAKSAAKSAPGGNVNALNWQTPDGISVKPLYTAEDIEGLPYTNTLPGFEPFIRGPQATMYA
VRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDHIPLDK
VSVSMTMNGAVLPVLAGYVVAAEEQGVSQDKLSGTIQNDILKEFMVRNTYIYPPQPSIRIIGDIIEYTAQNMPKFNSISI
SGYHMQEAGANQALELAFTLADGKEYVKTALGKGLDVDDFAGRLSFFWAIGMNFYLEVAKMRAARLLWCRIMKGFNARSP
KSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNSFDEAIALPTEFSSRIARNTQLIIQEETHIPHVI
DPWAGSYMMEKLTQDMADAAWAIIEEVEAMGGMTKAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYKLTTEDAIES
RDIDNVAVRDGQIERLKAIKAGRDGAAVQAALDALSAAAENNHGNLLDLSIKAVRLRATVGEVSDALEKVYGRHRADTQK
VTGVYAAAYDSAEGWENLKSEINAFAEAQGRRPRVMISKLGQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAI
ENDVHAVGVSTLAAGHKTLVPAIIAELKKQGADDIIVFVGGVIPRQDYEMLYEAGVKGIYGPGTPIPASAKDVLEQIKAA
VKA
>Mature_722_residues
SSKKPFPQPDFNPASLEAWAKSAAKSAPGGNVNALNWQTPDGISVKPLYTAEDIEGLPYTNTLPGFEPFIRGPQATMYAV
RPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDHIPLDKV
SVSMTMNGAVLPVLAGYVVAAEEQGVSQDKLSGTIQNDILKEFMVRNTYIYPPQPSIRIIGDIIEYTAQNMPKFNSISIS
GYHMQEAGANQALELAFTLADGKEYVKTALGKGLDVDDFAGRLSFFWAIGMNFYLEVAKMRAARLLWCRIMKGFNARSPK
SLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGTQSLHTNSFDEAIALPTEFSSRIARNTQLIIQEETHIPHVID
PWAGSYMMEKLTQDMADAAWAIIEEVEAMGGMTKAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYKLTTEDAIESR
DIDNVAVRDGQIERLKAIKAGRDGAAVQAALDALSAAAENNHGNLLDLSIKAVRLRATVGEVSDALEKVYGRHRADTQKV
TGVYAAAYDSAEGWENLKSEINAFAEAQGRRPRVMISKLGQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIE
NDVHAVGVSTLAAGHKTLVPAIIAELKKQGADDIIVFVGGVIPRQDYEMLYEAGVKGIYGPGTPIPASAKDVLEQIKAAV
KA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=704, Percent_Identity=64.4886363636364, Blast_Score=952, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=709, Percent_Identity=62.0592383638928, Blast_Score=894, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=704, Percent_Identity=63.4943181818182, Blast_Score=929, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 78259; Mature: 78127

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKKPFPQPDFNPASLEAWAKSAAKSAPGGNVNALNWQTPDGISVKPLYTAEDIEGLPY
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEECHHCCCCCCC
TNTLPGFEPFIRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLA
CCCCCCCHHHHCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEH
THRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDHIPLDKVSVSMTMNGAVLPVLAGYVV
HHCCCCCCCCEEECCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHE
AAEEQGVSQDKLSGTIQNDILKEFMVRNTYIYPPQPSIRIIGDIIEYTAQNMPKFNSISI
EECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGYHMQEAGANQALELAFTLADGKEYVKTALGKGLDVDDFAGRLSFFWAIGMNFYLEVAK
ECEEHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MRAARLLWCRIMKGFNARSPKSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGT
HHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QSLHTNSFDEAIALPTEFSSRIARNTQLIIQEETHIPHVIDPWAGSYMMEKLTQDMADAA
CCCCCCCCHHHEECCHHHHHHHHCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHH
WAIIEEVEAMGGMTKAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYKLTTEDAIES
HHHHHHHHHHCCHHHHHHCCCEEEEEEHHHHHHHHHCCCCCEEEEECCEEEECHHHHHHH
RDIDNVAVRDGQIERLKAIKAGRDGAAVQAALDALSAAAENNHGNLLDLSIKAVRLRATV
CCCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEHHHH
GEVSDALEKVYGRHRADTQKVTGVYAAAYDSAEGWENLKSEINAFAEAQGRRPRVMISKL
HHHHHHHHHHHHHCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
GQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIENDVHAVGVSTLAAGHKTLV
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
PAIIAELKKQGADDIIVFVGGVIPRQDYEMLYEAGVKGIYGPGTPIPASAKDVLEQIKAA
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VKA
HCC
>Mature Secondary Structure 
SSKKPFPQPDFNPASLEAWAKSAAKSAPGGNVNALNWQTPDGISVKPLYTAEDIEGLPY
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEECHHCCCCCCC
TNTLPGFEPFIRGPQATMYAVRPWTIRQYAGFSTAEESNAFYRKALAAGGQGVSVAFDLA
CCCCCCCHHHHCCCCCEEEEECCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEH
THRGYDSDHPRVTGDVGKAGVAIDSVEDMKILFDHIPLDKVSVSMTMNGAVLPVLAGYVV
HHCCCCCCCCEEECCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHE
AAEEQGVSQDKLSGTIQNDILKEFMVRNTYIYPPQPSIRIIGDIIEYTAQNMPKFNSISI
EECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGYHMQEAGANQALELAFTLADGKEYVKTALGKGLDVDDFAGRLSFFWAIGMNFYLEVAK
ECEEHHHCCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MRAARLLWCRIMKGFNARSPKSLMLRTHCQTSGWSLTEQDPYNNVVRTTIEAMAAVFGGT
HHHHHHHHHHHHHCCCCCCCHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
QSLHTNSFDEAIALPTEFSSRIARNTQLIIQEETHIPHVIDPWAGSYMMEKLTQDMADAA
CCCCCCCCHHHEECCHHHHHHHHCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHH
WAIIEEVEAMGGMTKAVDSGWAKLKIEAAAAEKQARIDSGKDVIVGVNKYKLTTEDAIES
HHHHHHHHHHCCHHHHHHCCCEEEEEEHHHHHHHHHCCCCCEEEEECCEEEECHHHHHHH
RDIDNVAVRDGQIERLKAIKAGRDGAAVQAALDALSAAAENNHGNLLDLSIKAVRLRATV
CCCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEHHHH
GEVSDALEKVYGRHRADTQKVTGVYAAAYDSAEGWENLKSEINAFAEAQGRRPRVMISKL
HHHHHHHHHHHHHCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
GQDGHDRGAKVVATAFADLGFDVDMGPLFQTPEECARQAIENDVHAVGVSTLAAGHKTLV
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
PAIIAELKKQGADDIIVFVGGVIPRQDYEMLYEAGVKGIYGPGTPIPASAKDVLEQIKAA
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VKA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]