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The map label for this gene is phbA [H]

Identifier: 91788013

GI number: 91788013

Start: 2231368

End: 2232546

Strand: Direct

Name: phbA [H]

Synonym: Bpro_2140

Alternate gene names: 91788013

Gene position: 2231368-2232546 (Clockwise)

Preceding gene: 91788012

Following gene: 91788014

Centisome position: 42.91

GC content: 62.43

Gene sequence:

>1179_bases
ATGGAAGACATTGTTATCGTTTCAGCAGGCCGCACGGCCGTTGGAAAATTTGGCGGTTCCCTGGCGAAAATGCCTGCAAC
CGAACTTGGCGCGGCCGTGATCAAGGCGGTGCTCGAGCGTTCCGGCCTGAGCGCCGAACAGGTGGGCGAAGTCATCCTCG
GCCAGGTTTTGGCCGCCGGGGTGGGACAGAATCCGGCGCGCCAGGCCGTGATCAAGGCGGGCTTCCCGCATGGCATTCCG
GGACTGACGATCAATGCCGTTTGCGGCTCCGGCCTCAAGGCGGTCATGTTGGCGGCGCAGTCTGTGGCGACTGGTGACAG
CGAAATCGTCATTGCCGGTGGTCAGGAGAACATGAGTGCGGCGCCGCACGTGTTGAACGGCTCGCGGGACGGCCAGCGCA
TGGGCGACTGGAAGATGATCGATTCGATGATTGTGGATGGCCTGTGGGACGTCTACAACCAGTACCACATGGGCATCACC
GCCGAGAATGTCGCCAAGAAATACGGCATTGACCGTGAGTCGCAGGACGCGCTGGCGCTGGCCAGTCAGACCAAGGCCGC
CGCTGCTCAGGACGCCGGTAAATTCAAGGACGAGATTATTCCGATTTCCATTCCGCAGAAAAAAGGCGACCCGCTGGTGT
TTGCGGCCGACGAGTTCATCAACCGAAAAACCAATGCAGAGGGCCTGGCCGGCCTGCGCCCCGCCTTTGACAAGGCCGGT
GGCGTCACGGCAGGCAATGCCTCGGGCCTGAACGACGGTGCGGCGGCGGTGATGGTCATGACAGCCAAAAAGGCTGCCGC
GCTCGGCCTGAAGCCGCTGGCGCGTATTGCAAGCTACGCCACGACCGGCCTGGACCCGGCCTACATGGGCATGGGCCCGG
TTCCGGCATCGACCAAGGCGCTGAAGCGCGCCGGCTGGAAGGCGCAGGATCTGGACTTGCTGGAGATCAATGAAGCCTTT
GCCGCACAGGCCTGCGCAGTGAACAAGGAAATGGGCTGGGACACCAGCAAGGTCAACGTCAATGGCGGTGCTATTGCCAT
CGGCCACCCGATTGGTGCCTCCGGTTGCCGCATCCTGGTGACGCTGCTGCACGAGATGGCGCGACGCGATGCCAAAAAAG
GTATTGCCAGCCTGTGTATTGGCGGTGGCATGGGGGTGGCACTCACACTGGAGCGCTGA

Upstream 100 bases:

>100_bases
GGTATCGAAAAGCCCATGGCAGACGCTCAACCGACGGGTACCTCCGGGAGAGCGTCACAACAAGATTTCGCAACAAGACT
TCACCACAAGGATAGACATC

Downstream 100 bases:

>100_bases
GTCCCAGCTAAAACAGTCTGATGCCGGCGCAATTACCCCGCTGAAGGCTATTGAATAGATAGCCGATCGGAATGGAGCAA
AGTAGATTAGGGTAAACAAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MEDIVIVSAGRTAVGKFGGSLAKMPATELGAAVIKAVLERSGLSAEQVGEVILGQVLAAGVGQNPARQAVIKAGFPHGIP
GLTINAVCGSGLKAVMLAAQSVATGDSEIVIAGGQENMSAAPHVLNGSRDGQRMGDWKMIDSMIVDGLWDVYNQYHMGIT
AENVAKKYGIDRESQDALALASQTKAAAAQDAGKFKDEIIPISIPQKKGDPLVFAADEFINRKTNAEGLAGLRPAFDKAG
GVTAGNASGLNDGAAAVMVMTAKKAAALGLKPLARIASYATTGLDPAYMGMGPVPASTKALKRAGWKAQDLDLLEINEAF
AAQACAVNKEMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMARRDAKKGIASLCIGGGMGVALTLER

Sequences:

>Translated_392_residues
MEDIVIVSAGRTAVGKFGGSLAKMPATELGAAVIKAVLERSGLSAEQVGEVILGQVLAAGVGQNPARQAVIKAGFPHGIP
GLTINAVCGSGLKAVMLAAQSVATGDSEIVIAGGQENMSAAPHVLNGSRDGQRMGDWKMIDSMIVDGLWDVYNQYHMGIT
AENVAKKYGIDRESQDALALASQTKAAAAQDAGKFKDEIIPISIPQKKGDPLVFAADEFINRKTNAEGLAGLRPAFDKAG
GVTAGNASGLNDGAAAVMVMTAKKAAALGLKPLARIASYATTGLDPAYMGMGPVPASTKALKRAGWKAQDLDLLEINEAF
AAQACAVNKEMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMARRDAKKGIASLCIGGGMGVALTLER
>Mature_392_residues
MEDIVIVSAGRTAVGKFGGSLAKMPATELGAAVIKAVLERSGLSAEQVGEVILGQVLAAGVGQNPARQAVIKAGFPHGIP
GLTINAVCGSGLKAVMLAAQSVATGDSEIVIAGGQENMSAAPHVLNGSRDGQRMGDWKMIDSMIVDGLWDVYNQYHMGIT
AENVAKKYGIDRESQDALALASQTKAAAAQDAGKFKDEIIPISIPQKKGDPLVFAADEFINRKTNAEGLAGLRPAFDKAG
GVTAGNASGLNDGAAAVMVMTAKKAAALGLKPLARIASYATTGLDPAYMGMGPVPASTKALKRAGWKAQDLDLLEINEAF
AAQACAVNKEMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMARRDAKKGIASLCIGGGMGVALTLER

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=52.1628498727735, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.2748091603053, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=44.0203562340967, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=42.0253164556962, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=30.5361305361305, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=33.2480818414322, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=59.9489795918367, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=58.7786259541985, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1787663, Length=405, Percent_Identity=42.7160493827161, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=42.6799007444169, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=36.9047619047619, Blast_Score=204, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.8974358974359, Blast_Score=330, Evalue=9e-91,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=41.0852713178295, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.4223918575064, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.3943661971831, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.0432569974555, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=39.4936708860759, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=38.676844783715, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=54.5918367346939, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=45.0127877237852, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.3846153846154, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=32.7146171693735, Blast_Score=192, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40198; Mature: 40198

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDIVIVSAGRTAVGKFGGSLAKMPATELGAAVIKAVLERSGLSAEQVGEVILGQVLAAG
CCCEEEEECCCHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VGQNPARQAVIKAGFPHGIPGLTINAVCGSGLKAVMLAAQSVATGDSEIVIAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCC
APHVLNGSRDGQRMGDWKMIDSMIVDGLWDVYNQYHMGITAENVAKKYGIDRESQDALAL
CCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
ASQTKAAAAQDAGKFKDEIIPISIPQKKGDPLVFAADEFINRKTNAEGLAGLRPAFDKAG
HHHHHHHHHHHHHHHHHCEEEEECCCCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCC
GVTAGNASGLNDGAAAVMVMTAKKAAALGLKPLARIASYATTGLDPAYMGMGPVPASTKA
CCCCCCCCCCCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHH
LKRAGWKAQDLDLLEINEAFAAQACAVNKEMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCCEEHHHHHHHHHHHCCHHCCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMARRDAKKGIASLCIGGGMGVALTLER
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure
MEDIVIVSAGRTAVGKFGGSLAKMPATELGAAVIKAVLERSGLSAEQVGEVILGQVLAAG
CCCEEEEECCCHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VGQNPARQAVIKAGFPHGIPGLTINAVCGSGLKAVMLAAQSVATGDSEIVIAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCC
APHVLNGSRDGQRMGDWKMIDSMIVDGLWDVYNQYHMGITAENVAKKYGIDRESQDALAL
CCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
ASQTKAAAAQDAGKFKDEIIPISIPQKKGDPLVFAADEFINRKTNAEGLAGLRPAFDKAG
HHHHHHHHHHHHHHHHHCEEEEECCCCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHCC
GVTAGNASGLNDGAAAVMVMTAKKAAALGLKPLARIASYATTGLDPAYMGMGPVPASTKA
CCCCCCCCCCCCCCEEEEEEEHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHH
LKRAGWKAQDLDLLEINEAFAAQACAVNKEMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCCEEHHHHHHHHHHHCCHHCCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMARRDAKKGIASLCIGGGMGVALTLER
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]