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The map label for this gene is icfG [H]

Identifier: 91787955

GI number: 91787955

Start: 2166140

End: 2167840

Strand: Reverse

Name: icfG [H]

Synonym: Bpro_2082

Alternate gene names: 91787955

Gene position: 2167840-2166140 (Counterclockwise)

Preceding gene: 91787956

Following gene: 91787952

Centisome position: 41.69

GC content: 72.19

Gene sequence:

>1701_bases
ATGACGCCCGACCCCGCCCCGCTCGCGCTGGTGGTGGACGACCAGCCGGTGACCCGCCTCATGGTGAAGCGGGCGCTGGA
GCGCTTCGGCTGCGCTCCGGTACTGGAGGCCGCCGACGGGATCGCGGCGCAGGCGATCCTGCGTGAGCACCCGGATGTCG
CGCTGGTTCTGACGGACATCATGATGCCCAGGATGGACGGGCTGGAGCTGCTGCACTGGGGGCGCGAGACGGTGCCGGGT
GCCATCTGGATCGTCCTCTCCGGGCTGGACACCTTCGACTCGGCGGTGGCGGCGATCCGGTTCGGGGCGTTCGACTTCCT
GCCGAAGCCGCCGCGGCTGGAAGAGATGGAGGTCTCGGTGCGCAACGCGCTGGAGCGGCGGCGGCTGCTGGCGGAGCAGG
CGCGGCTGCACGCGGAGCTGCAGCGAAAGGTGCGGGAGCTGGAGGAGAAGTCGGAGCTGCTGCGGCGCGACCTGGAGCGG
GCGGAGGTGATCCAGCGCGCGCTTCTGCCGGGCAGCCCGCCGCCGGTGGAGAGCTACTGCGTCCAGGCGGTCTACCGGCC
GGGACAGCACGTGGGCGGTGACCTCTACGACGTGGTCCGGCTCGGCGAGCGGCACCTGGCCTTCTACCTGGCGGACGCCA
CCGGTCACGGCGTCACCTCGGCGATGCTCTCGGTGCTGTTCAAGCAGCGGCTGGTGCTGGTGGACCCGGAGACGGGCCGC
GCGCTGGCACCGGCGGCGGTGCTGGACGCGGTGAACCGCTCGCTCTGCCAGTCGATCGAAGCGCCGGGTCTCTTTGTGAC
CGCCGTCATTGGCCTGCTCGACACGGTGGAGGGTAGCGTGACGCTGGCATCCGCGGGGCACCCGCCCGTGCTGCACGTGC
GCGAGGGCCGGGAGACGCGCCTGATCCGGCGCACGGGGCCGGCGCTGGGGCTGGCGCTGGATGCACGCTTCCACGAGGAG
CGGCTCTGGCTGGCGCCGGGCGATCGAATGCTCCTCTACACCGATGGGCTCCTCCCGTCGGGGACGGAGCGGGAGCTGGA
ACGGCTCAAGCGGGTACTCTCCATGCCGCTCTCCAGCGCGCAGGAGATGTTGGGGGAGTTGCGCGGTGGCGCCGCCACGG
ACCCGGACCCGGACGACGTGACCCTCCTCCTGATCGACGCGCACGCCGGCCCCTCCTCGTTCGACAACGGCGCCGCGAGC
CCCAACCTGACCGCCTCGGGCGCGGCGCAGCCGGGCGGCGAGGTCGTCTTCTACGGAGAGACGGAGGACGCCGTGCACCT
CGCGCTGCGCGGCCGGGCCACCTGGATGCACTGCGACGCCTTCTACGAGACCGCGCGTGCCGTACTGGAGGAGGGGCGGC
CGCTGGTGCTGGACCTCTCCGGCTGCGACTACCTGGACAGCACCTGCCTCGGCACGGTGCACGAGCTGGTCGGCCGGGGC
CGCGTGGTGCTTGCGGGGGTGACGCCTGTGGTGCGCGCGCTCTTCGAGGAGCTGAGCATGGATCGGGTGCTGGCCAGCAT
CCGCGAGGACGTTACCGCCGCGCCCGAGCTCTACGCGCTGAGCACCCGGCACGACGACCCGGCGGCGTGGCGTCAGCGGA
TACTGCACGCGCACGAGGCGCTCTCAGGGCTGAGCGAGCACAACCGCGAGGAGTTCCGGGGGGTGGTCGAGTCGCTGCGC
GGGGAGATAGACGGCGGATGA

Upstream 100 bases:

>100_bases
GAGGAGAAAAACCGATGATGCGTATAGAAGAAAAAGAAGAAAAACAGGGCGACGCACGGCATGTGTGGCACACCGCCTGC
GACCCTTTCCCTCGCACCCC

Downstream 100 bases:

>100_bases
TCGCCTGCGCAGATCCCGCCTGGTCCGCGCGCCGGGGCGCGTGCCGATGAACCCGCGCATCAATCAAGGCGCGGCCGGCA
CGGCGACTTCAACAAGACCC

Product: anti-sigma-factor antagonist domain-containing protein

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MTPDPAPLALVVDDQPVTRLMVKRALERFGCAPVLEAADGIAAQAILREHPDVALVLTDIMMPRMDGLELLHWGRETVPG
AIWIVLSGLDTFDSAVAAIRFGAFDFLPKPPRLEEMEVSVRNALERRRLLAEQARLHAELQRKVRELEEKSELLRRDLER
AEVIQRALLPGSPPPVESYCVQAVYRPGQHVGGDLYDVVRLGERHLAFYLADATGHGVTSAMLSVLFKQRLVLVDPETGR
ALAPAAVLDAVNRSLCQSIEAPGLFVTAVIGLLDTVEGSVTLASAGHPPVLHVREGRETRLIRRTGPALGLALDARFHEE
RLWLAPGDRMLLYTDGLLPSGTERELERLKRVLSMPLSSAQEMLGELRGGAATDPDPDDVTLLLIDAHAGPSSFDNGAAS
PNLTASGAAQPGGEVVFYGETEDAVHLALRGRATWMHCDAFYETARAVLEEGRPLVLDLSGCDYLDSTCLGTVHELVGRG
RVVLAGVTPVVRALFEELSMDRVLASIREDVTAAPELYALSTRHDDPAAWRQRILHAHEALSGLSEHNREEFRGVVESLR
GEIDGG

Sequences:

>Translated_566_residues
MTPDPAPLALVVDDQPVTRLMVKRALERFGCAPVLEAADGIAAQAILREHPDVALVLTDIMMPRMDGLELLHWGRETVPG
AIWIVLSGLDTFDSAVAAIRFGAFDFLPKPPRLEEMEVSVRNALERRRLLAEQARLHAELQRKVRELEEKSELLRRDLER
AEVIQRALLPGSPPPVESYCVQAVYRPGQHVGGDLYDVVRLGERHLAFYLADATGHGVTSAMLSVLFKQRLVLVDPETGR
ALAPAAVLDAVNRSLCQSIEAPGLFVTAVIGLLDTVEGSVTLASAGHPPVLHVREGRETRLIRRTGPALGLALDARFHEE
RLWLAPGDRMLLYTDGLLPSGTERELERLKRVLSMPLSSAQEMLGELRGGAATDPDPDDVTLLLIDAHAGPSSFDNGAAS
PNLTASGAAQPGGEVVFYGETEDAVHLALRGRATWMHCDAFYETARAVLEEGRPLVLDLSGCDYLDSTCLGTVHELVGRG
RVVLAGVTPVVRALFEELSMDRVLASIREDVTAAPELYALSTRHDDPAAWRQRILHAHEALSGLSEHNREEFRGVVESLR
GEIDGG
>Mature_565_residues
TPDPAPLALVVDDQPVTRLMVKRALERFGCAPVLEAADGIAAQAILREHPDVALVLTDIMMPRMDGLELLHWGRETVPGA
IWIVLSGLDTFDSAVAAIRFGAFDFLPKPPRLEEMEVSVRNALERRRLLAEQARLHAELQRKVRELEEKSELLRRDLERA
EVIQRALLPGSPPPVESYCVQAVYRPGQHVGGDLYDVVRLGERHLAFYLADATGHGVTSAMLSVLFKQRLVLVDPETGRA
LAPAAVLDAVNRSLCQSIEAPGLFVTAVIGLLDTVEGSVTLASAGHPPVLHVREGRETRLIRRTGPALGLALDARFHEER
LWLAPGDRMLLYTDGLLPSGTERELERLKRVLSMPLSSAQEMLGELRGGAATDPDPDDVTLLLIDAHAGPSSFDNGAASP
NLTASGAAQPGGEVVFYGETEDAVHLALRGRATWMHCDAFYETARAVLEEGRPLVLDLSGCDYLDSTCLGTVHELVGRGR
VVLAGVTPVVRALFEELSMDRVLASIREDVTAAPELYALSTRHDDPAAWRQRILHAHEALSGLSEHNREEFRGVVESLRG
EIDGG

Specific function: Involved in cross-regulation of inorganic carbon and glucose metabolisms [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=119, Percent_Identity=36.1344537815126, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003660
- InterPro:   IPR001932
- InterPro:   IPR010822 [H]

Pfam domain/function: PF00672 HAMP; PF07228 SpoIIE [H]

EC number: NA

Molecular weight: Translated: 61663; Mature: 61532

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDPAPLALVVDDQPVTRLMVKRALERFGCAPVLEAADGIAAQAILREHPDVALVLTDI
CCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHCCCCCEEHHHHH
MMPRMDGLELLHWGRETVPGAIWIVLSGLDTFDSAVAAIRFGAFDFLPKPPRLEEMEVSV
HHCCCCCHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHH
RNALERRRLLAEQARLHAELQRKVRELEEKSELLRRDLERAEVIQRALLPGSPPPVESYC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
VQAVYRPGQHVGGDLYDVVRLGERHLAFYLADATGHGVTSAMLSVLFKQRLVLVDPETGR
HHHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCCC
ALAPAAVLDAVNRSLCQSIEAPGLFVTAVIGLLDTVEGSVTLASAGHPPVLHVREGRETR
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCHHH
LIRRTGPALGLALDARFHEERLWLAPGDRMLLYTDGLLPSGTERELERLKRVLSMPLSSA
HHHHCCCCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHH
QEMLGELRGGAATDPDPDDVTLLLIDAHAGPSSFDNGAASPNLTASGAAQPGGEVVFYGE
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECC
TEDAVHLALRGRATWMHCDAFYETARAVLEEGRPLVLDLSGCDYLDSTCLGTVHELVGRG
CCCCEEEEEECCCEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
RVVLAGVTPVVRALFEELSMDRVLASIREDVTAAPELYALSTRHDDPAAWRQRILHAHEA
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHH
LSGLSEHNREEFRGVVESLRGEIDGG
HHHHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TPDPAPLALVVDDQPVTRLMVKRALERFGCAPVLEAADGIAAQAILREHPDVALVLTDI
CCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHCCCCCEEHHHHH
MMPRMDGLELLHWGRETVPGAIWIVLSGLDTFDSAVAAIRFGAFDFLPKPPRLEEMEVSV
HHCCCCCHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHH
RNALERRRLLAEQARLHAELQRKVRELEEKSELLRRDLERAEVIQRALLPGSPPPVESYC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
VQAVYRPGQHVGGDLYDVVRLGERHLAFYLADATGHGVTSAMLSVLFKQRLVLVDPETGR
HHHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCCC
ALAPAAVLDAVNRSLCQSIEAPGLFVTAVIGLLDTVEGSVTLASAGHPPVLHVREGRETR
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCHHH
LIRRTGPALGLALDARFHEERLWLAPGDRMLLYTDGLLPSGTERELERLKRVLSMPLSSA
HHHHCCCCCEEEEECCCCCCEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHH
QEMLGELRGGAATDPDPDDVTLLLIDAHAGPSSFDNGAASPNLTASGAAQPGGEVVFYGE
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECC
TEDAVHLALRGRATWMHCDAFYETARAVLEEGRPLVLDLSGCDYLDSTCLGTVHELVGRG
CCCCEEEEEECCCEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
RVVLAGVTPVVRALFEELSMDRVLASIREDVTAAPELYALSTRHDDPAAWRQRILHAHEA
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHH
LSGLSEHNREEFRGVVESLRGEIDGG
HHHHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8075401; 8905231 [H]