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The map label for this gene is clpP [H]

Identifier: 91787906

GI number: 91787906

Start: 2104007

End: 2104663

Strand: Direct

Name: clpP [H]

Synonym: Bpro_2030

Alternate gene names: 91787906

Gene position: 2104007-2104663 (Clockwise)

Preceding gene: 91787905

Following gene: 91787907

Centisome position: 40.46

GC content: 60.88

Gene sequence:

>657_bases
ATGATGGTCCGAAACAGCATTTACGGCGGCGCCTACGCCGGTCCGCAAGCCGGCGCGCAGGATGCGCAAGGCCTGGGCAT
GGTGCCCATGGTGATCGAGCAGTCCGGACGGGGCGAGCGCTCGTACGATATTTACTCGCGCCTGCTCAAGGAGCGTGTCA
TTTTCCTGGTCGGCCCGGTCAATGACCAGACCGCCAACCTGGTGGTGGCGCAACTGCTGTTCCTGGAAAGCGAAAATCCT
GACAAGGATATTTCCTTCTACATCAATTCCCCCGGGGGTTCGGTGACGGCGGGCATGGCCATTTACGACACCATGCAGTT
CATCAAACCGGATGTCTCGACGCTCTGCGTGGGCATGGCGGCCAGCATGGGCGCATTTTTGCTGTCGGCAGGTGCCAAGG
GCAAGCGCTTTTCGCTGCCCAATTCGCGTGTGATGATCCACCAGCCCTCGGGCGGTGCGCAGGGCCAGGCGACCGACATT
GAAATCCACGCCCGTGACATTCTGAAAACGCGCGACCAGCTCAATCGCATCCTGGCGGCCAACACCGGCCAGCCGATCGA
GAAAATTGAGCGCGACACCGAGCGCGACTATTTCCTGTTTGCCGAGGACGCCAAGGAGTATGGCCTGGTTGACCAGGTGA
TCTCCAGGCGCCCCTGA

Upstream 100 bases:

>100_bases
GGCGAAATTTCTCCTGAAGCTGGGGCTTGTGCCTGACTTGAAGTCGGGGGCACAGGCCCCAATTTATTTTAGGTACAGTA
CAAACATCTCTGGAGAAAAC

Downstream 100 bases:

>100_bases
GTCAAAAGCTTCTGGTTGCCCTGCAATAACGGCGTTTTCTGTAACTGAAACGCCGTTTTTTTATTGGTTATCATTAGGTA
ACACTTTCCTCTAACCCCCT

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MMVRNSIYGGAYAGPQAGAQDAQGLGMVPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLESENP
DKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTLCVGMAASMGAFLLSAGAKGKRFSLPNSRVMIHQPSGGAQGQATDI
EIHARDILKTRDQLNRILAANTGQPIEKIERDTERDYFLFAEDAKEYGLVDQVISRRP

Sequences:

>Translated_218_residues
MMVRNSIYGGAYAGPQAGAQDAQGLGMVPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLESENP
DKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTLCVGMAASMGAFLLSAGAKGKRFSLPNSRVMIHQPSGGAQGQATDI
EIHARDILKTRDQLNRILAANTGQPIEKIERDTERDYFLFAEDAKEYGLVDQVISRRP
>Mature_218_residues
MMVRNSIYGGAYAGPQAGAQDAQGLGMVPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLESENP
DKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTLCVGMAASMGAFLLSAGAKGKRFSLPNSRVMIHQPSGGAQGQATDI
EIHARDILKTRDQLNRILAANTGQPIEKIERDTERDYFLFAEDAKEYGLVDQVISRRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=200, Percent_Identity=56.5, Blast_Score=244, Evalue=5e-65,
Organism=Escherichia coli, GI1786641, Length=196, Percent_Identity=72.9591836734694, Blast_Score=307, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.8387096774194, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI20129427, Length=200, Percent_Identity=57, Blast_Score=251, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23780; Mature: 23780

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVRNSIYGGAYAGPQAGAQDAQGLGMVPMVIEQSGRGERSYDIYSRLLKERVIFLVGPV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHCEEEEEECC
NDQTANLVVAQLLFLESENPDKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTLCVGMA
CCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHH
ASMGAFLLSAGAKGKRFSLPNSRVMIHQPSGGAQGQATDIEIHARDILKTRDQLNRILAA
HHHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHC
NTGQPIEKIERDTERDYFLFAEDAKEYGLVDQVISRRP
CCCCHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MMVRNSIYGGAYAGPQAGAQDAQGLGMVPMVIEQSGRGERSYDIYSRLLKERVIFLVGPV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCHHHHHHHHHHCEEEEEECC
NDQTANLVVAQLLFLESENPDKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTLCVGMA
CCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHH
ASMGAFLLSAGAKGKRFSLPNSRVMIHQPSGGAQGQATDIEIHARDILKTRDQLNRILAA
HHHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHC
NTGQPIEKIERDTERDYFLFAEDAKEYGLVDQVISRRP
CCCCHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA