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The map label for this gene is lysR [H]

Identifier: 91787874

GI number: 91787874

Start: 2066097

End: 2066996

Strand: Direct

Name: lysR [H]

Synonym: Bpro_1998

Alternate gene names: 91787874

Gene position: 2066097-2066996 (Clockwise)

Preceding gene: 91787866

Following gene: 91787876

Centisome position: 39.73

GC content: 64.11

Gene sequence:

>900_bases
ATGCGCCTTCGCCACATCGAGGTCTTCAATGCCATCATGCTCACCGGCAGTGTCAGCGGCGCGGCGCGGCTGATCAATGT
CACCCAGCCGGCCGTCAGCCGTGTCCTGCAGCATGCGGAACTGCAGCTTGGTTTCTCGCTCTTTCAGCGCAGCAAGGGCC
GGCTCATCCCAACTTCCGAGGCGCTCACCCTGTACCCGCACATCGAGCGGCTGTTTGCGCAGCTCGATGAGGTGCAGCGT
CTGGCGGCTAACCTCAGGACGGGCGAGAGTGCCCGGGAGTTGCGCATCCTGACCGTGCTGGCGCTGAGCTACGAAATCCT
GCCGCACACCATCAAGCTGTTTCGCGTCAGGCATCCGGATGTGGCCATCACGGTCAAGGCCCTGCATTCGCCGCAAATTG
TTTCGGCATTGGCGTTGCAGGAGGGGGATGTCGGCTTTTTGTTCAGCCCGGTAGTGCATTCAGCGCTGGCGCAGGAGCAT
CTGGCCGATGGCCGCATGGTCTGTATCGCGCCCAAAGGCATGCTGACCGCGCGCCTGATCAAACGCGGCAGCGTTACGCT
GGCTGATTTGACCAAGGTGCCCGTCATCGGACTCGATGTGCTGGACCCGGTGGGCCGCAGCCTGAACCAGGCTTGTCGTG
AGGCCGGGGTGGGGCTGGAGTTTTCCATTACCGTGCAGACCTATCACTCGGCGCTGGCCCTGGCGCACCACGGGCTCGGC
ATTGCCGTGGTGGACACCTGCACGGCGGTATCCGCCGATCTGTCGCGCGTGGATGTGTTGGCGCTGGAGCCCCTGATTCC
GGTGCCCATCAAGGCTGTGCTGCCCGCGGGCAAGCCAGGCTCGGTCGTGGTGCGGGCGTTTGTGCGCTGCCTTCAGCAGG
CATTGGCCCGGACAGTCTGA

Upstream 100 bases:

>100_bases
CCAGACGTCCGCTTGAAGCCGGTTGAATGCACGCGACCGGTTGAGGGTGCCGCAGACCATAATCCGGAACTGTTCGAGAA
ACCGAGTCAACAGGACACCC

Downstream 100 bases:

>100_bases
ACGGGCTCCCGTTGTCCGCGCGGTGTCGTTCTCAGTCATGCTCAGGGGGTAAGGAGTCAGGGGCTCAGCAAGCGGTTGAT
GCGCTGCGCCGAACCAAATG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MRLRHIEVFNAIMLTGSVSGAARLINVTQPAVSRVLQHAELQLGFSLFQRSKGRLIPTSEALTLYPHIERLFAQLDEVQR
LAANLRTGESARELRILTVLALSYEILPHTIKLFRVRHPDVAITVKALHSPQIVSALALQEGDVGFLFSPVVHSALAQEH
LADGRMVCIAPKGMLTARLIKRGSVTLADLTKVPVIGLDVLDPVGRSLNQACREAGVGLEFSITVQTYHSALALAHHGLG
IAVVDTCTAVSADLSRVDVLALEPLIPVPIKAVLPAGKPGSVVVRAFVRCLQQALARTV

Sequences:

>Translated_299_residues
MRLRHIEVFNAIMLTGSVSGAARLINVTQPAVSRVLQHAELQLGFSLFQRSKGRLIPTSEALTLYPHIERLFAQLDEVQR
LAANLRTGESARELRILTVLALSYEILPHTIKLFRVRHPDVAITVKALHSPQIVSALALQEGDVGFLFSPVVHSALAQEH
LADGRMVCIAPKGMLTARLIKRGSVTLADLTKVPVIGLDVLDPVGRSLNQACREAGVGLEFSITVQTYHSALALAHHGLG
IAVVDTCTAVSADLSRVDVLALEPLIPVPIKAVLPAGKPGSVVVRAFVRCLQQALARTV
>Mature_299_residues
MRLRHIEVFNAIMLTGSVSGAARLINVTQPAVSRVLQHAELQLGFSLFQRSKGRLIPTSEALTLYPHIERLFAQLDEVQR
LAANLRTGESARELRILTVLALSYEILPHTIKLFRVRHPDVAITVKALHSPQIVSALALQEGDVGFLFSPVVHSALAQEH
LADGRMVCIAPKGMLTARLIKRGSVTLADLTKVPVIGLDVLDPVGRSLNQACREAGVGLEFSITVQTYHSALALAHHGLG
IAVVDTCTAVSADLSRVDVLALEPLIPVPIKAVLPAGKPGSVVVRAFVRCLQQALARTV

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=301, Percent_Identity=30.8970099667774, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788481, Length=196, Percent_Identity=31.6326530612245, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082132, Length=170, Percent_Identity=27.0588235294118, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32208; Mature: 32208

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRHIEVFNAIMLTGSVSGAARLINVTQPAVSRVLQHAELQLGFSLFQRSKGRLIPTSE
CCCCHHHHHHHHHEECCCCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ALTLYPHIERLFAQLDEVQRLAANLRTGESARELRILTVLALSYEILPHTIKLFRVRHPD
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEHEEEECCC
VAITVKALHSPQIVSALALQEGDVGFLFSPVVHSALAQEHLADGRMVCIAPKGMLTARLI
EEEEEEECCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
KRGSVTLADLTKVPVIGLDVLDPVGRSLNQACREAGVGLEFSITVQTYHSALALAHHGLG
HCCCEEEEHHCCCCEECHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCC
IAVVDTCTAVSADLSRVDVLALEPLIPVPIKAVLPAGKPGSVVVRAFVRCLQQALARTV
EEEEHHHHHHHHHHHHHHEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLRHIEVFNAIMLTGSVSGAARLINVTQPAVSRVLQHAELQLGFSLFQRSKGRLIPTSE
CCCCHHHHHHHHHEECCCCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ALTLYPHIERLFAQLDEVQRLAANLRTGESARELRILTVLALSYEILPHTIKLFRVRHPD
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEHEEEECCC
VAITVKALHSPQIVSALALQEGDVGFLFSPVVHSALAQEHLADGRMVCIAPKGMLTARLI
EEEEEEECCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
KRGSVTLADLTKVPVIGLDVLDPVGRSLNQACREAGVGLEFSITVQTYHSALALAHHGLG
HCCCEEEEHHCCCCEECHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCC
IAVVDTCTAVSADLSRVDVLALEPLIPVPIKAVLPAGKPGSVVVRAFVRCLQQALARTV
EEEEHHHHHHHHHHHHHHEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]