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The map label for this gene is gmk

Identifier: 91787231

GI number: 91787231

Start: 1375816

End: 1376436

Strand: Reverse

Name: gmk

Synonym: Bpro_1335

Alternate gene names: 91787231

Gene position: 1376436-1375816 (Counterclockwise)

Preceding gene: 91787232

Following gene: 91787230

Centisome position: 26.47

GC content: 58.62

Gene sequence:

>621_bases
ATGGACTACCCCGGAAACCTGTTTGTTGTGGCCGCCCCCAGTGGTGCGGGCAAATCCAGCCTGGTGAAGGCCCTGATGGA
GCTGGACTCAGCCATCCAGCCCGCCGTTTCACACACCACGCGGCCTCCACGCGGGCAGGAAAAGCATGGCAGGGAGTACT
TTTTCCTGTCGCCGGAAGAGTTTGACAGCATGGTACAGCGCGATGCATTTCTGGAGTGGGCGCATGTGCACGGGCACCGT
TACGGCACCTCGCGGCAGGCCATCGAAGAGCGCATCGCGCACGGCAAAGACGTGATTCTGGAGATTGATTTCCAGGGTGC
GATCAACATCAAGCGGATTTTCTCGAACGCCGTGCTGATTTTCATCCTCCCCCCGAGCTGGGAAGAATTGCGCTCCCGCC
TGCAGCGGCGCGGCGAAGACAGCCCCGAAGTCATCGAATTGAGGCTGAAAAACGCCGCCACCGAGATGGCCCAGGCCAGG
GAATTCGACTTCGTTATAATCAATGAGTTGTTTGAGCGGGCAGTTTTCGACCTGAAAACCATTGTCCATGCCCAGCGGCT
CAAGTTTTCGGCCCAGCGACGCGCTCGCGCCGAGACTTTCAGGGCCCTTCAAATTCCTTAA

Upstream 100 bases:

>100_bases
AGCAGATCCGCGAACAGGTGCAGAACATCGAGTGAGCCTGAGCGACAATCACTCAATACCGAATTACTACCAAATCAATA
GCAATTAACGCCCACTAAGC

Downstream 100 bases:

>100_bases
GTTATTGATCACACCGGAGATCACCATGGCCCGTATTACCGTCGAAGATTGCCTCGAAAAAATCCCCAACCGCTTCCAGC
TGGTTTTGGCCGCCACTTAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MDYPGNLFVVAAPSGAGKSSLVKALMELDSAIQPAVSHTTRPPRGQEKHGREYFFLSPEEFDSMVQRDAFLEWAHVHGHR
YGTSRQAIEERIAHGKDVILEIDFQGAINIKRIFSNAVLIFILPPSWEELRSRLQRRGEDSPEVIELRLKNAATEMAQAR
EFDFVIINELFERAVFDLKTIVHAQRLKFSAQRRARAETFRALQIP

Sequences:

>Translated_206_residues
MDYPGNLFVVAAPSGAGKSSLVKALMELDSAIQPAVSHTTRPPRGQEKHGREYFFLSPEEFDSMVQRDAFLEWAHVHGHR
YGTSRQAIEERIAHGKDVILEIDFQGAINIKRIFSNAVLIFILPPSWEELRSRLQRRGEDSPEVIELRLKNAATEMAQAR
EFDFVIINELFERAVFDLKTIVHAQRLKFSAQRRARAETFRALQIP
>Mature_206_residues
MDYPGNLFVVAAPSGAGKSSLVKALMELDSAIQPAVSHTTRPPRGQEKHGREYFFLSPEEFDSMVQRDAFLEWAHVHGHR
YGTSRQAIEERIAHGKDVILEIDFQGAINIKRIFSNAVLIFILPPSWEELRSRLQRRGEDSPEVIELRLKNAATEMAQAR
EFDFVIINELFERAVFDLKTIVHAQRLKFSAQRRARAETFRALQIP

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=37.7142857142857, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=37.7142857142857, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=37.7142857142857, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=27.6595744680851, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=30, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI111154074, Length=159, Percent_Identity=31.4465408805031, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4505237, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI262118263, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI21389483, Length=194, Percent_Identity=25.2577319587629, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=52.0833333333333, Blast_Score=194, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=38.0681818181818, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=38.0681818181818, Blast_Score=123, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71984092, Length=134, Percent_Identity=32.8358208955224, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=40.1098901098901, Blast_Score=136, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356141, Length=158, Percent_Identity=41.7721518987342, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI85816281, Length=131, Percent_Identity=31.2977099236641, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI85816106, Length=131, Percent_Identity=31.2977099236641, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45551002, Length=131, Percent_Identity=31.2977099236641, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI116007136, Length=174, Percent_Identity=30.4597701149425, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554481, Length=174, Percent_Identity=30.4597701149425, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554489, Length=174, Percent_Identity=30.4597701149425, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640542, Length=174, Percent_Identity=30.4597701149425, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=174, Percent_Identity=30.4597701149425, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161077626, Length=174, Percent_Identity=30.4597701149425, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330166, Length=127, Percent_Identity=29.1338582677165, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI221330162, Length=127, Percent_Identity=29.1338582677165, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_POLSJ (Q12DV7)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_548183.1
- ProteinModelPortal:   Q12DV7
- SMR:   Q12DV7
- STRING:   Q12DV7
- GeneID:   4011982
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_1335
- NMPDR:   fig|296591.1.peg.1923
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q12DV7
- ProtClustDB:   PRK00300
- BioCyc:   PSP296591:BPRO_1335-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23570; Mature: 23570

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYPGNLFVVAAPSGAGKSSLVKALMELDSAIQPAVSHTTRPPRGQEKHGREYFFLSPEE
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHH
FDSMVQRDAFLEWAHVHGHRYGTSRQAIEERIAHGKDVILEIDFQGAINIKRIFSNAVLI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEEE
FILPPSWEELRSRLQRRGEDSPEVIELRLKNAATEMAQAREFDFVIINELFERAVFDLKT
EEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IVHAQRLKFSAQRRARAETFRALQIP
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDYPGNLFVVAAPSGAGKSSLVKALMELDSAIQPAVSHTTRPPRGQEKHGREYFFLSPEE
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHH
FDSMVQRDAFLEWAHVHGHRYGTSRQAIEERIAHGKDVILEIDFQGAINIKRIFSNAVLI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEEE
FILPPSWEELRSRLQRRGEDSPEVIELRLKNAATEMAQAREFDFVIINELFERAVFDLKT
EEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IVHAQRLKFSAQRRARAETFRALQIP
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA