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The map label for this gene is gyaR [H]

Identifier: 91787165

GI number: 91787165

Start: 1311450

End: 1312448

Strand: Reverse

Name: gyaR [H]

Synonym: Bpro_1268

Alternate gene names: 91787165

Gene position: 1312448-1311450 (Counterclockwise)

Preceding gene: 91787166

Following gene: 91787164

Centisome position: 25.24

GC content: 68.37

Gene sequence:

>999_bases
ATGAATACAGCGGCATACGCCAGACCACGAATCGTCATTGCCGGAGACGCCGAACAGGCACTGCGACGGCTGGGCGACTG
GCGCAAGATTGATGCGCAGGCCGATGTGACCGCGCACCACCTGCCGCTACGCGGCGCGGCCCTGATCAACGCGCTGAAAG
ATGCCGACGCCGTGGTGCTGGTGCGCGACCGCACGCCCTTTGATGCGGCCTTGCTGGCCAGGCTGCCCACGTTGCGCTAC
CTGGTGTTTACCGGCACGCGCAACACCACCCTGGACCTGGCTGCGCTGGCAGCGCGCGACATTCCGGTCAGCCACACCGA
ATGGGGGCCGTCCAAGGAGAGCACCTGCGAGATGACCTGGTCGCTGATCCTGGCCGCTACGCGCCAGCTGGAGCAGCAAA
CGGCCCTGCTGCGCCGCGGCCAGTGGCGCGCGGACCAACCCGAACCCCTGGCCGGCGTGCTGCATGGCCAGACGCTGGGC
CTGATCGGCCTGGGCGAAATCGGCGGGCGCGTGGCCAAAGTCGGCCAGGCGCTGGGCATGAAGGTCATCACCTGGAGCCC
GCGCATGACGCCCGAGCGCGCCGCGCAGCACGGCGCCAGCGCGGTCACGCTGGAAGAACTGCTGGGCAGCGCCCAAGTCG
TCAGCCTGCACCTGGTACCAACGCCGGCGACACACCACCTGCTCAATGCACAGCGGCTGAAACTGATGCAGCCCGGCAGC
CTGCTCGTCAACACCTCGCGCTCCGCGCTGGTGGATGGCGCGGCGCTGGTCCAGGCGCTGGAACAGGGCCGGCCCGGCTT
TGCCGCGCTGGACGTGTTTGATGTGGATCCGCTGCCGATGGACGACCCGCTGCGCCGCATGCCCAATGTGCTGCTCACGC
CCCATCTGGGTTTTGTCACCGAGCCGGTGTACCAGCGATTCGCAGCCGGGGTCACGGAATGTCTGGAGGCCTGGCTGAAC
CGCCAGCCACTGATTCGGGTGGTGCCGGCTACCGCCTGA

Upstream 100 bases:

>100_bases
TGGGCGCCGGCAGAACCAGCGAATTGATCAACGCCTGCTGGGCCCTGGGCGCCGCCGCCAGCGTAGCGGCCGTGGTTGCA
CTCGCCACCCCCGAAAGCCG

Downstream 100 bases:

>100_bases
AGACCTTGTGCCAACAACCTGCTCCTTGCCCCCTTGACGGTCACGCGCCGGTTGGGGCGGCAGGGCTGGATTGAAACCTC
CGCTCCGGAGAGCGGCGGCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MNTAAYARPRIVIAGDAEQALRRLGDWRKIDAQADVTAHHLPLRGAALINALKDADAVVLVRDRTPFDAALLARLPTLRY
LVFTGTRNTTLDLAALAARDIPVSHTEWGPSKESTCEMTWSLILAATRQLEQQTALLRRGQWRADQPEPLAGVLHGQTLG
LIGLGEIGGRVAKVGQALGMKVITWSPRMTPERAAQHGASAVTLEELLGSAQVVSLHLVPTPATHHLLNAQRLKLMQPGS
LLVNTSRSALVDGAALVQALEQGRPGFAALDVFDVDPLPMDDPLRRMPNVLLTPHLGFVTEPVYQRFAAGVTECLEAWLN
RQPLIRVVPATA

Sequences:

>Translated_332_residues
MNTAAYARPRIVIAGDAEQALRRLGDWRKIDAQADVTAHHLPLRGAALINALKDADAVVLVRDRTPFDAALLARLPTLRY
LVFTGTRNTTLDLAALAARDIPVSHTEWGPSKESTCEMTWSLILAATRQLEQQTALLRRGQWRADQPEPLAGVLHGQTLG
LIGLGEIGGRVAKVGQALGMKVITWSPRMTPERAAQHGASAVTLEELLGSAQVVSLHLVPTPATHHLLNAQRLKLMQPGS
LLVNTSRSALVDGAALVQALEQGRPGFAALDVFDVDPLPMDDPLRRMPNVLLTPHLGFVTEPVYQRFAAGVTECLEAWLN
RQPLIRVVPATA
>Mature_332_residues
MNTAAYARPRIVIAGDAEQALRRLGDWRKIDAQADVTAHHLPLRGAALINALKDADAVVLVRDRTPFDAALLARLPTLRY
LVFTGTRNTTLDLAALAARDIPVSHTEWGPSKESTCEMTWSLILAATRQLEQQTALLRRGQWRADQPEPLAGVLHGQTLG
LIGLGEIGGRVAKVGQALGMKVITWSPRMTPERAAQHGASAVTLEELLGSAQVVSLHLVPTPATHHLLNAQRLKLMQPGS
LLVNTSRSALVDGAALVQALEQGRPGFAALDVFDVDPLPMDDPLRRMPNVLLTPHLGFVTEPVYQRFAAGVTECLEAWLN
RQPLIRVVPATA

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=285, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=34.0336134453782, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=34.0336134453782, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI145580578, Length=240, Percent_Identity=35, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557499, Length=240, Percent_Identity=35, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=238, Percent_Identity=34.453781512605, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI6912396, Length=214, Percent_Identity=30.8411214953271, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082289, Length=273, Percent_Identity=31.5018315018315, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789279, Length=277, Percent_Identity=31.4079422382672, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787645, Length=203, Percent_Identity=30.5418719211823, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081824, Length=145, Percent_Identity=33.1034482758621, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=30.7453416149068, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=239, Percent_Identity=29.2887029288703, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=303, Percent_Identity=27.7227722772277, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=288, Percent_Identity=28.8194444444444, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=302, Percent_Identity=25.4966887417219, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=158, Percent_Identity=32.2784810126582, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=31.294964028777, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=31.294964028777, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=31.294964028777, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=31.294964028777, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI62472511, Length=278, Percent_Identity=31.294964028777, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI19921140, Length=278, Percent_Identity=31.6546762589928, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI28571528, Length=173, Percent_Identity=34.1040462427746, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585516, Length=234, Percent_Identity=28.6324786324786, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574286, Length=230, Percent_Identity=28.2608695652174, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585514, Length=272, Percent_Identity=26.8382352941176, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574282, Length=272, Percent_Identity=26.8382352941176, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI45552429, Length=272, Percent_Identity=26.8382352941176, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574284, Length=272, Percent_Identity=26.8382352941176, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45551003, Length=272, Percent_Identity=26.8382352941176, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35951; Mature: 35951

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAAYARPRIVIAGDAEQALRRLGDWRKIDAQADVTAHHLPLRGAALINALKDADAVVL
CCCCCCCCCEEEEECCHHHHHHHHCCCEEECCCCCCEEECCCCHHHHHHHHHCCCCEEEE
VRDRTPFDAALLARLPTLRYLVFTGTRNTTLDLAALAARDIPVSHTEWGPSKESTCEMTW
EECCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
SLILAATRQLEQQTALLRRGQWRADQPEPLAGVLHGQTLGLIGLGEIGGRVAKVGQALGM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEECEEEEHHHHHHHHHHHHHHCC
KVITWSPRMTPERAAQHGASAVTLEELLGSAQVVSLHLVPTPATHHLLNAQRLKLMQPGS
EEEEECCCCCHHHHHHCCCCCEEHHHHHCCCEEEEEEEECCCHHHHHHCHHHHHEECCCC
LLVNTSRSALVDGAALVQALEQGRPGFAALDVFDVDPLPMDDPLRRMPNVLLTPHLGFVT
EEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHCCCEEECCCCCHHH
EPVYQRFAAGVTECLEAWLNRQPLIRVVPATA
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
MNTAAYARPRIVIAGDAEQALRRLGDWRKIDAQADVTAHHLPLRGAALINALKDADAVVL
CCCCCCCCCEEEEECCHHHHHHHHCCCEEECCCCCCEEECCCCHHHHHHHHHCCCCEEEE
VRDRTPFDAALLARLPTLRYLVFTGTRNTTLDLAALAARDIPVSHTEWGPSKESTCEMTW
EECCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
SLILAATRQLEQQTALLRRGQWRADQPEPLAGVLHGQTLGLIGLGEIGGRVAKVGQALGM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEECEEEEHHHHHHHHHHHHHHCC
KVITWSPRMTPERAAQHGASAVTLEELLGSAQVVSLHLVPTPATHHLLNAQRLKLMQPGS
EEEEECCCCCHHHHHHCCCCCEEHHHHHCCCEEEEEEEECCCHHHHHHCHHHHHEECCCC
LLVNTSRSALVDGAALVQALEQGRPGFAALDVFDVDPLPMDDPLRRMPNVLLTPHLGFVT
EEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHCCCEEECCCCCHHH
EPVYQRFAAGVTECLEAWLNRQPLIRVVPATA
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]