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The map label for this gene is pyrC' [H]

Identifier: 91787043

GI number: 91787043

Start: 1188388

End: 1189728

Strand: Direct

Name: pyrC' [H]

Synonym: Bpro_1146

Alternate gene names: 91787043

Gene position: 1188388-1189728 (Clockwise)

Preceding gene: 91787042

Following gene: 91787044

Centisome position: 22.85

GC content: 66.07

Gene sequence:

>1341_bases
TTGGGGCGGCCCGGCACAGCGGCCTTTTTTCGGAAAAACAAAATGAAACTTCTCATTAAAAACGGCCGAGTGATCGACCC
CGCTTCGGGGCTGGATGAAGTCTGTGATGTGGCCATTGCGGCGGGGCGCATTGTCTCGCTGAACCACACGACGGCCGATT
TTTCCCCCAACAAAACCCTGGATGCCACCGGCTGTATCGTGGCGCCCGGCCTGATCGACCTGTCGGCCCGGCTGCGCGAG
CCCGGCTATGAACACGAAGGCATGCTGGAGAGCGAGCTGGCCGCGGCGGTTGCAGGCGGTGTGACGAGTCTGGTCTGCCC
GCCGGATACCGACCCGGTCCTGGATGAACCTGGCCTGGTGGAGATGCTCAAGTTTCGTGCCGAAAAGCTGCACCAGTCGC
GTGTGTTCCCGCTGGGCGCGCTGACGCGGGCCCTTAAGGGCGAGGCGTTGACCGAAATGGTGGAGCTGACCGAAGCCGGC
TGCGTGGGGTTCAGCCAGGCCGAAGTGCCGCTGGCCAACACCCAGGTGCTGATGCGCGCCCTGCAGTACGCGACCACCTT
TGGCTACACCGTCTGGCTGCGCCCGCAGGAAATGCACCTGGGCCAGGGCGTGGCAGCCAGTGGCGCGCTGGCAACCCGCC
TGGGTTTGAGCGGTGTATCGGTGGCCGCCGAGACAATCGCCCTCCACACGATTTTCGAGTTGGTGCGCGCCACCGGCGCG
CGGGTGCACCTGTGCCGGATCAGCAGCGCCGCGGGGGTGGCCCTGGTGGGCAAGGCCAAGGCGGAAGGGCTGGACGTGAC
CTGCGACGTCAGCATCAACAGCCTGCATTTGACCGATGTCGATATCGGCTACTTCGACAGCCGCATGCGGCTGGATCCGC
CCCTTCGCCAGCAGCGCGACCGGGACGCCATTCGCCAGGGCCTGGCAGACGGCACGATTGACGCGCTGGTGTCCGACCAC
AACCCGGTCGACGAGGATGCCAAAACCCTGCCGTTTGCCGAGGCCGAAGCCGGCGCGACCGGCCTGGAACTGTTGCTGGG
CCTGGCCTGCAAATGGGGTGCTGACAGTCAGGCTGGCATGGCCCGTGCTCTGGCGGTGCTGACCAGCGAGCCGGCGCGCG
TACTTGGCAACTCCCTGGGCACGCTGCAGGCCAGCGCCGGCCGGCTGGTCAAAGGGGGCATGGCGGATTTGTGCGTGTTC
GACCCGGCCAGCGAGTGGATGGTTGAGCCGCAAGCCTTGCGCAGCCAGGGCAAGCACACGCCTTTTTCCGGCTATCAGCT
CCCTGCGCGCGTGCGCTGGACGGTGGTCGGCGGGCAGCTGGCTTATGAAGCTTCGCGTTAA

Upstream 100 bases:

>100_bases
AGGGGGTTGAACTTCGCTTGGGGCGGCCCGGCGCTTCGTTCGTGACCCCCTCGCTTGTCGCTTCGCGTACTGCTCTGCCC
ACCAAGGGGGCTGGCCTAGC

Downstream 100 bases:

>100_bases
GCACACGTCCCGGACTGCATGAAGCTGCTGGGCGTTTGCTGGAAGCTGCTGCGAGCCACGGCCCACGCGGTGGTTGGTTT
CCTGACAATCAAGTTATTGT

Product: dihydroorotase

Products: Allantoate; H+ [C]

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MGRPGTAAFFRKNKMKLLIKNGRVIDPASGLDEVCDVAIAAGRIVSLNHTTADFSPNKTLDATGCIVAPGLIDLSARLRE
PGYEHEGMLESELAAAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRAEKLHQSRVFPLGALTRALKGEALTEMVELTEAG
CVGFSQAEVPLANTQVLMRALQYATTFGYTVWLRPQEMHLGQGVAASGALATRLGLSGVSVAAETIALHTIFELVRATGA
RVHLCRISSAAGVALVGKAKAEGLDVTCDVSINSLHLTDVDIGYFDSRMRLDPPLRQQRDRDAIRQGLADGTIDALVSDH
NPVDEDAKTLPFAEAEAGATGLELLLGLACKWGADSQAGMARALAVLTSEPARVLGNSLGTLQASAGRLVKGGMADLCVF
DPASEWMVEPQALRSQGKHTPFSGYQLPARVRWTVVGGQLAYEASR

Sequences:

>Translated_446_residues
MGRPGTAAFFRKNKMKLLIKNGRVIDPASGLDEVCDVAIAAGRIVSLNHTTADFSPNKTLDATGCIVAPGLIDLSARLRE
PGYEHEGMLESELAAAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRAEKLHQSRVFPLGALTRALKGEALTEMVELTEAG
CVGFSQAEVPLANTQVLMRALQYATTFGYTVWLRPQEMHLGQGVAASGALATRLGLSGVSVAAETIALHTIFELVRATGA
RVHLCRISSAAGVALVGKAKAEGLDVTCDVSINSLHLTDVDIGYFDSRMRLDPPLRQQRDRDAIRQGLADGTIDALVSDH
NPVDEDAKTLPFAEAEAGATGLELLLGLACKWGADSQAGMARALAVLTSEPARVLGNSLGTLQASAGRLVKGGMADLCVF
DPASEWMVEPQALRSQGKHTPFSGYQLPARVRWTVVGGQLAYEASR
>Mature_445_residues
GRPGTAAFFRKNKMKLLIKNGRVIDPASGLDEVCDVAIAAGRIVSLNHTTADFSPNKTLDATGCIVAPGLIDLSARLREP
GYEHEGMLESELAAAVAGGVTSLVCPPDTDPVLDEPGLVEMLKFRAEKLHQSRVFPLGALTRALKGEALTEMVELTEAGC
VGFSQAEVPLANTQVLMRALQYATTFGYTVWLRPQEMHLGQGVAASGALATRLGLSGVSVAAETIALHTIFELVRATGAR
VHLCRISSAAGVALVGKAKAEGLDVTCDVSINSLHLTDVDIGYFDSRMRLDPPLRQQRDRDAIRQGLADGTIDALVSDHN
PVDEDAKTLPFAEAEAGATGLELLLGLACKWGADSQAGMARALAVLTSEPARVLGNSLGTLQASAGRLVKGGMADLCVFD
PASEWMVEPQALRSQGKHTPFSGYQLPARVRWTVVGGQLAYEASR

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=378, Percent_Identity=25.9259259259259, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1786722, Length=450, Percent_Identity=25.7777777777778, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87082175, Length=446, Percent_Identity=22.4215246636771, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=415, Percent_Identity=24.8192771084337, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18859883, Length=214, Percent_Identity=29.4392523364486, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.5 [C]

Molecular weight: Translated: 47176; Mature: 47044

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRPGTAAFFRKNKMKLLIKNGRVIDPASGLDEVCDVAIAAGRIVSLNHTTADFSPNKTL
CCCCCCCHHHCCCCEEEEEECCCEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
DATGCIVAPGLIDLSARLREPGYEHEGMLESELAAAVAGGVTSLVCPPDTDPVLDEPGLV
CCCCCEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHH
EMLKFRAEKLHQSRVFPLGALTRALKGEALTEMVELTEAGCVGFSQAEVPLANTQVLMRA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LQYATTFGYTVWLRPQEMHLGQGVAASGALATRLGLSGVSVAAETIALHTIFELVRATGA
HHHHHHCCEEEEEEHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
RVHLCRISSAAGVALVGKAKAEGLDVTCDVSINSLHLTDVDIGYFDSRMRLDPPLRQQRD
EEEEEEECCCCCEEEEECCCCCCCCEEEEEEECEEEEEEEECCCCCCCCCCCCCHHHHHH
RDAIRQGLADGTIDALVSDHNPVDEDAKTLPFAEAEAGATGLELLLGLACKWGADSQAGM
HHHHHHCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHH
ARALAVLTSEPARVLGNSLGTLQASAGRLVKGGMADLCVFDPASEWMVEPQALRSQGKHT
HHHHHHHHCCCHHHHCCCCCCEECCCCCEECCCCCCEEEECCCHHHHCCHHHHHCCCCCC
PFSGYQLPARVRWTVVGGQLAYEASR
CCCCCCCCCEEEEEEECCEEEEECCC
>Mature Secondary Structure 
GRPGTAAFFRKNKMKLLIKNGRVIDPASGLDEVCDVAIAAGRIVSLNHTTADFSPNKTL
CCCCCCHHHCCCCEEEEEECCCEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
DATGCIVAPGLIDLSARLREPGYEHEGMLESELAAAVAGGVTSLVCPPDTDPVLDEPGLV
CCCCCEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHH
EMLKFRAEKLHQSRVFPLGALTRALKGEALTEMVELTEAGCVGFSQAEVPLANTQVLMRA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LQYATTFGYTVWLRPQEMHLGQGVAASGALATRLGLSGVSVAAETIALHTIFELVRATGA
HHHHHHCCEEEEEEHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
RVHLCRISSAAGVALVGKAKAEGLDVTCDVSINSLHLTDVDIGYFDSRMRLDPPLRQQRD
EEEEEEECCCCCEEEEECCCCCCCCEEEEEEECEEEEEEEECCCCCCCCCCCCCHHHHHH
RDAIRQGLADGTIDALVSDHNPVDEDAKTLPFAEAEAGATGLELLLGLACKWGADSQAGM
HHHHHHCCCCCCHHHHHCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHH
ARALAVLTSEPARVLGNSLGTLQASAGRLVKGGMADLCVFDPASEWMVEPQALRSQGKHT
HHHHHHHHCCCHHHHCCCCCCEECCCCCEECCCCCCEEEECCCHHHHCCHHHHHCCCCCC
PFSGYQLPARVRWTVVGGQLAYEASR
CCCCCCCCCEEEEEEECCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Allantoin; H2O [C]

Specific reaction: Allantoin + H2O --> Allantoate + H+ [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: Dithiothreitol; p-Chloromercuribenzene-sulphonic acid [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]