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The map label for this gene is nrdB [H]

Identifier: 91787004

GI number: 91787004

Start: 1138740

End: 1139960

Strand: Reverse

Name: nrdB [H]

Synonym: Bpro_1106

Alternate gene names: 91787004

Gene position: 1139960-1138740 (Counterclockwise)

Preceding gene: 91787005

Following gene: 91787003

Centisome position: 21.92

GC content: 58.56

Gene sequence:

>1221_bases
ATGTTGACCTGGGACGAAGAAGTCAAACCATCGCTGCAAAAATCTCATGCCAGCGGCTCGACCGACAGCCGCTCGATGGA
ACTTCCGCCTCTTTCTTCCGATGAGCCTCAAGCCCAGGTGCGCATGCTGCACGATGGCGCTTACGCTCCGGCTGCGCCAG
CGGCTCAAGCGGCACCTGCAGTGAGCGGCACACCGCCAACCGCGCTGCGCGTCAAGGCTTCAGACAAACGCATCATCAAC
GGCCAGACCGACGTCAATCAGCTGGTACCGTTCAAATACAAATGGGCCTGGGAGAAGTACCTGGCGACCTGCGCCAACCA
CTGGATGCCGCAGGAAGTCAACATGACACGCGACATTGCACTGTGGAAAGACCCGAACGGATTGACCGAGGACGAGCGTC
GCCTGGTCAAGCGCAACCTCGGTTTCTTTGTCACTGCCGACTCACTGGCTGCCAACAACATCGTGCTGGGCACCTACCGC
CACATCACGGCGCCCGAGTGCCGCCAGTTTCTGCTGCGCCAGGCCTTCGAGGAAGCCATTCACACCCACGCCTACCAGTA
CATCACCGAGTCGCTGGGCCTGGACGAGGCTGAAATCTTCAACGCCTACAACGAGGTGCAATCCATCAAGGACAAGGACC
AGTTCCTGATCCCGTTCATTGAAGTCATTTCCGACCCCCACTTCAAGACCGGTACCACCGAAGCTGACCAGACCCTGCTC
AAGTCCCTGATCGTGTTTGCCTGCCTGATGGAAGGCCTGTTCTTCTATGTCGGCTTCACGCAGATCCTGGCGCTCGGCCG
CCAGAACAAGATGACGGGTGCGGCCGAGCAGTACCAGTACATCCTGCGCGACGAGTCCATGCACTGCAATTTCGGCATCG
ACCTGATCAACCAGCTCAAGCTCGAGAACCCCCACCTCTGGACCGCCGAGTTCAAGGCCGAGATCAAGGCCCTGTTCCTC
AAGGCCGTGGAGCTGGAGTACCGCTACGCCGAGGACACCATGCCCCGCGGCGTGCTCGGACTCAATGCCTCCATGTTCAA
AGGCTACCTGCGCTACATCGCCAATCGCCGAGCCACGCAAATTGGACTTGAAACTCTCTTCCCCAACGAGGAGAATCCGT
TTCCATGGATGAGCGAAATGATCGACCTGAAAAAAGAACGCAATTTCTTCGAGACCCGTGTGATCGAGTACCAGTCAGGC
GGCGCCCTGTCGTGGGATTGA

Upstream 100 bases:

>100_bases
TGATTCGATGTAATTGAGCAACACTAATTTACAGCGATGTGAATGAACACTTTTCATTTTGTATCGCTGCTTTCATAATC
CCAAAGAATTGGAAACCTTT

Downstream 100 bases:

>100_bases
TCCCGGACTGAATGACGCAAGACACGTAAAAAAATAATGATTTCTAGAATTGCAATGACCAATGACGCTACCGCAGAGTG
CGCGTTGGGCTTTGCTCCTG

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLTWDEEVKPSLQKSHASGSTDSRSMELPPLSSDEPQAQVRMLHDGAYAPAAPAAQAAPAVSGTPPTALRVKASDKRIIN
GQTDVNQLVPFKYKWAWEKYLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRLVKRNLGFFVTADSLAANNIVLGTYR
HITAPECRQFLLRQAFEEAIHTHAYQYITESLGLDEAEIFNAYNEVQSIKDKDQFLIPFIEVISDPHFKTGTTEADQTLL
KSLIVFACLMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKAEIKALFL
KAVELEYRYAEDTMPRGVLGLNASMFKGYLRYIANRRATQIGLETLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSG
GALSWD

Sequences:

>Translated_406_residues
MLTWDEEVKPSLQKSHASGSTDSRSMELPPLSSDEPQAQVRMLHDGAYAPAAPAAQAAPAVSGTPPTALRVKASDKRIIN
GQTDVNQLVPFKYKWAWEKYLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRLVKRNLGFFVTADSLAANNIVLGTYR
HITAPECRQFLLRQAFEEAIHTHAYQYITESLGLDEAEIFNAYNEVQSIKDKDQFLIPFIEVISDPHFKTGTTEADQTLL
KSLIVFACLMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKAEIKALFL
KAVELEYRYAEDTMPRGVLGLNASMFKGYLRYIANRRATQIGLETLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSG
GALSWD
>Mature_406_residues
MLTWDEEVKPSLQKSHASGSTDSRSMELPPLSSDEPQAQVRMLHDGAYAPAAPAAQAAPAVSGTPPTALRVKASDKRIIN
GQTDVNQLVPFKYKWAWEKYLATCANHWMPQEVNMTRDIALWKDPNGLTEDERRLVKRNLGFFVTADSLAANNIVLGTYR
HITAPECRQFLLRQAFEEAIHTHAYQYITESLGLDEAEIFNAYNEVQSIKDKDQFLIPFIEVISDPHFKTGTTEADQTLL
KSLIVFACLMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLKLENPHLWTAEFKAEIKALFL
KAVELEYRYAEDTMPRGVLGLNASMFKGYLRYIANRRATQIGLETLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSG
GALSWD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=363, Percent_Identity=26.1707988980716, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4557845, Length=359, Percent_Identity=27.5766016713092, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI260064013, Length=359, Percent_Identity=27.5766016713092, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI42544136, Length=346, Percent_Identity=25.7225433526012, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=27.3648648648649, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=27.7397260273973, Blast_Score=98, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17551968, Length=355, Percent_Identity=26.7605633802817, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=22.6973684210526, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322434, Length=331, Percent_Identity=29.9093655589124, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.125, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=26.875, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 46285; Mature: 46285

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTWDEEVKPSLQKSHASGSTDSRSMELPPLSSDEPQAQVRMLHDGAYAPAAPAAQAAPA
CCCCCHHHCHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHEEHCCCCCCCCCCCHHCCCC
VSGTPPTALRVKASDKRIINGQTDVNQLVPFKYKWAWEKYLATCANHWMPQEVNMTRDIA
CCCCCCCEEEEECCCCEEECCCCCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEE
LWKDPNGLTEDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAI
EEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
HTHAYQYITESLGLDEAEIFNAYNEVQSIKDKDQFLIPFIEVISDPHFKTGTTEADQTLL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
KSLIVFACLMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHC
LENPHLWTAEFKAEIKALFLKAVELEYRYAEDTMPRGVLGLNASMFKGYLRYIANRRATQ
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHCHHHH
IGLETLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSGGALSWD
HHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHEEEECCCCCCCCC
>Mature Secondary Structure
MLTWDEEVKPSLQKSHASGSTDSRSMELPPLSSDEPQAQVRMLHDGAYAPAAPAAQAAPA
CCCCCHHHCHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHEEHCCCCCCCCCCCHHCCCC
VSGTPPTALRVKASDKRIINGQTDVNQLVPFKYKWAWEKYLATCANHWMPQEVNMTRDIA
CCCCCCCEEEEECCCCEEECCCCCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEE
LWKDPNGLTEDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAI
EEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
HTHAYQYITESLGLDEAEIFNAYNEVQSIKDKDQFLIPFIEVISDPHFKTGTTEADQTLL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
KSLIVFACLMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQLK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHC
LENPHLWTAEFKAEIKALFLKAVELEYRYAEDTMPRGVLGLNASMFKGYLRYIANRRATQ
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHCHHHH
IGLETLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQSGGALSWD
HHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]