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The map label for this gene is hutC [H]

Identifier: 91786943

GI number: 91786943

Start: 1071267

End: 1072076

Strand: Reverse

Name: hutC [H]

Synonym: Bpro_1044

Alternate gene names: 91786943

Gene position: 1072076-1071267 (Counterclockwise)

Preceding gene: 91786944

Following gene: 91786942

Centisome position: 20.62

GC content: 65.93

Gene sequence:

>810_bases
ATGAACTCCAATCTGCATATCCTGCCCAAACCGGCACGCGAAACCGACGCCAAAATCGGCACCCCCGCCGGGGCCGACCA
GTTGTCGCCCAATGTCGCGCGTTACCAGCAGGTCAAGGACTTTGTGTCGCGCAAGATCCAGGACGGCACCTGGAAGGCCG
GCGACCGCCTGCCGTCCGAGCACGAGTTGGTGGTGCAGTTCGGCCTGTCGCGCATGACCGTCAACCGGGCCTTGCGCGAA
CTGGTGGAGCAGGGCCGCATCAAGCGCATTGCCGGGGTGGGCAGCTTCGTGGCCGACGACAAACCGCAAGCCAACCTGCT
GCAGATCGCGCGCCTGTCCGATGACATCCGGCGCCGCGGCCACGATTACCAGTGCCGGGTCATCACGGTGGAGCGCATTT
CGGCCTCGCTGGACATCGCCTCCTCGCTGGGACTGCACACCGGCGAGTCGGTGTTTCACTCGGTCTGCGTGCACCTGGAA
GACGGCGTGCCCATGCAGCTGGAAGACCGCTATGTCAACCCGCGCATGGCGCCCGCTTTCGGGCAGCAGGATTTCACGCT
GGAGCAGCCTTCAGACTTTCTGGTGCGCACGGTGCTGTTCGACCAGATGGAACATGTGGTCGATGCCGTGCTGCCCACGC
GCGAGCAGGCCGCGCTGCTGCAGATGGACGCCGGCCAGCCCTGCCTGCTGCTGACCCGCCGCACCTGGATGCGGGAAGAC
CCCATCACCCTGGTGCGCTGCCTGCACCCAGGCATGCGTTACCGGCTGGGTAGCCGCTTTCGCACCGACGGCAATGCCGT
CACCGGCTGA

Upstream 100 bases:

>100_bases
CTCAAGGCGCGCCTGACCGAAGAGATTCGCGCCGAGTCGATGGCGTCCGCCGAACATTGACATGCATTGACCCGCGCCAC
CCACCGCTCCAACCACCACA

Downstream 100 bases:

>100_bases
CGCGACGGGCCACCCCGGCGAGCCAGCCAGCCAGCAAGTAAACAAACGAATAAAAACTTCTTTATCATCGATTCCGACAA
CTTGTATATACAGGACTAGA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MNSNLHILPKPARETDAKIGTPAGADQLSPNVARYQQVKDFVSRKIQDGTWKAGDRLPSEHELVVQFGLSRMTVNRALRE
LVEQGRIKRIAGVGSFVADDKPQANLLQIARLSDDIRRRGHDYQCRVITVERISASLDIASSLGLHTGESVFHSVCVHLE
DGVPMQLEDRYVNPRMAPAFGQQDFTLEQPSDFLVRTVLFDQMEHVVDAVLPTREQAALLQMDAGQPCLLLTRRTWMRED
PITLVRCLHPGMRYRLGSRFRTDGNAVTG

Sequences:

>Translated_269_residues
MNSNLHILPKPARETDAKIGTPAGADQLSPNVARYQQVKDFVSRKIQDGTWKAGDRLPSEHELVVQFGLSRMTVNRALRE
LVEQGRIKRIAGVGSFVADDKPQANLLQIARLSDDIRRRGHDYQCRVITVERISASLDIASSLGLHTGESVFHSVCVHLE
DGVPMQLEDRYVNPRMAPAFGQQDFTLEQPSDFLVRTVLFDQMEHVVDAVLPTREQAALLQMDAGQPCLLLTRRTWMRED
PITLVRCLHPGMRYRLGSRFRTDGNAVTG
>Mature_269_residues
MNSNLHILPKPARETDAKIGTPAGADQLSPNVARYQQVKDFVSRKIQDGTWKAGDRLPSEHELVVQFGLSRMTVNRALRE
LVEQGRIKRIAGVGSFVADDKPQANLLQIARLSDDIRRRGHDYQCRVITVERISASLDIASSLGLHTGESVFHSVCVHLE
DGVPMQLEDRYVNPRMAPAFGQQDFTLEQPSDFLVRTVLFDQMEHVVDAVLPTREQAALLQMDAGQPCLLLTRRTWMRED
PITLVRCLHPGMRYRLGSRFRTDGNAVTG

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=206, Percent_Identity=28.1553398058252, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082252, Length=210, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1790540, Length=139, Percent_Identity=32.3741007194245, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790118, Length=138, Percent_Identity=26.0869565217391, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 30222; Mature: 30222

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNLHILPKPARETDAKIGTPAGADQLSPNVARYQQVKDFVSRKIQDGTWKAGDRLPSE
CCCCCEEECCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HELVVQFGLSRMTVNRALRELVEQGRIKRIAGVGSFVADDKPQANLLQIARLSDDIRRRG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCC
HDYQCRVITVERISASLDIASSLGLHTGESVFHSVCVHLEDGVPMQLEDRYVNPRMAPAF
CCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCC
GQQDFTLEQPSDFLVRTVLFDQMEHVVDAVLPTREQAALLQMDAGQPCLLLTRRTWMRED
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCEEEEHHHHHCCCC
PITLVRCLHPGMRYRLGSRFRTDGNAVTG
HHHHHHHHCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNSNLHILPKPARETDAKIGTPAGADQLSPNVARYQQVKDFVSRKIQDGTWKAGDRLPSE
CCCCCEEECCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HELVVQFGLSRMTVNRALRELVEQGRIKRIAGVGSFVADDKPQANLLQIARLSDDIRRRG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCC
HDYQCRVITVERISASLDIASSLGLHTGESVFHSVCVHLEDGVPMQLEDRYVNPRMAPAF
CCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCC
GQQDFTLEQPSDFLVRTVLFDQMEHVVDAVLPTREQAALLQMDAGQPCLLLTRRTWMRED
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCEEEEHHHHHCCCC
PITLVRCLHPGMRYRLGSRFRTDGNAVTG
HHHHHHHHCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]