Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 91786653

GI number: 91786653

Start: 768639

End: 770108

Strand: Reverse

Name: zwf [H]

Synonym: Bpro_0751

Alternate gene names: 91786653

Gene position: 770108-768639 (Counterclockwise)

Preceding gene: 91786659

Following gene: 91786652

Centisome position: 14.81

GC content: 64.22

Gene sequence:

>1470_bases
ATGAGTTTTGATCTCATCCTGTTTGGCGGCACCGGCGATCTGGTGTGGCGAAAAATCATGCCCGCGCTGTTCCAGGCCTT
CCGGCACGGCTCACTCCCCCCGGGGGGTCGCATTGTGGGTGTGGCACGTGACGCCCTGTCCGACGACCAGTACCGTGCCC
TGATCAAGAGCCGCTTCGACCAGGTGGAACTGGCCAAGCGACCCAGCGAGGAGGAGTTTTCGCGTTTTGCGGCCCTGCTC
AGCTACCTGCGCATGGATTTATCCAACCCGGCCGACTATGCAAGCCTTGCAGCCAAGCTGCAGCAACGGCCGGCCGAGGT
GGTGGTGATGTATGTGGCGACCGCCCCCAGCCTGTTCACCACGGTGTGCGAGCAGATGGCGGCCGCAGGTCTGAATGGTC
CGCAGACCCGCGTGGTGCTTGAAAAGCCGCTGGGTCACGACCTCGCCTCCAACCGCGCCATCAACAAGACAGTGCGCAGC
GTGCTGCAGGAGGATCAGATCTTCCGCATTGACCATTATCTGGGCAAGCCATCGGTGCAAAACCTGTTTGCACTGCGCTT
TGGCAACTCGCTGTTCGAGCCGCTGTGGCGCCGCGAGACGATTGCCAACATCCAGATCACGATTGCCGAAGACCTCGGTG
TTGAAAAACGCGGTGCGTTTTACGACAGCACCGGGGCGCTGCGCGACATGGTGCAAAACCATGCGCTGCAATTGCTGTGT
GCCATCGGCATGGAGCCGCCCATCAACTCGCACGCCGATGCCATCCGCGATGAAAAGCTCAAGGTGCTGCGCTCACTCAA
GGCCTGGACGCCGGAAACCCTGAGCCAGCACGTCGTGCGCGGCCAGTACGCCGCTGGCAGCATCGACGGCGAGGCCGTGC
CGGGCTACCGCGATGAAAAGGGGGTCGATCCGGACAGCGCCACGGAGACCTTTGTGGCCCTGCGTACCGAGATTGCCAAC
TGGCGCTGGGCGGGCGTGCCCTTTTACATACGCACAGGCAAGCGGCTGGCGGGCCGGGATGCGCATATCGAGGTGAACTT
CCGGCCGGCGCCGCACGCCATTTTCCAGTCCCCCCTGGTGGAGTCGAATGTCGGCAACCGCCTGGTGATCAACCTGCAGC
CCAAGGACGGCCTGGAGCTGCATCTGCTGGCCCAGGGCTCGCACCAGCGCCATGACCGCGGCACCCCCTCGTTGGTGCCG
GTGCAGCTCGACCTGGACTTCGACAAGCGATTCGGCGCGGAGCGCGTGGGCGCCTACGAGCGGCTGCTGCTCGACGTGAT
CGCCGGGCGGCTCAACCTCTTTGTGCGCAGCGATGAGCAGGAGGAAGCTTGGCGCTGGGTCGAACCCATTCTGGACAGCT
GGAGCAGCCAGCCAGCCGGACCCCGCCCCTACGCGGCAGGCACATGGGGCCCCAGCGCGGCGAGTGCCATGATTGCGCGC
GATGGCTATTGCTGGAGCGAGGAATGTTAG

Upstream 100 bases:

>100_bases
TTGAGTTACCATTATGCCAAATTAATGTGAAACTAAATTACAAAGCAGCTCTGGCAGCTTTCCGGCAACTTCCGATTAAT
CACCTCGACAAGGTTTTTTC

Downstream 100 bases:

>100_bases
CCCCCACGCTCCCCACTGCGTGTGGTTCGCTGCCCCCCGGGGGGGCCGCCCCGCCTGCGGCCCGGCAAAGCCGGTTCCGC
GGCTCGGACTGGTGTTTTGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSFDLILFGGTGDLVWRKIMPALFQAFRHGSLPPGGRIVGVARDALSDDQYRALIKSRFDQVELAKRPSEEEFSRFAALL
SYLRMDLSNPADYASLAAKLQQRPAEVVVMYVATAPSLFTTVCEQMAAAGLNGPQTRVVLEKPLGHDLASNRAINKTVRS
VLQEDQIFRIDHYLGKPSVQNLFALRFGNSLFEPLWRRETIANIQITIAEDLGVEKRGAFYDSTGALRDMVQNHALQLLC
AIGMEPPINSHADAIRDEKLKVLRSLKAWTPETLSQHVVRGQYAAGSIDGEAVPGYRDEKGVDPDSATETFVALRTEIAN
WRWAGVPFYIRTGKRLAGRDAHIEVNFRPAPHAIFQSPLVESNVGNRLVINLQPKDGLELHLLAQGSHQRHDRGTPSLVP
VQLDLDFDKRFGAERVGAYERLLLDVIAGRLNLFVRSDEQEEAWRWVEPILDSWSSQPAGPRPYAAGTWGPSAASAMIAR
DGYCWSEEC

Sequences:

>Translated_489_residues
MSFDLILFGGTGDLVWRKIMPALFQAFRHGSLPPGGRIVGVARDALSDDQYRALIKSRFDQVELAKRPSEEEFSRFAALL
SYLRMDLSNPADYASLAAKLQQRPAEVVVMYVATAPSLFTTVCEQMAAAGLNGPQTRVVLEKPLGHDLASNRAINKTVRS
VLQEDQIFRIDHYLGKPSVQNLFALRFGNSLFEPLWRRETIANIQITIAEDLGVEKRGAFYDSTGALRDMVQNHALQLLC
AIGMEPPINSHADAIRDEKLKVLRSLKAWTPETLSQHVVRGQYAAGSIDGEAVPGYRDEKGVDPDSATETFVALRTEIAN
WRWAGVPFYIRTGKRLAGRDAHIEVNFRPAPHAIFQSPLVESNVGNRLVINLQPKDGLELHLLAQGSHQRHDRGTPSLVP
VQLDLDFDKRFGAERVGAYERLLLDVIAGRLNLFVRSDEQEEAWRWVEPILDSWSSQPAGPRPYAAGTWGPSAASAMIAR
DGYCWSEEC
>Mature_488_residues
SFDLILFGGTGDLVWRKIMPALFQAFRHGSLPPGGRIVGVARDALSDDQYRALIKSRFDQVELAKRPSEEEFSRFAALLS
YLRMDLSNPADYASLAAKLQQRPAEVVVMYVATAPSLFTTVCEQMAAAGLNGPQTRVVLEKPLGHDLASNRAINKTVRSV
LQEDQIFRIDHYLGKPSVQNLFALRFGNSLFEPLWRRETIANIQITIAEDLGVEKRGAFYDSTGALRDMVQNHALQLLCA
IGMEPPINSHADAIRDEKLKVLRSLKAWTPETLSQHVVRGQYAAGSIDGEAVPGYRDEKGVDPDSATETFVALRTEIANW
RWAGVPFYIRTGKRLAGRDAHIEVNFRPAPHAIFQSPLVESNVGNRLVINLQPKDGLELHLLAQGSHQRHDRGTPSLVPV
QLDLDFDKRFGAERVGAYERLLLDVIAGRLNLFVRSDEQEEAWRWVEPILDSWSSQPAGPRPYAAGTWGPSAASAMIARD
GYCWSEEC

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=495, Percent_Identity=35.5555555555556, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI108773793, Length=495, Percent_Identity=35.5555555555556, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI52145310, Length=503, Percent_Identity=27.037773359841, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1788158, Length=487, Percent_Identity=42.7104722792608, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17538218, Length=493, Percent_Identity=33.2657200811359, Blast_Score=284, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6324088, Length=501, Percent_Identity=34.7305389221557, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24643352, Length=493, Percent_Identity=34.6855983772819, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24643350, Length=493, Percent_Identity=34.6855983772819, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI221513548, Length=496, Percent_Identity=29.2338709677419, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54439; Mature: 54308

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLILFGGTGDLVWRKIMPALFQAFRHGSLPPGGRIVGVARDALSDDQYRALIKSRFD
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCHHHHHHHHHHHH
QVELAKRPSEEEFSRFAALLSYLRMDLSNPADYASLAAKLQQRPAEVVVMYVATAPSLFT
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHEEEEEECCCHHHHH
TVCEQMAAAGLNGPQTRVVLEKPLGHDLASNRAINKTVRSVLQEDQIFRIDHYLGKPSVQ
HHHHHHHHCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHHCCEEEHHHHCCCCCHH
NLFALRFGNSLFEPLWRRETIANIQITIAEDLGVEKRGAFYDSTGALRDMVQNHALQLLC
HHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCCCCCCCCEECCHHHHHHHHHHHHHHHHH
AIGMEPPINSHADAIRDEKLKVLRSLKAWTPETLSQHVVRGQYAAGSIDGEAVPGYRDEK
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVDPDSATETFVALRTEIANWRWAGVPFYIRTGKRLAGRDAHIEVNFRPAPHAIFQSPLV
CCCCCHHHHHHHHHHHHHCCCEECCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHCCCH
ESNVGNRLVINLQPKDGLELHLLAQGSHQRHDRGTPSLVPVQLDLDFDKRFGAERVGAYE
HCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCHHHHCCHHHHHHHH
RLLLDVIAGRLNLFVRSDEQEEAWRWVEPILDSWSSQPAGPRPYAAGTWGPSAASAMIAR
HHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHC
DGYCWSEEC
CCCCCCCCC
>Mature Secondary Structure 
SFDLILFGGTGDLVWRKIMPALFQAFRHGSLPPGGRIVGVARDALSDDQYRALIKSRFD
CEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCHHHHHHHHHHHH
QVELAKRPSEEEFSRFAALLSYLRMDLSNPADYASLAAKLQQRPAEVVVMYVATAPSLFT
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHEEEEEECCCHHHHH
TVCEQMAAAGLNGPQTRVVLEKPLGHDLASNRAINKTVRSVLQEDQIFRIDHYLGKPSVQ
HHHHHHHHCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHHCCEEEHHHHCCCCCHH
NLFALRFGNSLFEPLWRRETIANIQITIAEDLGVEKRGAFYDSTGALRDMVQNHALQLLC
HHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCCCCCCCCEECCHHHHHHHHHHHHHHHHH
AIGMEPPINSHADAIRDEKLKVLRSLKAWTPETLSQHVVRGQYAAGSIDGEAVPGYRDEK
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVDPDSATETFVALRTEIANWRWAGVPFYIRTGKRLAGRDAHIEVNFRPAPHAIFQSPLV
CCCCCHHHHHHHHHHHHHCCCEECCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHCCCH
ESNVGNRLVINLQPKDGLELHLLAQGSHQRHDRGTPSLVPVQLDLDFDKRFGAERVGAYE
HCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCHHHHCCHHHHHHHH
RLLLDVIAGRLNLFVRSDEQEEAWRWVEPILDSWSSQPAGPRPYAAGTWGPSAASAMIAR
HHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHC
DGYCWSEEC
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]