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The map label for this gene is gor [H]

Identifier: 91786548

GI number: 91786548

Start: 652495

End: 653874

Strand: Reverse

Name: gor [H]

Synonym: Bpro_0643

Alternate gene names: 91786548

Gene position: 653874-652495 (Counterclockwise)

Preceding gene: 91786549

Following gene: 91786547

Centisome position: 12.57

GC content: 64.35

Gene sequence:

>1380_bases
ATGCAAACTTTTGATTTTGACCTTTTCGTCATCGGCGGCGGCAGCGGCGGCGTGCGCGCCGCCCGCATGTCGGCACAGCG
CGGTGCCCGCGTGGCGCTGGCCGAAGTCGCCGCCATGGGCGGCACCTGCGTAAATGTGGGCTGCATCCCGAAAAAGCTCT
ACAGCTACGCCGCCCATTACGGCGACAGTTTTGAAGAGTCGCATGGCTTTGGCTGGGTCGGCGAGGCCCCCACCTTCGAC
TGGGACCTCCTCAAGGCCAACCGGGCCCGCGAGATTTCACGGCTCAACGGCGTCTATGTGCAGCTGCTCACGAGCGCCGA
AGTGACCATCATCGAGGGCTGGGCCCGCCTGCTGGATGCGCACACAGTGGAAGTCGACGGCAGGCGATTCACGGCCAAAA
ACGTCCTGGTCTCGACCGGCGGCACCCCCACCGTGCCCGCCATCACCGGCCGTGAGCATGTGGTGACCTCCGACCAGATG
TTCGACCTCAGCCCCTTCCCCAAGCGCCTGCTGGTGGTGGGCGGCGGTTATATCGCCTGCGAGTTCGCCTCGATCTTCAA
CGGCCTGGGCTCCCAGGTCACCCAGGTCCATCGCCGAGACAAGCTTCTGACGGGCTTTGACGACGACGTGCGCCGCTTCA
TTGCCGGGGAAATGAGCAAAACCGGCATCAATCTGCAACTGGGCACGCATATCAGCGCCATCACCAAAACAGACGACGGG
CTGCAGGTGGAGGTGAAAGACTCGCAGGACAAGCCGGCCAGCTTCCTGGTGGACAGCGTGCTGTATGCCACCGGCCGCGT
GCCCAATGCCAGCGGGATCGGGCTGGAAACCGTGGGTGTGGCGGTGAACAGGGTGGGCGCGATCCAGGTGAATGCGCAGT
ACCAGACCTCCGTGCCGTCCATCTACGCGCTCGGGGACGTGACCGCGCGCCTGCAGCTGACGCCCGTGGCGCTGGGCGAG
GCGATGGTGGTGGTGGACCATCTGTTTGGCCCGACCGACGGCAAGAAGCCCAGGGGCATGAGCTACGACTTCGTTCCCAC
CGCCGTGTTCACCCATCCCAATATCGGGACGGTCGGGTATTCGGAAGCCGATGCCCGCGAACAATTCGGCGCCATCCGTG
TGTACCGCACCGATTTCAAGGCGCTCAAACATACCTTGAGCGGCAGCACCGAGCGCACACTGATGAAGCTGCTGGTTGAA
GATGCCACCGACCGCGTGGTGGGCCTGCACATGGTGGGACCGGACGCAGGCGAGATCGTGCAGGGCTTTGCCGTGGCCAT
GAAGGCCGGGGCCACCAAGGCCGTGTTTGACAGCACCATTGGCATCCACCCGACGGCCGCCGAAGAGTTTGTGACCATGC
GGGAGCCGGTCAAGGCCTGA

Upstream 100 bases:

>100_bases
CACGCCCGGCTGTTGCCCATGCGCACCCGGGTGTTCATCGAGTGGATCAAGAAGGAACTCAAGGACTTCCAGTCCTGAAG
ACTGAAAAAGGAAAGAGCGC

Downstream 100 bases:

>100_bases
GAGCCTGCGGGCGATAGCTCTATGATGGAATGAAATCAAGAATCCCCCGCCATGCCCTACCTGCCCCCCTTCATTGCCCC
GACCCGCTACTCCGACCCCG

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MQTFDFDLFVIGGGSGGVRAARMSAQRGARVALAEVAAMGGTCVNVGCIPKKLYSYAAHYGDSFEESHGFGWVGEAPTFD
WDLLKANRAREISRLNGVYVQLLTSAEVTIIEGWARLLDAHTVEVDGRRFTAKNVLVSTGGTPTVPAITGREHVVTSDQM
FDLSPFPKRLLVVGGGYIACEFASIFNGLGSQVTQVHRRDKLLTGFDDDVRRFIAGEMSKTGINLQLGTHISAITKTDDG
LQVEVKDSQDKPASFLVDSVLYATGRVPNASGIGLETVGVAVNRVGAIQVNAQYQTSVPSIYALGDVTARLQLTPVALGE
AMVVVDHLFGPTDGKKPRGMSYDFVPTAVFTHPNIGTVGYSEADAREQFGAIRVYRTDFKALKHTLSGSTERTLMKLLVE
DATDRVVGLHMVGPDAGEIVQGFAVAMKAGATKAVFDSTIGIHPTAAEEFVTMREPVKA

Sequences:

>Translated_459_residues
MQTFDFDLFVIGGGSGGVRAARMSAQRGARVALAEVAAMGGTCVNVGCIPKKLYSYAAHYGDSFEESHGFGWVGEAPTFD
WDLLKANRAREISRLNGVYVQLLTSAEVTIIEGWARLLDAHTVEVDGRRFTAKNVLVSTGGTPTVPAITGREHVVTSDQM
FDLSPFPKRLLVVGGGYIACEFASIFNGLGSQVTQVHRRDKLLTGFDDDVRRFIAGEMSKTGINLQLGTHISAITKTDDG
LQVEVKDSQDKPASFLVDSVLYATGRVPNASGIGLETVGVAVNRVGAIQVNAQYQTSVPSIYALGDVTARLQLTPVALGE
AMVVVDHLFGPTDGKKPRGMSYDFVPTAVFTHPNIGTVGYSEADAREQFGAIRVYRTDFKALKHTLSGSTERTLMKLLVE
DATDRVVGLHMVGPDAGEIVQGFAVAMKAGATKAVFDSTIGIHPTAAEEFVTMREPVKA
>Mature_459_residues
MQTFDFDLFVIGGGSGGVRAARMSAQRGARVALAEVAAMGGTCVNVGCIPKKLYSYAAHYGDSFEESHGFGWVGEAPTFD
WDLLKANRAREISRLNGVYVQLLTSAEVTIIEGWARLLDAHTVEVDGRRFTAKNVLVSTGGTPTVPAITGREHVVTSDQM
FDLSPFPKRLLVVGGGYIACEFASIFNGLGSQVTQVHRRDKLLTGFDDDVRRFIAGEMSKTGINLQLGTHISAITKTDDG
LQVEVKDSQDKPASFLVDSVLYATGRVPNASGIGLETVGVAVNRVGAIQVNAQYQTSVPSIYALGDVTARLQLTPVALGE
AMVVVDHLFGPTDGKKPRGMSYDFVPTAVFTHPNIGTVGYSEADAREQFGAIRVYRTDFKALKHTLSGSTERTLMKLLVE
DATDRVVGLHMVGPDAGEIVQGFAVAMKAGATKAVFDSTIGIHPTAAEEFVTMREPVKA

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=37.7440347071584, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI148277065, Length=479, Percent_Identity=36.1169102296451, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI33519430, Length=479, Percent_Identity=36.1169102296451, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI33519428, Length=479, Percent_Identity=36.1169102296451, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI33519426, Length=479, Percent_Identity=36.1169102296451, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI148277071, Length=479, Percent_Identity=36.1169102296451, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI291045266, Length=433, Percent_Identity=35.5658198614319, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=36.4210526315789, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI291045268, Length=431, Percent_Identity=32.7146171693735, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=30.3225806451613, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=39.5402298850575, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1786307, Length=450, Percent_Identity=28.2222222222222, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082354, Length=469, Percent_Identity=27.5053304904051, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87081717, Length=462, Percent_Identity=29.2207792207792, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789065, Length=225, Percent_Identity=28.8888888888889, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71983419, Length=459, Percent_Identity=39.4335511982571, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71983429, Length=459, Percent_Identity=39.4335511982571, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=32.1576763485477, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=32.3210412147505, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=34.156378600823, Blast_Score=221, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=38.8059701492537, Blast_Score=309, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=29.247311827957, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=26.1241970021413, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=37.9746835443038, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=37.9746835443038, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=37.9746835443038, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=36.1344537815126, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=32.3275862068966, Blast_Score=228, Evalue=8e-60,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49135; Mature: 49135

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFDFDLFVIGGGSGGVRAARMSAQRGARVALAEVAAMGGTCVNVGCIPKKLYSYAAHY
CCCEEEEEEEEECCCCCCHHHHHHHHCCCEEHHHHHHHCCCCEEEECCCHHHHHHHHHHC
GDSFEESHGFGWVGEAPTFDWDLLKANRAREISRLNGVYVQLLTSAEVTIIEGWARLLDA
CCCCHHCCCCCCCCCCCCCCHHHHHCHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHCC
HTVEVDGRRFTAKNVLVSTGGTPTVPAITGREHVVTSDQMFDLSPFPKRLLVVGGGYIAC
EEEEECCCEEEECEEEEECCCCCCCCEECCCCEEEECCCEECCCCCCCEEEEEECCEEEE
EFASIFNGLGSQVTQVHRRDKLLTGFDDDVRRFIAGEMSKTGINLQLGTHISAITKTDDG
EHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCEEEEECCCEEEEEECCCC
LQVEVKDSQDKPASFLVDSVLYATGRVPNASGIGLETVGVAVNRVGAIQVNAQYQTSVPS
EEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCEEEEEECCEECCCCCC
IYALGDVTARLQLTPVALGEAMVVVDHLFGPTDGKKPRGMSYDFVPTAVFTHPNIGTVGY
EEEECCEEEEEEEEEEHHCCHHEEEHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
SEADAREQFGAIRVYRTDFKALKHTLSGSTERTLMKLLVEDATDRVVGLHMVGPDAGEIV
CCCHHHHHHCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHH
QGFAVAMKAGATKAVFDSTIGIHPTAAEEFVTMREPVKA
HHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MQTFDFDLFVIGGGSGGVRAARMSAQRGARVALAEVAAMGGTCVNVGCIPKKLYSYAAHY
CCCEEEEEEEEECCCCCCHHHHHHHHCCCEEHHHHHHHCCCCEEEECCCHHHHHHHHHHC
GDSFEESHGFGWVGEAPTFDWDLLKANRAREISRLNGVYVQLLTSAEVTIIEGWARLLDA
CCCCHHCCCCCCCCCCCCCCHHHHHCHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHCC
HTVEVDGRRFTAKNVLVSTGGTPTVPAITGREHVVTSDQMFDLSPFPKRLLVVGGGYIAC
EEEEECCCEEEECEEEEECCCCCCCCEECCCCEEEECCCEECCCCCCCEEEEEECCEEEE
EFASIFNGLGSQVTQVHRRDKLLTGFDDDVRRFIAGEMSKTGINLQLGTHISAITKTDDG
EHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCEEEEECCCEEEEEECCCC
LQVEVKDSQDKPASFLVDSVLYATGRVPNASGIGLETVGVAVNRVGAIQVNAQYQTSVPS
EEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCEEEEEECCEECCCCCC
IYALGDVTARLQLTPVALGEAMVVVDHLFGPTDGKKPRGMSYDFVPTAVFTHPNIGTVGY
EEEECCEEEEEEEEEEHHCCHHEEEHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
SEADAREQFGAIRVYRTDFKALKHTLSGSTERTLMKLLVEDATDRVVGLHMVGPDAGEIV
CCCHHHHHHCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHH
QGFAVAMKAGATKAVFDSTIGIHPTAAEEFVTMREPVKA
HHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]