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The map label for this gene is aphA [H]

Identifier: 91786330

GI number: 91786330

Start: 433121

End: 434182

Strand: Reverse

Name: aphA [H]

Synonym: Bpro_0420

Alternate gene names: 91786330

Gene position: 434182-433121 (Counterclockwise)

Preceding gene: 91786331

Following gene: 91786329

Centisome position: 8.35

GC content: 70.62

Gene sequence:

>1062_bases
ATGCAGGCCTTCTTTGCCGACGACCAGCTGCTGCACGACCCGCAGCAGTTCATGCGGCTGGGCCGGATCTGCAAGCCGAC
CGACCTGCCGGCCCGGGCCCACGCCCTGCAGGCCGCGCTGGCAGCCCATGGCATAGCCGTGGCCACGCCGCCGGACTATG
GGCGCGCCCCACTGGAGACCGTGCACAGCACCGACTACCTCGACTTCCTGGAGGGTGCCTACGCGCGCTGGACGGCCGTG
AAGCTGCCCGGGCTCGAACCCGGCATCGAGGTGCTGCCCAACCTGTCGCCGTATTGCAGCGGCCATGTCAATGCGGCGCG
CGGGCCGTGCCCGTCGCCCTCCGTCGTGGCCCAGGCGGGTTACTACCTGCGCGACCTGTCCTGCCCCATCGGTCCCCACA
CCTGGCATTCGGTGCTGCGCTCGGCGCACAGTGCCGTGGCCGCCGCCGACGCGGTGTGCCAGACCGGTGACGCCGCCTAT
GCACTGTGCCGTCCCTCGGGCCACCATGCCTGCCGCGACAGCGCCAGCGGCTTTTGCTACGTGAACAACAGCGCCTGTGC
CGCGCACCGGCTGCTGCAGCACTACGGCCGCGTGGCGGTGCTCGACGTGGACGCCCACCACGGCGACGGCACCCAGCACA
TCTTCTACGACAGCGCCGACGTGCTGACCGTGTCGATGCACGCCGACCCGGCCGGCTACTACCCGTTCTACAGCGGCTAC
GCACACGAGCGCGGCGCCGGGGCCGGCGCGGGCTGCAACCTGAACCTGCCGCTGCCGCACGGCGCCGGCAGCGAGCCCTT
CCTGCAGGCGCTGGATGCGGGGCTGGCGGCGCTGCGCGACTTCGCTCCACGGGCGCTGGTGCTGCCGCTCGGCTTCGACA
CCTACAAGGACGATCCGGTGAGCGTGCTCAAGGTCGAGATCGATGCCTACCGCCAGGTCGGCGAACGAGCCGGGGCGCTG
GGCCTGCCCACGGTGATCGTGCAGGAGGGCGGCTACAAGGTGGACGCCATGGGCATGGCGCTGGACGCATTTCTTGGTGG
TTTTCAGGCAGGCCGATCATGA

Upstream 100 bases:

>100_bases
TGGCGTTCTGCCCGCCGCTGATCATCACGGCCGCACAGGTCGACGAGATGTTTGCCCGCTTCGACCGGGCCATGGTCCGG
CTGGAGCAGGAGCAGCCGTG

Downstream 100 bases:

>100_bases
GCCGGCGCAGGAGTTGGGCATGACCCGGAATATCCGCATCAACCGCGAGCGCTTGTGGCGTTCCTTGATGGACCTGGCCG
CCATCGGCGCCACGCCCAAG

Product: histone deacetylase superfamily protein protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MQAFFADDQLLHDPQQFMRLGRICKPTDLPARAHALQAALAAHGIAVATPPDYGRAPLETVHSTDYLDFLEGAYARWTAV
KLPGLEPGIEVLPNLSPYCSGHVNAARGPCPSPSVVAQAGYYLRDLSCPIGPHTWHSVLRSAHSAVAAADAVCQTGDAAY
ALCRPSGHHACRDSASGFCYVNNSACAAHRLLQHYGRVAVLDVDAHHGDGTQHIFYDSADVLTVSMHADPAGYYPFYSGY
AHERGAGAGAGCNLNLPLPHGAGSEPFLQALDAGLAALRDFAPRALVLPLGFDTYKDDPVSVLKVEIDAYRQVGERAGAL
GLPTVIVQEGGYKVDAMGMALDAFLGGFQAGRS

Sequences:

>Translated_353_residues
MQAFFADDQLLHDPQQFMRLGRICKPTDLPARAHALQAALAAHGIAVATPPDYGRAPLETVHSTDYLDFLEGAYARWTAV
KLPGLEPGIEVLPNLSPYCSGHVNAARGPCPSPSVVAQAGYYLRDLSCPIGPHTWHSVLRSAHSAVAAADAVCQTGDAAY
ALCRPSGHHACRDSASGFCYVNNSACAAHRLLQHYGRVAVLDVDAHHGDGTQHIFYDSADVLTVSMHADPAGYYPFYSGY
AHERGAGAGAGCNLNLPLPHGAGSEPFLQALDAGLAALRDFAPRALVLPLGFDTYKDDPVSVLKVEIDAYRQVGERAGAL
GLPTVIVQEGGYKVDAMGMALDAFLGGFQAGRS
>Mature_353_residues
MQAFFADDQLLHDPQQFMRLGRICKPTDLPARAHALQAALAAHGIAVATPPDYGRAPLETVHSTDYLDFLEGAYARWTAV
KLPGLEPGIEVLPNLSPYCSGHVNAARGPCPSPSVVAQAGYYLRDLSCPIGPHTWHSVLRSAHSAVAAADAVCQTGDAAY
ALCRPSGHHACRDSASGFCYVNNSACAAHRLLQHYGRVAVLDVDAHHGDGTQHIFYDSADVLTVSMHADPAGYYPFYSGY
AHERGAGAGAGCNLNLPLPHGAGSEPFLQALDAGLAALRDFAPRALVLPLGFDTYKDDPVSVLKVEIDAYRQVGERAGAL
GLPTVIVQEGGYKVDAMGMALDAFLGGFQAGRS

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI8923769, Length=168, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI13128860, Length=168, Percent_Identity=33.9285714285714, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073088, Length=177, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13128862, Length=322, Percent_Identity=26.3975155279503, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI20070354, Length=228, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI169234807, Length=206, Percent_Identity=31.0679611650485, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI148539870, Length=206, Percent_Identity=31.0679611650485, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI13128864, Length=191, Percent_Identity=31.413612565445, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI153085395, Length=237, Percent_Identity=31.2236286919831, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI293336691, Length=141, Percent_Identity=34.7517730496454, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI17158039, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI30795204, Length=203, Percent_Identity=30.0492610837438, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI30795202, Length=203, Percent_Identity=30.0492610837438, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI262073092, Length=102, Percent_Identity=37.2549019607843, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI226529806, Length=132, Percent_Identity=40.9090909090909, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI62750349, Length=142, Percent_Identity=36.6197183098592, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI62750347, Length=142, Percent_Identity=36.6197183098592, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17534739, Length=209, Percent_Identity=32.0574162679426, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193206283, Length=202, Percent_Identity=32.6732673267327, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17540332, Length=202, Percent_Identity=32.6732673267327, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540334, Length=202, Percent_Identity=32.6732673267327, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=312, Percent_Identity=26.6025641025641, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=168, Percent_Identity=30.952380952381, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17537347, Length=293, Percent_Identity=25.938566552901, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI193209491, Length=191, Percent_Identity=29.8429319371728, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324307, Length=290, Percent_Identity=29.6551724137931, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321244, Length=209, Percent_Identity=30.622009569378, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323999, Length=170, Percent_Identity=31.1764705882353, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325325, Length=129, Percent_Identity=29.4573643410853, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281360899, Length=228, Percent_Identity=34.6491228070175, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642142, Length=230, Percent_Identity=34.3478260869565, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642144, Length=230, Percent_Identity=34.3478260869565, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642146, Length=230, Percent_Identity=34.3478260869565, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644244, Length=168, Percent_Identity=33.9285714285714, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24657891, Length=211, Percent_Identity=31.2796208530806, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360799, Length=142, Percent_Identity=36.6197183098592, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360801, Length=142, Percent_Identity=36.6197183098592, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641720, Length=148, Percent_Identity=35.8108108108108, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37345; Mature: 37345

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAFFADDQLLHDPQQFMRLGRICKPTDLPARAHALQAALAAHGIAVATPPDYGRAPLET
CCCCCCCCHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCHHH
VHSTDYLDFLEGAYARWTAVKLPGLEPGIEVLPNLSPYCSGHVNAARGPCPSPSVVAQAG
HHCCHHHHHHHCHHHEEEEEECCCCCCCHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHCC
YYLRDLSCPIGPHTWHSVLRSAHSAVAAADAVCQTGDAAYALCRPSGHHACRDSASGFCY
HHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEEE
VNNSACAAHRLLQHYGRVAVLDVDAHHGDGTQHIFYDSADVLTVSMHADPAGYYPFYSGY
ECCCHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCC
AHERGAGAGAGCNLNLPLPHGAGSEPFLQALDAGLAALRDFAPRALVLPLGFDTYKDDPV
CCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
SVLKVEIDAYRQVGERAGALGLPTVIVQEGGYKVDAMGMALDAFLGGFQAGRS
EEEEEEHHHHHHHHHHCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQAFFADDQLLHDPQQFMRLGRICKPTDLPARAHALQAALAAHGIAVATPPDYGRAPLET
CCCCCCCCHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCHHH
VHSTDYLDFLEGAYARWTAVKLPGLEPGIEVLPNLSPYCSGHVNAARGPCPSPSVVAQAG
HHCCHHHHHHHCHHHEEEEEECCCCCCCHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHCC
YYLRDLSCPIGPHTWHSVLRSAHSAVAAADAVCQTGDAAYALCRPSGHHACRDSASGFCY
HHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCEEEE
VNNSACAAHRLLQHYGRVAVLDVDAHHGDGTQHIFYDSADVLTVSMHADPAGYYPFYSGY
ECCCHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCC
AHERGAGAGAGCNLNLPLPHGAGSEPFLQALDAGLAALRDFAPRALVLPLGFDTYKDDPV
CCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
SVLKVEIDAYRQVGERAGALGLPTVIVQEGGYKVDAMGMALDAFLGGFQAGRS
EEEEEEHHHHHHHHHHCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]