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The map label for this gene is hemB [H]

Identifier: 91786156

GI number: 91786156

Start: 267796

End: 268845

Strand: Reverse

Name: hemB [H]

Synonym: Bpro_0245

Alternate gene names: 91786156

Gene position: 268845-267796 (Counterclockwise)

Preceding gene: 91786178

Following gene: 91786155

Centisome position: 5.17

GC content: 65.62

Gene sequence:

>1050_bases
GTGGCCGCGGCGAAGGTTTGGCACAATTTGGCCATGACCCTGCATGCCTCCAACTTCGCCCCCTTCCCCCTGGGCCGGCC
CCGGCGCCTGCGCCGCGACAGCTTTACCCGCAACCTGGTCCGCGAAAACGTCCTCAGCGCGCACGACCTGATCTACCCGG
TTTTTGTCACCGACGGCAGTCAGCGCCGCGAAGCCGTCGCCTCGATGCCGGGCGTGGAGCGGCTCAGCCTGGATTTGCTG
CTGCCGGTGGCCGAAGAGTGCGTCAAGCTGGGCATACCGGTCATGGCGCTGTTTCCGGTGATCGACGGCTCGCTGAAGAC
CCCCGATGGGCGGGAGGCCCTGAACCCTGAAGGCCTGGTGCCGCGGGTGGTGCGCGAGCTGAAGAAGCGGTTTCCCGAAC
TGGGCGTGATGACCGACGTGGCACTGGACCCCTTCACCAGCCACGGCCAGGACGGGCTGCCTGACCCGACCGGCTACATC
CTGAACGATGAAACCATTGAGGTCCTGGTCGGCCAGGCGCTGACCCAGGCCGAAGCCGGCGTGGACATCGTGGCACCCAG
CGACATGATGGACGGCCGGATCGGCGCGATCCGCCAGGCGCTGGAAGGCAAAAAGCTCATACACACCCGCATCATGGCTT
ACAGCGCCAAATACGCCAGTGCCTTTTACGGCCCCTTCCGCGACGCGGTCGGCTCCGCCGGCAACCTGGGCAAGGCCGAC
AAAAAGGTCTACCAGATGGACCCGGGCAACAGCGACGAAGCCCTGCGCGAGGTGGCGATGGACATTGCCGAGGGCGCCGA
CATGGTGATGGTCAAGCCCGGCATGCCCTACCTGGACGTGGTGCGGCGCGTGAAAGACGAATTTCAGGTGCCGACCTTTG
CCTACCAGGTCAGTGGCGAGTACGCCATGCTCAAGGCCGCGGCCCAGAACGGCTGGCTGGACCACGACGCGGTGATGATG
GAAAGTCTGCTGGCCTTCAAGCGGGCCGGTGCAGACGGCGTGCTGACCTACTTTGCGATAGACGCCGCCAGGCAGTTGCG
GCAAGCCTGA

Upstream 100 bases:

>100_bases
ACCACCCCGGGCGGGCCTTGGCAATGGTGGTTTGGAGCGAATCCGGCAATTTCAAGCCGCTACAAAGCGGCGCGCCAACA
GCCCACCGGGTAAATAATTC

Downstream 100 bases:

>100_bases
GAGCGCCTTTCTGCCTTGCCGCGCCGCCCGGGCTACGATCAGAAGAGTAGCCTGGCACAGTCATCTGGCAAGGGCTACAG
GCCAATTTGATACTTACTGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MAAAKVWHNLAMTLHASNFAPFPLGRPRRLRRDSFTRNLVRENVLSAHDLIYPVFVTDGSQRREAVASMPGVERLSLDLL
LPVAEECVKLGIPVMALFPVIDGSLKTPDGREALNPEGLVPRVVRELKKRFPELGVMTDVALDPFTSHGQDGLPDPTGYI
LNDETIEVLVGQALTQAEAGVDIVAPSDMMDGRIGAIRQALEGKKLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKAD
KKVYQMDPGNSDEALREVAMDIAEGADMVMVKPGMPYLDVVRRVKDEFQVPTFAYQVSGEYAMLKAAAQNGWLDHDAVMM
ESLLAFKRAGADGVLTYFAIDAARQLRQA

Sequences:

>Translated_349_residues
MAAAKVWHNLAMTLHASNFAPFPLGRPRRLRRDSFTRNLVRENVLSAHDLIYPVFVTDGSQRREAVASMPGVERLSLDLL
LPVAEECVKLGIPVMALFPVIDGSLKTPDGREALNPEGLVPRVVRELKKRFPELGVMTDVALDPFTSHGQDGLPDPTGYI
LNDETIEVLVGQALTQAEAGVDIVAPSDMMDGRIGAIRQALEGKKLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKAD
KKVYQMDPGNSDEALREVAMDIAEGADMVMVKPGMPYLDVVRRVKDEFQVPTFAYQVSGEYAMLKAAAQNGWLDHDAVMM
ESLLAFKRAGADGVLTYFAIDAARQLRQA
>Mature_348_residues
AAAKVWHNLAMTLHASNFAPFPLGRPRRLRRDSFTRNLVRENVLSAHDLIYPVFVTDGSQRREAVASMPGVERLSLDLLL
PVAEECVKLGIPVMALFPVIDGSLKTPDGREALNPEGLVPRVVRELKKRFPELGVMTDVALDPFTSHGQDGLPDPTGYIL
NDETIEVLVGQALTQAEAGVDIVAPSDMMDGRIGAIRQALEGKKLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKADK
KVYQMDPGNSDEALREVAMDIAEGADMVMVKPGMPYLDVVRRVKDEFQVPTFAYQVSGEYAMLKAAAQNGWLDHDAVMME
SLLAFKRAGADGVLTYFAIDAARQLRQA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=43.8311688311688, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI87081728, Length=322, Percent_Identity=45.0310559006211, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=38.4364820846906, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21358291, Length=295, Percent_Identity=42.0338983050847, Blast_Score=234, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 38160; Mature: 38029

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAKVWHNLAMTLHASNFAPFPLGRPRRLRRDSFTRNLVRENVLSAHDLIYPVFVTDGS
CCHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCH
QRREAVASMPGVERLSLDLLLPVAEECVKLGIPVMALFPVIDGSLKTPDGREALNPEGLV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCH
PRVVRELKKRFPELGVMTDVALDPFTSHGQDGLPDPTGYILNDETIEVLVGQALTQAEAG
HHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCC
VDIVAPSDMMDGRIGAIRQALEGKKLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKAD
EEEECCCHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KKVYQMDPGNSDEALREVAMDIAEGADMVMVKPGMPYLDVVRRVKDEFQVPTFAYQVSGE
CEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCC
YAMLKAAAQNGWLDHDAVMMESLLAFKRAGADGVLTYFAIDAARQLRQA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAAKVWHNLAMTLHASNFAPFPLGRPRRLRRDSFTRNLVRENVLSAHDLIYPVFVTDGS
CHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCH
QRREAVASMPGVERLSLDLLLPVAEECVKLGIPVMALFPVIDGSLKTPDGREALNPEGLV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCH
PRVVRELKKRFPELGVMTDVALDPFTSHGQDGLPDPTGYILNDETIEVLVGQALTQAEAG
HHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCC
VDIVAPSDMMDGRIGAIRQALEGKKLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKAD
EEEECCCHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KKVYQMDPGNSDEALREVAMDIAEGADMVMVKPGMPYLDVVRRVKDEFQVPTFAYQVSGE
CEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCC
YAMLKAAAQNGWLDHDAVMMESLLAFKRAGADGVLTYFAIDAARQLRQA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]