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The map label for this gene is ghrA [H]

Identifier: 91785966

GI number: 91785966

Start: 54049

End: 54975

Strand: Reverse

Name: ghrA [H]

Synonym: Bpro_0053

Alternate gene names: 91785966

Gene position: 54975-54049 (Counterclockwise)

Preceding gene: 91785967

Following gene: 91785965

Centisome position: 1.06

GC content: 65.16

Gene sequence:

>927_bases
ATGACATTTCTATATAAAGCCGATCCCGAGCGCGGCGCCGTATGGCGCCAGTTGTTTGCCCAAAAAGCGCCGCAGCGCGA
GTTCCGTATCTGGCCCGATATCGGCGACCCCGAAAGAGTCCGCTTCCTGGCAGCCTGGGAACCGCCCAAAGACATTGAAA
AAACCTTCCCGAATCTCGAGGTGCTGTTTTCCATAGGCGCCGGTGTGGACCAGTTCGACCTGTCCGTGCTGCCGCCCGAA
TTGCCGGTGGTGCGCATGGTCGAGCCGGGTCTGGTCCATGGCATGGTCGAATACGCCTGCTTCGCGGTGCTGGGGCTGCA
CCGCAACATACCGCTTTACCAGCGCCAGCAGCGCGCGGCCCGCTGGCAGGCGCTGCCGGTCATGCCGGCCGCCGAGCGGC
GCGTCGGCGTGCTGGGCCTGGGCAGCCTGGGCCAGGCCGTGCTGGCCCAGTTGCGTACCTTTGGTTTTGACTGCGCGGGC
TGGAGCCGGTCGCAACACCATGTCGAAGGCGTGCAGTGTTTTGCCGGCCAGGACTCGCTGCCCGATTTTCTGGCGCGCAC
CGACATACTGATATGCCTGCTGCCTTTGACGCCCGAGACGCGCGGCATGCTCAATCACCGGATTTTTGCCGGCCTGCCGC
AGGGCGCCGCGCTGGTGCACGTGGGCCGTGGCCAGCACCTCGTCACCGACGATCTGCTGGGCGCGCTGGCCAGCGGCCAG
CTCAGCGAAGCGGTGATCGATGTCTGCGACCCCGAACCGCCACCAGCCGGCCATCCGTTCTGGCAACACCCCAACATCTG
GCTCACGCCGCATATCGGCAGCATGACCCAGCCTGAAAGCGCGGTCGATGTGATGCTGGACAACCTGCGACGCTACGAAG
CCGGCGAGACCATGACCGGGCTGGTGAACCGCACGCGCGGTTACTAA

Upstream 100 bases:

>100_bases
GTGCGCGGGCCGGCCTTGCAGCGCGATGCCGATGTGCGTTTATTCGCGCTGGCCGGCCAGGCTCTGGGTTAATTTGAATC
CATGAGGCTGGAAGTCCGAG

Downstream 100 bases:

>100_bases
AAACTAAAACGCGCGCCGCACGATCTGCTGCCAGTGCTTTCACAACAGCAGGCTGCTTCACCGCAAGCACCCAAAGCAGC
AGCAGTCACCAGCGATTGCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTFLYKADPERGAVWRQLFAQKAPQREFRIWPDIGDPERVRFLAAWEPPKDIEKTFPNLEVLFSIGAGVDQFDLSVLPPE
LPVVRMVEPGLVHGMVEYACFAVLGLHRNIPLYQRQQRAARWQALPVMPAAERRVGVLGLGSLGQAVLAQLRTFGFDCAG
WSRSQHHVEGVQCFAGQDSLPDFLARTDILICLLPLTPETRGMLNHRIFAGLPQGAALVHVGRGQHLVTDDLLGALASGQ
LSEAVIDVCDPEPPPAGHPFWQHPNIWLTPHIGSMTQPESAVDVMLDNLRRYEAGETMTGLVNRTRGY

Sequences:

>Translated_308_residues
MTFLYKADPERGAVWRQLFAQKAPQREFRIWPDIGDPERVRFLAAWEPPKDIEKTFPNLEVLFSIGAGVDQFDLSVLPPE
LPVVRMVEPGLVHGMVEYACFAVLGLHRNIPLYQRQQRAARWQALPVMPAAERRVGVLGLGSLGQAVLAQLRTFGFDCAG
WSRSQHHVEGVQCFAGQDSLPDFLARTDILICLLPLTPETRGMLNHRIFAGLPQGAALVHVGRGQHLVTDDLLGALASGQ
LSEAVIDVCDPEPPPAGHPFWQHPNIWLTPHIGSMTQPESAVDVMLDNLRRYEAGETMTGLVNRTRGY
>Mature_307_residues
TFLYKADPERGAVWRQLFAQKAPQREFRIWPDIGDPERVRFLAAWEPPKDIEKTFPNLEVLFSIGAGVDQFDLSVLPPEL
PVVRMVEPGLVHGMVEYACFAVLGLHRNIPLYQRQQRAARWQALPVMPAAERRVGVLGLGSLGQAVLAQLRTFGFDCAGW
SRSQHHVEGVQCFAGQDSLPDFLARTDILICLLPLTPETRGMLNHRIFAGLPQGAALVHVGRGQHLVTDDLLGALASGQL
SEAVIDVCDPEPPPAGHPFWQHPNIWLTPHIGSMTQPESAVDVMLDNLRRYEAGETMTGLVNRTRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=226, Percent_Identity=29.646017699115, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI23308577, Length=282, Percent_Identity=27.3049645390071, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI145580578, Length=271, Percent_Identity=26.9372693726937, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4557499, Length=271, Percent_Identity=26.9372693726937, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4557497, Length=235, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI61743967, Length=235, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI145580575, Length=273, Percent_Identity=26.7399267399267, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081824, Length=300, Percent_Identity=38, Blast_Score=208, Evalue=4e-55,
Organism=Escherichia coli, GI87082289, Length=252, Percent_Identity=28.1746031746032, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=254, Percent_Identity=26.7716535433071, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=262, Percent_Identity=26.7175572519084, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=225, Percent_Identity=26.2222222222222, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28574286, Length=171, Percent_Identity=35.672514619883, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574284, Length=171, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585514, Length=171, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28574282, Length=171, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45552429, Length=168, Percent_Identity=33.9285714285714, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45551003, Length=168, Percent_Identity=33.9285714285714, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921140, Length=242, Percent_Identity=26.4462809917355, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585516, Length=143, Percent_Identity=32.1678321678322, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571528, Length=142, Percent_Identity=30.2816901408451, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34204; Mature: 34073

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLYKADPERGAVWRQLFAQKAPQREFRIWPDIGDPERVRFLAAWEPPKDIEKTFPNLE
CCEEEECCCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHEEEEEECCCCHHHHHHCCCCE
VLFSIGAGVDQFDLSVLPPELPVVRMVEPGLVHGMVEYACFAVLGLHRNIPLYQRQQRAA
EEEECCCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RWQALPVMPAAERRVGVLGLGSLGQAVLAQLRTFGFDCAGWSRSQHHVEGVQCFAGQDSL
HHHCCCCCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCEEEECCCCCC
PDFLARTDILICLLPLTPETRGMLNHRIFAGLPQGAALVHVGRGQHLVTDDLLGALASGQ
HHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHCCH
LSEAVIDVCDPEPPPAGHPFWQHPNIWLTPHIGSMTQPESAVDVMLDNLRRYEAGETMTG
HHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
LVNRTRGY
HHHHCCCC
>Mature Secondary Structure 
TFLYKADPERGAVWRQLFAQKAPQREFRIWPDIGDPERVRFLAAWEPPKDIEKTFPNLE
CEEEECCCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHEEEEEECCCCHHHHHHCCCCE
VLFSIGAGVDQFDLSVLPPELPVVRMVEPGLVHGMVEYACFAVLGLHRNIPLYQRQQRAA
EEEECCCCCCCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RWQALPVMPAAERRVGVLGLGSLGQAVLAQLRTFGFDCAGWSRSQHHVEGVQCFAGQDSL
HHHCCCCCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCEEEECCCCCC
PDFLARTDILICLLPLTPETRGMLNHRIFAGLPQGAALVHVGRGQHLVTDDLLGALASGQ
HHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHCCH
LSEAVIDVCDPEPPPAGHPFWQHPNIWLTPHIGSMTQPESAVDVMLDNLRRYEAGETMTG
HHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHH
LVNRTRGY
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA