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The map label for this gene is polC [H]

Identifier: 91785922

GI number: 91785922

Start: 9806

End: 10417

Strand: Direct

Name: polC [H]

Synonym: Bpro_0009

Alternate gene names: 91785922

Gene position: 9806-10417 (Clockwise)

Preceding gene: 91785921

Following gene: 91785923

Centisome position: 0.19

GC content: 67.48

Gene sequence:

>612_bases
GTGAAACCCATTGCTGTCATCGACTTCGAAACCACGGGCCTGTCGCCGGCCATGGGCGACCGCGCCACCGAGGTGGCCAT
CGTGCTGGTGGAGGGCGGCCGGGTGGTGGACCGCTTTCAGAGCCTGATGAACGCGGGGGTGCGCATCCCGGCCTTCATCA
CCAGCCTGACGGGCATCACCAATGCGATGGTGGCCTCCGCGCCCGATGCCGCGACCGTCATGACTGACGCCAACCGCTTT
GTGGGCAACGCGCCGCTGGTGGCGCACAACGCCTCGTTTGACCGCAAGTTCTGGGAGGCCGAGCTAAGCCGTGCAGGGGA
GAGGGCGAGCCAGCCGTTTGCCTGCACCATGCTGGTGTCCAGGAGGCTCTACCCCCAGGCGCCTAGCCATAAACTGGGCG
TGCTGGTCGATTACCACCACTTGCCTAAAGCGGGCCGCGCCCACCGGGCACTGGCCGATGCGGAAATGGCGGCGTCGCTG
CTGGGCCAGATTCAGCATGACCTGCGTAGCCGCCACGGCGTGGACCGACCCGACCATGCCCTGCTGATGGCCTTGCAGCG
CTGCGCCAAGCCGGCGGTGCGCGCGCTGATGGCGCAATACACCGGCGCGTGA

Upstream 100 bases:

>100_bases
GCCATCACGATGGCGGTGGGTTTGGTGGCCTGGGCCGGGTTTGCGTTCTGGGCCCACGGCGTGCTGATCGGCGTGCGGCC
GCTGGGCTGATGGCGGCTTT

Downstream 100 bases:

>100_bases
ACCGGGGCGTGTTGACGGTGTCTTATGGCGCGGGTCACTGGCACATTCATTTTTCCCCCTTGTCTTCTTGTCGTGTCTTC
ACTCGCGGCGCTGTCTGACA

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MKPIAVIDFETTGLSPAMGDRATEVAIVLVEGGRVVDRFQSLMNAGVRIPAFITSLTGITNAMVASAPDAATVMTDANRF
VGNAPLVAHNASFDRKFWEAELSRAGERASQPFACTMLVSRRLYPQAPSHKLGVLVDYHHLPKAGRAHRALADAEMAASL
LGQIQHDLRSRHGVDRPDHALLMALQRCAKPAVRALMAQYTGA

Sequences:

>Translated_203_residues
MKPIAVIDFETTGLSPAMGDRATEVAIVLVEGGRVVDRFQSLMNAGVRIPAFITSLTGITNAMVASAPDAATVMTDANRF
VGNAPLVAHNASFDRKFWEAELSRAGERASQPFACTMLVSRRLYPQAPSHKLGVLVDYHHLPKAGRAHRALADAEMAASL
LGQIQHDLRSRHGVDRPDHALLMALQRCAKPAVRALMAQYTGA
>Mature_203_residues
MKPIAVIDFETTGLSPAMGDRATEVAIVLVEGGRVVDRFQSLMNAGVRIPAFITSLTGITNAMVASAPDAATVMTDANRF
VGNAPLVAHNASFDRKFWEAELSRAGERASQPFACTMLVSRRLYPQAPSHKLGVLVDYHHLPKAGRAHRALADAEMAASL
LGQIQHDLRSRHGVDRPDHALLMALQRCAKPAVRALMAQYTGA

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 21865; Mature: 21865

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIAVIDFETTGLSPAMGDRATEVAIVLVEGGRVVDRFQSLMNAGVRIPAFITSLTGIT
CCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHH
NAMVASAPDAATVMTDANRFVGNAPLVAHNASFDRKFWEAELSRAGERASQPFACTMLVS
HHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RRLYPQAPSHKLGVLVDYHHLPKAGRAHRALADAEMAASLLGQIQHDLRSRHGVDRPDHA
HHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLMALQRCAKPAVRALMAQYTGA
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPIAVIDFETTGLSPAMGDRATEVAIVLVEGGRVVDRFQSLMNAGVRIPAFITSLTGIT
CCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHH
NAMVASAPDAATVMTDANRFVGNAPLVAHNASFDRKFWEAELSRAGERASQPFACTMLVS
HHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RRLYPQAPSHKLGVLVDYHHLPKAGRAHRALADAEMAASLLGQIQHDLRSRHGVDRPDHA
HHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLMALQRCAKPAVRALMAQYTGA
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]